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1. 发明申请

US20080286319A9 Antimicrobial surfaces and methods for preparing antimicrobial surfaces 审中-公开
标题翻译：抗微生物表面和制备抗菌表面的方法
公开(公告)号：US20080286319A9
公开(公告)日：2008-11-20
申请号：US10887029
申请日：2004-07-07
申请人： Alan Russell , Richard Koepsel , Sang Lee , Krzysztof Matyjaszewski
发明人： Alan Russell , Richard Koepsel , Sang Lee , Krzysztof Matyjaszewski
IPC分类号： A01N25/34
CPC分类号： A01N33/12 , A01N57/34 , A61L2/232
摘要： The present invention relates to biocidal articles. In an embodiment the biocidal article comprises a plurality of polymers having biocidally active groups. The polymers are attached to a surface and may have a polydispersity less than 3. The biocidally active groups may comprise at least one of a quaternary ammonium salt, a quaternary phosphonium salt or a chloroamine. The attached polymers may be any microstructure, topology or composition, such as, a homopolymer, block copolymer, multiblock copolymer, a random copolymer, graft polymer, a branched or a hyperbranched polymer, and a gradient copolymer. The present invention also comprises a process for the preparation of a biocidal article. Embodiments of the process comprise polymerizing radically polymerizable monomers from an initiator attached to a surface, wherein at least a portion of the monomers comprise a group capable of being converted to a biocidally active group, and converting the group to the biocidally active group.
摘要翻译：本发明涉及杀生物制品。在一个实施方案中，杀生物制品包含多个具有生物活性基团的聚合物。聚合物连接到表面并且可以具有小于3的多分散性。生物活性基团可以包含季铵盐，季鏻盐或氯胺中的至少一种。连接的聚合物可以是任何微结构，拓扑结构或组合物，例如均聚物，嵌段共聚物，多嵌段共聚物，无规共聚物，接枝聚合物，支链或超支化聚合物和梯度共聚物。本发明还包括制备杀生物制品的方法。该方法的实施方案包括将可自由基聚合的单体从附着于表面的引发剂聚合，其中至少一部分单体包含能够转化为生物活性基团的基团，并将该基团转化为生物活性基团。

2. 发明申请

US20060008490A1 Antimicrobial surfaces and methods for preparing antimicrobial surfaces 审中-公开
标题翻译：抗微生物表面和制备抗菌表面的方法
公开(公告)号：US20060008490A1
公开(公告)日：2006-01-12
申请号：US10887029
申请日：2004-07-07
申请人： Alan Russell , Richard Koepsel , Sang Lee , Krzysztof Matyjaszewski
发明人： Alan Russell , Richard Koepsel , Sang Lee , Krzysztof Matyjaszewski
IPC分类号： A01N25/34
CPC分类号： A01N33/12 , A01N57/34 , A61L2/232
摘要： The present invention relates to biocidal articles. In an embodiment the biocidal article comprises a plurality of polymers having biocidally active groups. The polymers are attached to a surface and may have a polydispersity less than 3. The biocidally active groups may comprise at least one of a quaternary ammonium salt, a quaternary phosphonium salt or a chloroamine. The attached polymers may be any microstructure, topology or composition, such as, a homopolymer, block copolymer, multiblock copolymer, a random copolymer, graft polymer, a branched or a hyperbranched polymer, and a gradient copolymer. The present invention also comprises a process for the preparation of a biocidal article. Embodiments of the process comprise polymerizing radically polymerizable monomers from an initiator attached to a surface, wherein at least a portion of the monomers comprise a group capable of being converted to a biocidally active group, and converting the group to the biocidally active group.
摘要翻译：本发明涉及杀生物制品。在一个实施方案中，杀生物制品包含多个具有生物活性基团的聚合物。聚合物连接到表面并且可以具有小于3的多分散性。生物活性基团可以包含季铵盐，季鏻盐或氯胺中的至少一种。连接的聚合物可以是任何微结构，拓扑结构或组合物，例如均聚物，嵌段共聚物，多嵌段共聚物，无规共聚物，接枝聚合物，支链或超支化聚合物和梯度共聚物。本发明还包括制备杀生物制品的方法。该方法的实施方案包括将可自由基聚合的单体从附着于表面的引发剂聚合，其中至少一部分单体包含能够转化为生物活性基团的基团，并将该基团转化为生物活性基团。

3. 发明申请

US20070232699A1 Self assembled nanostructures and mehods for preparing the same 失效
标题翻译：自组装纳米结构和制备方法
公开(公告)号：US20070232699A1
公开(公告)日：2007-10-04
申请号：US11237838
申请日：2005-09-27
申请人： Alan Russell , Richard Koepsel , Sang Lee
发明人： Alan Russell , Richard Koepsel , Sang Lee
IPC分类号： A61K31/16 , C07C237/16
CPC分类号： C07C233/38 , A61K9/1274 , A61K31/14 , A61K31/16 , B82Y5/00 , Y02A50/473 , Y10S977/712 , Y10S977/797 , Y10S977/882 , Y10T428/2982
摘要： The present invention provides amphiphilic diacetylene compounds, and compositions and self-assembled nanotubes containing the same. Also provided are methods of producing the compounds, compositions, and nanotubes of the invention, and methods of destroying or inhibiting the growth or proliferation of microorganisms using the nanotubes of the present invention.
摘要翻译：本发明提供两亲性乙炔化合物，以及含有该双乙炔化合物的组合物和自组装纳米管。还提供了制备本发明的化合物，组合物和纳米管的方法，以及使用本发明的纳米管破坏或抑制微生物生长或增殖的方法。

4. 发明申请

US20070122441A1 Biocidal surfaces, articles with biocidal surface agents and methods of synthesizing and evaluating biocidal surface agents 审中-公开
标题翻译：杀生物表面，具有杀生物表面活性剂的制品和合成和评估杀生物剂的方法
公开(公告)号：US20070122441A1
公开(公告)日：2007-05-31
申请号：US11601949
申请日：2006-11-20
申请人： Hironobu Murata , Richard Koespel , Sang Lee , Alan Russell
发明人： Hironobu Murata , Richard Koespel , Sang Lee , Alan Russell
IPC分类号： A01N57/00 , A01N25/00
CPC分类号： A01N25/34 , A01N33/12 , A01N37/36 , A01N43/40 , A01N55/00
摘要： A biocidal article, includes a surface including a plurality of polymers covalently attached to the surface. The polymers include biocidal cationic groups. The polymers have a molecular weight distribution or polydispersity less than 3. A grafting density of the polymers on the surface is controlled, average degree of polymerization of the polymers is controlled and repeat units of the polymers are chosen to provide a predetermined charge density arising from the cationic groups. A method of analyzing biocidal activity of biocidal surface agents includes the steps: attaching a plurality of chemical entities to one or more surfaces so that at least one physiochemical property is varied, each of the chemical entities comprising at least one biocidally active component; and exposing the chemical entities to at least one biological agent to determine the effect of the at least one physiochemical property upon biocidal activity. The biocidal activity can, for example, be antibacterial activity or sporicidal activity. The at least one physiochemical property can, for example, be varied in a preferably systematic manner.
摘要翻译：杀生物制品包括包含共价连接在表面上的多个聚合物的表面。聚合物包括杀生物阳离子基团。聚合物具有小于3的分子量分布或多分散性。控制聚合物在表面上的接枝密度，控制聚合物的平均聚合度，并且选择聚合物的重复单元以提供由阳离子基团。分析杀生物表面活性剂的杀生物活性的方法包括以下步骤：将多个化学实体连接到一个或多个表面，使得至少一个理化特性变化，每个化学实体包含至少一种生物活性成分; 以及将所述化学实体暴露于至少一种生物试剂以确定所述至少一种理化化学性质对杀生物活性的影响。杀生物活性可以例如是抗菌活性或杀孢子活性。至少一种理化特性可以例如以优选系统的方式变化。

5. 发明申请

US20070151167A1 Wear-resistant boride composites with high percentage of reinforcement phase 有权
标题翻译：耐磨硼化物复合材料具有高比例的强化相
公开(公告)号：US20070151167A1
公开(公告)日：2007-07-05
申请号：US11325292
申请日：2006-01-04
申请人： Bruce Cook , Joel Harringa , Alan Russell , Justin Peters , Atiq Ahmed
发明人： Bruce Cook , Joel Harringa , Alan Russell , Justin Peters , Atiq Ahmed
IPC分类号： C09K3/14 , B24D3/02
CPC分类号： C04B35/645 , C04B35/5805 , C04B35/58057 , C04B35/58071 , C04B2235/3804 , C04B2235/3808 , C04B2235/3813 , C04B2235/76 , C04B2235/77 , C04B2235/785 , C04B2235/80 , C04B2235/96
摘要： A highly wear resistant sintered, hot pressed, or otherwise compacted ceramic composite material is described, consisting of two discrete phases of the form AlxMgyB14 where x and y≦1 or like hard, orthorhombic compounds, and TiB2 or like Group IVB transition metal di-borides, and with an unexpectedly high content of transition metal di-boride in the range from 40 to 90 percent (28 to 85 volume percent).
摘要翻译：描述了一种高度耐磨的烧结，热压或其它压实的陶瓷复合材料，其由以下形式的两个离散相组成：Al x Si x Y B 14， / SUB>其中x和y <= 1或类似硬的正交化合物和TiB 2 N 2或类似的IVB族过渡金属二硼化物，并且具有出乎意料的高含量的过渡金属二硼化物范围从40％到90％（28％到85％）。

6. 发明申请

US20050274439A1 Intermetallic articles of manufacture having high room temperature ductility 审中-公开
标题翻译：具有高室温延展性的金属间制品
公开(公告)号：US20050274439A1
公开(公告)日：2005-12-15
申请号：US11120547
申请日：2005-05-03
申请人： Karl Gschneidner , Alexandra Tsokol , Vitalij Pecharsky , Alan Russell
发明人： Karl Gschneidner , Alexandra Tsokol , Vitalij Pecharsky , Alan Russell
IPC分类号： C21D7/00 , C22C1/02 , C22C5/06 , C22C28/00
CPC分类号： A44C27/002 , A61L27/04 , C01B3/0031 , C01B3/0036 , C01B3/0047 , C01B3/0052 , C01B3/0057 , C01B3/0063 , C01B3/0068 , C01B3/503 , C01B3/505 , C01B3/508 , C21D7/00 , C21D2201/04 , C22C1/02 , C22C5/00 , C22C28/00 , F28F21/08 , H01M4/383 , H01M8/04216 , Y02E60/327 , Y02P70/56
摘要： Article of manufacture fabricated by plastic deformation of an intermetallic compound comprising R and M, such as an RM intermetallic compound and a higher order compound thereof, having a CsCl-type ordered crystal structure wherein R is one or more rare earth elements and M is one or more non-rare earth metals. The article of manufacture has a tensile elongation of at least about 5% prior to fracture when tensile tested at room temperature in ambient air. The article of manufacture also can be fabricated by plastic deformation of an intermetallic compound comprising a M′M compound and a higher order compound thereof having a CsCl-type ordered crystal structure wherein M′ and M are one or more different non-rare earth metals.
摘要翻译：包含R和M的金属间化合物如RM金属间化合物及其高级化合物的塑性变形制造的制品，其具有CsCl型有序晶体结构，其中R是一种或多种稀土元素，M是一种或更多的非稀土金属。在室温下在环境空气中进行拉伸试验时，制品在断裂之前的拉伸伸长率至少为5％。制品也可以通过包含M'M化合物和具有CsCl型有序晶体结构的高级化合物的金属间化合物的塑性变形来制造，其中M'和M是一种或多种不同的非稀土金属。

7. 发明申请

US20050100748A1 Ultra-hard low friction coating based on AlMgB14 for reduced wear of MEMS and other tribological components and system 有权
标题翻译：基于AlMgB14的超硬低摩擦涂层，减少MEMS和其他摩擦组件和系统的磨损
公开(公告)号：US20050100748A1
公开(公告)日：2005-05-12
申请号：US10946051
申请日：2004-09-21
申请人： Bruce Cook , Yun Tian , Joel Harringa , Alan Constant , Alan Russell , Palaniappa Molian
发明人： Bruce Cook , Yun Tian , Joel Harringa , Alan Constant , Alan Russell , Palaniappa Molian
IPC分类号： B32B15/04 , B81B3/00 , B81B7/00 , C23C14/06 , C23C14/28 , C23C16/00
CPC分类号： C23C14/067 , B81B3/0075 , B81C2201/032 , C23C14/28 , Y10S428/938 , Y10T428/12736 , Y10T428/1275 , Y10T428/31678
摘要： Performance and reliability of microelectromechanical system (MEMS) components enhanced dramatically through the incorporation of protective thin film coatings. Current-generation MEMS devices prepared by the LIGA technique employ transition metals such as Ni, Cu, Fe, or alloys thereof, and hence lack stability in oxidizing, corrosive, and/or high temperature environments. Fabrication of a superhard, self-lubricating coating based on a ternary boride compound AlMgB14 is described in this letter as a potential breakthrough in protective coating technology for LIGA microdevices. Nanoindentation tests show that hardness of AlMgB14 films prepared by pulsed laser deposition ranges from 45 GPa to 51 GPa, when deposited at room temperature and 573 K, respectively. Extremely low friction coefficients of 0.04-0.05, which are thought to result from a self-lubricating effect, have also been confirmed by nanoscratch tests on the AlMgB14 films. Transmission electron microscopy studies show that the as-deposited films are amorphous, regardless of substrate temperature; however, analysis of FTIR spectra suggests that the higher substrate temperature facilitates formation of the B12 icosahedral framework, therefore leading to the higher hardness.
摘要翻译：微机电系统（MEMS）组件的性能和可靠性通过并入保护性薄膜涂层而显着提高。通过LIGA技术制备的当前一代MEMS器件采用过渡金属如Ni，Cu，Fe或其合金，因此在氧化，腐蚀性和/或高温环境中缺乏稳定性。在本文中描述了基于三元硼化物AlMgB 14的超硬自润滑涂层的制造，作为LIGA微型器件的保护涂层技术的潜在突破。纳米压痕测试显示，当分别在室温和573K下沉积时，通过脉冲激光沉积制备的AlMgB 14 N膜的硬度范围为45GPa至51GPa。认为是由自润滑效应引起的非常低的摩擦系数0.04-0.05也已经通过AlMgB 14膜的纳米尺度试验证实。透射电子显微镜研究表明，沉积膜是无定形的，不管基底温度如何; 然而，FTIR光谱的分析表明较高的底物温度有助于形成B 12二十面体骨架，因此导致更高的硬度。

8. 发明申请

US20140303366A1 Certain 1H-Imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-Imidazo[4,5-b]pyrazin-2-ols and Methods for Their Use 审中-公开
标题翻译：某些1H-咪唑并[4,5-b]吡嗪-2（3H） - 酮和1H-咪唑并[4,5-b]吡嗪-2-酮及其使用方法
公开(公告)号：US20140303366A1
公开(公告)日：2014-10-09
申请号：US14246230
申请日：2014-04-07
申请人： Aaron Hinken , Fady Malik , Malar Pannirselvam , Alan Russell
发明人： Aaron Hinken , Fady Malik , Malar Pannirselvam , Alan Russell
IPC分类号： C07D487/04 , C07D519/00
摘要： Provided is a method of treating myasthenia gravis in a patient by administering to the patient an effective amount of a skeletal muscle troponin activator, or a pharmaceutically acceptable salt thereof.
摘要翻译：提供一种通过向患者施用有效量的骨骼肌肌钙蛋白激活剂或其药学上可接受的盐来治疗患者重症肌无力的方法。

9. 发明申请

US20060024786A1 WASP and N-WASP constructs and methods of expressing such constructs 审中-公开
标题翻译： WASP和N-WASP构建体和表达此类构建体的方法
公开(公告)号：US20060024786A1
公开(公告)日：2006-02-02
申请号：US11150487
申请日：2005-06-10
申请人： Nenad Tomasevic , Alan Russell , Manping Wang , Roman Sakowicz , Christophe Beraud
发明人： Nenad Tomasevic , Alan Russell , Manping Wang , Roman Sakowicz , Christophe Beraud
IPC分类号： C07H21/04 , C12P21/06 , C12N9/16
CPC分类号： C07K14/47
摘要： WASP and N-WASP proteins are provided that can be expressed in soluble form, including fusion proteins that contain full-length WASP and N-WASP. The proteins retain at least partial activity of full length WASP or N-WASP and some of the proteins fully recapitulate the activity of full-length WASP and N-WASP. Methods for expressing full-length WASP and N-WASP are also provided.
摘要翻译：提供WASP和N-WASP蛋白，其可以以可溶形式表达，包括含有全长WASP和N-WASP的融合蛋白。蛋白质保持全长WASP或N-WASP的至少部分活性，并且一些蛋白质完全概括了全长WASP和N-WASP的活性。还提供了表达全长WASP和N-WASP的方法。

10. 发明申请

US20050279185A1 Ultra-hard boride-based metal matrix reinforcement 有权
标题翻译：超硬硼化物基金属基体强化
公开(公告)号：US20050279185A1
公开(公告)日：2005-12-22
申请号：US10871933
申请日：2004-06-18
申请人： Bruce Cook , Alan Russell , Joel Harringa , S. Biner , Iver Anderson
发明人： Bruce Cook , Alan Russell , Joel Harringa , S. Biner , Iver Anderson
IPC分类号： C22C29/14 , C22C32/00 , C22C49/14
CPC分类号： C22C49/14 , B22F2998/00 , C22C32/0073 , B22F3/02 , B22F3/10 , B22F3/14 , C22C1/1036
摘要： A composite of M/AlMgB14 or M alloy/AlMgB14 is synthesized, where M=Al, Ti, W, or Cu. Small particles and/or fibers of AlMgB14 are distributed throughout a metal matrix to strengthen the resulting composite.
摘要翻译：合成M / AlMgB 14或M合金/ AlMgB 14 N的复合物，其中M = Al，Ti，W或Cu。 AlMgB 14的小颗粒和/或纤维分布在整个金属基体中以加强所得的复合材料。

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