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1. 发明授权

US5733871A Methods for the treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration 失效
标题翻译：治疗与缺血，缺氧或神经变性相关的神经元损伤的方法
公开(公告)号：US5733871A
公开(公告)日：1998-03-31
申请号：US30429
申请日：1995-03-16
申请人： Brian J. Alps , Christine Mary Brown , Franklin D. Collins , Caroline J. Emmett , Michael Spedding , Deborah Russell , Seth P. Finklestein , Michael A. Moskowitz , Roger Lewis Whiting
发明人： Brian J. Alps , Christine Mary Brown , Franklin D. Collins , Caroline J. Emmett , Michael Spedding , Deborah Russell , Seth P. Finklestein , Michael A. Moskowitz , Roger Lewis Whiting
IPC分类号： A61K38/18 , A61K38/00 , A61K38/16 , A61K38/27 , A61K38/28
CPC分类号： A61K38/185 , A61K38/1825
摘要： Intravenous administration and pharmaceutically acceptable compositions of neurotrophic factors for treating neuronal damage in the central nervous system of individuals in need of such treatment are disclosed. The neuronal damage associated with ischemia, hypoxia, or neurodegeneration may result from stroke or cardiac arrest. This invention provides for the intravenous administration of neurotrophic factors such as bFGF, aFGF, NGF, CNTF, BDNF, NT3, NT4, IGF-I and IGF-II.
摘要翻译： PCT No.PCT / US92 / 09618 Sec。 371日期1995年3月16日 102（e）1995年3月16日PCT PCT 1991年11月6日PCT公布。出版物WO93 / 08828 日期：1993年5月13日公开了用于治疗需要这种治疗的个体的中枢神经系统中神经元损伤的神经营养因子的静脉内给药和药学上可接受的组合物。与缺血，缺氧或神经变性相关的神经元损伤可能是由卒中或心脏停搏引起的。本发明提供神经营养因子如bFGF，aFGF，NGF，CNTF，BDNF，NT3，NT4，IGF-1和IGF-II的静脉内施用。

2. 发明授权

US5935795A Glial cell line-derived neurotrophic factor antibody 失效
标题翻译：胶质细胞系衍生的神经营养因子抗体
公开(公告)号：US5935795A
公开(公告)日：1999-08-10
申请号：US452242
申请日：1995-05-26
申请人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
发明人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
IPC分类号： A61K38/00 , A61K9/00 , A61K9/22 , A61K31/00 , A61K39/395 , A61M37/00 , A61P25/00 , A61P25/16 , A61P25/26 , A61P25/28 , C07H15/12 , C07K20060101 , C07K1/20 , C07K1/22 , C07K14/47 , C07K14/475 , C07K14/52 , C07K16/00 , C07K16/24 , C12N20060101 , C12N1/21 , C12N1/22 , C12N5/02 , C12N5/06 , C12N5/08 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/06 , C12P21/08 , C12R1/19 , C12R1/91 , C07K16/22 , C12N5/12 , G01N33/53
CPC分类号： A61K9/0085 , C07K14/475 , A61K38/00 , Y10S530/809 , Y10S530/839
摘要： A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process. Antibodies to GDNF are disclosed, as well as methods for identifying members of the GDNF family of neurotrophic factors.
摘要翻译：已经鉴定了一种称为神经胶质细胞系衍生的神经营养因子（GDNF）的新型神经营养因子，并从B49胶质母细胞瘤细胞的无血清生长条件培养基中分离。编码GDNF的大鼠和人类基因已被克隆并测序。已经将编码GDNF的基因亚克隆到载体中，并且该载体已经用于转化宿主细胞，以便在重组DNA过程中产生生物活性的GDNF。公开了GDNF的抗体，以及用于鉴定GDNF家族神经营养因子成员的方法。

3. 发明授权

US5011914A Purified ciliary neurotrophic factor 失效
标题翻译：纯化的睫状神经营养因子
公开(公告)号：US5011914A
公开(公告)日：1991-04-30
申请号：US293851
申请日：1989-01-05
申请人： Franklin D. Collins , Leu-Fen Lin
发明人： Franklin D. Collins , Leu-Fen Lin
IPC分类号： A61K38/00 , C07K14/475 , C07K16/22
CPC分类号： C07K14/475 , C07K16/22 , A61K38/00
摘要： A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNFT) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. The purification is carried out by lowering the pH of the crude nerve extract preparation to form a precipitate which is removed and discarded; raising the pH to about 6.3 followed by ammonium sulfate fractionation; chromatofocusing a solution containing a second precipitate obtained from the 30% to 60% ammonium sulfate containing solution; subjecting the fractions obtained by chromatofocusing to sodium dodecyl sulfate (SDS)-polyacrylamide gel electrophoresis (PAGE); and performing reversed-phase high-performance liquid chromatography (HPLC) on the SDS-PAGE eluate.Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described.
摘要翻译：要求提供睫状神经营养因子（CNTF），特别是坐骨神经CNTF（SN-CNFT）。本文所述的SN-CNTF是单一蛋白质物质，并且具有比粗提取物增加至大于25,000倍的比活性。通过降低粗神经提取物制剂的pH以形成除去并丢弃的沉淀物来进行纯化; 将pH升高至约6.3，随后进行硫酸铵分级; 将含有30％至60％含硫酸铵的溶液得到的含有第二沉淀的溶液进行色谱聚焦; 将通过色谱聚焦获得的级分进行十二烷基硫酸钠（SDS） - 聚丙烯酰胺凝胶电泳（PAGE）; 并在SDS-PAGE洗脱液上进行反相高效液相色谱（HPLC）。还提供了该SN-CNTF的氨基酸数据。此外，还提供了使用该数据提供SN-CNTF探针和筛选cDNA和基因组文库的方法。描述了用于生产SN-CNTF的重组DNA方法。

4. 发明授权

US5780600A Purified ciliary neurotrophic factor 失效
标题翻译：纯化的睫状神经营养因子
公开(公告)号：US5780600A
公开(公告)日：1998-07-14
申请号：US448909
申请日：1995-05-24
申请人： Franklin D. Collins , Leu-Fen Lin , Drzislav Mismer , Christine Ko
发明人： Franklin D. Collins , Leu-Fen Lin , Drzislav Mismer , Christine Ko
IPC分类号： C12N15/09 , A61K35/30 , A61K38/00 , A61K38/22 , A61P25/00 , A61P25/28 , C07K1/14 , C07K1/20 , C07K14/435 , C07K14/475 , C07K14/48 , C07K14/52 , C07K16/22 , C12N1/21 , C12N5/10 , C12N15/06 , C12N15/12 , C12N15/18 , C12N15/31 , C12N15/74 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C07K14/475 , C07K16/22 , A61K38/00
摘要： A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract. Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described. Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.
摘要翻译：要求提供睫状神经营养因子（CNTF），特别是坐骨神经CNTF（SN-CNTF）。本文所述的SN-CNTF是单一蛋白质物质，并且具有比粗提取物增加至大于25,000倍的比活性。还提供了该SN-CNTF的氨基酸数据。此外，还提供了使用该数据提供SN-CNTF探针和筛选cDNA和基因组文库的方法。描述了用于生产SN-CNTF的重组DNA方法。提供编码兔和人CNTF的核酸序列。提供重组表达系统用于生产生物活性CNTF。

5. 发明授权

US4997929A Purified ciliary neurotrophic factor 失效
标题翻译：纯化的睫状神经营养因子
公开(公告)号：US4997929A
公开(公告)日：1991-03-05
申请号：US404533
申请日：1989-09-08
申请人： Franklin D. Collins , Leu-Fen Lin
发明人： Franklin D. Collins , Leu-Fen Lin
IPC分类号： A61K38/00 , C07K14/475 , C07K16/22 , C12N15/12
CPC分类号： C07K16/22 , C07K14/475 , A61K38/00
摘要： A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF(SN-CNFT) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract.Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described.Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.
摘要翻译：要求提供睫状神经营养因子（CNTF），特别是坐骨神经CNTF（SN-CNFT）。本文所述的SN-CNTF是单一蛋白质物质，并且具有比粗提取物增加至大于25,000倍的比活性。还提供了该SN-CNTF的氨基酸数据。此外，还提供了使用该数据提供SN-CNTF探针和筛选cDNA和基因组文库的方法。描述了用于生产SN-CNTF的重组DNA方法。提供编码兔和人CNTF的核酸序列。提供重组表达系统用于生产生物活性CNTF。

6. 发明授权

US06362319B1 Glial cell line-derived neurotrophic factor 失效
标题翻译：神经胶质细胞系衍生的神经营养因子
公开(公告)号：US06362319B1
公开(公告)日：2002-03-26
申请号：US08452229
申请日：1995-05-26
申请人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
发明人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
IPC分类号： C07K14475
CPC分类号： A61K9/0085 , A61K38/00 , C07K14/475 , Y10S530/809 , Y10S530/839
摘要： A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.
摘要翻译：已经鉴定并分离了一种称为神经胶质神经营养因子（GDNF）的新型神经营养因子，其从B49胶质母细胞瘤细胞的无血清生长条件培养基中分离。编码GDNF的大鼠和人类基因已被克隆并测序。编码GDNF的基因已经被亚克隆到载体中，并且该载体已被用于转化宿主细胞，以便在重组DNA过程中产生生物活性的GDNF。

7. 发明授权

US6093802A Glial cell line-derived neurotrophic factor 失效
标题翻译：神经胶质细胞系衍生的神经营养因子
公开(公告)号：US6093802A
公开(公告)日：2000-07-25
申请号：US451374
申请日：1995-05-26
申请人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
发明人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
IPC分类号： A61K38/00 , A61K9/00 , A61K9/22 , A61K31/00 , A61K39/395 , A61M37/00 , A61P25/00 , A61P25/16 , A61P25/26 , A61P25/28 , C07H15/12 , C07K20060101 , C07K1/20 , C07K1/22 , C07K14/47 , C07K14/475 , C07K14/52 , C07K16/00 , C07K16/24 , C12N20060101 , C12N1/21 , C12N1/22 , C12N5/02 , C12N5/06 , C12N5/08 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/06 , C12P21/08 , C12R1/19 , C12R1/91 , C07K14/48
CPC分类号： A61K9/0085 , C07K14/475 , A61K38/00 , Y10S530/809 , Y10S530/839
摘要： A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.
摘要翻译：已经鉴定了一种称为神经胶质细胞系衍生的神经营养因子（GDNF）的新型神经营养因子，并从B49胶质母细胞瘤细胞的无血清生长条件培养基中分离。编码GDNF的大鼠和人类基因已被克隆并测序。编码GDNF的基因已经被亚克隆到载体中，并且该载体已被用于转化宿主细胞，以便在重组DNA过程中产生生物活性的GDNF。

8. 发明授权

US5141856A Expression of purified ciliary neurotrophic factor 失效
标题翻译：纯化神经营养因子的表达
公开(公告)号：US5141856A
公开(公告)日：1992-08-25
申请号：US458564
申请日：1989-12-28
申请人： Franklin D. Collins , Leu-Fen Lin , Drzislav Mismer , Christine Ko
发明人： Franklin D. Collins , Leu-Fen Lin , Drzislav Mismer , Christine Ko
IPC分类号： C12N15/09 , A61K35/30 , A61K38/00 , A61K38/22 , A61P25/00 , A61P25/28 , C07K1/14 , C07K1/20 , C07K14/435 , C07K14/475 , C07K14/48 , C07K14/52 , C07K16/22 , C12N1/21 , C12N5/10 , C12N15/06 , C12N15/12 , C12N15/18 , C12N15/31 , C12N15/74 , C12P21/00 , C12P21/02 , C12R1/19 , C12R1/91
CPC分类号： C07K14/475 , C07K16/22 , A61K38/00
摘要： A ciliary neurotrophic factor (CNTF), particularly sciatic nerve CNTF (SN-CNTF) is claimed. The SN-CNTF described herein is a single protein species and has a specific activity that increased to greater than 25,000-fold from crude extract.Amino acid data for this SN-CNTF is also provided. In addition, methods for using this data for providing SN-CNTF probes and for screening cDNA and genomic libraries are also provided. Recombinant-DNA methods for the production of SN-CNTF are described.Nucleic acid sequences encoding rabbit and human CNTF are provided. A recombinant expression system is provided for producing biologically active CNTF.

9. 发明授权

US07226758B1 Nucleic acids encoding glial cell line-derived neurotrophic factor (GDNF) 失效
标题翻译：编码胶质细胞系的神经营养因子（GDNF）的核酸
公开(公告)号：US07226758B1
公开(公告)日：2007-06-05
申请号：US08182183
申请日：1992-09-17
申请人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
发明人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
IPC分类号： C12N15/18 , C12N15/85 , C12N15/63 , C12N15/70
CPC分类号： A61K9/0085 , A61K38/00 , C07K14/475 , Y10S530/809 , Y10S530/839
摘要： A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.
摘要翻译：已经鉴定了一种称为神经胶质细胞系衍生的神经营养因子（GDNF）的新型神经营养因子，并从B49胶质母细胞瘤细胞的无血清生长条件培养基中分离。编码GDNF的大鼠和人类基因已被克隆并测序。编码GDNF的基因已经被亚克隆到载体中，并且该载体已被用于转化宿主细胞，以便在重组DNA过程中产生生物活性的GDNF。

10. 发明授权

US06221376B1 Glial cell line-derived neurotrophic factor 失效
标题翻译：神经胶质细胞系衍生的神经营养因子
公开(公告)号：US06221376B1
公开(公告)日：2001-04-24
申请号：US08935268
申请日：1997-09-22
申请人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
发明人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
IPC分类号： A61F200
CPC分类号： A61K9/0085 , A61K38/00 , C07K14/475 , Y10S530/809 , Y10S530/839
摘要： A novel neurotrophic factor referred to as glial cell line-derived neurotrophic factor (GDNF) has been identified. Genes encoding GDNF have been cloned and sequenced. Methods and devices are disclosed for the delivery of GDNF using either an implantable cell which expresses human GDNF or a biocompatible semipermeable membrane containing genetically engineered cells which express and secrete the neurotrophic factor.
摘要翻译：已经鉴定了称为神经胶质细胞系衍生的神经营养因子（GDNF）的新型神经营养因子。编码GDNF的基因已被克隆并测序。公开了使用表达人GDNF的可植入细胞或含有表达和分泌神经营养因子的基因工程细胞的生物相容性半透膜的GDNF递送方法和装置。

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