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1. 发明申请

US20120135458A1 CLOSED LOOP MONITORING OF AUTOMATED MOLECULAR PATHOLOGY SYSTEM 有权
标题翻译：自动分子病理学系统闭环监测
公开(公告)号：US20120135458A1
公开(公告)日：2012-05-31
申请号：US12957203
申请日：2010-11-30
申请人： Alex David Corwin , Robert John Filkins , Jun Xie , Christopher James Sevinsky , Kashan Ali Shaikh
发明人： Alex David Corwin , Robert John Filkins , Jun Xie , Christopher James Sevinsky , Kashan Ali Shaikh
IPC分类号： G01N1/30 , C12M1/36
CPC分类号： G01N1/312 , G01N2001/368
摘要： A closed loop automated method for staining of a biological sample is provided. The method comprises providing a biological sample, staining at least a portion of the biological sample by flowing in a reagent, monitoring one or more optical characteristics of the biological sample, and calculating a figure of merit based on at least one of the optical characteristics. An automated device for iterative staining of a biological sample is also provided.
摘要翻译：提供了一种用于染色生物样品的闭环自动化方法。该方法包括提供生物样品，通过在试剂中流动来染色生物样品的至少一部分，监测生物样品的一种或多种光学特性，以及基于至少一种光学特性来计算品质因数。还提供了用于生物样品的迭代染色的自动化装置。

2. 发明授权

US08673643B2 Closed loop monitoring of automated molecular pathology system 有权
标题翻译：自动分子病理系统闭环监测
公开(公告)号：US08673643B2
公开(公告)日：2014-03-18
申请号：US12957203
申请日：2010-11-30
申请人： Alex David Corwin , Robert John Filkins , Jun Xie , Christopher James Sevinsky , Kashan Ali Shaikh
发明人： Alex David Corwin , Robert John Filkins , Jun Xie , Christopher James Sevinsky , Kashan Ali Shaikh
IPC分类号： G01N35/02 , G01N33/53 , B05D3/00 , G01N1/31 , G01N1/30 , G01N33/48
CPC分类号： G01N1/312 , G01N2001/368
摘要： A closed loop automated method for staining of a biological sample is provided. The method comprises providing a biological sample, staining at least a portion of the biological sample by flowing in a reagent, monitoring one or more optical characteristics of the biological sample, and calculating a figure of merit based on at least one of the optical characteristics. An automated device for iterative staining of a biological sample is also provided.
摘要翻译：提供了一种用于染色生物样品的闭环自动化方法。该方法包括提供生物样品，通过在试剂中流动来染色生物样品的至少一部分，监测生物样品的一种或多种光学特性，以及基于至少一种光学特性来计算品质因数。还提供了用于生物样品的迭代染色的自动装置。

3. 发明申请

US20140001337A1 SYSTEMS AND METHODS FOR PROCESSING AND IMAGING OF BIOLOGICAL SAMPLES 有权
标题翻译：用于处理和成像生物样品的系统和方法
公开(公告)号：US20140001337A1
公开(公告)日：2014-01-02
申请号：US13538898
申请日：2012-06-29
申请人： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
发明人： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
IPC分类号： H01L27/146
CPC分类号： G01N1/312
摘要： A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
摘要翻译：一种用于处理和成像第一和第二多个样品的方法，包括处理来自所述第一多个样品的至少一个样品，对来自所述第一多个样品的所述至少一个样品进行成像，同时能够同时处理至少一个样品从第二多个样本; 以及对来自所述第二多个样本的所述至少一个处理的样品进行成像。

4. 发明授权

US09164015B2 Systems and methods for processing and imaging of biological samples 有权
标题翻译：用于生物样品处理和成像的系统和方法
公开(公告)号：US09164015B2
公开(公告)日：2015-10-20
申请号：US13538898
申请日：2012-06-29
申请人： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
发明人： Alex David Corwin , Robert John Filkins , Jun Xie , Nannan Chen , Kashan Ali Shaikh
IPC分类号： H01L27/146 , G01N1/31
CPC分类号： G01N1/312
摘要： A method for processing and imaging a first and second plurality of samples, comprising processing at least one sample from the first plurality of samples, imaging the at least one sample from the first plurality of samples, while being capable of simultaneously processing at least one sample from the second plurality of samples; and imaging the at least one processed sample from the second plurality of samples.
摘要翻译：一种用于处理和成像第一和第二多个样品的方法，包括处理来自所述第一多个样品的至少一个样品，对来自所述第一多个样品的所述至少一个样品进行成像，同时能够同时处理至少一个样品从第二多个样本; 以及对来自所述第二多个样本的所述至少一个处理的样品进行成像。

5. 发明授权

US08449838B2 Devices and methods for batch processing magnetic bead assays 有权
标题翻译：用于批量处理磁珠测定的装置和方法
公开(公告)号：US08449838B2
公开(公告)日：2013-05-28
申请号：US12839872
申请日：2010-07-20
申请人： Kashan Ali Shaikh , Christopher Michael Puleo , Jun Xie , Hansong Zeng , Li Zhu
发明人： Kashan Ali Shaikh , Christopher Michael Puleo , Jun Xie , Hansong Zeng , Li Zhu
IPC分类号： B01L3/00 , G01N33/533
CPC分类号： B01L3/00 , B01L3/502761 , B01L2200/0621 , B01L2200/0668 , B01L2300/0877 , B01L2400/043 , B03C1/0332 , B03C1/286 , B03C2201/18 , B03C2201/26 , G01N33/533 , G01N35/0098
摘要： A microfluidic device for batch processing magnetic bead assays and having one or more microfluidic sample channels, comprising, one or more micromagnets seated in a fixture; and an actuator; wherein a portion of each micromagnet is in releasable operative association with one or more of the microfluidic sample channels, and another portion of each micromagnet is in releasable operative association with the actuator; and methods for using the same.
摘要翻译：一种用于批量处理磁珠测定并具有一个或多个微流体样品通道的微流体装置，包括：一个或多个坐在固定装置中的微电磁体; 和致动器; 其中每个微磁体的一部分与一个或多个微流体样品通道可释放地相关联，并且每个微型磁体的另一部分与致动器可释放地可操作地相关联; 和使用它们的方法。

6. 发明申请

US20120021931A1 DEVICES AND METHODS FOR BATCH PROCESSING MAGNETIC BEAD ASSAYS 有权
标题翻译：用于批量处理磁珠测试的装置和方法
公开(公告)号：US20120021931A1
公开(公告)日：2012-01-26
申请号：US12839872
申请日：2010-07-20
申请人： Kashan Ali Shaikh , Christopher Michael Puleo , Jun Xie , Hansong Zeng , Li Zhu
发明人： Kashan Ali Shaikh , Christopher Michael Puleo , Jun Xie , Hansong Zeng , Li Zhu
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： B01L3/00 , B01L3/502761 , B01L2200/0621 , B01L2200/0668 , B01L2300/0877 , B01L2400/043 , B03C1/0332 , B03C1/286 , B03C2201/18 , B03C2201/26 , G01N33/533 , G01N35/0098
摘要： A microfluidic device for batch processing magnetic bead assays and having one or more microfluidic sample channels, comprising, one or more micromagnets seated in a fixture; and an actuator; wherein a portion of each micromagnet is in releasable operative association with one or more of the microfluidic sample channels, and another portion of each micromagnet is in releasable operative association with the actuator; and methods for using the same.
摘要翻译：一种用于批量处理磁珠测定并具有一个或多个微流体样品通道的微流体装置，包括：一个或多个坐在固定装置中的微电磁体; 和致动器; 其中每个微磁体的一部分与一个或多个微流体样品通道可释放地相关联，并且每个微型磁体的另一部分与致动器可释放地可操作地相关联; 和使用它们的方法。

7. 发明申请

US20120135449A1 ITERATIVE STAINING OF BIOLOGICAL SAMPLES 审中-公开
标题翻译：生物样本的迭代染色
公开(公告)号：US20120135449A1
公开(公告)日：2012-05-31
申请号：US13365525
申请日：2012-02-03
申请人： Jun Xie , Robert John Filkins , Fiona Mary Ginty , Michael Christopher Montalto , Anup Sood , Jeffrey Bernard Fortin , Wei-Cheng Tian , Michael John Gerdes
发明人： Jun Xie , Robert John Filkins , Fiona Mary Ginty , Michael Christopher Montalto , Anup Sood , Jeffrey Bernard Fortin , Wei-Cheng Tian , Michael John Gerdes
IPC分类号： G01N21/75 , C12M1/34
CPC分类号： G01N1/312
摘要： Automated methods and devices that facilitate iterative staining of biological samples from imaging applications are provided. The methods include the steps of providing a small volume flow cell containing a biological sample, applying a stain to the biological sample, combining at least two precursor reagents to form an activated destaining agent and wherein the activated destaining agent decomposition rate is greater than or similar to the destaining reaction rate, flowing the destaining agent over the biological sample at a flow rate that is greater than the decomposition rate of the activated destaining agent, and releasing the sample from the flow cell wherein the integrity of the sample is intact. The process of staining, combining and flowing may be iteratively repeated. Also disclosed herein are devices for iterative staining of biological samples comprising a flow cell, in fluid communication with a premixer, wherein the volume capacity of the premixer is smaller than about five times the volume capacity of the flow cell.
摘要翻译：提供了促进成像应用中生物样品的迭代染色的自动化方法和装置。所述方法包括以下步骤：提供含有生物样品的小体积流动池，向生物样品施加染色，将至少两种前体试剂结合以形成活化的脱色剂，并且其中所述活化脱色剂分解速率大于或等于以脱色反应速率使脱色剂以大于活化脱色剂的分解速率的流速流过生物样品，并将样品从流动池中释放出来，其中样品的完整性是完整的。染色，组合和流动的过程可以迭代地重复。本文还公开了用于重复染色生物样品的装置，其包括与预混合器流体连通的流动池，其中预混合器的体积容量小于流动池的体积容量的约五倍。

8. 发明申请

US20090253163A1 ITERATIVE STAINING OF BIOLOGICAL SAMPLES 审中-公开
标题翻译：生物样本的迭代染色
公开(公告)号：US20090253163A1
公开(公告)日：2009-10-08
申请号：US12061044
申请日：2008-04-02
申请人： Jun Xie , Fiona Ginty , Robert John Filkins , Michael Christopher Montalto , Anup Sood , Jeffrey Bernard Fortin , Wei-Cheng Tian , Michael John Gerdes
发明人： Jun Xie , Fiona Ginty , Robert John Filkins , Michael Christopher Montalto , Anup Sood , Jeffrey Bernard Fortin , Wei-Cheng Tian , Michael John Gerdes
IPC分类号： G01N1/30 , C12M1/34 , C12M1/36
CPC分类号： G01N1/312
摘要： Automated methods and devices that facilitate iterative staining of biological samples from imaging applications are provided. The methods include the steps of providing a small volume flow cell containing a biological sample, applying a stain to the biological sample, combining at least two precursor reagents to form an activated destaining agent and wherein the activated destaining agent decomposition rate is greater than or similar to the destaining reaction rate, and flowing the destaining agent over the biological sample at a flow rate that is greater than the decomposition rate of the activated destaining agent. The process of staining, combining and flowing may be iteratively repeated. Also disclosed herein are devices for iterative staining of biological samples comprising a flow cell, in fluid communication with a premixer, wherein the volume capacity of the premixer is smaller than about five times the volume capacity of the flow cell.
摘要翻译：提供了促进成像应用中生物样品的迭代染色的自动化方法和装置。所述方法包括以下步骤：提供含有生物样品的小体积流动池，向生物样品施加染色，将至少两种前体试剂结合以形成活化的脱色剂，并且其中所述活化脱色剂分解速率大于或等于与脱色反应速率相关联，并使脱色剂以大于活化脱色剂分解速率的流速流过生物样品。染色，组合和流动的过程可以迭代地重复。本文还公开了用于重复染色生物样品的装置，其包括与预混合器流体连通的流动池，其中预混合器的体积容量小于流动池的体积容量的约五倍。

9. 发明授权

US09521233B2 Method and device for recording data of terminal 有权
标题翻译：记录终端数据的方法和装置
公开(公告)号：US09521233B2
公开(公告)日：2016-12-13
申请号：US13522525
申请日：2010-09-17
申请人： Jun Xie
发明人： Jun Xie
IPC分类号： G06F15/173 , H04M1/725 , H04M1/656 , H04L12/70 , H04L12/64 , H04M3/42
CPC分类号： H04M1/72522 , H04L2012/563 , H04L2012/5636 , H04L2012/5652 , H04L2012/6443 , H04L2463/121 , H04M1/656 , H04M3/42221 , H04M2250/60
摘要： A method and device for recording data of a terminal are disclosed. The method includes: setting a relation condition list for triggering recording among function modules, and setting a corresponding random probability generator for each function module; determining whether to start recording data, and whether to end the data recording operation in accordance with the relation condition list or the random probability generator, during the operation process of each function module; and sending the respective data packets obtained by recording to a data management module for storage after the data record operation of each function module is ended. By adopting the method and device, fuzzy recording can be performed on data of the terminal, and data of different function modules can be stored centrally, and a query operation is simplified.
摘要翻译：公开了一种用于记录终端数据的方法和装置。该方法包括：设置用于在功能模块之间触发记录的关系条件列表，并为每个功能模块设置相应的随机概率发生器; 在每个功能模块的操作过程中，确定是否开始记录数据，以及是否根据关系条件列表或随机概率发生器结束数据记录操作; 并且在每个功能模块的数据记录操作结束之后将通过记录获得的各个数据包发送到数据管理模块进行存储。通过采用该方法和装置，可以对终端的数据执行模糊记录，可以集中存储不同功能模块的数据，简化查询操作。

10. 发明授权

US08734809B2 AAV's and uses thereof 有权
标题翻译： AAV及其用途
公开(公告)号：US08734809B2
公开(公告)日：2014-05-27
申请号：US13322164
申请日：2010-04-23
申请人： Guangping Gao , Terence Flotte , Jun Xie
发明人： Guangping Gao , Terence Flotte , Jun Xie
IPC分类号： A61K39/23 , A61K39/235 , A61K39/12 , C12N15/00 , C12P21/06
CPC分类号： C07K14/005 , A61K31/7088 , A61K35/76 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2750/14122 , C12N2750/14143 , C12N2750/14145
摘要： The invention in some aspects relates to recombinant adeno-associated viruses having distinct tissue targeting capabilities. In some aspects, the invention relates to gene transfer methods using the recombinant adeno-associate viruses. In some aspects, the invention relates to isolated AAV capsid proteins and isolated nucleic acids encoding the same.
摘要翻译：本发明在某些方面涉及具有不同组织靶向能力的重组腺相关病毒。在一些方面，本发明涉及使用重组腺相关病毒的基因转移方法。在一些方面，本发明涉及分离的AAV衣壳蛋白和编码其的分离的核酸。

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