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1. 发明申请

US20070248533A1 Stabilized and Lyophilized Radiopharmaceutical Agents For Destroying Tumors 审中-公开
标题翻译：稳定和冻干放射性药物用于破坏肿瘤
公开(公告)号：US20070248533A1
公开(公告)日：2007-10-25
申请号：US11570771
申请日：2005-06-17
申请人： John Kuperus , Robert McKenzie Jr. , Brooke Schumm III
发明人： John Kuperus , Robert McKenzie Jr. , Brooke Schumm III
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/10 , A61K51/1241
摘要： A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.
摘要翻译：通过设计用于快速冷冻和脱水放射性药物组合物以最小化自动放射分解的装置，以稳定的，可运输的冻干形式制备放射性诊断性放射性药物的新方法。该方法提出了快速冷却和去除环境蒸汽，然后在消除爆炸性液氧的潜力时进行超冷去除。在稳定化之后，放射性诊断放射性药物不需要进一步冷藏或冷藏储存，包括关于运输。优选的组合物可以通过加入合适的稀释剂“现场”重构，以使放射性药物复合物以所需浓度进入溶液。

2. 发明申请

US20070189965A1 Copper-complex isonitrile positron emission tomography (pet) imaging agent and method 审中-公开
标题翻译：铜复合异腈正电子发射断层扫描（pet）成像剂及方法
公开(公告)号：US20070189965A1
公开(公告)日：2007-08-16
申请号：US11570774
申请日：2005-06-17
申请人： John Kuperus , Robert Mckenzie , Brooke Schumm
发明人： John Kuperus , Robert Mckenzie , Brooke Schumm
IPC分类号： A61K51/00
CPC分类号： A61K51/12 , A61K51/02 , A61K51/0406 , A61K51/0476
摘要： A novel method is set out of preparation of Copper isonitrile as a radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized from by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The Copper radiopharmaceutical is can be reconstituted and administered to a patient. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.
摘要翻译：通过设计用于快速冷冻和脱水放射性药物组合物以最小化自动放射分解的装置冻干的铜装置制备铜异腈作为放射性诊断性放射性药物的新颖方法。铜放射性药物可以重建并给予患者。该方法提出了快速冷却和去除环境蒸汽，然后在消除爆炸性液氧的潜力时进行超冷去除。在稳定化之后，放射性诊断放射性药物不需要进一步冷藏或冷藏储存，包括关于运输。优选的组合物可以通过加入合适的稀释剂“现场”重构，以使放射性药物复合物以所需浓度进入溶液。

3. 发明授权

US06834657B1 Absorbant pad for applying anti-coagulant 失效
标题翻译：用于抗凝剂的吸收垫
公开(公告)号：US06834657B1
公开(公告)日：2004-12-28
申请号：US10364639
申请日：2003-02-12
申请人： John Kuperus
发明人： John Kuperus
IPC分类号： B08B100
CPC分类号： A01N33/12 , A01N43/16 , A01N25/34 , A01N25/02 , A01N2300/00
摘要： A sterile, absorbent, lint-free, soft, and at least slightly abrasive pad is impregnated with an anti-coagulant. The pad is packaged in a sterile pouch and the pouch is opened to apply the anti-coagulant to an intravenous device such as a catheter or stent device, to clean blood from a used needle or to decontaminate an operating room surface. The anti-coagulant is preferably heparin-benzalkonium chloride formulated in a solution of 1.5% heparin-benzalkonium chloride by weight or volume, containing 850 USP heparin units per milliliter in a solvent such as isopropyl alcohol.
摘要翻译：用抗凝剂浸渍无菌，吸收性，无绒，柔软和至少轻微研磨的垫。衬垫被包装在无菌袋中并且打开袋以将抗凝剂施用到诸如导管或支架装置的静脉内装置上，以清洁使用过的针头的血液或去除手术室表面。抗凝剂优选为在溶剂如异丙醇中配制在1.5％肝素 - 苯扎氯铵重量或体积的溶液中，每毫升含有850个USP肝素单位/毫升的肝素 - 苯扎氯铵。

4. 发明授权

US4581221A Ulcer detection 失效
标题翻译：溃疡检测
公开(公告)号：US4581221A
公开(公告)日：1986-04-08
申请号：US527188
申请日：1983-08-29
申请人： John Kuperus
发明人： John Kuperus
IPC分类号： A61K51/04 , A61K49/00 , A61K43/00
CPC分类号： A61K51/04 , A61K2123/00
摘要： A carrier material is combined with Tc-99m and the resulting radiolabeled reagent is combined with a known ulcer-specific compound. The resultant agent, because of the ulcer-specific compound, tends to accumulate at the site of an ulcer in the digestive tract. The presence of localized concentrations of Tc-99m in the digestive tract indicates the existence and location of an ulcer. The Tc-99m is detected in the digestive tract by conventional radioimaging procedures.
摘要翻译：将载体材料与Tc-99m组合，并将所得放射性标记的试剂与已知的溃疡特异性化合物组合。由于溃疡特异性化合物，所得到的药剂倾向于在消化道溃疡部位积聚。在消化道中局部浓度Tc-99m的存在表明溃疡的存在和位置。通过常规的放射成像程序在消化道中检测到Tc-99m。

5. 发明申请

US20070128109A1 STABILIZED AND LYOPHILIZED RADIOPHARMACEUTICAL AGENTS FOR DESTROYING TUMORS 审中-公开
标题翻译：用于破坏肿瘤的稳定和延长的放射治疗剂
公开(公告)号：US20070128109A1
公开(公告)日：2007-06-07
申请号：US11614895
申请日：2006-12-21
申请人： John Kuperus , Robert McKenzie , Brooke Schumm
发明人： John Kuperus , Robert McKenzie , Brooke Schumm
IPC分类号： A61K51/00
CPC分类号： A61K51/10
摘要： A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.
摘要翻译：通过设计用于快速冷冻和脱水放射性药物组合物以最小化自动放射分解的装置，以稳定的，可运输的冻干形式制备放射性诊断性放射性药物的新方法。该方法提出了快速冷却和去除环境蒸汽，然后在消除爆炸性液氧的潜力时进行超冷去除。在稳定化之后，放射性诊断放射性药物不需要进一步冷藏或冷藏储存，包括关于运输。优选的组合物可以通过加入合适的稀释剂“现场”重构，以使放射性药物复合物以所需浓度进入溶液。

6. 发明申请

US20070104646A1 STABILIZED AND LYOPHILIZED RADIOPHARMACEUTICAL AGENTS 审中-公开
标题翻译：稳定和无害化的放射性核素
公开(公告)号：US20070104646A1
公开(公告)日：2007-05-10
申请号：US11614882
申请日：2006-12-21
申请人： John Kuperus , Robert McKenzie , Brooke Schumm
发明人： John Kuperus , Robert McKenzie , Brooke Schumm
IPC分类号： A61K51/00
CPC分类号： A61K51/10 , A61K51/1241 , A61K51/1282
摘要： A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration.
摘要翻译：通过设计用于快速冷冻和脱水放射性药物组合物以最小化自动放射分解的装置，以稳定的，可运输的冻干形式制备放射性诊断性放射性药物的新方法。该方法提出了快速冷却和去除环境蒸汽，然后在消除爆炸性液氧的潜力时进行超冷去除。在稳定化之后，放射性诊断放射性药物不需要进一步冷藏或冷藏储存，包括关于运输。优选的组合物可以通过加入合适的稀释剂“现场”重构，以使放射性药物复合物以所需浓度进入溶液。

7. 发明授权

US07148393B1 Ion-specific radiodecontamination method and treatment for radiation patients 有权
标题翻译：离子特异性放射治疗方法和放射治疗
公开(公告)号：US07148393B1
公开(公告)日：2006-12-12
申请号：US10419635
申请日：2003-04-22
申请人： John Kuperus
发明人： John Kuperus
IPC分类号： G21F9/00 , G21F9/16 , C01G56/00 , C01G57/00
CPC分类号： G21F9/125 , G21F9/16 , G21F9/28
摘要： A surface contaminated by a radioactive isotope is cleaned by applying to it a solution that contains an ion-specific resin that is weakly bonded to an ion and a weak anion solution including a carrier, water, and an ion that frees the radioactive isotope from the contaminated surface. The radioactive isotope bonds with the ion-specific resin, replacing the ion weakly bonded to said ion-specific resin. In a preferred embodiment, the ion-specific resin is made in the counterion form of citrate, the ion that is weakly bonded to the ion-specific resin is citrate, the carrier is glycerin, the water is de-ionized or distilled, and the ion that frees the radioactive isotope from the contaminated surface is salicylate.
摘要翻译：被放射性同位素污染的表面通过向其施加包含与离子弱结合的离子特异性树脂和包含载体，水和离子的弱阴离子溶液的溶液来清洗，所述离子特异性树脂将放射性同位素从受污染的表面。放射性同位素与离子特异性树脂结合，代替与所述离子特异性树脂弱结合的离子。在优选的实施方案中，离子特异性树脂以柠檬酸盐的抗衡离子形式制成，与离子特异性树脂弱结合的离子是柠檬酸盐，载体是甘油，水被去离子化或蒸馏，使放射性同位素从受污染的表面释放的离子是水杨酸盐。

8. 发明申请

US20050281737A1 STABLILIZED AND LYOPHILIZED RADIOPHARMACEUTICAL AGENTS 失效
标题翻译：稳定化和无害化的放射性核素
公开(公告)号：US20050281737A1
公开(公告)日：2005-12-22
申请号：US10904099
申请日：2004-10-22
申请人： John Kuperus , Robert McKenzie , Brooke Schumm
发明人： John Kuperus , Robert McKenzie , Brooke Schumm
IPC分类号： A61K51/00 , A61K51/12 , F26B5/06
CPC分类号： A61K51/10 , A61K51/1241 , A61K51/1282
摘要： A novel method is set out of preparation of radioactive diagnostic radiopharmaceutical in a stable, shippable, lyophilized form by an apparatus designed to rapidly flash freeze and dehydrate a radiopharmaceutical composition to minimize auto radiolysis. The method proposes rapid cooling and removal of ambient vapor, and then ultra cold removal when the potential of explosive liquid oxygen is eliminated. The radioactive diagnostic radiopharmaceutical requires no further cold or refrigerated storage, including with respect to shipping, subsequent to stabilization. The preferred composition can be reconstituted “on site” by the addition of a suitable diluent to bring the radiopharmaceutical complex into solution at a desired concentration
摘要翻译：通过设计用于快速冷冻和脱水放射性药物组合物以最小化自动放射分解的装置，以稳定的，可运输的冻干形式制备放射性诊断性放射性药物的新方法。该方法提出了快速冷却和去除环境蒸汽，然后在消除爆炸性液氧的潜力时进行超冷去除。在稳定化之后，放射性诊断放射性药物不需要进一步冷藏或冷藏储存，包括关于运输。优选的组合物可以通过加入合适的稀释剂“现场”重建，以使放射性药物复合物以所需浓度

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