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1. 发明申请

US20140045274A1 Method for Harvesting Nanoparticles and Sequestering Biomarkers 有权
标题翻译：收获纳米颗粒和螯合生物标志物的方法
公开(公告)号：US20140045274A1
公开(公告)日：2014-02-13
申请号：US13776631
申请日：2013-02-25
申请人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M. Dunlap , Alexis Patanarut
发明人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M. Dunlap , Alexis Patanarut
IPC分类号： G01N1/40
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译：描述从溶液中收集分析物的捕获颗粒和使用它们的方法。捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。捕获颗粒可用于分离和鉴定混合物中存在的分析物。它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

2. 发明授权

US09383299B2 Method for harvesting nanoparticles and sequestering biomarkers 有权
公开(公告)号：US09383299B2
公开(公告)日：2016-07-05
申请号：US13776631
申请日：2013-02-25
申请人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
发明人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
IPC分类号： B01D39/16 , G01N1/40 , B01D15/00 , B01D15/02 , B01D15/38 , B01J20/26 , B82Y15/00 , B01D15/34
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.

3. 发明授权

US08382987B2 Method for harvesting nanoparticles and sequestering biomarkers 有权
标题翻译：收获纳米颗粒和螯合生物标志物的方法
公开(公告)号：US08382987B2
公开(公告)日：2013-02-26
申请号：US12194371
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
IPC分类号： B01D39/16
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译：描述从溶液中收集分析物的捕获颗粒和使用它们的方法。捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。捕获颗粒可用于分离和鉴定混合物中存在的分析物。它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

4. 发明申请

US20090087346A1 Method for Harvesting Nanoparticles and Sequestering Biomarkers 有权
标题翻译：收获纳米颗粒和螯合生物标志物的方法
公开(公告)号：US20090087346A1
公开(公告)日：2009-04-02
申请号：US12194371
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M. Dunlap , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M. Dunlap , Alexis Patanarut
IPC分类号： B01J20/24 , G01N30/00 , B01J20/26
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译：描述从溶液中收集分析物的捕获颗粒和使用它们的方法。捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。捕获颗粒可用于分离和鉴定混合物中存在的分析物。它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

5. 发明授权

US08497137B2 Smart hydrogel particles for biomarker harvesting 有权
标题翻译：用于生物标志物收获的智能水凝胶颗粒
公开(公告)号：US08497137B2
公开(公告)日：2013-07-30
申请号：US12194360
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
IPC分类号： G01N33/545
CPC分类号： G01N33/5432 , G01N33/5436 , Y10T428/2989 , Y10T428/2998 , Y10T436/25375
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译：描述从溶液中收集分析物的捕获颗粒和使用它们的方法。捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。捕获颗粒可用于分离和鉴定混合物中存在的分析物。它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

6. 发明申请

US20120164749A1 Smart Hydrogel Particles for Biomarker Harvesting 有权
标题翻译：用于生物标记收获的智能水凝胶颗粒
公开(公告)号：US20120164749A1
公开(公告)日：2012-06-28
申请号：US12194360
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
IPC分类号： G01N1/18 , C08F220/56 , B82Y40/00
CPC分类号： G01N33/5432 , G01N33/5436 , Y10T428/2989 , Y10T428/2998 , Y10T436/25375
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译：描述从溶液中收集分析物的捕获颗粒和使用它们的方法。捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。捕获颗粒可用于分离和鉴定混合物中存在的分析物。它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

7. 发明申请

US20130085076A1 BORRELIA BURGDORFERI BACTERIAL ANTIGEN DIAGNOSIC TEST USING POLYMERIC BAIT CONTAINING CAPTURE PARTICLES 审中-公开
标题翻译： BORRELIA BURGDORFERI细菌抗原测试使用含聚合物颗粒的聚合物
公开(公告)号：US20130085076A1
公开(公告)日：2013-04-04
申请号：US13513568
申请日：2010-12-01
申请人： Temple Douglas , Alessandra Luchini , Claudia Fredolini , Davide Tamburro , Lance Liotta
发明人： Temple Douglas , Alessandra Luchini , Claudia Fredolini , Davide Tamburro , Lance Liotta
IPC分类号： G01N33/569
CPC分类号： G01N33/56911 , G01N33/54313 , G01N2333/20 , G01N2469/10 , Y02A50/57
摘要： The invention relates to both a sensitive method for the capture and detection of low-abundance Borrelia burgdorferi (Bb) bacterial antigens allowing for the diagnosis of Lyme Disease using standard immunoassays. Furthermore, this invention allows the antigen to be identified in a sample of urine, serum, or other biological fluids isolated from humans and animals. The invention provides a method to capture, concentrate, separate and specifically quantify the abundance of Bb antigens using immunoassays. The detection of Bb Outer Surface Protein A is presented as an example of the disclosed invention. High sensitivity levels, low cost and easily collected biofluids allow this technology to reach patients in clinics as well as POC applications for the early detection of Lyme disease prior to seroconversion. A kit containing necessary reagents and the method for diagnosis, monitoring or assessing lyme disease using an immunoassay such as an ELISA, western blot or RPPMA is disclosed.
摘要翻译：本发明涉及用于捕获和检测低丰度伯氏疏螺旋体（Bb）细菌抗原的敏感方法，其允许使用标准免疫测定法诊断莱姆病。此外，本发明允许在从人和动物分离的尿液，血清或其他生物流体的样品中鉴定抗原。本发明提供了使用免疫测定法捕获，浓缩，分离和特异性定量Bb抗原丰度的方法。 Bb外表面蛋白A的检测作为本发明的一个例子。高灵敏度水平，低成本和易于收集的生物流体使得该技术可以在诊所和POC应用中接触患者，以便在血清转化前早期发现莱姆病。公开了含有必需试剂的试剂盒和使用免疫测定如ELISA，western印迹或RPPMA进行诊断，监测或评估淋巴细胞疾病的方法。

8. 发明申请

US20120083422A1 Glioblastoma Biomarkers, and Methods and Compositions 审中-公开
标题翻译：胶质母细胞瘤生物标记物，方法和组合物
公开(公告)号：US20120083422A1
公开(公告)日：2012-04-05
申请号：US13152204
申请日：2011-06-02
申请人： Claudius Mueller , Lance Liotta , Emanuel Petricoin , Virginia Espina
发明人： Claudius Mueller , Lance Liotta , Emanuel Petricoin , Virginia Espina
IPC分类号： C12Q1/02 , C40B30/04 , C40B30/06
CPC分类号： G01N33/57407 , G01N2800/52
摘要： Glioblastoma multiforme biomarkers, methods, and compositions are provided. Methods of selecting a treatment for a patient with a brain neoplasm, including Glioblastoma multiforme, are provided. Methods of treating a patient at risk for Glioblastoma multiforme are provided.
摘要翻译：提供多形性成胶质细胞瘤生物标志物，方法和组合物。提供了选择对包括多形性成胶质细胞瘤在内的脑肿瘤患者的治疗方法。提供了治疗多形性成胶质细胞瘤风险的患者的方法。

9. 发明授权

US07794952B2 Biomarker isolation and use thereof to characterize physiological state 有权
标题翻译：生物标志物分离及其用于表征生理状态
公开(公告)号：US07794952B2
公开(公告)日：2010-09-14
申请号：US11639414
申请日：2006-12-15
申请人： Lance Liotta , Emanuel Petricoin
发明人： Lance Liotta , Emanuel Petricoin
IPC分类号： G01N33/53
CPC分类号： G01N33/6848 , G01N33/57415 , G01N33/57449 , G01N2333/4703 , G01N2333/976 , G01N2400/02
摘要： The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.
摘要翻译：本发明涉及用于表征生物体系的生理状态的组合物和方法，包括细胞，组织，器官和整个生物体。该方法涉及从生物系统捕获生物标志物，并将其存在或不存在与生理状态相关联。生物标志物可以从系统中捕获，然后使用任何合适的分析系统进行检测以确定其存在或不存在。在一个实施方案中，本发明涉及一种检测从单个受试者获得的血清或血浆样品中的多肽生物标志物的方法，该亲和配体能够结合来自同一亲本分子的多种不同的多肽生物标志物。

10. 发明申请

US20070275483A1 Biomarker isolation and use thereof to characterize physiological state 有权
标题翻译：生物标志物分离及其用于表征生理状态
公开(公告)号：US20070275483A1
公开(公告)日：2007-11-29
申请号：US11639414
申请日：2006-12-15
申请人： Lance Liotta , Emanuel Petricoin
发明人： Lance Liotta , Emanuel Petricoin
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/6848 , G01N33/57415 , G01N33/57449 , G01N2333/4703 , G01N2333/976 , G01N2400/02
摘要： The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.
摘要翻译：本发明涉及用于表征生物体系的生理状态的组合物和方法，包括细胞，组织，器官和整个生物体。该方法涉及从生物系统捕获生物标志物，并将其存在或不存在与生理状态相关联。生物标志物可以从系统中捕获，然后使用任何合适的分析系统进行检测以确定其存在或不存在。在一个实施方案中，本发明涉及一种检测从单个受试者获得的血清或血浆样品中的多肽生物标志物的方法，该亲和配体能够结合来自同一亲本分子的多种不同的多肽生物标志物。

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