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1. 发明授权

US09383299B2 Method for harvesting nanoparticles and sequestering biomarkers 有权
公开(公告)号：US09383299B2
公开(公告)日：2016-07-05
申请号：US13776631
申请日：2013-02-25
申请人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
发明人： Alessandra Luchini Kunkel , Lance Liotta , Emanuel Petricoin , Barney Bishop , Francesco Meani , Claudia Fredolini , Thomas M Dunlap , Alexis Patanarut
IPC分类号： B01D39/16 , G01N1/40 , B01D15/00 , B01D15/02 , B01D15/38 , B01J20/26 , B82Y15/00 , B01D15/34
CPC分类号： G01N1/405 , B01D15/00 , B01D15/02 , B01D15/34 , B01D15/3804 , B01D15/3861 , B01J20/26 , B01J20/261 , B01J20/264 , B01J20/265 , B01J2220/54 , B82Y15/00 , G01N33/54313 , G01N33/545 , Y10T436/255
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.

2. 发明申请

US20120083422A1 Glioblastoma Biomarkers, and Methods and Compositions 审中-公开
标题翻译：胶质母细胞瘤生物标记物，方法和组合物
公开(公告)号：US20120083422A1
公开(公告)日：2012-04-05
申请号：US13152204
申请日：2011-06-02
申请人： Claudius Mueller , Lance Liotta , Emanuel Petricoin , Virginia Espina
发明人： Claudius Mueller , Lance Liotta , Emanuel Petricoin , Virginia Espina
IPC分类号： C12Q1/02 , C40B30/04 , C40B30/06
CPC分类号： G01N33/57407 , G01N2800/52
摘要： Glioblastoma multiforme biomarkers, methods, and compositions are provided. Methods of selecting a treatment for a patient with a brain neoplasm, including Glioblastoma multiforme, are provided. Methods of treating a patient at risk for Glioblastoma multiforme are provided.
摘要翻译：提供多形性成胶质细胞瘤生物标志物，方法和组合物。提供了选择对包括多形性成胶质细胞瘤在内的脑肿瘤患者的治疗方法。提供了治疗多形性成胶质细胞瘤风险的患者的方法。

3. 发明授权

US07794952B2 Biomarker isolation and use thereof to characterize physiological state 有权
标题翻译：生物标志物分离及其用于表征生理状态
公开(公告)号：US07794952B2
公开(公告)日：2010-09-14
申请号：US11639414
申请日：2006-12-15
申请人： Lance Liotta , Emanuel Petricoin
发明人： Lance Liotta , Emanuel Petricoin
IPC分类号： G01N33/53
CPC分类号： G01N33/6848 , G01N33/57415 , G01N33/57449 , G01N2333/4703 , G01N2333/976 , G01N2400/02
摘要： The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.
摘要翻译：本发明涉及用于表征生物体系的生理状态的组合物和方法，包括细胞，组织，器官和整个生物体。该方法涉及从生物系统捕获生物标志物，并将其存在或不存在与生理状态相关联。生物标志物可以从系统中捕获，然后使用任何合适的分析系统进行检测以确定其存在或不存在。在一个实施方案中，本发明涉及一种检测从单个受试者获得的血清或血浆样品中的多肽生物标志物的方法，该亲和配体能够结合来自同一亲本分子的多种不同的多肽生物标志物。

4. 发明申请

US20100159486A1 BIOMARKERS FOR NEUROLOGICAL CONDITIONS 审中-公开
标题翻译：生物标志物用于神经病学条件
公开(公告)号：US20100159486A1
公开(公告)日：2010-06-24
申请号：US12513032
申请日：2007-11-01
申请人： Lance A. Liotta , Wediong Zhou , Wolff Kirsch , Virginia Espina , Emanuel Petricoin, III , Mark Ross , Claudius Mueller , Shino Magaki
发明人： Lance A. Liotta , Wediong Zhou , Wolff Kirsch , Virginia Espina , Emanuel Petricoin, III , Mark Ross , Claudius Mueller , Shino Magaki
IPC分类号： G01N33/53 , C12Q1/02 , G01N33/566 , G01N33/00 , C07K16/18
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/2871
摘要： Low molecular weight (LMW) peptides have been discovered that are indicative of neurological conditions, such as Alzheimer's Disease (AD), cognitive impairment and brain microhemmorhages. Evaluating patient samples for the presence of such LMW peptides is an effective means of detecting neurological conditions and monitoring the progression of the disease. The LMW peptides are particularly useful in detecting neurological conditions during the early stages without invasive procedures.
摘要翻译：已经发现了低分子量（LMW）肽，其指示诸如阿尔茨海默氏病（AD），认知障碍和脑微血管损伤之类的神经病学状况。评估患者样本中存在这样的LMW肽是检测神经系统疾病和监测疾病进展的有效手段。 LMW肽特别可用于在早期阶段检测神经系统疾病而无侵入性手术。

5. 发明申请

US20070275483A1 Biomarker isolation and use thereof to characterize physiological state 有权
标题翻译：生物标志物分离及其用于表征生理状态
公开(公告)号：US20070275483A1
公开(公告)日：2007-11-29
申请号：US11639414
申请日：2006-12-15
申请人： Lance Liotta , Emanuel Petricoin
发明人： Lance Liotta , Emanuel Petricoin
IPC分类号： G01N33/53 , C12Q1/68
CPC分类号： G01N33/6848 , G01N33/57415 , G01N33/57449 , G01N2333/4703 , G01N2333/976 , G01N2400/02
摘要： The present invention relates to compositions and methods for characterizing the physiological state of a living system, including cells, tissues, organs, and whole organisms. The methods involve capturing biomarkers from the living system, and correlating their presence or absence to a physiological state. The biomarkers can be captured from the system, and then detected using any suitable analytical system to determine their presence or absence. In one embodiment, the invention relates to a method of detecting a polypeptide biomarker in a blood serum or plasma sample obtained from a single subject with an affinity ligand which is capable of binding to a plurality of different polypeptide biomarkers derived from the same parental molecule.
摘要翻译：本发明涉及用于表征生物体系的生理状态的组合物和方法，包括细胞，组织，器官和整个生物体。该方法涉及从生物系统捕获生物标志物，并将其存在或不存在与生理状态相关联。生物标志物可以从系统中捕获，然后使用任何合适的分析系统进行检测以确定其存在或不存在。在一个实施方案中，本发明涉及一种检测从单个受试者获得的血清或血浆样品中的多肽生物标志物的方法，该亲和配体能够结合来自同一亲本分子的多种不同的多肽生物标志物。

6. 发明申请

US20050043593A9 Process for discriminating between biological states based on hidden patterns from biological data 有权
公开(公告)号：US20050043593A9
公开(公告)日：2005-02-24
申请号：US09906661
申请日：2001-07-18
申请人： Ben Hitt , Emanuel Petricoin III , Peter Levine , Lance Liotta
发明人： Ben Hitt , Emanuel Petricoin III , Peter Levine , Lance Liotta
IPC分类号： G01N27/62 , G01N33/48 , G06F19/00 , G01N33/50 , C12Q1/68 , A61B5/00
CPC分类号： G06F19/24 , G06F19/00 , G06F19/20 , G16H10/40 , G16H50/70 , Y10S707/99933 , Y10S707/99943
摘要： The invention describes a process for determining a biological state through the discovery and analysis of hidden or non-obvious, discriminatory biological data patterns. The biological data can be from health data, clinical data, or from a biological sample, (e.g., a biological sample from a human, e.g., serum, blood, saliva, plasma, nipple aspirants, synovial fluids, cerebrospinal fluids, sweat, urine, fecal matter, tears, bronchial lavage, swabbings, needle aspirantas, semen, vaginal fluids, pre-ejaculate.), etc. which is analyzed to determine the biological state of the donor. The biological state can be a pathologic diagnosis, toxicity state, efficacy of a drug, prognosis of a disease, etc. Specifically, the invention concerns processes that discover hidden discriminatory biological data patterns (e.g., patterns of protein expression in a serum sample that classify the biological state of an organ) that describe biological states.

7. 发明申请

US20120164749A1 Smart Hydrogel Particles for Biomarker Harvesting 有权
标题翻译：用于生物标记收获的智能水凝胶颗粒
公开(公告)号：US20120164749A1
公开(公告)日：2012-06-28
申请号：US12194360
申请日：2008-08-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , Barney Bishop , Caterina Longo , Virginia Espina , Alexis Patanarut
IPC分类号： G01N1/18 , C08F220/56 , B82Y40/00
CPC分类号： G01N33/5432 , G01N33/5436 , Y10T428/2989 , Y10T428/2998 , Y10T436/25375
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译：描述从溶液中收集分析物的捕获颗粒和使用它们的方法。捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。当对颗粒施加刺激时，捕获颗粒的孔径是可变的，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。捕获颗粒的聚合物基质由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。捕获颗粒可用于分离和鉴定混合物中存在的分析物。它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

8. 发明申请

US20110318336A1 Identification and Treatment of Aggressive Lung Cancer Tumors 审中-公开
标题翻译：侵袭性肺癌肿瘤的鉴别与治疗
公开(公告)号：US20110318336A1
公开(公告)日：2011-12-29
申请号：US13075163
申请日：2011-03-29
申请人： Emanuel Petricoin, III , Julia Wulfkuhle , Angela Zupa
发明人： Emanuel Petricoin, III , Julia Wulfkuhle , Angela Zupa
IPC分类号： A61K39/395 , A61K31/517 , A61P35/00 , A61K31/506 , A61K31/404 , C40B40/10 , C40B30/04 , A61K31/5377
CPC分类号： G01N33/6884 , A61K31/00 , G01N33/57423 , G01N2800/02
摘要： This invention relates to the identification and treatment of aggressive lung cancer tumors in patients. More particularly, it provides a method of identifying patients with non-small cell lung carcinoma (NSCLC) who have an aggressive node-negative (N0) tumor and a likelihood of a poor overall survival. The method comprises the step of determining if one or more of certain identified proteins are activated in tumor cells obtained from the patient's tumor, wherein the activation of one or more of the proteins indicates that the patient has an aggressive N0 tumor and is likely to have a poor overall-survival. The invention also provides a method for selecting a treatment for an NSCLC patient with an N0 tumor and a method for treating such patients. It further provides a kit for identifying an NSCLC patient with an aggressive N0 tumor and a likelihood of a poor overall survival and a pharmaceutical composition for treating such patients.
摘要翻译：本发明涉及患者侵袭性肺癌肿瘤的鉴别和治疗。更具体地，其提供了鉴定具有侵袭性淋巴结阴性（N0）肿瘤和总生存差的可能性的非小细胞肺癌（NSCLC）患者的方法。该方法包括确定某些鉴定的蛋白质中的一种或多种是否在从患者肿瘤获得的肿瘤细胞中被活化的步骤，其中一种或多种蛋白质的活化指示患者具有侵略性的N0肿瘤并且可能具有总体生存差本发明还提供了用于选择具有N0肿瘤的NSCLC患者的治疗方法和用于治疗这种患者的方法。它进一步提供了一种用于鉴定具有侵袭性N0肿瘤的NSCLC患者和总体存活差的可能性的试剂盒和用于治疗这种患者的药物组合物。

9. 发明授权

US07935518B2 Smart hydrogel particles for biomarker harvesting 有权
标题翻译：用于生物标志物收获的智能水凝胶颗粒
公开(公告)号：US07935518B2
公开(公告)日：2011-05-03
申请号：US12033701
申请日：2008-02-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , David Geho
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , David Geho
IPC分类号： G01N33/545
CPC分类号： B01J20/26 , B01D15/34 , B01J20/265 , B01J20/28078 , B01J20/28095 , B01J2220/54 , C12Q1/6816 , G01N33/54313 , G01N33/54353 , G01N33/5436 , Y10S435/81 , Y10S436/808 , Y10T436/255 , C12Q2565/518
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles may be changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles may be made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译：描述从溶液中收集分析物的捕获颗粒和使用它们的方法。捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。当对颗粒施加刺激时，捕获颗粒的孔径可以变化，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。捕获颗粒的聚合物基质可以由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。捕获颗粒可用于分离和鉴定混合物中存在的分析物。它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

10. 发明申请

US20090148961A1 SMART HYDROGEL PARTICLES FOR BIOMARKER HARVESTING 有权
标题翻译：用于生物标记收集的SMART HYDROGEL颗粒
公开(公告)号：US20090148961A1
公开(公告)日：2009-06-11
申请号：US12033701
申请日：2008-02-19
申请人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , David Geho
发明人： Alessandra Luchini , Lance Liotta , Emanuel Petricoin , David Geho
IPC分类号： G01N33/543 , B01J19/00 , G01N27/00 , G01N21/00 , G01N21/64 , C12M1/00 , C08J9/16
CPC分类号： B01J20/26 , B01D15/34 , B01J20/265 , B01J20/28078 , B01J20/28095 , B01J2220/54 , C12Q1/6816 , G01N33/54313 , G01N33/54353 , G01N33/5436 , Y10S435/81 , Y10S436/808 , Y10T436/255 , C12Q2565/518
摘要： Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles may be changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles may be made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
摘要翻译：描述从溶液中收集分析物的捕获颗粒和使用它们的方法。捕获颗粒由具有允许分析物进入捕获颗粒的孔径的聚合物基质构成。当对颗粒施加刺激时，捕获颗粒的孔径可以变化，允许改变颗粒的孔径，使得目标分析物保留在颗粒内。捕获颗粒的聚合物基质可以由具有结构单体和亲和单体的共聚物制成，亲和单体具有将分析物吸引到捕获颗粒的性质。捕获颗粒可用于分离和鉴定混合物中存在的分析物。它们也可用于保护在收获时通常会降解的分析物，并将低分析物浓缩在液体中的丰度低。

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