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1. 发明申请

US20080167377A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20080167377A1
公开(公告)日：2008-07-10
申请号：US11954815
申请日：2007-12-12
申请人： Alessandra Gaiba , Mark Patrick Healy , Christopher Norbert Johnson , Susan Roomans , Steven James Stanway , Martin Edward Swarbrick
发明人： Alessandra Gaiba , Mark Patrick Healy , Christopher Norbert Johnson , Susan Roomans , Steven James Stanway , Martin Edward Swarbrick
IPC分类号： A61K31/195 , C07C229/42 , A61P29/00
CPC分类号： C07C235/56
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1, R2, R3, R4, R5, m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R 1，R 2，R 3，R 3， 4，R 5，m，n和X如说明书中所定义; 制备这种化合物的方法; 包含这些化合物的药物组合物; 并在药物中使用这些化合物。

2. 发明授权

US08314147B2 Benzamide derivatives as EP4 receptor agonists 失效
标题翻译：苯甲酰胺衍生物作为EP4受体激动剂
公开(公告)号：US08314147B2
公开(公告)日：2012-11-20
申请号：US12519219
申请日：2007-12-12
申请人： Alessandra Gaiba , Mark Patrick Healy , Christopher Norbert Johnson , Susan Roomans , Steven James Stanway , Martin Edward Swarbrick
发明人： Alessandra Gaiba , Mark Patrick Healy , Christopher Norbert Johnson , Susan Roomans , Steven James Stanway , Martin Edward Swarbrick
IPC分类号： A61K31/195
CPC分类号： C07C235/56
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1, R2, R3, R4, R5, m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R1，R2，R3，R4，R5，m，n和X如说明书中所定义; 制备这种化合物的方法; 包含这些化合物的药物组合物; 并在药物中使用这些化合物。

3. 发明申请

US20100022650A1 Benzamide Derivatives As EP4 Receptor Agonists 失效
标题翻译：苯甲酰胺衍生物作为EP4受体激动剂
公开(公告)号：US20100022650A1
公开(公告)日：2010-01-28
申请号：US12519219
申请日：2007-12-12
申请人： Alessandra Gaiba , Mark Patrick Healy , Christopher Norbert Johnson , Susan Roomans , Steven James Stanway , Martin Edward Swarbrick
发明人： Alessandra Gaiba , Mark Patrick Healy , Christopher Norbert Johnson , Susan Roomans , Steven James Stanway , Martin Edward Swarbrick
IPC分类号： A61K31/196 , C07C229/40 , A61P29/00 , A61P25/00
CPC分类号： C07C235/56
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1, R2, R3, R4, R5, m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R1，R2，R3，R4，R5，m，n和X如说明书中所定义; 制备这种化合物的方法; 包含这些化合物的药物组合物; 并在药物中使用这些化合物。

4. 发明申请

US20100305166A1 NOVEL COMPOUNDS 失效
标题翻译：新型化合物
公开(公告)号：US20100305166A1
公开(公告)日：2010-12-02
申请号：US12740216
申请日：2008-10-30
申请人： Alessandra Gaiba , Susan Roomans , Martin Edward Swarbrick
发明人： Alessandra Gaiba , Susan Roomans , Martin Edward Swarbrick
IPC分类号： A61K31/44 , C07C229/38 , A61K31/195 , A61P29/00 , A61P19/08 , A61P25/28 , A61P13/12 , C07D213/80 , C07D257/04 , A61K31/41
CPC分类号： C07C235/52 , C07D213/30 , C07D213/80 , C07D257/04
摘要： A compound of formula (I) or salts thereof, wherein R1, R2, R3, R4, n and X are as defined in the specification; a process for preparing such compounds, a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其盐，其中R1，R2，R3，R4，n和X如说明书中所定义; 制备这些化合物的方法，包含这些化合物的药物组合物; 并在药物中使用这些化合物。

5. 发明授权

US08293798B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US08293798B2
公开(公告)日：2012-10-23
申请号：US12740216
申请日：2008-10-30
申请人： Alessandra Gaiba , Susan Roomans , Martin Edward Swarbrick
发明人： Alessandra Gaiba , Susan Roomans , Martin Edward Swarbrick
IPC分类号： A01N37/18 , A01N43/40 , A61K31/165 , A61K31/435 , C07C233/00 , C07C235/00 , C07C237/00 , C07D213/00
CPC分类号： C07C235/52 , C07D213/30 , C07D213/80 , C07D257/04
摘要： A compound of formula (I) or salts thereof, wherein R1, R2, R3, R4, n and X are as defined in the specification; a process for preparing such compounds, a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其盐，其中R1，R2，R3，R4，n和X如说明书中所定义; 制备这些化合物的方法，包含这些化合物的药物组合物; 并在药物中使用这些化合物。

6. 发明申请

US20100179168A1 ARYL AND HETEROARYL SULPHONAMIDES AS GROWTH HORMONE SECRETAGOGUE RECEPTOR AGONISTS 审中-公开
标题翻译： ARYL和HETEROARYL SULPHONAMIDES作为生长激素秘密吸收激素
公开(公告)号：US20100179168A1
公开(公告)日：2010-07-15
申请号：US12296965
申请日：2007-04-13
申请人： Emma Louise Blaney , David Kenneth Dean , Alessandra Gaiba , Nigel Paul King , Jason Witherington
发明人： Emma Louise Blaney , David Kenneth Dean , Alessandra Gaiba , Nigel Paul King , Jason Witherington
IPC分类号： A61K31/497 , C07D307/36 , C07D405/12 , C07D333/22 , A61K31/341 , A61K31/381 , A61K31/443 , A61P1/00 , A61P1/04 , A61P1/06 , A61P9/00 , A61P19/10
CPC分类号： C07C311/29 , C07D307/38 , C07D333/18 , C07D405/12
摘要： The present invention therefore provides compounds of formula (I) or pharmaceutically acceptable salts thereof: (I) processes for their preparation, pharmaceutical compositions containing the same and to their use in the treatment of gastrointestinal and other disorders.
摘要翻译：因此，本发明提供式（I）化合物或其药学上可接受的盐：（I）其制备方法，含有该化合物的药物组合物及其在治疗胃肠道和其它疾病中的用途。

7. 发明申请

US20070259877A1 Piperazine Derivatives Useful for the Treatment of Gastrointestinal Disorders 失效
标题翻译：哌嗪衍生物可用于治疗胃肠道疾病
公开(公告)号：US20070259877A1
公开(公告)日：2007-11-08
申请号：US11572715
申请日：2005-07-26
申请人： David Dean , Alessandra Gaiba , Nigel King , Andrew Takle , Jason Witherington
发明人： David Dean , Alessandra Gaiba , Nigel King , Andrew Takle , Jason Witherington
IPC分类号： A61K31/4965 , A61K31/497 , A61P1/00 , C07D403/12 , C07D405/12 , C07D409/12
CPC分类号： C07D295/135 , C07D207/27 , C07D215/36 , C07D231/12 , C07D261/10 , C07D263/32 , C07D265/28 , C07D271/12 , C07D307/10 , C07D333/08 , C07D333/62 , C07D409/04 , C07D409/14 , C07D413/04 , C07D495/04
摘要： The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors. Pharmaceutical compositions comprising the compounds methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R a，R b，R c，R c，其中，R e，R e，R f和Y如说明书中所定义。化合物是生长激素促分泌素（GHS）受体的部分或全部激动剂。还提供了包含化合物的制备方法的化合物的药物组合物，化合物的用途和涉及化合物的方法。

8. 发明授权

US07381728B2 Piperazine derivatives useful for the treatment of gastrointestinal disorders 失效
标题翻译：哌嗪衍生物可用于治疗胃肠道疾病
公开(公告)号：US07381728B2
公开(公告)日：2008-06-03
申请号：US11572715
申请日：2005-07-26
申请人： David Kenneth Dean , Alessandra Gaiba , Nigel Paul King , Andrew Kenneth Takle , Jason Witherington
发明人： David Kenneth Dean , Alessandra Gaiba , Nigel Paul King , Andrew Kenneth Takle , Jason Witherington
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号： C07D295/135 , C07D207/27 , C07D215/36 , C07D231/12 , C07D261/10 , C07D263/32 , C07D265/28 , C07D271/12 , C07D307/10 , C07D333/08 , C07D333/62 , C07D409/04 , C07D409/14 , C07D413/04 , C07D495/04
摘要： The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors. Pharmaceutical compositions comprising the compounds methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R a，R b，R c，R c，其中，R e，R e，R f和Y如说明书中所定义。化合物是生长激素促分泌素（GHS）受体的部分或全部激动剂。还提供了包含化合物的制备方法的化合物的药物组合物，化合物的用途和涉及化合物的方法。

9. 发明授权

US06987119B2 Imidazol-2-carboxamide derivatives as raf kinase inhibitors 失效
标题翻译：咪唑-2-甲酰胺衍生物作为raf激酶抑制剂
公开(公告)号：US06987119B2
公开(公告)日：2006-01-17
申请号：US10220675
申请日：2001-03-02
申请人： Alessandra Gaiba , Andrew Kenneth Takle , David Matthew Wilson
发明人： Alessandra Gaiba , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/44 , C07D401/04
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heterocyclyl, heterocyclyl-C1-6alkyl, heteroaryl, or heteroarylC1-6alkyl any of which except hydrogen may be optionally substituted; R2 and R3 independently represent hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heteroaryl, heteroarylC1-6alkyl, heterocyclyl, or heterocyclylC1-6alkyl any one of which except hydrogen may be optionally substituted, or R2 and R3 together with the nitrogen atom to which they are attached form a 4- to 10-membered optionally substituted monocyclic or bicyclic ring; Ar is an aryl or heteroaryl ring either of which may be optionally substituted; one of X1 and X2 is N and the other is NR4, wherein R4 is hydrogen, C1-6alkyl, or arylC1-6alkyl; or pharmaceutically acceptable salts thereof; their use as inhibitors of Raf kinases and pharmaceutical compositions containing them.
摘要翻译：式（I）的化合物：其中X是O，CH 2，S或NH，或X-R 1部分是氢; V是CH或N; R 1是氢，C 1-6烷基，C 3-7环烷基，芳基，芳基C 1-6 烷基，杂环基，杂环基-C 1-6烷基，杂芳基或杂芳基C 1-6烷基，除氢以外的任何一个可以任选被取代; R 2和R 3独立地表示氢，C 1-6烷基，C 3-7环烷基，芳基，芳基C 1-6烷基，杂芳基，杂芳基C 1-6烷基，杂环基或杂环基C 1-6烷基，除氢以外的任何一个可以任选地被取代，或者R 2和R 3与它们所连接的氮原子一起形成4-至10-元任选取代的单环或双环; Ar是任选被取代的芳基或杂芳基环; X 1和X 2之一是N，另一个是NR 4，其中R 4是氢， C 1-6烷基或芳基C 1-6烷基; 或其药学上可接受的盐; 它们用作Raf激酶的抑制剂和含有它们的药物组合物。

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