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    • 2. 发明申请
    • Copper-complex isonitrile positron emission tomography (pet) imaging agent and method
    • 铜复合异腈正电子发射断层扫描(pet)成像剂及方法
    • US20070189965A1
    • 2007-08-16
    • US11570774
    • 2005-06-17
    • John KuperusRobert MckenzieBrooke Schumm
    • John KuperusRobert MckenzieBrooke Schumm
    • A61K51/00
    • A61K51/12A61K51/02A61K51/0406A61K51/0476
    • A novel method is set out of preparation of Copper isonitrile as a radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized from by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The Copper radiopharmaceutical is can be reconstituted and administered to a patient. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.
    • 通过设计用于快速冷冻和脱水放射性药物组合物以最小化自动放射分解的装置冻干的铜装置制备铜异腈作为放射性诊断性放射性药物的新颖方法。 铜放射性药物可以重建并给予患者。 该方法提出了快速冷却和去除环境蒸汽,然后在消除爆炸性液氧的潜力时进行超冷去除。 在稳定化之后,放射性诊断放射性药物不需要进一步冷藏或冷藏储存,包括关于运输。 优选的组合物可以通过加入合适的稀释剂“现场”重构,以使放射性药物复合物以所需浓度进入溶液。