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1. 发明申请

US20090149843A1 Tattoo Removal and Other Dermatological Treatments using Multi-Photon Processing 失效
标题翻译：纹身去除和其他使用多光子处理的皮肤病治疗
公开(公告)号：US20090149843A1
公开(公告)日：2009-06-11
申请号：US12136943
申请日：2008-06-11
申请人： Alexander Smits , Szymon Suckewer
发明人： Alexander Smits , Szymon Suckewer
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2017/00769 , A61B2018/00452
摘要： A system and method for providing multi-photon processing treatment to a patient. A localized, multi-photon processing event is initiated within a vicinity of an unwanted pigment in order to remove the pigment. The multi-photon processing event requires a relatively low energy, but very intense, pulse of light. The low amount of energy per pulse allows ablation of the material to be highly localized, with negligible thermal damage to surrounding material. The multi-photon event may be initiated by focusing a suitable electromagnetic pulse, such as a 2 mJ laser pulse having a 100 to 300 femtoseconds pulse duration, into a focal volume small enough that the intensity exceeds 1011 Watts/cm2. A suitably configured Ti:Sapphire solid state laser may provide such pulses at 1-10 kHz. By repeating the multi-photon processing event along the location of a tattoo, the tattoo may be removed with no damage to the surrounding tissue.
摘要翻译：一种用于向患者提供多光子处理处理的系统和方法。在不想要的颜料附近开始局部化的多光子处理事件以去除颜料。多光子处理事件需要相对较低的能量但非常强烈的光脉冲。每个脉冲的能量低，允许材料的消融被高度局部化，对周围材料的热损伤可以忽略不计。可以通过将合适的电磁脉冲（例如具有100至300飞秒脉冲持续时间的2mJ激光脉冲）聚焦到足够小以致强度超过1011瓦/ cm 2的焦距体积中来启动多光子事件。适当配置的Ti：蓝宝石固态激光器可以提供1-10kHz的脉冲。通过沿着纹身的位置重复多光子处理事件，可以去除纹身而不损坏周围的组织。

2. 发明授权

US09351826B2 Cataract removal using ultra-short pulse lasers 有权
标题翻译：使用超短脉冲激光去除白内障
公开(公告)号：US09351826B2
公开(公告)日：2016-05-31
申请号：US14269170
申请日：2014-05-04
申请人： Szymon Suckewer , Peter Hersh , Alexander Smits , Richard Register
发明人： Szymon Suckewer , Peter Hersh , Alexander Smits , Richard Register
IPC分类号： A61B18/20 , A61F2/16 , A61F9/008
CPC分类号： A61F2/1613 , A61F9/00834 , A61F2009/0087 , A61F2009/0088 , A61F2009/00887
摘要： A system and method of replacing a lens to treat a cataract is disclosed. Cataractous tissue is ablated via a multi-photon process using focused, ultra-short laser pulses. Multi-photon ablation requires an energy intensity between 1013 to 1015 W/cm2. Using lasers having femto-second duration pulses, this intensity is achieved with 50 micro-Joules of energy, allowing material disruption with very little heating or shock. The multi-photon ablated material is removed through a micro-channel that leads from the multi-photon ablated region to at least the surface of the eye. Once the material is removed a pre-polymer fluid is injected in to fill the void. This polymerizes into a gel once inside the lens. The polymerized, transformed material matches both the transparency to visible light and the Young's modulus of healthy lens.
摘要翻译：公开了一种更换镜片以治疗白内障的系统和方法。白内障组织通过使用聚焦的超短激光脉冲的多光子过程消融。多光子消融需要1013〜1015W / cm2的能量强度。使用具有毫微微秒持续时间脉冲的激光器，以强度为50微焦的能量实现该强度，从而允许材料中断，非常少的加热或冲击。通过从多光子烧蚀区域引导至至少眼睛表面的微通道去除多光子消融材料。一旦去除材料，就注入预聚物流体以填充空隙。透镜内聚合成凝胶。聚合的转化材料与透明度与可见光和健康透镜的杨氏模量相匹配。

3. 发明申请

US20150290030A1 Cataract Removal using Ultra-Short Pulse Lasers 有权
标题翻译：使用超短脉冲激光去除白内障
公开(公告)号：US20150290030A1
公开(公告)日：2015-10-15
申请号：US14269170
申请日：2014-05-04
申请人： Szymon Suckewer , Peter Hersh , Alexander Smits , Richard Register
发明人： Szymon Suckewer , Peter Hersh , Alexander Smits , Richard Register
IPC分类号： A61F9/008 , A61F2/16
CPC分类号： A61F2/1613 , A61F9/00834 , A61F2009/0087 , A61F2009/0088 , A61F2009/00887
摘要： A system and method of replacing a lens to treat a cataract is disclosed. Cataractous tissue is ablated via a multi-photon process using focused, ultra-short laser pulses. Multi-photon ablation requires an energy intensity between 1013 to 1015 W/cm2. Using lasers having femto-second duration pulses, this intensity is achieved with 50 micro-Joules of energy, allowing material disruption with very little heating or shock. The multi-photon ablated material is removed through a micro-channel that leads from the multi-photon ablated region to at least the surface of the eye. Once the material is removed a pre-polymer fluid is injected in to fill the void. This polymerizes into a gel once inside the lens. The polymerized, transformed material matches both the transparency to visible light and the Young's modulus of healthy lens.
摘要翻译：公开了一种更换镜片以治疗白内障的系统和方法。白内障组织通过使用聚焦的超短激光脉冲的多光子过程消融。多光子消融需要1013〜1015W / cm2的能量强度。使用具有毫微微秒持续时间脉冲的激光器，以强度为50微焦的能量实现该强度，从而允许材料中断，非常少的加热或冲击。通过从多光子烧蚀区域引导至至少眼睛表面的微通道去除多光子消融材料。一旦去除材料，就注入预聚物流体以填充空隙。透镜内聚合成凝胶。聚合的转化材料与透明度与可见光和健康透镜的杨氏模量相匹配。

4. 发明授权

US08382744B2 Method and device for cornea reshaping by intrastromal tissue removal 有权
标题翻译：通过胸腔内组织去除角膜重塑的方法和装置
公开(公告)号：US08382744B2
公开(公告)日：2013-02-26
申请号：US11843498
申请日：2007-08-22
申请人： Szymon Suckewer , Peter Hersh , Alexander Smits , Anatoli Morozov
发明人： Szymon Suckewer , Peter Hersh , Alexander Smits , Anatoli Morozov
IPC分类号： A61F9/007
CPC分类号： A61F9/008 , A61F9/00827 , A61F2009/00872 , A61F2009/0088
摘要： A method and device for flapless, intrastromal keratomileusis for the correction of myopia, hyperopia and astigmatism, i.e., for vision correction by corneal reshaping without creating a flap. Ultra-short laser pulses are used to create a temporary micro-channel extending to an end point located within the cornea. A second series of ultra-short laser pulses are then delivered to photo-ablate material in the vicinity of the micro-channel end-point. The photo-ablated material may exit through the micro-channel used to deliver the laser pulses, or via a separate micro-channel. With the micro-channel oriented substantially normal to the optical axis of the cornea, and by continuing to supply the ultra-short laser pulses in the appropriate number while moving the point of ablation along the micro-channel, the photo-ablation of the intrastromal tissue may continue in a controlled fashion and the cornea reshaped in a predetermined manner without creating a flap.
摘要翻译：一种用于矫正近视，远视和散光的无瓣膜，基质内角膜磨镶术的方法和装置，即用于通过角膜重塑而不产生瓣片的视力矫正。使用超短激光脉冲来产生延伸到位于角膜内的终点的临时微通道。然后将第二系列的超短激光脉冲输送到微通道终点附近的光蚀刻材料。光消融材料可以通过用于传递激光脉冲的微通道，或通过单独的微通道离开。由于微通道取向为基本上垂直于角膜的光轴，并且通过在沿着微通道移动消融点的同时继续供应适当数量的超短激光脉冲，则基质内的光消融组织可以以受控的方式继续，并且角膜以预定方式重新成形，而不产生瓣。

5. 发明申请

US20080051772A1 Method and Device for Cornea Reshaping by Intrastromal Tissue Removal 有权
标题翻译：通过体内组织去除角膜重塑的方法和装置
公开(公告)号：US20080051772A1
公开(公告)日：2008-02-28
申请号：US11843498
申请日：2007-08-22
申请人： Szymon Suckewer , Peter Hersh , Alexander Smits , Anatoli Morozov
发明人： Szymon Suckewer , Peter Hersh , Alexander Smits , Anatoli Morozov
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61F9/00827 , A61F2009/00872 , A61F2009/0088
摘要： A method and device for flapless, intrastromal keratomileusis for the correction of myopia, hyperopia and astigmatism, i.e., for vision correction by corneal reshaping without creating a flap. Ultra-short laser pulses are used to create a temporary micro-channel extending to an end point located within the cornea. A second series of ultra-short laser pulses are then delivered to photo-ablate material in the vicinity of the micro-channel end-point. The photo-ablated material may exit through the micro-channel used to deliver the laser pulses, or via a separate micro-channel. With the micro-channel oriented substantially normal to the optical axis of the cornea, and by continuing to supply the ultra-short laser pulses in the appropriate number while moving the point of ablation along the micro-channel, the photo-ablation of the intrastromal tissue may continue in a controlled fashion and the cornea reshaped in a predetermined manner without creating a flap.
摘要翻译：一种用于矫正近视，远视和散光的无瓣膜，基质内角膜磨镶术的方法和装置，即用于通过角膜重塑而不产生瓣片的视力矫正。使用超短激光脉冲来产生延伸到位于角膜内的终点的临时微通道。然后将第二系列的超短激光脉冲输送到微通道终点附近的光蚀刻材料。光消融材料可以通过用于传递激光脉冲的微通道，或通过单独的微通道离开。由于微通道取向为基本上垂直于角膜的光轴，并且通过在沿着微通道移动消融点的同时继续供应适当数量的超短激光脉冲，则基质内的光消融组织可以以受控的方式继续，并且角膜以预定方式重新成形，而不产生瓣。

6. 发明授权

US08596281B2 Devices, methods and compositions for presbyopia correction using ultrashort pulse laser 有权
标题翻译：使用超短脉冲激光器进行老花眼矫正的装置，方法和组成
公开(公告)号：US08596281B2
公开(公告)日：2013-12-03
申请号：US12087507
申请日：2007-03-05
申请人： Szymon Suckewer , Alexander Smits , Peter Hersh , Richard Register , Gary Kunkel , Anatoli Morozov
发明人： Szymon Suckewer , Alexander Smits , Peter Hersh , Richard Register , Gary Kunkel , Anatoli Morozov
IPC分类号： A61F9/008
CPC分类号： A61F9/00838 , A61B3/13 , A61F2009/0087 , A61F2009/00895
摘要： The invention relates to devices, compositions and methods used to improve vision and/or to treat an eye lens disease or condition. In some embodiments, the invention relates to altering or removing eye lens material for the treatment of presbyopia. In additional embodiments, the invention relates to placing compositions in a lens of an eye to improve elasticity of the lens both therapeutically by improving elasticity and/or improving refractive properties and/or prophylactically by preventing renewed stiffening and/or renewed deterioration of the lens refractive properties. In further embodiments, the invention relates to devices and methods of obtaining and analyzing data for use in altering the lens to optimize its elasticity and/or refractive properties.
摘要翻译：本发明涉及用于改善视力和/或治疗眼晶状体疾病或病症的装置，组合物和方法。在一些实施方案中，本发明涉及改变或去除用于治疗老花眼的眼晶状体材料。在另外的实施方案中，本发明涉及将组合物放置在眼睛的晶状体中，以通过改善弹性和/或改善屈光性能和/或通过防止透镜折射的新的加强和/或再次劣化来预防性地改善透镜的弹性属性。在另外的实施例中，本发明涉及获得和分析用于改变透镜以优化其弹性和/或折射性质的数据的装置和方法。

7. 发明授权

US08187256B2 Tattoo removal and other dermatological treatments using multi-photon processing 失效
标题翻译：使用多光子处理纹身去除和其他皮肤病治疗
公开(公告)号：US08187256B2
公开(公告)日：2012-05-29
申请号：US12136943
申请日：2008-06-11
申请人： Alexander J Smits , Szymon Suckewer
发明人： Alexander J Smits , Szymon Suckewer
IPC分类号： A61B18/20
CPC分类号： A61B18/203 , A61B2017/00769 , A61B2018/00452
摘要： A system and method for providing multi-photon processing treatment to a patient. A localized, multi-photon processing event is initiated within a vicinity of an unwanted pigment in order to remove the pigment. The multi-photon processing event requires a relatively low energy, but very intense, pulse of light. The low amount of energy per pulse allows ablation of the material to be highly localized, with negligible thermal damage to surrounding material. The multi-photon event may be initiated by focusing a suitable electromagnetic pulse, such as a 2 mJ laser pulse having a 100 to 300 femtoseconds pulse duration, into a focal volume small enough that the intensity exceeds 1011 Watts/cm2. A suitably configured Ti:Sapphire solid state laser may provide such pulses at 1-10 kHz. By repeating the multi-photon processing event along the location of a tattoo, the tattoo may be removed with no damage to the surrounding tissue.
摘要翻译：一种用于向患者提供多光子处理处理的系统和方法。在不想要的颜料附近开始局部化的多光子处理事件以去除颜料。多光子处理事件需要相对较低的能量但非常强烈的光脉冲。每个脉冲的能量低，允许材料的消融被高度局部化，对周围材料的热损伤可以忽略不计。可以通过将合适的电磁脉冲（例如具有100至300飞秒脉冲持续时间的2mJ激光脉冲）聚焦到足够小以致强度超过1011瓦/ cm 2的焦距体积中来启动多光子事件。适当配置的Ti：蓝宝石固态激光器可以提供1-10kHz的脉冲。通过沿着纹身的位置重复多光子处理事件，可以去除纹身而不损坏周围的组织。

8. 发明授权

US08186321B2 Method and apparatus for operating traveling spark igniter at high pressure 有权
标题翻译：在高压下运行火花点火器的方法和装置
公开(公告)号：US08186321B2
公开(公告)日：2012-05-29
申请号：US12313927
申请日：2008-11-26
申请人： Artur P. Suckewer , Szymon Suckewer , Frederick H. Selmon, III
发明人： Artur P. Suckewer , Szymon Suckewer , Frederick H. Selmon, III
IPC分类号： F02P3/02
CPC分类号： H05H1/48 , F02P3/08 , F02P3/0807 , F02P3/0815 , F02P9/007 , F02P23/04 , H01T13/50
摘要： An ignition circuit and a method of operating an igniter (preferably a traveling spark igniter) in an internal combustion engine, including a high pressure engine. A high voltage is applied to electrodes of the igniter, sufficient to cause breakdown to occur between the electrodes, resulting in a high current electrical discharge in the igniter, over a surface of an isolator between the electrodes, and formation of a plasma kernel in a fuel-air mixture adjacent said surface. Following breakdown, a sequence of one or more lower voltage and lower current pulses is applied to said electrodes, with a low “simmer” current being sustained through the plasma between pulses, preventing total plasma recombination and allowing the plasma kernel to move toward a free end of the electrodes with each pulse.
摘要翻译：一种点火电路和在包括高压发动机的内燃机中操作点火器（优选行进火花点火器）的方法。高电压施加到点火器的电极上，足以在电极之间发生击穿，导致点火器中的高电流放电，在电极之间的隔离器的表面上，以及在电极中形成等离子体核邻近所述表面的燃料 - 空气混合物。在击穿之后，将一个或多个较低电压和较低电流脉冲的序列施加到所述电极，其中通过脉冲之间的等离子体维持低的“煨”电流，防止总等离子体复合并允许等离子体内核朝着空闲状态移动每个脉冲端电极。

9. 发明申请

US20070062502A1 Method and apparatus for operating traveling spark igniter at high pressure 有权
标题翻译：在高压下运行火花点火器的方法和装置
公开(公告)号：US20070062502A1
公开(公告)日：2007-03-22
申请号：US11407850
申请日：2006-04-19
申请人： Artur Suckewer , Szymon Suckewer , Frederick Selmon
发明人： Artur Suckewer , Szymon Suckewer , Frederick Selmon
IPC分类号： F02P3/02
CPC分类号： H05H1/48 , F02P3/08 , F02P3/0807 , F02P3/0815 , F02P9/007 , F02P23/04 , H01T13/50
摘要： An ignition circuit and a method of operating an igniter (preferably a traveling spark igniter) in an internal combustion engine, including a high pressure engine. A high voltage is applied to electrodes of the igniter, sufficient to cause breakdown to occur between the electrodes, resulting in a high current electrical discharge in the igniter, over a surface of an isolator between the electrodes, and formation of a plasma kernel in a fuel-air mixture adjacent said surface. Following breakdown, a sequence of one or more lower voltage and lower current pulses is applied to said electrodes, with a low “simmer” current being sustained through the plasma between pulses, preventing total plasma recombination and allowing the plasma kernel to move toward a free end of the electrodes with each pulse.
摘要翻译：一种点火电路和在包括高压发动机的内燃机中操作点火器（优选行进火花点火器）的方法。高电压施加到点火器的电极上，足以在电极之间发生击穿，导致点火器中的高电流放电，在电极之间的隔离器的表面上，以及在电极中形成等离子体核邻近所述表面的燃料 - 空气混合物。在击穿之后，将一个或多个较低电压和较低电流脉冲的序列施加到所述电极，其中通过脉冲之间的等离子体维持低的“煨”电流，防止总等离子体复合并允许等离子体内核朝着空闲状态移动每个脉冲端电极。

10. 发明授权

US08915907B2 Tattoo removal with two laser beams via multi-photon processes 有权
标题翻译：通过多光子过程使用两个激光束进行纹身去除
公开(公告)号：US08915907B2
公开(公告)日：2014-12-23
申请号：US13781287
申请日：2013-02-28
申请人： Szymon Suckewer
发明人： Szymon Suckewer
IPC分类号： A61B18/20 , A61B18/00 , A61B17/00
CPC分类号： A61B18/203 , A61B18/20 , A61B2017/00769 , A61B2018/00452 , A61B2018/00458 , A61B2018/00577 , A61B2018/2025 , A61B2018/207
摘要： A method for removing tattoos using two laser beams and a multi-photon process is disclosed. A 0.1 to 100 nsec pulse secondary laser beam focused to 108 W/cm2 creates a temporary channel from the skin surface to the tattoo pigment. A 100 fsec pulse main laser beam is then guided through the channel to the pigment and focused to sufficient intensity, i.e., 1012 W/cm2 or more, to initiate a multi-photon process that breaks up the pigment, disrupting its light reflecting properties. The channel allows the main laser beam unobstructed passage to the pigments, resulting in efficient use of the main laser. The pigment fragments escape through the temporary channel or diffuse into the blood stream. A suitably configured Ti/Sapphire laser beam is split into two components, with an uncompressed component used as the secondary laser beam, and a compressed component as the main laser beam.
摘要翻译：公开了一种使用两个激光束和多光子过程去除纹身的方法。聚焦到108W / cm 2的0.1至100nsec脉冲次级激光束产生从皮肤表面到纹身颜料的临时通道。然后将100fsec脉冲主激光束通过通道引导至颜料并聚焦至足够的强度，即1012W / cm 2以上，以引发分解颜料的多光子过程，破坏其光反射性能。该通道允许主激光束无阻碍地通向颜料，从而有效地使用主激光器。颜料碎片通过临时通道逃逸或扩散到血液中。将适当配置的Ti / Sapphire激光束分为两部分，其中未压缩部件用作次级激光束，压缩部件用作主激光束。

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