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1. 发明申请

US20070244053A1 Use of a CD40:CD154 binding interruptor to prevent counter-adaptive immune responses, particularly graft rejection 审中-公开
标题翻译：使用CD40：CD154结合阻断剂来防止反适应性免疫反应，特别是移植排斥反应
公开(公告)号：US20070244053A1
公开(公告)日：2007-10-18
申请号：US11638218
申请日：2006-12-12
申请人： Allan Kirk , David Harlan , David Thomas , Michael Kauffman , Linda Burkly
发明人： Allan Kirk , David Harlan , David Thomas , Michael Kauffman , Linda Burkly
IPC分类号： A61K39/395 , A61K38/00 , C07K14/705 , C07K16/28 , A61K38/17
CPC分类号： A61K38/13 , A61K31/00 , A61K31/445 , A61K31/57 , A61K38/17 , A61K39/395 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/545 , C07K14/70521 , C07K16/2875 , C07K2317/24 , A61K2300/00
摘要： Compositions and methods disclosed herein capitalize on the discovery that rejection of a tissue graft can be inhibited using a CD40:CD154 binding interrupter, either alone or in combination with another immunomodulator or immunosuppressor. An advantageous, synergistic combination includes a CD40:CD154 binding interrupter and a CD28 signaling interrupter. An exemplary CD40:CD154 binding interrupter is an anti-CD154 monoclonal antibody, such as an antibody having the antigen-specific binding characteristics of the 5c8 monoclonal antibody. An exemplary CD28 signaling interrupter is a CTLA4-Ig fusion protein. The disclosed compositions and methods unexpectedly can be used to prolong survival of grafted tissue in a recipient host, to reverse acute graft rejection, and to attenuate immunological consequences of the failure of grafted tissue.
摘要翻译：本文中公开的组合物和方法利用CD40：CD154结合中断器单独或与另一种免疫调节剂或免疫抑制剂组合来抑制组织移植物的排斥的发现。有利的协同组合包括CD40：CD154结合中断和CD28信号传导中断。示例性CD40：CD154结合中断剂是抗CD154单克隆抗体，例如具有5c8单克隆抗体的抗原特异性结合特征的抗体。示例性的CD28信号传导中断是CTLA4-Ig融合蛋白。所公开的组合物和方法意外地可以用于延长受体宿主中移植组织的存活，逆转急性移植物排斥反应，并减轻移植组织失败的免疫学后果。

2. 发明申请

US20150018332A1 Nuclear Transport Modulators and Uses Thereof 有权
标题翻译：核运输调制器及其用途
公开(公告)号：US20150018332A1
公开(公告)日：2015-01-15
申请号：US14235342
申请日：2012-07-26
申请人： Vincent P. Sandanayaka , Sharon Shacham , Michael Kauffman , Sharon Shechter , Dilara McCauley , Yosef Landesman , William Senapedis , Jean-Richard Saint-Martin
发明人： Vincent P. Sandanayaka , Sharon Shacham , Michael Kauffman , Sharon Shechter , Dilara McCauley , Yosef Landesman , William Senapedis , Jean-Richard Saint-Martin
IPC分类号： C07D403/06 , C07D401/14 , C07D487/10 , C07D413/12 , C07D403/12 , C07D401/06 , C07D401/12
CPC分类号： C07D487/10 , C07D213/50 , C07D401/06 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12
摘要： The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
摘要翻译：本发明通常涉及核转运调节剂，例如CRM1抑制剂，更具体地涉及由式（I）表示的化合物或其药学上可接受的盐，其中变量如本文所定义和描述。本发明还包括结构式（I）化合物或其药学上可接受的盐或组合物的合成和用途，例如用于治疗，调节和/或预防与CRM1活性相关的生理条件。

3. 发明申请

US20050013310A1 Apparatus and method for unilateral topology discovery in network management 有权
标题翻译：网络管理中单向拓扑发现的装置和方法
公开(公告)号：US20050013310A1
公开(公告)日：2005-01-20
申请号：US10916597
申请日：2004-08-12
申请人： Kim Banker , Christopher Del Signore , Gavin Bowlby , Richard Feldman , Farivar Farzaneh , Michael Kauffman
发明人： Kim Banker , Christopher Del Signore , Gavin Bowlby , Richard Feldman , Farivar Farzaneh , Michael Kauffman
IPC分类号： H04L12/24 , H04L12/56 , H04L25/49 , H04L12/28
CPC分类号： H04L45/02 , H04L25/4908 , H04L41/0213 , H04L41/046 , H04L41/12 , H04L45/04
摘要： A system for reducing the cost of network managment by using a proxy agent and subchannel communications so fewer SNMP licenses and fewer protocol stacks are needed. Subchannel communication is achieved in a plurality of different embodiments. Embodiments having single subchannel transceivers, multiple transceivers, single multiplexer and multiple multiplexers are disclosed. An NMS process using routing table CRC to automatically detect when the NMS topology information is incorrect and automated topology discovery is disclosed. A process for automated discovery of redundant cables during automated topology discovery is disclosed.
摘要翻译：通过使用代理代理和子通道通信来降低网络管理成本的系统，因此需要更少的SNMP许可证和更少的协议栈。在多个不同的实施例中实现子信道通信。公开了具有单个子信道收发机，多个收发器，单个多路复用器和多个多路复用器的实施例。使用路由表CRC自动检测NMS拓扑信息何时不正确并自动拓扑发现的NMS过程。公开了在自动拓扑发现期间自动发现冗余电缆的过程。

4. 发明申请

US20100289594A1 MODULATOR DRIVER CIRCUIT HAVING CHIRPED COMPONENTS 有权
标题翻译：具有CHIREED组件的调制器驱动电路
公开(公告)号：US20100289594A1
公开(公告)日：2010-11-18
申请号：US12465607
申请日：2009-05-13
申请人： Jeffrey S. Bostak , Vincent G. Dominic , Parmijit Samra , Michael Kauffman
发明人： Jeffrey S. Bostak , Vincent G. Dominic , Parmijit Samra , Michael Kauffman
IPC分类号： H03C1/00 , G02F1/00
CPC分类号： G02F1/0327 , H03C1/34
摘要： Embodiments of the present invention provide arrays of electrical circuits having one or more chirped elements or components for providing output signals to corresponding arrays of electro-optic devices. Certain embodiments of the present invention include a plurality of modulator driver circuits, each of the plurality of driver circuits configured to be substantially identical to each other and provide a corresponding one of a plurality of modulator drive signals to a respective one of a plurality of electro-optic modulators, each of the plurality of modulator driver circuits being chirped to provide a desired output to the corresponding electro-optic modulator for enhanced operation. Each of the plurality of modulator driver circuits comprises a plurality of electrical components, at least one of the electrical components being chirped such that a design or operating parameter of the electrical component differs from an electrical component having a similar function in at least one of the remaining modulator driver circuits of the plurality of driver circuit. In certain embodiments, each of the plurality of modulator driver circuits is provided on a common substrate.
摘要翻译：本发明的实施例提供了具有一个或多个啁啾元件或部件的电路阵列，用于向相应的电光器件阵列提供输出信号。本发明的某些实施例包括多个调制器驱动器电路，多个驱动电路中的每一个被配置为彼此基本相同，并且将多个调制器驱动信号中的相应一个调制器驱动信号提供给多个电子多个调制器驱动器电路中的每个调制器驱动器电路被啁啾以向相应的电光调制器提供期望的输出以增强操作。多个调制器驱动器电路中的每一个包括多个电气部件，电气部件中的至少一个被啁啾，使得电气部件的设计或操作参数与具有类似功能的电气部件的不同之处在于至少一个多个驱动电路的剩余调制器驱动电路。在某些实施例中，多个调制器驱动电路中的每一个设置在公共基板上。

5. 发明申请

US20120141124A1 INTERCONNECTION SYSTEM AND METHOD 有权
标题翻译：互连系统与方法
公开(公告)号：US20120141124A1
公开(公告)日：2012-06-07
申请号：US12960566
申请日：2010-12-06
申请人： Brad T. Darnell , Michael Kauffman , David K. Wong
发明人： Brad T. Darnell , Michael Kauffman , David K. Wong
IPC分类号： H04B10/12
CPC分类号： H04L49/40 , H04L49/351
摘要： The present disclosure provides a system, apparatus and method to transport data across a network node, as part of a network infrastructure of an optical transmission system. According to the various embodiments of the disclosure, a base architecture is provided which includes interconnectivity providing high throughput, while mitigating factors which may lead to signal loss or signal degradation. The base architecture is easily expandable to accommodate additional traffic.
摘要翻译：本公开提供了作为光传输系统的网络基础设施的一部分通过网络节点传输数据的系统，装置和方法。根据本公开的各种实施例，提供了基础架构，其包括提供高吞吐量的互连性，同时减轻可能导致信号丢失或信号劣化的因素。基础架构易于扩展，以适应额外的流量。

6. 发明授权

US07848369B1 Optical modulator drive circuit with integrated low power output bias voltage control 有权
标题翻译：光调制器驱动电路具有集成的低功耗输出偏置电压控制
公开(公告)号：US07848369B1
公开(公告)日：2010-12-07
申请号：US12343356
申请日：2008-12-23
申请人： Jeffrey S. Bostak , Ting-Kuang Chiang , Michael Kauffman
发明人： Jeffrey S. Bostak , Ting-Kuang Chiang , Michael Kauffman
IPC分类号： H01S3/10
CPC分类号： G02F1/0121 , G02F2203/20
摘要： A modulator drive circuit provides a modulator drive signal to modulate an optical signal for transport across a network infrastructure. The modulator drive circuit powered by an adjustable voltage source, such that the modulator drive signal is generated from a data signal and the adjustable voltage source, an AC component of the modulator drive signal being derived from the data signal while a DC component of the modulator drive signal being derived from the adjustable voltage source. An array of such modulator drive circuits are provided on a single substrate.
摘要翻译：调制器驱动电路提供调制器驱动信号以调制用于跨网络基础设施传输的光信号。调制器驱动电路由可调电压源供电，使得调制器驱动信号由数据信号和可调电压源产生，调制器驱动信号的AC分量从数据信号导出，而调制器的DC分量驱动信号源自可调电压源。这种调制器驱动电路的阵列设置在单个基板上。

7. 发明申请

US20090196615A1 DISPERSION MAPPING OF TRANSMITTED CHANNELS IN A WDM SYSTEM 有权
标题翻译： WDM系统中传输通道的分布映射
公开(公告)号：US20090196615A1
公开(公告)日：2009-08-06
申请号：US12025115
申请日：2008-02-04
申请人： Michael Kauffman
发明人： Michael Kauffman
IPC分类号： H04J14/02
CPC分类号： H04J14/02 , H04B10/07951
摘要： Chromatic dispersion is determined based on the arrival times of different frames of data in a wavelength division multiplexed (WDM) system having an optical communication link. Namely, a first frame is transmitted on a first optical channel, which is supplied to the optical communication link. A second frame is then transmitted on a second optical channel and the transmission time difference between the two frames is obtained. At a receive end, the difference in arrival times of the two frames is measured to obtain a relative time delay between the first and second frames. The relative time delay is the sum of the transmission time difference and the propagation time difference (the time difference attributable to chromatic dispersion) between the two frames. Thus, by subtracting the transmission time difference from the relative time delay, the propagation time difference can be obtained. The chromatic dispersion in units of picoseconds/nm can be obtained by dividing the propagation time difference by the difference in wavelength between the first and second optical channels.
摘要翻译：基于具有光通信链路的波分复用（WDM）系统中的不同数据帧的到达时间来确定色散。也就是说，在提供给光通信链路的第一光信道上发送第一帧。然后在第二光信道上发送第二帧，并且获得两帧之间的传输时间差。在接收端，测量两帧的到达时间差，以获得第一和第二帧之间的相对时间延迟。相对时间延迟是两帧之间的传输时间差和传播时间差（归因于色散的时间差）之和。因此，通过从相对时间延迟减去传输时间差，可以获得传播时间差。通过将传播时间差除以第一和第二光学通道之间的波长差，可以获得以皮秒/ nm为单位的色散。

8. 发明授权

US08513230B2 Nuclear transport modulators and uses thereof 有权
标题翻译：核运输调节剂及其用途
公开(公告)号：US08513230B2
公开(公告)日：2013-08-20
申请号：US13041377
申请日：2011-03-05
申请人： Sharon Shacham , Michael Kauffman , Vincent P. Sandanayaka , Sharon Shechter
发明人： Sharon Shacham , Michael Kauffman , Vincent P. Sandanayaka , Sharon Shechter
IPC分类号： A61K31/4245 , A61P9/10 , C07D413/06 , C07D413/14
CPC分类号： C07D409/04 , A61K31/4196 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/505 , C07D207/337 , C07D231/12 , C07D233/64 , C07D249/08 , C07D257/04 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/04 , C07D417/12
摘要： The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity such as in treating cancer and other neoplastic disorders, inflammatory diseases, disorders of abnormal tissue growth and fibrosis including cardiomyopathy, pulmonary fibrosis, hepatic fibrosis, glomerulonephritis, and other renal disorders, and for the treatment of viral infections (both acute and chronic).
摘要翻译：本发明一般涉及核转运调节剂领域，例如CRM1抑制剂，更具体地涉及新的取代杂环唑化合物，这些化合物及其药物组合物的合成和用途，例如在治疗，调节和/或预防与CRM1活性相关的生理条件，例如治疗癌症和其它肿瘤性疾病，炎症性疾病，异常组织生长障碍和纤维化，包括心肌病，肺纤维化，肝纤维化，肾小球性肾炎和其他肾脏疾病，以及用于治疗病毒感染（急性和慢性）。

9. 发明授权

US08253508B2 Modulator driver circuit having chirped components 有权
标题翻译：具有啁啾组件的调制器驱动电路
公开(公告)号：US08253508B2
公开(公告)日：2012-08-28
申请号：US12465607
申请日：2009-05-13
申请人： Jeffrey S. Bostak , Vincent G. Dominic , Parmijit Samra , Michael Kauffman
发明人： Jeffrey S. Bostak , Vincent G. Dominic , Parmijit Samra , Michael Kauffman
IPC分类号： H03C1/08
CPC分类号： G02F1/0327 , H03C1/34
摘要： Embodiments of the present invention provide arrays of electrical circuits having one or more chirped elements or components for providing output signals to corresponding arrays of electro-optic devices. Certain embodiments of the present invention include a plurality of modulator driver circuits, each of the plurality of driver circuits configured to be substantially identical to each other and provide a corresponding one of a plurality of modulator drive signals to a respective one of a plurality of electro-optic modulators, each of the plurality of modulator driver circuits being chirped to provide a desired output to the corresponding electro-optic modulator for enhanced operation. Each of the plurality of modulator driver circuits comprises a plurality of electrical components, at least one of the electrical components being chirped such that a design or operating parameter of the electrical component differs from an electrical component having a similar function in at least one of the remaining modulator driver circuits of the plurality of driver circuit. In certain embodiments, each of the plurality of modulator driver circuits is provided on a common substrate.
摘要翻译：本发明的实施例提供了具有一个或多个啁啾元件或部件的电路阵列，用于向相应的电光器件阵列提供输出信号。本发明的某些实施例包括多个调制器驱动器电路，多个驱动电路中的每一个被配置为彼此基本相同，并且将多个调制器驱动信号中的相应一个调制器驱动信号提供给多个电子多个调制器驱动器电路中的每个调制器驱动器电路被啁啾以向相应的电光调制器提供期望的输出以增强操作。多个调制器驱动器电路中的每一个包括多个电气部件，电气部件中的至少一个被啁啾化，使得电气部件的设计或操作参数与具有类似功能的电气部件在至少一个多个驱动电路的剩余调制器驱动电路。在某些实施例中，多个调制器驱动电路中的每一个设置在公共基板上。

10. 发明授权

US09428490B2 Nuclear transport modulators and uses thereof 有权
标题翻译：核运输调节剂及其用途
公开(公告)号：US09428490B2
公开(公告)日：2016-08-30
申请号：US14235342
申请日：2012-07-26
申请人： Vincent P. Sandanayaka , Sharon Shacham , Michael Kauffman , Sharon Shechter , Dilara McCauley , Yosef Landesman , William Senapedis , Jean-Richard Saint-Martin
发明人： Vincent P. Sandanayaka , Sharon Shacham , Michael Kauffman , Sharon Shechter , Dilara McCauley , Yosef Landesman , William Senapedis , Jean-Richard Saint-Martin
IPC分类号： C07D403/06 , C07D403/12 , C07D401/14 , C07D405/14 , C07D401/08 , C07D401/12 , C07D403/14 , C07D413/12 , C07D487/10 , C07D401/06
CPC分类号： C07D487/10 , C07D213/50 , C07D401/06 , C07D401/08 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12
摘要： The invention generally relates to nuclear transport modulators, e.g CRM1 inhibitors, and more particularly to a compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula (I), or a pharmaceutically acceptable salt or composition thereof, e.g, in the treatment, modulation and/or prevention of physiological conditions associated with CRM1 activity.
摘要翻译：本发明通常涉及核转运调节剂，例如CRM1抑制剂，更具体地涉及由式（I）表示的化合物或其药学上可接受的盐，其中变量如本文所定义和描述。本发明还包括结构式（I）化合物或其药学上可接受的盐或组合物的合成和用途，例如用于治疗，调节和/或预防与CRM1活性相关的生理条件。

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