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1. 发明授权

US5741518A Composition composed of an aqueous dispersion of stabilized vesicles of nonionic amphiphilic lipids 失效
公开(公告)号：US5741518A
公开(公告)日：1998-04-21
申请号：US698658
申请日：1996-08-16
申请人： Alain Ribier , Jean-Thierry Simonnet , Rose-Marie Handjani , Nadia Terren
发明人： Alain Ribier , Jean-Thierry Simonnet , Rose-Marie Handjani , Nadia Terren
IPC分类号： A61K8/14 , A61K8/39 , A61K8/49 , A61K8/60 , A61K8/70 , A61K8/86 , A61Q1/02 , A61Q19/00 , A61Q19/08 , A61K9/127
CPC分类号： A61Q19/08 , A61K8/14 , A61K8/39 , A61K8/4973 , A61K8/4993 , A61K8/60 , A61K8/70 , A61K8/86 , A61Q19/00 , B82Y5/00 , A61Q1/02 , A61Q19/007 , Y10T428/2984
摘要： The vesicles are prepared from a lipid phase containing a mixture of nonionic amphiphilic lipids consisting of a mixture of esters of at least one polyol chosen from the group composed of polyethylene glycol containing from 1 to 60 ethylene oxide units, sorbitan, sorbitan bearing 2 to 60 ethylene oxide units, glycerol bearing 2 to 30 ethylene oxide units, polyglycerols containing 2 to 15 glycerol units, sucroses, and glucoses bearing 2 to 30 ethylene oxide units and of at least one fatty acid containing a saturated or unsaturated, linear or branched C.sub.5 -C.sub.17 alkyl chain, the number of alkyl chains per polyol group being between 1 and 10, the mixture being stabilized with ionic amphiphilic lipid or lipids chosen from the group composed of those which impart a pH of between 5.5 and 7.5 to the dispersion.

2. 发明授权

US5866158A Composition composed of an aqueous dispersion of stabilized vesicles of nonionic amphiphilic lipids 失效
标题翻译：由非离子两亲性脂质稳定的囊泡的水性分散体组成的组合物
公开(公告)号：US5866158A
公开(公告)日：1999-02-02
申请号：US736936
申请日：1996-10-28
申请人： Alain Ribier , Jean-Thierry Simonnet , Rose-Marie Handjani , Nadia Terren
发明人： Alain Ribier , Jean-Thierry Simonnet , Rose-Marie Handjani , Nadia Terren
IPC分类号： A61K8/14 , A61K8/39 , A61K8/49 , A61K8/60 , A61K8/70 , A61K8/86 , A61Q1/02 , A61Q19/00 , A61Q19/08 , A61K9/127 , A61K7/00
CPC分类号： A61Q19/08 , A61K8/14 , A61K8/39 , A61K8/4973 , A61K8/4993 , A61K8/60 , A61K8/70 , A61K8/86 , A61Q19/00 , B82Y5/00 , A61Q1/02 , A61Q19/007 , Y10T428/2984
摘要： The vesicles are prepared from a lipid phase containing a mixture of nonionic amphiphilic lipids consisting of a mixture of esters of at least one polyol chosen from the group composed of polyethylene glycol containing from 1 to 60 ethylene oxide units, sorbitan, sorbitan bearing 2 to 60 ethylene oxide units, glycerol bearing 2 to 30 ethylene oxide units, polyglycerols containing 2 to 15 glycerol units, sucroses, and glucoses bearing 2 to 30 ethylene oxide units and of at least one fatty acid containing a saturated or unsaturated, linear or branched C.sub.5 -C.sub.17 alkyl chain, the number of alkyl chains per polyol group being between 1 and 10, the mixture being stabilized with ionic amphiphilic lipid or lipids chosen from the group composed of those which impart a pH of between 5.5 and 7.5 to the dispersion.
摘要翻译：囊泡由含有由至少一种选自含有1至60个环氧乙烷单元的聚乙二醇组成的组中的至少一种多元醇的混合物组成的非离子两亲性脂质混合物的脂质相制备，脱水山梨醇，含有2-60个环氧乙烷单元，含有2至30个环氧乙烷单元的甘油，含有2至15个甘油单元的聚甘油，含有2至30个环氧乙烷单元的蔗糖和葡萄糖，以及至少一种含有饱和或不饱和直链或支链C5- C17烷基链，每个多元醇基团的烷基链数在1和10之间，混合物用离子两亲性脂质或选自由赋予分散体5.5至7.5的pH组成的组中的脂质稳定。

3. 发明授权

US5556617A Composition providing a lasting cosmetic and/or pharmaceutical treatment of the upper epidermal layers by topical application on the skin 失效
标题翻译：组合物通过局部施用在皮肤上提供持久的化妆品和/或药物治疗上表皮层
公开(公告)号：US5556617A
公开(公告)日：1996-09-17
申请号：US473359
申请日：1995-06-07
申请人： Alain Ribier , Pascal Richart , Rose-Marie Handjani
发明人： Alain Ribier , Pascal Richart , Rose-Marie Handjani
IPC分类号： A61K8/04 , A61K8/11 , A61K8/14 , A61K8/31 , A61K8/37 , A61K8/65 , A61K8/67 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/92 , A61K9/50 , A61K9/51 , A61Q17/04 , A61Q19/00 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/11 , A61K8/37 , A61K8/678 , A61K9/5138 , A61K9/5146 , B82Y5/00 , A61K2800/413 , A61K2800/43 , A61Q17/04 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10T428/2984 , Y10T428/2985
摘要： A composition containing, in a suitable carrier, nanoparticles of one or more nonbiodegradable polymer(s) encapsulating an oily phase which contains at least one active oil and/or at least one carrier oil and/or at least one active ingredient in an active oil and/or a carrier oil. At least one active ingredient is chosen from those with prolonged cosmetic and/or pharmaceutical activity. The nanocapsules have a size of 100-1000 nm.
摘要翻译：一种组合物，其在合适的载体中含有包封油相的一种或多种不可生物降解的聚合物的纳米颗粒，该聚合物在活性油中含有至少一种活性油和/或至少一种载体油和/或至少一种活性成分和/或载体油。选自具有延长的化妆品和/或药物活性的那些的至少一种活性成分。纳米胶囊的尺寸为100-1000nm。

4. 发明授权

US4608211A Process for preparing lipid vesicles by vaporisation of solvents 失效
标题翻译：通过溶剂蒸发制备脂质囊泡的方法
公开(公告)号：US4608211A
公开(公告)日：1986-08-26
申请号：US587653
申请日：1984-03-08
申请人： Rose-Marie Handjani , Alain Ribier , Manlio M. Maurelli
发明人： Rose-Marie Handjani , Alain Ribier , Manlio M. Maurelli
IPC分类号： A61K9/133 , A61K9/127 , B01J13/02 , A61K9/50 , A61K9/64
CPC分类号： A61K9/1277 , Y10S436/829 , Y10T428/2984
摘要： A process for preparing large unilamellar lipid vesicles is disclosed which process comprises preparing unilamellar lipid vesicles having an average diameter of at least 1,000 .ANG., each of these vesicles consisting of a spheroidal lipid lamella containing a substance to be encapsulated, which process comprises dissolving one or more lipids intended to form the lamella of the vesicles in at least one water-insoluble solvent, conditioning the resulting lipid solution at a pressure P.sub.1 and at a temperature .theta..sub.1, dissolving the substance to be encapsulated in water to obtain an aqueous phase, conditioning said aqueous phase at a pressure P.sub.2 and a temperature .theta..sub.2, injecting the lipid solution into the aqueous phase at a low flow rate so as initially to form droplets and so that solvent of the lipid solution vaporises on coming into contact with the said aqueous phase, the pressure P.sub.2 being less than P.sub.1 and less than the vapor pressure of the solvent in the said droplets at the temperature .theta..sub.2.
摘要翻译：公开了一种制备大单层脂质囊泡的方法，该方法包括制备平均直径至少为1000的单层脂质小泡，这些囊泡由包含待包被物质的球状脂质薄片组成，该方法包括将一个或多个更多的脂质旨在在至少一种水不溶性溶剂中形成泡囊的薄片，在压力P1和温度θ下调节所得脂质溶液，将待包封的物质溶解在水中以获得水相，调理所述水相在压力P2和温度θ2下，以低流速将脂质溶液注入水相中，以便最初形成液滴，使得脂质溶液的溶剂在与所述水相接触时蒸发压力P2小于P1且小于t处所述液滴中溶剂的蒸气压温度θ2。

5. 发明授权

US5993831A Composition providing a lasting cosmetic and/or pharmaceutical treatment of the upper epidermal layers by topical application on the skin 失效
标题翻译：组合物通过局部施用在皮肤上提供持久的化妆品和/或药物治疗上表皮层
公开(公告)号：US5993831A
公开(公告)日：1999-11-30
申请号：US50315
申请日：1993-05-10
申请人： Alain Ribier , Pascal Richart , Rose-Marie Handjani
发明人： Alain Ribier , Pascal Richart , Rose-Marie Handjani
IPC分类号： A61K8/04 , A61K8/11 , A61K8/14 , A61K8/31 , A61K8/37 , A61K8/65 , A61K8/67 , A61K8/73 , A61K8/86 , A61K8/89 , A61K8/891 , A61K8/92 , A61K9/50 , A61K9/51 , A61Q17/04 , A61Q19/00 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/11 , A61K8/37 , A61K8/678 , A61K9/5138 , A61K9/5146 , B82Y5/00 , A61K2800/413 , A61K2800/43 , A61Q17/04 , Y10S514/937 , Y10S514/938 , Y10S514/939 , Y10T428/2984 , Y10T428/2985
摘要： A composition containing, in a suitable carrier, nanoparticles of one or more nonbiodegradable polymer(s) encapsulating an oily phase which contains at least one active oil and/or at least one carrier oil and/or at least one active ingredient in an active oil and/or a carrier oil. At least one active ingredient is chosen from those with prolonged cosmetic and/or pharmaceutical activity. The nanocapsules have a size of 100-1000 nm.
摘要翻译： PCT No.PCT / FR92 / 00824 Sec。 371日期：1993年5月18日 102（e）日期1993年5月18日PCT提交1992年8月27日PCT公布。公开号WO93 / 05753 日本1993年4月1日在合适载体中含有一种或多种包封至少一种活性油和/或至少一种载体油和/或至少一种活性物质的油相的不可生物降解的聚合物的纳米颗粒的组合物活性油和/或载体油中的成分。选自具有延长的化妆品和/或药物活性的那些的至少一种活性成分。纳米胶囊的尺寸为100-1000nm。

6. 发明授权

US5290565A Composition for promoting healing 失效
标题翻译：组合促进愈合
公开(公告)号：US5290565A
公开(公告)日：1994-03-01
申请号：US882423
申请日：1992-05-13
申请人： Alexandre Zysman , Henri Sebag , Guy Vanlerberghe , Rose-Marie Handjani , Alain Ribier
发明人： Alexandre Zysman , Henri Sebag , Guy Vanlerberghe , Rose-Marie Handjani , Alain Ribier
IPC分类号： A61K9/127 , A61K31/08 , A61K31/23
CPC分类号： A61K31/23 , A61K31/08 , A61K9/1272 , Y10S424/13 , Y10S514/937 , Y10S514/941 , Y10T428/2984
摘要： Composition for promoting healing containing, as a healing agent, nonionic vesicles obtained from a lipid mixture containing at least one nonionic lipid having the formula; ##STR1## wherein R is either at least one C.sub.16 -C.sub.18 radical, or R'CO wherein R' is at least one C.sub.15 -C.sub.17 alkyl radical, in combination with cholesterol and, optionally, dicetylphosphate or tetracetylphospate.This composition can be used topically to accelerate the scarring of wounds.
摘要翻译：用于促进愈合的组合物，其含有由含有至少一种具有下式的非离子脂质的脂质混合物获得的非离子囊泡作为愈合剂; （*化学结构*）其中R是至少一个C16-C18基团或R'CO，其中R'是至少一个C15-C17烷基，与胆固醇和任选的磷酸二鲸蜡酯或四乙酰基磷酸酯组合。该组合物可以局部用于加速伤口的瘢痕形成。

7. 发明授权

US5079227A Perfume composition, with a continuous aqueous phase, having a high concentration of perfume 失效
标题翻译：香料组合物，具有连续的水性相，具有高浓度的香气
公开(公告)号：US5079227A
公开(公告)日：1992-01-07
申请号：US561464
申请日：1990-08-01
申请人： Rose-Marie Handjani , Arlette Zabotto , Alain Ribier , Jacqueline Griat
发明人： Rose-Marie Handjani , Arlette Zabotto , Alain Ribier , Jacqueline Griat
IPC分类号： A61K8/00 , A61K8/14 , A61Q13/00
CPC分类号： A61Q13/00 , A61K8/14
摘要： A perfume composition, with an aqueous phase, having a high concentration of perfume, which contains:a) vesicles which are obtained from at least one non-ionic lipid derived from a linear or branched polyglycerol, associated with a stabilizer present in a proportion of 1 to 10% by weight based on the lipid, the vesicles having an average diameter of between 0.01 .mu. and 1 .mu. and the lipids which form the vesicles representing 0.2 to 4% by weight of the total composition; andb) a perfume in the form of droplets having an average diameter of between 0.1 .mu. and 1 .mu. and being present in the composition in amounts of between 3 and 20% by weight based on the total composition, the total ratio of the lipid or lipids of the vesicles to the perfume being between 0.05 and 0.2.
摘要翻译：一种具有水相的具有高浓度香料的香料组合物，其包含：a）囊泡，其由至少一种衍生自直链或支链聚甘油的非离子脂质获得，所述非离子脂质与稳定剂相关，所述稳定剂以一定比例 1至10重量％，基于脂质，囊泡的平均直径为0.01至1微米，形成囊泡的脂质占总组合物的0.2-4重量％和b）平均直径为0.1至1微米的液滴形式的香料，并且基于总组合物，基于总组合物的总脂肪比例或组合物的总比例存在于组合物中的量为3至20重量％囊泡对香料的脂质在0.05至0.2之间。

8. 发明授权

US06203802B1 Composition for the cosmetic and/or pharmaceutical treatment of the upper layers of the epidermis by topical application to the skin, and corresponding preparation process 失效
标题翻译：通过局部施用于皮肤进行化妆品和/或药物处理表皮上层的组合物及相应的制备方法
公开(公告)号：US06203802B1
公开(公告)日：2001-03-20
申请号：US08195081
申请日：1994-02-14
申请人： Rose-Marie Handjani , Alain Ribier
发明人： Rose-Marie Handjani , Alain Ribier
IPC分类号： A61K748
CPC分类号： B01F17/0092 , A61K8/0279 , A61K8/11 , A61K8/34 , A61K8/375 , A61K8/678 , A61K8/8164 , A61K8/85 , A61K8/90 , A61K8/925 , A61K9/5138 , A61K9/5146 , A61K9/5153 , A61K9/5192 , A61K2800/413 , A61K2800/56 , A61Q19/00 , B01F17/0028 , B01F17/005 , B82Y5/00 , Y10S514/951
摘要： Composition comprising biodegradable nanoparticles encapsulating oils which are active and/or which contain an active ingredient having a cosmetic and/or pharmaceutical action in the upper layers of the epidermis. The nanoparticles are preferably prepared from a polymer of (C2-C12) alkyl cyanoacrylate.
摘要翻译：包含可生物降解的纳米颗粒的组合物，其包封具有活性的和/或含有在表皮上层具有化妆品和/或药物作用的活性成分的油。纳米颗粒优选由（C 2 -C 12）烷基氰基丙烯酸酯的聚合物制备。

9. 发明授权

US5925364A Cosmetic or dermatological composition comprising an oil-in-water emulsion comprising oily globules with a lamellar liquid crystal coating 失效
标题翻译：化妆品或皮肤病学组合物，其包含水包油乳液，其包含具有片状液晶涂层的油性球
公开(公告)号：US5925364A
公开(公告)日：1999-07-20
申请号：US540165
申请日：1995-10-06
申请人： Alain Ribier , Jean-Thierry Simonnet , Jacques Michelet
发明人： Alain Ribier , Jean-Thierry Simonnet , Jacques Michelet
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/29 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/66 , A61K8/73 , A61K8/92 , A61K8/97 , A61K9/127 , A61P17/08 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K7/48
CPC分类号： A61Q19/00 , A61K8/0295 , A61K8/062 , A61K8/608 , A61K9/1274 , B82Y5/00 , A61K2800/21 , A61Q17/04 , A61Q19/08 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/938 , Y10S514/939 , Y10S514/94 , Y10S514/941 , Y10S514/942 , Y10S514/943
摘要： The present invention relates to a cosmetic or dermatological composition comprising an emulsion of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic compound which is cosmetically or dermatologically active is individually coated with a monolamellar or aligolamellar layer obtained from at least one lipophilic surface-active agent, from at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of less than 500 nanometers.
摘要翻译：本发明涉及一种化妆品或皮肤病学组合物，其包含由油状球形成的水包油型乳液，每一种乳状液体均设置有层状液晶涂层并分散在水相中。含有至少一种化学或皮肤病学活性的亲油性化合物的每个油状球体分别用至少一种亲脂性表面活性剂和至少一种离子性表面活性剂从至少一种亲脂性表面活性剂获得的单层或聚乙烯醇层涂覆两性脂质赋予乳液pH为5.5至7.5，涂覆的油状球体的平均直径小于500纳米。

10. 发明授权

US6066328A Cosmetic or dermatological composition comprising an oil-in-water emulsion comprising oily globules with a lamellar liquid crystal coating 有权
标题翻译：化妆品或皮肤病学组合物，其包含水包油乳液，其包含具有片状液晶涂层的油性球
公开(公告)号：US6066328A
公开(公告)日：2000-05-23
申请号：US185502
申请日：1998-11-04
申请人： Alain Ribier , Jean-Thierry Simonnet , Jacques Michelet
发明人： Alain Ribier , Jean-Thierry Simonnet , Jacques Michelet
IPC分类号： A61K8/30 , A61K8/00 , A61K8/02 , A61K8/06 , A61K8/29 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/36 , A61K8/37 , A61K8/39 , A61K8/41 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/66 , A61K8/73 , A61K8/92 , A61K8/97 , A61K9/127 , A61P17/08 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A51K7/48
CPC分类号： A61Q19/00 , A61K8/0295 , A61K8/062 , A61K8/608 , A61K9/1274 , B82Y5/00 , A61K2800/21 , A61Q17/04 , A61Q19/08 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/938 , Y10S514/939 , Y10S514/94 , Y10S514/941 , Y10S514/942 , Y10S514/943
摘要： The present invention relates to a cosmetic or dermatological composition comprising an emulsion of oil-in-water type formed of oily globules which are each provided with a lamellar liquid crystal coating and are dispersed in an aqueous phase. Each oily globule containing at least one lipophilic compound which is cosmetically or dermatologically active is individually coated with a monolamellar or oligolamellar layer obtained from at least one lipophilic surface-active agent, from at least one hydrophilic surface-active agent and from at least one ionic amphiphilic lipid imparting to the emulsion a pH ranging from 5.5 to 7.5, the coated oily globules having a mean diameter of less than 500 nanometers.
摘要翻译：本发明涉及一种化妆品或皮肤病学组合物，其包含由油状球形成的水包油型乳液，每一种乳状液体均设置有层状液晶涂层并分散在水相中。含有至少一种化学或皮肤病学活性的亲脂性化合物的每个油状球体分别用至少一种亲脂性表面活性剂和至少一种离子性表面活性剂从至少一种亲脂性表面活性剂获得的单层或多层膜单独涂覆两性脂质赋予乳液pH为5.5至7.5，涂覆的油状球体的平均直径小于500纳米。

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