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1. 发明申请

US20070166726A1 Method for detecting radiation exposure 失效
标题翻译：辐射暴露检测方法
公开(公告)号：US20070166726A1
公开(公告)日：2007-07-19
申请号：US11370079
申请日：2006-03-06
申请人： Albert Fornace , Sally Amundson , Jeffrey Trent
发明人： Albert Fornace , Sally Amundson , Jeffrey Trent
IPC分类号： C12Q1/68 , C07H21/04 , C12M3/00
CPC分类号： C12Q1/689 , C12Q1/68 , C12Q1/6888 , C12Q2600/106 , C12Q2600/158 , C12Q2565/501 , C12Q2523/313
摘要： A method is disclosed for detecting exposure of organisms to biologically significant or hazardous amounts of ionizing radiation. The method uses nucleic acid microarray hybridization to evaluate biological effects, such as patterns of expression of genes after radiation exposure. Numerous genes are provided which have been found to be responsive to radiation exposure in a variety of cell lines. These genes are incorporated into probe sets, which are exposed to a labeled nucleic acid composition from a test cell, such as cDNA reverse transcribed from mRNA in the test cell, which specifically hybridizes to members of the probe set when the cell has been exposed to a biologically significant amount of ionizing radiation. Whether the nucleic acid composition hybridizes to the nucleic acid molecules representing genes that are differentially expressed is determined. The invention also includes methods for determining a dose response relationship between radiation exposure and differential expression of one or more genes, for example to determine a probable radiation dose in cells that have actually or potentially been exposed to the ionizing radiation. The invention also includes probe sets and microarrays used in this method.
摘要翻译：公开了一种用于检测生物体对生物显着或有害量的电离辐射的暴露的方法。该方法使用核酸微阵列杂交来评估生物学效应，例如辐射暴露后基因表达的模式。已经发现已经发现许多基因对多种细胞系中的辐射暴露有反应。将这些基因并入探针组中，其从测试细胞暴露于标记的核酸组合物，例如在测试细胞中从mRNA反向转录的cDNA，当细胞暴露于细胞时，该特异性与探针组的成员杂交生物显着量的电离辐射。确定核酸组合物是否与表达差异表达基因的核酸分子杂交。本发明还包括用于确定辐射暴露与一种或多种基因的差异表达之间的剂量反应关系的方法，例如确定实际上或潜在地暴露于电离辐射的细胞中的可能的辐射剂量。本发明还包括在该方法中使用的探针组和微阵列。

2. 发明申请

US20090023645A1 AIB1, a novel steroid receptor co-activator 审中-公开
标题翻译： AIB1，一种新型类固醇受体共激活剂
公开(公告)号：US20090023645A1
公开(公告)日：2009-01-22
申请号：US11789761
申请日：2007-04-24
申请人： Paul Meltzer , Jeffrey Trent
发明人： Paul Meltzer , Jeffrey Trent
IPC分类号： A61K38/17 , C12Q1/68 , A61K31/711 , A61P35/04 , A61K38/02
CPC分类号： C07K14/4705 , A01K2217/05 , A01K2217/075 , A61K38/00
摘要： The invention features a substantially pure DNA which includes a sequence encoding a novel steroid receptor co-activator which is overexpressed in breast cancer cells, diagnostic assays for steroid hormone-responsive cancers, and screening assays to identify compounds which inhibit an interaction of the co-activator with the steroid hormone.
摘要翻译：本发明的特征在于基本上纯的DNA，其包括编码在乳腺癌细胞中过表达的新型类固醇受体共激活物的序列，以及用于类固醇激素反应性癌症的诊断测定法，以及筛选测定化合物的序列，激素与类固醇激素。

3. 发明授权

US08898621B2 Methods and systems for implementing a logical programming model 有权
标题翻译：实现逻辑编程模型的方法和系统
公开(公告)号：US08898621B2
公开(公告)日：2014-11-25
申请号：US12845002
申请日：2010-07-28
申请人： Jeffrey Trent
发明人： Jeffrey Trent
IPC分类号： G06F9/44 , G06F9/50
CPC分类号： G06F9/5072 , G06F8/20
摘要： Embodiments of the invention provide systems and methods for implementing a logical programming model that separates a resource from its state and processes the resource and the state of the resource independently. According to one embodiment, a method of method for implementing a logical programming model can comprise defining a resource and defining one or more state objects for the resource. An application can be defined including at least one instance of the defined resource and at least one instance of the defined one or more state objects. Logic of the application can handle the one or more state objects independent from the resource.
摘要翻译：本发明的实施例提供了用于实现将资源与其状态分离并且独立地处理资源和资源状态的逻辑编程模型的系统和方法。根据一个实施例，用于实现逻辑编程模型的方法的方法可以包括定义资源并为资源定义一个或多个状态对象。可以定义应用程序，其包括定义的资源的至少一个实例和所定义的一个或多个状态对象的至少一个实例。应用程序的逻辑可以处理独立于资源的一个或多个状态对象。

4. 发明授权

US06562589B1 AIB1, a novel steroid receptor co-activator 失效
公开(公告)号：US06562589B1
公开(公告)日：2003-05-13
申请号：US09125635
申请日：1998-08-21
申请人： Paul Meltzer , Jeffrey Trent
发明人： Paul Meltzer , Jeffrey Trent
IPC分类号： C07H2104
CPC分类号： C07K14/4705 , A01K2217/05 , A01K2217/075 , A61K38/00
摘要： The invention features a substantially pure DNA which includes a sequence encoding a novel steroid receptor co-activator which is overexpressed in breast cancer cells, diagnostic assays for steroid hormone-responsive cancers, and screening assays to identify compounds which inhibit an interaction of the co-activator with the steroid hormone.

5. 发明申请

US20110088044A1 METHODS AND SYSTEMS FOR IMPLEMENTING A LOGICAL PROGRAMMING MODEL 有权
标题翻译：实现逻辑编程模型的方法和系统
公开(公告)号：US20110088044A1
公开(公告)日：2011-04-14
申请号：US12845002
申请日：2010-07-28
申请人： Jeffrey Trent
发明人： Jeffrey Trent
IPC分类号： G06F9/44
CPC分类号： G06F9/5072 , G06F8/20
摘要： Embodiments of the invention provide systems and methods for implementing a logical programming model that separates a resource from its state and processes the resource and the state of the resource independently. According to one embodiment, a method of method for implementing a logical programming model can comprise defining a resource and defining one or more state objects for the resource. An application can be defined including at least one instance of the defined resource and at least one instance of the defined one or more state objects. Logic of the application can handle the one or more state objects independent from the resource.
摘要翻译：本发明的实施例提供了用于实现将资源与其状态分离并且独立地处理资源和资源状态的逻辑编程模型的系统和方法。根据一个实施例，用于实现逻辑编程模型的方法的方法可以包括定义资源并为资源定义一个或多个状态对象。可以定义应用程序，其包括定义的资源的至少一个实例和所定义的一个或多个状态对象的至少一个实例。应用程序的逻辑可以处理独立于资源的一个或多个状态对象。

6. 发明授权

US5658730A Methods of human prostate cancer diagnosis 失效
标题翻译：人前列腺癌诊断方法
公开(公告)号：US5658730A
公开(公告)日：1997-08-19
申请号：US376364
申请日：1994-12-23
申请人： John McGill , Carla Van Den Berg , Jeffrey Trent , Daniel Von Hoff , Paul Meltzer
发明人： John McGill , Carla Van Den Berg , Jeffrey Trent , Daniel Von Hoff , Paul Meltzer
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6841 , C12Q1/6886 , C12Q2600/112 , Y10S436/813
摘要： Disclosed are diagnostic techniques for the detection of human prostate cancer. Genetic probes and methods useful in monitoring the progression and diagnosis of prostate cancer are described. The invention relates particularly to hybridization methods for evaluating the prevalence of gene amplification in a limited regions of human chromosome 8q24.
摘要翻译：公开了用于检测人前列腺癌的诊断技术。描述了用于监测前列腺癌进展和诊断的遗传探针和方法。本发明特别涉及用于评估人染色体8q24的有限区域中基因扩增的流行的杂交方法。

7. 发明授权

US08438251B2 Methods and systems for implementing a virtual storage network 有权
标题翻译：用于实现虚拟存储网络的方法和系统
公开(公告)号：US08438251B2
公开(公告)日：2013-05-07
申请号：US12845009
申请日：2010-07-28
申请人： Jeffrey Trent
发明人： Jeffrey Trent
IPC分类号： G06F15/16 , G06F12/00
CPC分类号： H04L67/1097 , G06F3/067
摘要： Embodiments of the invention provide systems and methods for implementing a virtual Storage Area Network (SAN) in software. According to one embodiment, a method for implementing a virtual SAN can comprise defining an application for accessing a computing grid for storing information wherein defining the application for accessing the computing grid for storing the information comprises defining a resource and defining one or more state objects for the resource, wherein the one or more state objects are handled independent from the resource. For example, the computing grid can comprise an Oracle Coherence grid. Such a computing grid can maintain a primary copy and a backup copy of the information and provides the backup of the information if the primary copy is unavailable. The information stored on the computing grid can be accessed via the application.
摘要翻译：本发明的实施例提供了以软件实现虚拟存储区域网络（SAN）的系统和方法。根据一个实施例，用于实现虚拟SAN的方法可以包括定义用于访问用于存储信息的计算网格的应用，其中定义用于访问用于存储信息的计算网格的应用的应用包括定义资源并定义一个或多个状态对象所述资源，其中所述一个或多个状态对象独立于所述资源被处理。例如，计算网格可以包括Oracle Coherence网格。这样的计算网格可以维护信息的主要副本和备份副本，并且如果主副本不可用，则提供信息的备份。可以通过应用程序访问存储在计算网格上的信息。

8. 发明申请

US20110185340A1 SOFTWARE MODELING FRAMEWORK 有权
标题翻译：软件建模框架
公开(公告)号：US20110185340A1
公开(公告)日：2011-07-28
申请号：US12695082
申请日：2010-01-27
申请人： Jeffrey Trent , Lawrence Feigen
发明人： Jeffrey Trent , Lawrence Feigen
IPC分类号： G06F9/44
CPC分类号： G06F8/20 , G06F8/35 , G06F9/44526
摘要： A system and method for providing a software modeling framework which supports different types of dependency injection and other software modeling or software development frameworks, and which allows software developers to develop models that strategically layer different components for different implementations. A service provider interface (SPI) enables different DI frameworks to be incorporated into the system; while an application provider interface (API) enable machines or implementations to be constructed. Extenders can be modeled so that, for example a particular bundle requires a handler for a particular configuration manifest entry; while a particular module provides handling of that manifest entry.
摘要翻译：一种用于提供软件建模框架的系统和方法，该框架支持不同类型的依赖注入和其他软件建模或软件开发框架，并允许软件开发人员开发不同实现策略层次不同组件的模型。服务提供商接口（SPI）使不同的DI框架可以并入系统; 而应用程序提供程序接口（API）可以构建机器或实现。扩展器可以被建模，以便例如特定的捆绑包需要特定配置清单条目的处理程序; 而特定的模块提供对该清单条目的处理。

9. 发明申请

US20110087848A1 METHODS AND SYSTEMS FOR IMPLEMENTING A VIRTUAL STORAGE NETWORK 有权
标题翻译：实现虚拟存储网络的方法和系统
公开(公告)号：US20110087848A1
公开(公告)日：2011-04-14
申请号：US12845009
申请日：2010-07-28
申请人： Jeffrey Trent
发明人： Jeffrey Trent
IPC分类号： G06F12/00
CPC分类号： H04L67/1097 , G06F3/067
摘要： Embodiments of the invention provide systems and methods for implementing a virtual Storage Area Network (SAN) in software. According to one embodiment, a method for implementing a virtual SAN can comprise defining an application for accessing a computing grid for storing information wherein defining the application for accessing the computing grid for storing the information comprises defining a resource and defining one or more state objects for the resource, wherein the one or more state objects are handled independent from the resource. For example, the computing grid can comprise an Oracle Coherence grid. Such a computing grid can maintain a primary copy and a backup copy of the information and provides the backup of the information if the primary copy is unavailable. The information stored on the computing grid can be accessed via the application.
摘要翻译：本发明的实施例提供了以软件实现虚拟存储区域网络（SAN）的系统和方法。根据一个实施例，用于实现虚拟SAN的方法可以包括定义用于访问用于存储信息的计算网格的应用，其中定义用于访问用于存储信息的计算网格的应用的应用包括定义资源并定义一个或多个状态对象所述资源，其中所述一个或多个状态对象独立于所述资源被处理。例如，计算网格可以包括Oracle Coherence网格。这样的计算网格可以维护信息的主要副本和备份副本，并且如果主副本不可用，则提供信息的备份。可以通过应用程序访问存储在计算网格上的信息。

10. 发明授权

US08863074B2 Software modeling framework 有权
标题翻译：软件建模框架
公开(公告)号：US08863074B2
公开(公告)日：2014-10-14
申请号：US12695082
申请日：2010-01-27
申请人： Jeffrey Trent , Lawrence Feigen
发明人： Jeffrey Trent , Lawrence Feigen
IPC分类号： G06F9/44 , G06F9/445
CPC分类号： G06F8/20 , G06F8/35 , G06F9/44526
摘要： A system and method for providing a software modeling framework which supports different types of dependency injection and other software modeling or software development frameworks, and which allows software developers to develop models that strategically layer different components for different implementations. A service provider interface (SPI) enables different DI frameworks to be incorporated into the system; while an application provider interface (API) enable machines or implementations to be constructed. Extenders can be modeled so that, for example a particular bundle requires a handler for a particular configuration manifest entry; while a particular module provides handling of that manifest entry.
摘要翻译：一种用于提供软件建模框架的系统和方法，该框架支持不同类型的依赖注入和其他软件建模或软件开发框架，并允许软件开发人员开发不同实现策略层次不同组件的模型。服务提供商接口（SPI）使不同的DI框架可以并入系统; 而应用程序提供程序接口（API）可以构建机器或实现。扩展器可以被建模，以便例如特定的捆绑包需要特定配置清单条目的处理程序; 而特定的模块提供对该清单条目的处理。

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