专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4135514A Osmotic releasing system for administering ophthalmic drug to eye of animal 失效
标题翻译：渗透性释放系统，用于将眼药物用于动物眼
公开(公告)号：US4135514A
公开(公告)日：1979-01-23
申请号：US775989
申请日：1977-03-09
申请人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
发明人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
IPC分类号： A61F6/14 , A61F9/00 , A61K9/00 , A61M31/00
CPC分类号： A61K9/0051 , A61F6/14 , A61F6/144 , A61F9/0017 , A61K9/0004 , A61K9/0039
摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid, or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
摘要翻译：公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。该试剂可溶于流体并且表现出跨越半透性壁抵抗流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，该溶质表现出穿过半透壁的渗透压梯度，抵抗流体。在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度设备。

2. 发明授权

US4096238A Method for administering drug to the gastrointestinal tract 失效
标题翻译：向胃肠道施用药物的方法
公开(公告)号：US4096238A
公开(公告)日：1978-06-20
申请号：US775774
申请日：1977-03-09
申请人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
发明人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
IPC分类号： A61F6/14 , A61F9/00 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0051 , A61F6/14 , A61F6/144 , A61F9/0017 , A61K9/0004 , A61K9/0039
摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
摘要翻译：公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。该试剂可溶于流体并且表现出跨越半透性壁对流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，其表现出穿过半透壁的渗透压梯度抵抗流体。在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度设备。

3. 发明授权

US4093708A Osmotic releasing device having a plurality of release rate patterns 失效
标题翻译：渗透释放装置具有多个释放速率模式
公开(公告)号：US4093708A
公开(公告)日：1978-06-06
申请号：US775988
申请日：1977-03-09
申请人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
发明人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
IPC分类号： A61F6/14 , A61F9/00 , A61K9/00 , A61K9/22
CPC分类号： A61K9/0051 , A61F6/14 , A61F6/144 , A61F9/0017 , A61K9/0004 , A61K9/0039
摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
摘要翻译：公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。在选择的环境中侵蚀以改变装置的释放速率图案的图案率控制材料层被承载在远离隔室的半透壁上。该试剂可溶于流体并且表现出跨越半透性壁对流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，其表现出穿过半透壁的渗透压梯度抵抗流体。在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度设备。

4. 发明授权

US4036227A Osmotic releasing device having a plurality of release rate patterns 失效
标题翻译：渗透释放装置具有多个释放速率模式
公开(公告)号：US4036227A
公开(公告)日：1977-07-19
申请号：US536006
申请日：1974-12-23
申请人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
发明人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
IPC分类号： A61F6/14 , A61F9/00 , A61K9/00 , A61M37/00
CPC分类号： A61K9/0004 , A61F6/14 , A61F6/144 , A61F9/0017
摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid, or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
摘要翻译：公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。该试剂可溶于流体并且表现出跨越半透性壁抵抗流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，该溶质表现出穿过半透壁的渗透压梯度，抵抗流体。在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度设备。

5. 发明授权

US4142526A Osmotic releasing system with means for changing release therefrom 失效
标题翻译：渗透释放系统，具有改变其释放的装置
公开(公告)号：US4142526A
公开(公告)日：1979-03-06
申请号：US775987
申请日：1977-03-09
申请人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
发明人： Alejandro Zaffaroni , Alan S. Michaels , Felix Theeuwes
IPC分类号： A61F6/14 , A61F9/00 , A61K9/00 , A61M31/00 , A61M37/00
CPC分类号： A61K9/0051 , A61F6/14 , A61F6/144 , A61F9/0017 , A61K9/0004 , A61K9/0039
摘要： An osmotic device for releasing a useful agent at different release rate patterns from the device in a selected environment is disclosed. The device is comprised of a wall surrounding and forming a compartment as a means for containing a useful agent and having a passageway for releasing the agent. The wall is comprised in at least a part of a material permeable to an external fluid and impermeable to the agent. A layer of a pattern rate controlling material that erodes in a selected environment for changing the release rate pattern of the device is carried on the semipermeable wall distant from the compartment. The agent is soluble in the fluid and exhibits an osmotic pressure gradient across the semipermeable wall against the fluid, or the agent has limited solubility and is admixed with an osmotically effective solute soluble in the fluid that exhibits an osmotic pressure gradient across the semipermeable wall against the fluid. In operation, agent is released from the device at different release rate patterns by the pattern rate controlling material eroding at a controlled rate to increase the amount of fluid available to the semipermeable wall for imbibition, which fluid is imbibed through the wall into the compartment producing a solution of the soluble agent or a solution of the osmotically effective solute containing the agent which is released through the passageway to the exterior of the device at a rate controlled by the permeability of the semipermeable wall and the osmotic pressure gradient across the wall of the device.
摘要翻译：公开了一种用于在所选环境中从设备以不同释放速率模式释放有用试剂的渗透装置。该装置包括围绕并形成隔室的壁，作为用于容纳有用试剂并具有用于释放试剂的通道的装置。所述壁包括在对外部流体可渗透并且对所述试剂不可渗透的材料的至少一部分中。在选择的环境中侵蚀以改变装置的释放速率图案的图案速率控制材料层被承载在远离隔室的半透壁上。该试剂可溶于流体并且表现出跨越半透性壁抵抗流体的渗透压梯度，或者该试剂具有有限的溶解度，并且与可溶于流体的渗透压有效溶质混合，该溶质表现出穿过半透壁的渗透压梯度，抵抗流体。在操作中，通过模式速率控制材料以受控的速率以不同的释放速率模式从设备释放试剂，以增加半渗透壁可用于吸入的流体的量，该流体通过壁被吸入隔室产生将可溶性试剂或含有该试剂的渗透有效溶质的溶液的溶液以通过该通道释放的渗透压力通过半透壁的渗透率和穿过该壁的渗透压梯度设备。

6. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

7. 发明授权

US5141750A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5141750A
公开(公告)日：1992-08-25
申请号：US271122
申请日：1988-11-14
申请人： Eun Soo Lee , Felix Theeuwes , Patrick Wong S. L. , Su Il Yum , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick Wong S. L. , Su Il Yum , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability emables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性可以从序列和并发应用用于管理诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

8. 发明授权

US5071656A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5071656A
公开(公告)日：1991-12-10
申请号：US271207
申请日：1988-11-14
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Alejandro Zaffaroni
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/7069 , A61K31/21 , A61K9/7084 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

9. 发明申请

US20130028953A1 Transdermal Delivery Systems for Sufentanil 审中-公开
标题翻译：舒芬太尼透皮给药系统
公开(公告)号：US20130028953A1
公开(公告)日：2013-01-31
申请号：US13486711
申请日：2012-06-01
申请人： Su II Yum , Felix Theeuwes
发明人： Su II Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61P29/00 , A61K31/4535
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

10. 发明授权

US08246977B2 Transdermal delivery systems 有权
标题翻译：透皮递送系统
公开(公告)号：US08246977B2
公开(公告)日：2012-08-21
申请号：US11665813
申请日：2005-10-21
申请人： Su Il Yum , Felix Theeuwes
发明人： Su Il Yum , Felix Theeuwes
IPC分类号： A61K9/70 , A61K31/445
CPC分类号： A61K9/703 , A61F2013/0296 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/4535 , A61M35/00
摘要： Transdermal delivery systems for administering sufentanil through the skin are provided. The systems contain a sufficient amount of sufentanil to induce and maintain a constant state of analgesia when applied to a subject. The systems are characterized as having one or more features including a high degree of dosage form rate control over flux of sufentanil from the system, a high net flux of sufentanil from the system through the skin, lack of a permeation enhancer, an adhesive member demonstrating superior shear time, a low coefficient of variation in the net flux of sufentanil from the system, a high delivery efficiency, and a substantially constant steady state net flux of sufentanil from the system. Methods of using the transdermal delivery systems to administer a sufficient amount of sufentanil to induce and maintain analgesia for extended periods when applied to a subject are also provided.
摘要翻译：提供了通过皮肤施用舒芬太尼的透皮递送系统。当施用于受试者时，该系统含有足量的舒芬太尼以诱导和保持恒定的止痛状态。该系统的特征在于具有一个或多个特征，其包括对来自系统的舒芬太尼的通量的高剂量形式速率控制，来自系统通过皮肤的舒芬太尼的高净通量，缺乏渗透促进剂，优异的剪切时间，来自系统的舒芬太尼的净通量的低变异系数，高的输送效率和来自系统的舒芬太尼的稳定的稳态净通量。还提供了使用透皮递送系统施用足够量的舒芬太尼以在施用于受试者时延长期间诱导和维持止痛的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式