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    • 7. 发明授权
    • Steroid eluting electrode for peripheral nerve stimulation
    • 用于周围神经刺激的类固醇洗脱电极
    • US5265608A
    • 1993-11-30
    • US802953
    • 1991-12-05
    • Philip LeeKenneth StokesMichael Colson
    • Philip LeeKenneth StokesMichael Colson
    • A61N1/05A61B5/04
    • A61N1/0556
    • An improved electrode for establishing electrical contact with a nerve of a patient. This electrical contact may be used to sense neural activity on the nerve or to artificially stimulate it to perform various medical treatments. One embodiment of the electrode has an outer cuff of an insulating material which is sutured around the nerve to be contacted. A drug impregnated layer of material is positioned inside of the outer cuff. This material is a polymeric matrix which permits the drug to leach out at a predetermined rate. The drug is preferably a glucocortico steroid such as dexamethasone sodium phosphate. The actual electrical contact is produced by metallic foil which is positioned on the surface of the drug impregnated layer of material which is located inside of the cuff. A second embodiment employs a half cuff which is held in contact with the nerve tissue by being sutured to muscle tissue. The insulative substrate of the half cuff is a drug impregnated polymeric matrix. The electrode is a metallic disc, preferably round or oval in shape, which is recessed into the insulative substrate. An insulated lead electrically couples the metallic foil or metallic disc to an electronic circuit located remote from the nerve. The leaching out of the drug serves to control inflammation, irritation and swelling, and stabilizes the impedance and threshold of the nerve/electrode interface.
    • 用于与患者的神经建立电接触的改进的电极。 该电接触可用于感测神经上的神经活动或人为地刺激其进行各种医学治疗。 电极的一个实施例具有绝缘材料的外箍,其被缝合在要接触的神经周围。 药物浸渍的材料层位于外箍内侧。 该材料是允许药物以预定速率浸出的聚合物基质。 该药物优选为葡萄糖皮质类固醇,例如地塞米松磷酸钠。 实际的电接触由金属箔制成,该金属箔位于位于袖带内部的药物浸渍材料层的表面上。 第二实施例采用通过缝合到肌肉组织而与神经组织保持接触的半箍。 半箍的绝缘底物是药物浸渍的聚合物基质。 电极是金属盘,优选为圆形或椭圆形,其凹入绝缘基底。 绝缘引线将金属箔或金属盘电耦合到远离神经的电子电路。 药物中的浸出物用于控制炎症,刺激和肿胀,稳定神经/电极界面的阻抗和阈值。