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1. 发明申请

US20100105912A1 FLUORO-CONTAINING DERIVATIVES OF HYDROGENATED PYRIDO[4,3-b]INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE 审中-公开
标题翻译：具有神经保护和加强增强性能的氢化吡咯并[4,3-b]吲哚的含氟衍生物，制备和使用方法
公开(公告)号：US20100105912A1
公开(公告)日：2010-04-29
申请号：US12687854
申请日：2010-01-14
申请人： Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Vladimir Sokolov , Bogdan Beznosko
发明人： Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Vladimir Sokolov , Bogdan Beznosko
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.
摘要翻译：一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机制。

2. 发明申请

US20100056790A1 FLUORO-CONTAINING DERIVATIVES OF HYDROGENATED PYRIDO[4,3-B]INDOLES WITH NEUROPROTECTIVE AND COGNITION ENHANCING PROPERTIES, PROCESS FOR PREPARING, AND USE 有权
标题翻译：具有神经保护和加强增强性能的氢化吡咯并[4,3-B]吲哚的含氟衍生物，制备和使用方法
公开(公告)号：US20100056790A1
公开(公告)日：2010-03-04
申请号：US12621464
申请日：2009-11-18
申请人： Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Nadezhda Beznosko , Vladimir Sokolov
发明人： Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Nadezhda Beznosko , Vladimir Sokolov
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.
摘要翻译：一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机制。

3. 发明授权

US07935823B2 Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use 有权
标题翻译：具有神经保护和认知增强性质的氢化吡啶并[4,3-b]吲哚的含氟衍生物，制备和使用方法
公开(公告)号：US07935823B2
公开(公告)日：2011-05-03
申请号：US12621464
申请日：2009-11-18
申请人： Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Nadezhda Beznosko, legal representative , Julia Beznosko, legal representative , Vladimir Sokolov
发明人： Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Vladimir Sokolov
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.
摘要翻译：一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机制。

4. 发明申请

US20090221627A1 Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use 审中-公开
标题翻译：具有神经保护和认知增强性质的氢化吡啶并[4,3-b]吲哚的含氟衍生物，制备和使用方法
公开(公告)号：US20090221627A1
公开(公告)日：2009-09-03
申请号：US12284291
申请日：2008-09-19
申请人： Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Vladimir Sokolov , Nadezhcla Besnosko , Julia Beznosko
发明人： Alexey Aksinenko , Sergey Bachurin , Sergey Sablin , Bogdan Beznosko , Vladimir Sokolov , Nadezhcla Besnosko , Julia Beznosko
IPC分类号： A61K31/437 , A61K31/4353 , A61K31/13 , C07D471/04
CPC分类号： C07D471/04
摘要： Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.
摘要翻译：一些示例性实施方案包括吡啶并[4,3-b]吲哚的含氟衍生物（和其制备方法），其可以有效量施用于哺乳动物（包括人）用于治疗或预防神经系统疾病，包括AD，轻度认知障碍，老年和血管性痴呆，HD，ALS，帕金森病，艾滋病相关性痴呆，缺血性脑病，神经性疼痛，ADHD（注意缺陷障碍/多动症综合征），进食障碍如厌食贪食症，恐慌症，药物滥用如可卡因，乙醇，尼古丁和苯并二氮杂类药物，精神分裂症（特别是精神分裂症的认知缺陷），中风以及与脊髓损伤和/或头部损伤有关的疾病。这些衍生物也可用于治疗边缘人格障碍，肥胖症和用作胃保护剂。该化合物也可以用作“药理学工具”，用于研究在体内或体外对神经变性疾病的保护机制。

5. 发明授权

US08855499B2 Power recapture in an optical communications system 有权
标题翻译：光通信系统中的电源重新捕获
公开(公告)号：US08855499B2
公开(公告)日：2014-10-07
申请号：US13522520
申请日：2011-01-21
申请人： Vladimir Sokolov , James N. Kruchowski , Mark A. Nelson , Nathan E. Harff
发明人： Vladimir Sokolov , James N. Kruchowski , Mark A. Nelson , Nathan E. Harff
IPC分类号： H04B10/80 , H04J14/02
CPC分类号： H04J14/02 , H04B10/807
摘要： In an n-node optical communications system, energy harvesting photodetectors at each node receive extraneous electromagnetic wavelengths that are not used for communication or other purposes by the associated node. The energy harvesting photodetectors convert the unused electromagnetic energy into reusable electrical energy. The harvested electrical energy may be used as auxiliary power at the node or elsewhere in the communication system, or stored in a battery, capacitor, or other energy storage device. The system may be used in an “all-to-all” broadcast and select communication scheme or in some other broadcast and select interconnect system that has extraneous wavelengths at node receivers.
摘要翻译：在n节点光通信系统中，每个节点处的能量采集光电检测器接收不被关联节点用于通信或其他目的的外部电磁波长。能量收集光电探测器将未使用的电磁能转化为可重复使用的电能。收集的电能可以用作在通信系统中的节点处或其他地方的辅助电力，或者存储在电池，电容器或其他储能装置中。该系统可以用于“全对所有”广播和选择通信方案，或者在某些其他广播和选择在节点接收机处具有无关波长的互连系统。

6. 发明授权

US6060962A Phase angle modulator for microwaves 有权
标题翻译：微波相位调制器
公开(公告)号：US6060962A
公开(公告)日：2000-05-09
申请号：US167442
申请日：1998-10-06
申请人： Vladimir Sokolov , Robert M. Dwarkin
发明人： Vladimir Sokolov , Robert M. Dwarkin
IPC分类号： H01P1/185 , H03H7/20
CPC分类号： H01P1/185
摘要： An analog phase modulator is provided for linearly phase modulating a high carrier frequency input signal in proportion to an applied bias signal. A first variable reactance network, including at least a pair of variable reactance devices separated by an approximately 1/4 wave length transmission line segment, is capacitively coupled to an in-phase port of a power divider network, and a second identical variable reactance network is capacitively coupled to a quadrature phase shifted port of the power divider network. A bias source signal is applied to each of the first and second variable reactance networks through identical bias filters, each including a high impedance transmission line segment serially connected between the bias source and the variable reactance network, and a low impedance transmission line segment shunt segment at the juncture of the high impedance transmission line segment and the bias source input port.
摘要翻译：提供模拟相位调制器用于与施加的偏置信号成比例地线性相位调制高载波频率输入信号。包括至少一对可变电抗装置的第一可变电抗网络由大约+ E，fra 1/4 + EE波长传输线段分开，电容耦合到功率分配器网络的同相端口，以及第二相同的可变电抗网络电容耦合到功率分配器网络的正交相移端口。通过相同的偏置滤波器将偏置源信号施加到第一和第二可变电抗网络中的每一个，每个偏置滤波器包括串联连接在偏置源和可变电抗网络之间的高阻抗传输线段，以及低阻抗传输线段分路段在高阻抗传输线段和偏置源输入端口的接合处。

7. 发明授权

US5929644A Non-destructive method and apparatus for monitoring a selected semiconductor characteristic of a semiconductor sample during fabrication 失效
标题翻译：用于在制造期间监测半导体样品的选定半导体特性的非破坏性方法和装置
公开(公告)号：US5929644A
公开(公告)日：1999-07-27
申请号：US794221
申请日：1997-01-30
申请人： Vladimir Sokolov
发明人： Vladimir Sokolov
IPC分类号： G01N22/00 , G01R27/02
CPC分类号： G01N22/00
摘要： A non-destructive and non-invasive method for monitoring a selected characteristic of a fabricated semiconductor sample while inside a fabrication chamber and during the fabrication process, where selected materials are deposited on a planar surface of a wafer substrate in a fabrication chamber, employs one or more viewports in the walls of the fabrication chamber. A focused electromagnetic wave is generated external to the fabrication chamber, and directed through a viewport to impinge upon a selected portion of the planar surface of the wafer substrate at an oblique incident angle relative to the planar surface of the wafer substrate. In turn, a reflected electromagnetic wave emanating from the planar surface of the wafer substrate is detected. A signal processor then determines a reflection coefficient as a function of a selected characteristic of the focused electromagnetic wave and the reflected electromagnetic wave.
摘要翻译：一种非破坏性和非侵入性的方法，用于在制造室内和制造过程期间监测所制造的半导体样品的选定特性，其中所选择的材料沉积在制造室中的晶片衬底的平坦表面上，采用一个或更多的视口在制造室的壁中。聚焦的电磁波在制造室的外部产生，并且被引导通过视口以相对于晶片衬底的平坦表面的倾斜入射角撞击在晶片衬底的平面表面的选定部分上。反过来，检测从晶片基板的平面发出的反射电磁波。然后，信号处理器根据所聚焦的电磁波和反射的电磁波的选定特性确定反射系数。

8. 发明申请

US20110274394A1 OPTICAL EDGE CONNECTOR 有权
标题翻译：光学边缘连接器
公开(公告)号：US20110274394A1
公开(公告)日：2011-11-10
申请号：US13143997
申请日：2010-01-15
申请人： James N. Kruchowski , Vladimir Sokolov , Mark A. Nelson
发明人： James N. Kruchowski , Vladimir Sokolov , Mark A. Nelson
IPC分类号： G02B6/38
CPC分类号： G02B6/3829 , G02B6/2804 , G02B6/3885
摘要： A connector assembly for optically coupling a first optical device mounted on a first substrate to a second optical device mounted on a second substrate, where the first and second substrates are orthogonally oriented to each other, is presented. The connector assembly includes two connectors. The first connector has an optical waveguide array. The optical waveguide array further includes multiple parallel optical waveguides that are continuously redirected by a mirror oriented at a 45 degree angle to the optical waveguides. Likewise, the second connector also has an optical waveguide array further include multiple parallel optical waveguides continuously redirected by a mirror oriented at a 45 degree angle to the optical waveguides. The first connector is oriented orthogonally to the second connector and the first and second connectors are optically welded together in a back-to-back configuration.
摘要翻译：一种用于将安装在第一基板上的第一光学装置光学耦合到安装在第二基板上的第二和第二基板彼此正交定向的第二基板的连接器组件。连接器组件包括两个连接器。第一连接器具有光波导阵列。光波导阵列还包括多个平行的光波导，其通过与光波导成45度角定向的反射镜连续重定向。类似地，第二连接器还具有光波导阵列，还包括通过以45度角定向的反射镜连续重定向到光波导的多个平行光波导。第一连接器定向为与第二连接器正交，并且第一和第二连接器以背对背配置光学焊接在一起。

9. 发明授权

US06384691B1 Millimeter wave low phase noise signal source module 有权
标题翻译：毫米波低相位噪声信号源模块
公开(公告)号：US06384691B1
公开(公告)日：2002-05-07
申请号：US09526229
申请日：2000-03-15
申请人： Vladimir Sokolov
发明人： Vladimir Sokolov
IPC分类号： H03B518
CPC分类号： H01P5/10 , H03B5/187
摘要： A high frequency signal source module includes a housing have a high-Q dielectric puck and a transition enclosure employing an antipodal finline transition. A circuit module connected to the high-Q puck includes an oscillator circuit that cooperates with the high-Q puck, and a frequency doubling circuit. In turn, the output of the frequency doubler is coupled to the antipodal finline transition, and thence to the output standard rectangular waveguide.
摘要翻译：高频信号源模块包括具有高Q电介质圆盘的壳体和采用对称鳍片转换的过渡壳体。连接到高Q盘的电路模块包括与高Q盘配合的振荡器电路和倍频电路。反过来，倍频器的输出耦合到对称鳍片转换，从而耦合到输出标准矩形波导。

10. 发明授权

US5545924A Three dimensional package for monolithic microwave/millimeterwave integrated circuits 失效
标题翻译：用于单片微波/毫米波集成电路的三维封装
公开(公告)号：US5545924A
公开(公告)日：1996-08-13
申请号：US102685
申请日：1993-08-05
申请人： Athanase Contolatis , Vladimir Sokolov
发明人： Athanase Contolatis , Vladimir Sokolov
IPC分类号： H01L23/12 , H01L23/02 , H01L23/04 , H01L23/66 , H01L25/04 , H01L25/065 , H01L25/18 , H05K1/02 , H05K1/18 , H05K3/34 , H01L23/16
CPC分类号： H05K1/0243 , H01L23/66 , H01L25/0657 , H01L2223/6627 , H01L2224/45014 , H01L2224/48091 , H01L2225/0651 , H01L2225/06555 , H01L2225/06572 , H01L2225/06589 , H01L24/48 , H01L2924/00014 , H01L2924/01079 , H01L2924/01087 , H01L2924/14 , H01L2924/1423 , H01L2924/19033 , H01L2924/3011 , H05K1/182 , H05K2201/10454 , H05K2201/10727 , H05K3/0061 , H05K3/3442
摘要： A three-dimensional interconnect package is provided for monolithic microwave/millimeterwave integrated circuits. A mating substrate for receiving an MMIC has transmission lines disposed over its surfaces. The mating substrate mounted substantially vertical in a base substrate which also has transmission lines for carrying microwave/millimeterwave signals. The transmission lines on both substrates are put in electrical contact and microwave/millimeterwave signals are transmitted between the substrates with a minimum of signal loss or reflection.
摘要翻译：为单片微波/毫米波集成电路提供了三维互连封装。用于接收MMIC的配合衬底具有设置在其表面上的传输线。配合基板基本上垂直安装在基板中，该基板还具有用于承载微波/毫米波信号的传输线。两个基板上的传输线被电接触，并且微波/毫米波信号以最少的信号丢失或反射在基板之间传输。

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