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1. 发明授权

US06987119B2 Imidazol-2-carboxamide derivatives as raf kinase inhibitors 失效
标题翻译：咪唑-2-甲酰胺衍生物作为raf激酶抑制剂
公开(公告)号：US06987119B2
公开(公告)日：2006-01-17
申请号：US10220675
申请日：2001-03-02
申请人： Alessandra Gaiba , Andrew Kenneth Takle , David Matthew Wilson
发明人： Alessandra Gaiba , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/44 , C07D401/04
CPC分类号： C07D401/04
摘要： Compounds of formula (I): wherein X is O, CH2, S or NH, or the moiety X—R1 is hydrogen; V is CH or N; R1 is hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heterocyclyl, heterocyclyl-C1-6alkyl, heteroaryl, or heteroarylC1-6alkyl any of which except hydrogen may be optionally substituted; R2 and R3 independently represent hydrogen, C1-6alkyl, C3-7cycloalkyl, aryl, arylC1-6alkyl, heteroaryl, heteroarylC1-6alkyl, heterocyclyl, or heterocyclylC1-6alkyl any one of which except hydrogen may be optionally substituted, or R2 and R3 together with the nitrogen atom to which they are attached form a 4- to 10-membered optionally substituted monocyclic or bicyclic ring; Ar is an aryl or heteroaryl ring either of which may be optionally substituted; one of X1 and X2 is N and the other is NR4, wherein R4 is hydrogen, C1-6alkyl, or arylC1-6alkyl; or pharmaceutically acceptable salts thereof; their use as inhibitors of Raf kinases and pharmaceutical compositions containing them.
摘要翻译：式（I）的化合物：其中X是O，CH 2，S或NH，或X-R 1部分是氢; V是CH或N; R 1是氢，C 1-6烷基，C 3-7环烷基，芳基，芳基C 1-6 烷基，杂环基，杂环基-C 1-6烷基，杂芳基或杂芳基C 1-6烷基，除氢以外的任何一个可以任选被取代; R 2和R 3独立地表示氢，C 1-6烷基，C 3-7环烷基，芳基，芳基C 1-6烷基，杂芳基，杂芳基C 1-6烷基，杂环基或杂环基C 1-6烷基，除氢以外的任何一个可以任选地被取代，或者R 2和R 3与它们所连接的氮原子一起形成4-至10-元任选取代的单环或双环; Ar是任选被取代的芳基或杂芳基环; X 1和X 2之一是N，另一个是NR 4，其中R 4是氢， C 1-6烷基或芳基C 1-6烷基; 或其药学上可接受的盐; 它们用作Raf激酶的抑制剂和含有它们的药物组合物。

2. 发明授权

US07381728B2 Piperazine derivatives useful for the treatment of gastrointestinal disorders 失效
标题翻译：哌嗪衍生物可用于治疗胃肠道疾病
公开(公告)号：US07381728B2
公开(公告)日：2008-06-03
申请号：US11572715
申请日：2005-07-26
申请人： David Kenneth Dean , Alessandra Gaiba , Nigel Paul King , Andrew Kenneth Takle , Jason Witherington
发明人： David Kenneth Dean , Alessandra Gaiba , Nigel Paul King , Andrew Kenneth Takle , Jason Witherington
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号： C07D295/135 , C07D207/27 , C07D215/36 , C07D231/12 , C07D261/10 , C07D263/32 , C07D265/28 , C07D271/12 , C07D307/10 , C07D333/08 , C07D333/62 , C07D409/04 , C07D409/14 , C07D413/04 , C07D495/04
摘要： The invention provides compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ra, Rb, Rc, Rd, Re, Rf and Y are as defined in the specification. The compounds are partial or full agonists at the growth hormone secretagogue (GHS) receptors. Pharmaceutical compositions comprising the compounds methods of preparing the compounds, uses of the compounds and methods involving the compounds are also provided.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，其中R a，R b，R c，R c，其中，R e，R e，R f和Y如说明书中所定义。化合物是生长激素促分泌素（GHS）受体的部分或全部激动剂。还提供了包含化合物的制备方法的化合物的药物组合物，化合物的用途和涉及化合物的方法。

3. 发明授权

US07375105B2 Pyridine substituted furan derivatives as Raf kinase inhibitors 失效
标题翻译：吡啶取代的呋喃衍生物作为Raf激酶抑制剂
公开(公告)号：US07375105B2
公开(公告)日：2008-05-20
申请号：US10488650
申请日：2002-09-05
申请人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
发明人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/5377 , A61K31/4545 , A61K31/443 , C07D413/14 , C07D211/32 , C07D405/04
CPC分类号： C07D405/04 , C07D405/14
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy. Wherein X is O, CH2 CO, S or NH, or the moiety X—R1 is hydrogen; Y1 and Y2 independently represent CH or N; Ar is a mono- or fused bicyclic aromatic or heteroaromatic group which may be optionally substituted; one of X1 and X2 is selected from O, S or NR11 and the other is CH, wherein R11 is hydrogen, C1-6alkyl, aryl or arylC1-6alkyl.
摘要翻译：化合物及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。其中X是O，CH 2 CO，S或NH，或者X-R 1部分是氢; Y 1和Y 2独立地表示CH或N; Ar是可以任选取代的单或二稠合双环芳族或杂芳族基团; X 1和X 2之一选自O，S或NR 11，另一个是CH，其中R 11， / SUP>是氢，C 1-6烷基，芳基或芳基C 1-6烷基。

4. 发明授权

US07297694B2 Pyridylfurans and pyrroles as Raf kinase inhibitors 失效
标题翻译：吡咯烷基呋喃和吡咯作为Raf激酶抑制剂
公开(公告)号：US07297694B2
公开(公告)日：2007-11-20
申请号：US10488576
申请日：2002-09-05
申请人： David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
发明人： David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/506 , A61K31/443 , A61K31/4439 , C07D401/04 , C07D405/04 , C07D405/14 , C07D407/14
CPC分类号： C07D401/04 , A61K31/44 , A61K31/505 , C07D405/04 , C07D405/14
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译：化合物及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。

5. 发明授权

US07452906B2 Pyridine derivatives as Raf kinase inhibitors 失效
标题翻译：吡啶衍生物作为Raf激酶抑制剂
公开(公告)号：US07452906B2
公开(公告)日：2008-11-18
申请号：US10488580
申请日：2002-09-05
申请人： Mark James Bamford , David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
发明人： Mark James Bamford , David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/445 , C07D401/14 , C07D405/14 , C07D413/14
CPC分类号： C07D405/04 , C07D405/14
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译：化合物及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。

6. 发明授权

US07446106B2 Pyridylfurans and pyrroles as Raf kinase inhibitors 失效
标题翻译：吡咯烷基呋喃和吡咯作为Raf激酶抑制剂
公开(公告)号：US07446106B2
公开(公告)日：2008-11-04
申请号：US10488577
申请日：2002-09-05
申请人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
发明人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： C07D401/04 , C07D405/04 , A61K31/44
CPC分类号： C07D401/04 , A61K31/44 , A61K31/505 , C07D405/04
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译：化合物及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。

7. 发明授权

US07282500B2 Imidazole-2-carboxamide derivatives as Raf kinase inhibitors 失效
标题翻译：咪唑-2-甲酰胺衍生物作为Raf激酶抑制剂
公开(公告)号：US07282500B2
公开(公告)日：2007-10-16
申请号：US10478153
申请日：2002-05-20
申请人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
发明人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/5377 , C07D401/14 , C07D413/14
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, use as Raf Kinase Inhibitors and treatment methods for neurotraumatic diseases and cancer.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，相应的药物组合物，用作Raf激酶抑制剂和用于神经损伤疾病和癌症的治疗方法。

8. 发明授权

US07297693B2 Nitrogen-containing heterocyclic compounds and their use as Raf inhibitors 失效
标题翻译：含氮杂环化合物及其作为Raf抑制剂的用途
公开(公告)号：US07297693B2
公开(公告)日：2007-11-20
申请号：US10488579
申请日：2002-09-05
申请人： Mark James Bamford , David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
发明人： Mark James Bamford , David Kenneth Dean , Antoinette Naylor , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/506 , A61K31/443 , A61K31/4439 , C07D401/04 , C07D405/04 , C07D405/14 , C07D407/14
CPC分类号： C07D451/04 , C07D405/04 , C07D405/14 , C07D409/04
摘要： Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy.
摘要翻译：化合物及其作为药物的用途，特别是用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂。

9. 发明授权

US07199137B2 Imidazole derivatives as Raf kinase inhibitors 失效
标题翻译：咪唑衍生物作为Raf激酶抑制剂
公开(公告)号：US07199137B2
公开(公告)日：2007-04-03
申请号：US10380891
申请日：2001-09-19
申请人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
发明人： David Kenneth Dean , Andrew Kenneth Takle , David Matthew Wilson
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D401/04 , A61K49/0021 , C07D401/14 , C07D405/14
摘要： Novel compounds (I) and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac hypertrophy wherein Ar is a group of formula a) or b).
摘要翻译：新型化合物（I）及其作为药物特别用作治疗神经创伤性疾病，癌症，慢性神经变性，疼痛，偏头痛和心脏肥大的Raf激酶抑制剂的用途，其中Ar是式a）或b）的基团。

10. 发明授权

US07956083B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US07956083B2
公开(公告)日：2011-06-07
申请号：US12864933
申请日：2009-02-17
申请人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
发明人： Christopher Norbert Johnson , David G. Jones , Xi Liang , David Timothy MacPherson , Aaron B Miller , Steven James Stanway , Andrew Kenneth Takle , Giancarlo Trani , Antoinette Wilson
IPC分类号： A01N43/38 , C07D209/04
CPC分类号： C07D209/08
摘要： The present invention relates to novel indole derivatives having pharmacological activity, processes for their preparation, compositions containing them and the use of these compounds in the treatment of estrogen receptor beta mediated diseases.
摘要翻译：本发明涉及具有药理活性的新型吲哚衍生物，其制备方法，含有它们的组合物以及这些化合物在治疗雌激素受体β介导的疾病中的用途。

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