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    • 3. 发明授权
    • Polyamino-polyamide crosslinked with crosslinking agent
    • US4277581A
    • 1981-07-07
    • US57684
    • 1979-07-16
    • Guy VanlerbergheHenri SebagJean-Francois GrollierAlexandre Zysman
    • Guy VanlerbergheHenri SebagJean-Francois GrollierAlexandre Zysman
    • A61K8/88A61Q5/00A61Q5/02A61Q5/04A61Q5/06A61Q5/12C08G69/48
    • A61Q5/12A61K8/88A61Q5/00A61Q5/02A61Q5/04A61Q5/06C08G69/48
    • A cosmetic composition for the hair comprises at least one water-soluble crosslinked polymer obtained by crosslinking a polyamino-polyamide with a crosslinking agent, said polyamino-polyamide being prepared by the polycondensation of (a) an acidic compound selected from the group consisting of (i) organic dicarboxylic acid, (ii) ethylenically unsaturated aliphatic mono- or di-carboxylic acid, (iii) ester of said acids of (i) and (ii), and (iv) mixtures of (i), (ii) and (iii) on (b) a polyamine selected from the group consisting of bis-primary and mono- and bis-secondary polyalkylene polyamines, said polyamine (b) being replaceable by a member selected from the group consisting of (1) 0-20 mole percent hexamethylene diamine, (2) 0-40 mole percent bis-primary amine and (3) 0-40 mole percent bis-secondary amine, said crosslinking agent being selected from the group consisting of (a') simple bi-functional compounds selected from bis-halohydrins, bis-azetidinium, bis-haloacyl diamine and alkyl bis-halides, (b') oligomers obtained by the reaction of (1') a compound selected from the group consisting of the compounds in (a') above or an epihalohydrin,a bis-epoxide, or a bis-unsaturated derivative with (2') a compound reactive with the compound in (1'), and (c') the quaternized compounds comprising said crosslinked polymer alkylated with an alkylating agent selected from the group consisting of (a) epoxides, (b) ethylenically unsaturated compounds, (c) chloroacetic acid, and (d) alkane sultone selected from the group consisting of propane sultone and butane sultone. The crosslinking agent is employed in amounts of 0.025-0.35 mole per amine group in said polyamino-polyamide. The said crosslinked polymer is soluble in water in amounts of 10 weight percent thereof without essentially any gel formation and a 10 weight percent aqueous solution of the said crosslinked polymer has a viscosity greater than 3 centipoises at 25.degree. C.
    • 4. 发明授权
    • Hair conditioning compositions containing crosslinked polyaminopolyamides
    • 含有交联聚氨基多酰胺的调理组合物
    • US4172887A
    • 1979-10-30
    • US762804
    • 1977-01-26
    • Guy VanlerbergheHenri SebagJean-Francois GrollierAlexandre Zysman
    • Guy VanlerbergheHenri SebagJean-Francois GrollierAlexandre Zysman
    • A61K8/88A61Q5/00A61Q5/02A61Q5/04A61Q5/06A61Q5/12A61K7/06A61K7/08A61K7/09A61K7/11
    • A61Q5/12A61K8/88A61Q5/06A61Q5/02A61Q5/04Y10S424/02
    • A cosmetic composition for the hair comprises at least one water-soluble crosslinked polymer selected from the group consisting of (1) crosslinked polymer obtained by crosslinking a polyamino-polyamide with a crosslinking agent, said polyamino-polyamide being prepared by the polycondensation of (a) an acidic compound selected from the group consisting of (i) organic dicarboxylic acid, (ii) ethylenically unsaturated aliphatic mono- or di- carboxylic acid, (iii) ester of said acids of (i) and (ii), and (iv) mixtures of (i), (ii) and (iii) on (b) a polyamine selected from the group consisting of bis primary and mono- or bis-secondary polyalkylene polyamines, said polyamine (b) being replaceable by a member selected from the group consisting of (1) 0-20 mole percent hexamethylene diamine, (2) 0-40 mole percent bis-primary amine and (3) 0-40 mole percent bis-secondary amine, said crosslinking agent being selected from the group consisting of epihalohydrins, diepoxides, dianhydrides and bis unsaturated derivatives, and being employed in amounts of 0.025-0.35 mole per amine group in said polyamino-polyamide and (2) the crosslinked polymer of (1) alkylated with an alkylating agent selected from the group consisting of (a) epoxides, (b) ethylenically unsaturated compounds, (c) chloroacetic acid, and (d) alkane sultone selected from the group consisting of propane sultone and butane sultone. The said crosslinked polymer is soluble in water in amounts of 10 weight percent thereof without essentially any gel formation and a 10 weight percent aqueous solution of the said crosslinked polymer has a viscosity greater than 3 centipoises at 25.degree. C.
    • 用于毛发的化妆品组合物包含至少一种水溶性交联聚合物,其选自(1)通过交联聚氨基 - 聚酰胺与交联剂交联而获得的交联聚合物,所述聚氨基聚酰胺是通过(a )选自(i)有机二羧酸,(ii)烯键式不饱和脂族单或二羧酸的酸性化合物,(iii)所述酸(i)和(ii)的酯和(iv (i),(ii)和(iii)的混合物在(b)选自双原料和单 - 或二 - 仲聚亚烷基多胺的多胺中,所述多胺(b)可以由选自 由(1)0-20摩尔%六亚甲基二胺,(2)0-40摩尔%双 - 伯胺和(3)0-40摩尔%双仲胺组成的组,所述交联剂选自 的表卤代醇,二环氧化物,二酐和双 不饱和衍生物,并且在所述聚氨基聚酰胺中以每个胺基计0.025-0.35摩尔的量使用(2)(1)烷基化剂与(a)环氧化物,(b)的烷基化剂烷基化的交联聚合物 )烯键式不饱和化合物,(c)氯乙酸和(d)选自丙烷磺内酯和丁烷磺内酯的烷基磺内酯。 所述交联聚合物以10重量%的量溶解在水中而基本上没有任何凝胶形成,并且所述交联聚合物的10重量%水溶液的粘度在25℃下具有大于3厘泊的粘度。
    • 9. 发明授权
    • 4-hydroxyisoxazole derivatives, method of preparing same, and cosmetic
and pharmaceutical compositions containing them
    • 4-羟基异恶唑衍生物,其制备方法,以及含有它们的化妆品和药物组合物
    • US4940575A
    • 1990-07-10
    • US371058
    • 1989-06-26
    • Alexandre ZysmanHenri Sebag
    • Alexandre ZysmanHenri Sebag
    • A61K8/49A61K31/42A61Q17/04C07D261/18
    • A61Q17/04A61K8/49C07D261/18
    • 4-Hydroxyisoxazole derivatives corresponding to the formula: ##STR1## wherein: R represents a linear or branched alkyl or hydroxyalkyl radical with 1 to 23 carbon atoms, a linear or branched alkenyl radical with 2 to 23 carbon atoms, a phenyl radical, or a benzyl radical, andR.sub.1 represents OR.sub.2, --NHR.sub.3, or --NH--NHR.sub.4,R.sub.2 represents a hydrogen atom or an alkyl radical with 1 to 24 carbon atoms,R.sub.3 represents a hydrogen atom, an alkyl radical with 1 to 20 carbon atoms, or a ##STR2## radical, where n is 2 to 3 and r' and r" are identical or different, representing a hydrogen atom or a lower alkyl radical or forming a heterocycle when taken together such as morpholine, piperidine, or piperazine,R.sub.4 represents a hydrogen atom or a benzyl radical,and the salts of the formula (I) compounds.These derivatives are applicable to therapeutic and cosmetic fields, in particular to counteract the harmful effects of the sun.
    • 对应于下式的4-羟基异恶唑衍生物:其中:R表示具有1至23个碳原子的直链或支链烷基或羟烷基,具有2至23个碳原子的直链或支链烯基,苯基 或苄基,R 1表示OR 2,-NHR 3或-NH-NHR 4,R 2表示氢原子或碳原子数1〜24的烷基,R 3表示氢原子,碳原子数1〜20的烷基 原子或基团,其中n为2至3,并且r'和r“相同或不同,表示氢原子或低级烷基,或当形成杂环时,如吗啉,哌啶或 哌嗪,R 4表示氢原子或苄基,和式(I)化合物的盐。 这些衍生物适用于治疗和美容领域,特别是抵消太阳的有害影响。