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1. 发明授权

US5284660A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5284660A
公开(公告)日：1994-02-08
申请号：US933423
申请日：1992-08-21
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Robert M. Gale , Alejandro Zaffaroni
IPC分类号： A61K9/00 , A61K9/22 , A61K9/70 , A61F13/00
CPC分类号： A61K9/7084 , A61K9/7069 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

2. 发明授权

US5071656A Delayed onset transdermal delivery device 失效
标题翻译：延迟发作透皮递送装置
公开(公告)号：US5071656A
公开(公告)日：1991-12-10
申请号：US271207
申请日：1988-11-14
申请人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Alejandro Zaffaroni
发明人： Eun Soo Lee , Felix Theeuwes , Patrick S. L. Wong , Su Il Yum , Alejandro Zaffaroni
IPC分类号： A61K9/70 , A61K31/21
CPC分类号： A61K9/7069 , A61K31/21 , A61K9/7084 , A61K9/7092
摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in a predetermined temporal pattern at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.
摘要翻译：描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。合适的方法包括设置在释放表面和试剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初对试剂不渗透，然后变为可渗透的。可以提供由一个或多个这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

3. 发明授权

US4564364A Active agent dispenser 失效
标题翻译：活性剂分配器
公开(公告)号：US4564364A
公开(公告)日：1986-01-14
申请号：US498381
申请日：1983-05-26
申请人： Alejandro Zaffaroni , Patrick S. L. Wong
发明人： Alejandro Zaffaroni , Patrick S. L. Wong
IPC分类号： B01J4/00 , A61K9/20 , A61K9/26 , A61K9/70 , A61M31/00 , A61F15/00
CPC分类号： A61K9/7023 , A61K9/2086 , A61M31/002 , A61F2013/0296
摘要： The release pattern of a dispersion type active agent dispenser can be improved by forming the device from a depleted zone containing the agent at a concentration no greater than the saturation and a non-depleted zone containing the agent dispersed in the matrix at a uniform concentration greater than saturation. The depleted zone is disposed between the surface through which the agent is to be dispensed and at least a substantial portion of the non-depleted zone with the interface therebetween disposed at a non-uniform distance from the releasing surface. Certain embodiments are particularly useful for the transdermal administration of drugs.
摘要翻译：分散型活性剂分配器的释放模式可以通过从不含饱和度的含有试剂的贫化区形成装置，并且以均匀的浓度将含有分散在基质中的试剂的非贫化区形成，比饱和度。耗尽区设置在待分配试剂的表面和至少大部分的非耗尽区之间，其间的界面设置在与释放表面不均匀的距离处。某些实施方案对于透皮给药药物特别有用。

4. 发明授权

US5198229A Self-retaining gastrointestinal delivery device 失效
标题翻译：自体胃肠输送装置
公开(公告)号：US5198229A
公开(公告)日：1993-03-30
申请号：US710607
申请日：1991-06-05
申请人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen
发明人： Patrick S. L. Wong , Felix Theeuwes , Steven D. Larsen
IPC分类号： A61K9/00
CPC分类号： A61K9/0065 , A61K9/0004
摘要： The present invention is directed to a fluid-imbibing drug delivery device having a first, low density such that it floats in the stomach contents for a predetermined prolonged period of time, during which prolonged period of time it dispenses a drug or other active agent to the stomach, and having a second, higher density such that the device exits the stomach at the end of the predetermined prolonged period of time.
摘要翻译：本发明涉及一种流体吸收药物递送装置，其具有第一低密度，使得其在胃内容物中漂浮预定的较长时间段，在此期间，其将药物或其它活性剂分配到胃，并且具有第二较高密度，使得装置在预定的较长时间段结束时离开胃。

5. 发明授权

US4986987A Pulsed drug delivery 失效
标题翻译：脉冲给药
公开(公告)号：US4986987A
公开(公告)日：1991-01-22
申请号：US312845
申请日：1989-02-21
申请人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
发明人： Atul D. Ayer , Felix Theeuwes , Patrick S. L. Wong
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form comprising (1) an immediately available dose of a beneficial drug followed by a timed delayed dose of drug, or (2) a timed delayed dose of drug.
摘要翻译：一种剂型，其包含（1）立即可用的有效药物剂量，然后是药物的定时延迟剂量，或（2）定时延迟剂量的药物。

6. 发明授权

US4957494A Multi-layer delivery system 失效
标题翻译：多层交付系统
公开(公告)号：US4957494A
公开(公告)日：1990-09-18
申请号：US283631
申请日：1988-12-13
申请人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff
发明人： Patrick S. L. Wong , Felix Theeuwes , James B. Eckenhoff
IPC分类号： A61K9/00 , A61M31/00
CPC分类号： A61M31/002 , A61K9/0004
摘要： A dispenser for use in a fluid environment which is capable of delivery of plurality of discrete drug containing layers in any desired delivery pattern or profile. The dispenser comprises a rigid housing containing a plurality of drug layers which may be separated by drug-free layers. An outlet is provided at one end of the housing and a fluid actuated driving means is provided between the other end of the housing and the drug layers. The portion of the housing in proximity to the driving means has a controlled permeability to water whereby, upon immersion in a fluid environment the drug layers are driven towards the outlet. Various delivery patterns are possible by appropriate selection of the comparison and dimensions of the drug and drug-free layers.
摘要翻译：一种在流体环境中使用的分配器，其能够以任何期望的输送模式或轮廓递送多个离散的含药层。分配器包括容纳多个药物层的刚性壳体，其可由无药物层分离。出口设在壳体的一端，并且流体驱动的驱动装置设置在壳体的另一端和药物层之间。壳体靠近驱动装置的部分对水具有受控的渗透性，因此当浸入流体环境中时，药物层朝着出口被驱动。可以通过适当选择药物和无药物层的比较和尺寸来实现各种递送模式。

7. 发明授权

US4765989A Osmotic device for administering certain drugs 失效
标题翻译：用于给予某些药物的渗透装置
公开(公告)号：US4765989A
公开(公告)日：1988-08-23
申请号：US902915
申请日：1986-09-02
申请人： Patrick S. L. Wong , Brian L. Barclay , Joseph C. Deters , Felix Theeuwes
发明人： Patrick S. L. Wong , Brian L. Barclay , Joseph C. Deters , Felix Theeuwes
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains an osmotic composition comprising a beneficial drug selected from the group consisting of nifedipine, prazosin and doxazosin, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.
摘要翻译：公开了渗透系统，其包括围绕隔室的至少一部分半渗透材料的壁。隔室含有渗透组合物，其包含选自硝苯地平，哌唑嗪和多沙唑嗪的有益药物，以及第二和不同的渗透组合物。墙壁上的通道将第一个组合物与系统的外部连接起来。

8. 发明授权

US4751071A Composition comprising salbutamol 失效
标题翻译：组合物包含沙丁胺醇
公开(公告)号：US4751071A
公开(公告)日：1988-06-14
申请号：US1135
申请日：1987-01-07
申请人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
发明人： Paul R. Magruder , Brian Barclay , Patrick S. L. Wong , Felix Theeuwes
IPC分类号： A61K9/00 , A61M31/00 , A61J3/07
CPC分类号： A61K9/0004 , A61M31/002
摘要： An osmotic delivery system is disclosed for delivering a useful agent at a controlled and constant rate modulated by a pulsed delivery of the useful agent to an environment of use.
摘要翻译：公开了一种渗透递送系统，用于以受控和恒定的速率递送有用的试剂，该有效试剂通过有用试剂的脉冲输送调节到使用环境。

9. 发明授权

US6120803A Prolonged release active agent dosage form adapted for gastric retention 有权
公开(公告)号：US6120803A
公开(公告)日：2000-09-19
申请号：US131923
申请日：1998-08-10
申请人： Patrick S. L. Wong , Liang-Chang Dong , David E. Edgren , Felix Theeuwes , Phyllis I. Gardner , Francisco Jao , Jason J. Wan
发明人： Patrick S. L. Wong , Liang-Chang Dong , David E. Edgren , Felix Theeuwes , Phyllis I. Gardner , Francisco Jao , Jason J. Wan
IPC分类号： A61K47/22 , A61K9/00 , A61K9/20 , A61K9/22 , A61K9/26 , A61K31/341 , A61K31/522 , A61K45/00 , A61P31/12
CPC分类号： A61K9/0065 , A61K9/2072
摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

10. 发明授权

US5324280A Osmotic dosage system for delivering a formulation comprising liquid carrier and drug 失效
标题翻译：用于递送包含液体载体和药物的制剂的渗透剂量系统
公开(公告)号：US5324280A
公开(公告)日：1994-06-28
申请号：US502705
申请日：1990-04-02
申请人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
发明人： Patrick S. L. Wong , Felix Theeuwes , Brian L. Barclay , Michael H. Dealey
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译：公开了用于将有益剂制剂递送到使用环境的渗透系统。渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。

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