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1. 发明授权

US09238052B2 Method for producing Hippocastanaceae plant seed extract 有权
标题翻译：生产海马科植物种子提取物的方法
公开(公告)号：US09238052B2
公开(公告)日：2016-01-19
申请号：US12867092
申请日：2009-02-10
申请人： Akiyo Kameyama , Tsutomu Fujimura
发明人： Akiyo Kameyama , Tsutomu Fujimura
IPC分类号： A61K36/77
CPC分类号： A61K36/77
摘要： To provide a method for producing a Hippocastanaceae plant seed extract which is less colored and is suitably incorporated into a composition such as a pharmaceutical product or a cosmetic composition. A method for producing a Hippocastanaceae plant seed extract, which includes removing hulls from seeds of a Hippocastanaceae plant, followed by extraction with a solvent.
摘要翻译：提供一种生产较少着色的Hippocastanaceae植物种子提取物的方法，并适当地并入到诸如药物产品或化妆品组合物的组合物中。一种生产海马科植物种子提取物的方法，其包括从海马科植物种子中除去壳体，然后用溶剂萃取。

2. 发明授权

US08853174B2 Agent for preventing or ameliorating skin aging 有权
标题翻译：防止或改善皮肤老化的药剂
公开(公告)号：US08853174B2
公开(公告)日：2014-10-07
申请号：US12867958
申请日：2009-02-26
申请人： Akiyo Kameyama , Tsutomu Fujimura
发明人： Akiyo Kameyama , Tsutomu Fujimura
IPC分类号： A01N43/04 , A61K31/70 , A61Q19/08 , A61K8/63 , A61K8/97 , C07H15/256
CPC分类号： C07H15/256 , A61K8/63 , A61K8/97 , A61Q19/08
摘要： An agent for preventing or ameliorating skin aging, which exhibits a more excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin. An agent for preventing or ameliorating skin aging, containing triterpenoid saponins represented by the following formula (1) as an active ingredient, wherein at least one of R1 and R2 is a tigloyl group and the other represents a tigloyl group or an angeloyl group; R3 represents a methyl group or a hydroxymethyl group; and R4 represents Glc, Xyl or Gal.
摘要翻译：用于预防或改善皮肤老化的剂，其对抑制皮肤或皱纹皮肤上的皱纹的形成抑制或改善具有更好的效果。一种用于预防或改善皮肤老化的药剂，其含有由下式（1）表示的三萜皂苷作为活性成分，其中R1和R2中的至少一个是二酰基，另一个代表二酰基或异基酰基; R3表示甲基或羟甲基; R4表示Glc，Xyl或Gal。

3. 发明申请

US20100310689A1 Method for Producing Hippocastanaceae Plant Seed Extract 有权
标题翻译：生产海马科植物种子提取物的方法
公开(公告)号：US20100310689A1
公开(公告)日：2010-12-09
申请号：US12867092
申请日：2009-02-10
申请人： Akiyo Kameyama , Tsutomu Fujimura
发明人： Akiyo Kameyama , Tsutomu Fujimura
IPC分类号： A61K36/00
CPC分类号： A61K36/77
摘要： To provide a method for producing a Hippocastanaceae plant seed extract which is less colored and is suitably incorporated into a composition such as a pharmaceutical product or a cosmetic composition. A method for producing a Hippocastanaceae plant seed extract, which includes removing hulls from seeds of a Hippocastanaceae plant, followed by extraction with a solvent.
摘要翻译：提供一种生产较少着色的Hippocastanaceae植物种子提取物的方法，并适当地并入到诸如药物产品或化妆品组合物的组合物中。一种生产海马科植物种子提取物的方法，其包括从海马科植物种子中除去壳体，然后用溶剂萃取。

4. 发明申请

US20100331272A1 Agent for Preventing or Ameliorating Skin Aging 有权
标题翻译：防止或改善皮肤老化的代理
公开(公告)号：US20100331272A1
公开(公告)日：2010-12-30
申请号：US12867958
申请日：2009-02-26
申请人： Akiyo Kameyama , Tsutomu Fujimura
发明人： Akiyo Kameyama , Tsutomu Fujimura
IPC分类号： A61K31/70 , C07H15/24 , A61P17/00
CPC分类号： C07H15/256 , A61K8/63 , A61K8/97 , A61Q19/08
摘要： An agent for preventing or ameliorating skin aging, which exhibits a more excellent effect on the suppression of formation, or the amelioration, of wrinkles on the skin or sagging skin. An agent for preventing or ameliorating skin aging, containing triterpenoid saponins represented by the following formula (1) as an active ingredient, wherein at least one of R1 and R2 is a tigloyl group and the other represents a tigloyl group or an angeloyl group; R3 represents a methyl group or a hydroxymethyl group; and R4 represents Glc, Xyl or Gal.
摘要翻译：用于预防或改善皮肤老化的剂，其对抑制皮肤或皱纹皮肤上的皱纹的形成抑制或改善具有更好的效果。一种用于预防或改善皮肤老化的药剂，其含有由下式（1）表示的三萜皂苷作为活性成分，其中R1和R2中的至少一个是二酰基，另一个代表二酰基或异基酰基; R3表示甲基或羟甲基; R4表示Glc，Xyl或Gal。

5. 发明授权

US07351716B2 Dermatological preparations 有权
标题翻译：皮肤病学准备
公开(公告)号：US07351716B2
公开(公告)日：2008-04-01
申请号：US10731249
申请日：2003-12-10
申请人： Masahide Hoshino , Yoshiya Sugai , Akiyo Kameyama , Hiroaki Saito , Yoshinori Nishizawa , Yutaka Takagi
发明人： Masahide Hoshino , Yoshiya Sugai , Akiyo Kameyama , Hiroaki Saito , Yoshinori Nishizawa , Yutaka Takagi
IPC分类号： A61K7/48 , A61K7/00 , A61K7/06 , C07C233/18
CPC分类号： C07C233/20 , A61K8/42 , A61Q5/00 , A61Q5/02 , A61Q17/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07C233/18
摘要： The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R1 represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, R2 represents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and R3 represents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
摘要翻译：本发明涉及含有下式（1）表示的二酰胺衍生物的皮肤病学制剂：（其中，R 1表示可被取代的具有1〜22个碳原子的直链或支链烃基通过一个或多个羟基和/或烷氧基，R 2表示具有1至12个碳原子的直链或支链二价烃基，R 3表示直链或支链的具有1至42个碳原子的二价烃基）。该二酰胺衍生物（1）能够从根本上提高角质层的保水能力和阻隔功能，混溶性和混合稳定性优异，可以低成本有效地制备。

6. 发明授权

US06685953B1 External preparation compositions 有权
标题翻译：外用制剂组合物
公开(公告)号：US06685953B1
公开(公告)日：2004-02-03
申请号：US09926270
申请日：2001-10-04
申请人： Masahide Hoshino , Yoshiya Sugai , Akiyo Kameyama , Hiroaki Saito , Yoshinori Nishizawa , Yutaka Takagi
发明人： Masahide Hoshino , Yoshiya Sugai , Akiyo Kameyama , Hiroaki Saito , Yoshinori Nishizawa , Yutaka Takagi
IPC分类号： A61K3116
CPC分类号： C07C233/20 , A61K8/42 , A61Q5/00 , A61Q5/02 , A61Q17/00 , A61Q19/00 , A61Q19/007 , A61Q19/08 , C07C233/18
摘要： The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R1 represents a linear or branched hydrocarbon group having 1 to 22 carbon atoms which may be substituted by one or more hydroxy and/or alkoxy groups, R2 represents a linear or branched divalent hydrocarbon group having 1 to 12 carbon atoms, and R3 represents a linear or branched divalent hydrocarbon group having 1 to 42 carbon atoms). This diamide derivative (1) is capable of fundamentally improving the water retention capacity and barrier functions of the horny layer, is excellent in miscibility and mixing stability and can be prepared efficiently at a low cost.
摘要翻译：本发明涉及含有下式（1）表示的二酰胺衍生物的皮肤病学制剂：其中，R 1表示可被一个或多个羟基取代的具有1至22个碳原子的直链或支链烃基和/或烷氧基，R 2表示具有1至12个碳原子的直链或支链二价烃基，R 3表示具有1至42个碳原子的直链或支链二价烃基）。该二酰胺衍生物（1）能够从根本上提高角质层的保水能力和阻隔功能，混溶性和混合稳定性优异，可以低成本有效地制备。

7. 发明授权

US09056119B2 VEGF production promoter 有权
标题翻译： VEGF生产启动子
公开(公告)号：US09056119B2
公开(公告)日：2015-06-16
申请号：US13805798
申请日：2011-07-01
申请人： Akiyo Kameyama , Sachie Ueda
发明人： Akiyo Kameyama , Sachie Ueda
IPC分类号： A61K31/704 , A61K8/63 , A61K31/7048 , A61Q5/00 , A61Q19/00 , C07J71/00
CPC分类号： A61K31/704 , A61K8/63 , A61K31/7048 , A61K2800/78 , A61Q5/00 , A61Q19/00 , C07J53/004 , C07J71/00 , C07J71/0005 , C07J71/0026
摘要： Provided are a VEGF production promoter, a hair quality improver, and an external preparation for skin, each of which has a VEGF production promoting activity and can be used as a pharmaceutical agent, a cosmetic, a food, or a material therefor.The VEGF production promoter, the hair quality improver, and the external preparation for skin each comprises, as an active ingredient, a cycloartane-type glycoside represented by the following general formula (1) (where R represents a xylose residue or an arabinose residue, and the ring D moiety represents any one of the following moieties a to f (where R1 represents a hydrogen atom or a methyl group, R2 represents a hydrogen atom or an acetyl group, R3 represents a hydrogen atom or a hydroxyl, group, R4 represents a hydrogen atom or a hydroxyl group, and Ac represents an acetyl group)).
摘要翻译：提供了VEGF生产促进剂，毛发质量改良剂和皮肤外用剂，其各自具有VEGF生产促进活性，并且可以用作药剂，化妆品，食品或其材料。 VEGF生成促进剂，毛发质量改良剂，皮肤外用剂均含有作为活性成分的由以下通式（1）表示的环阿糖型糖苷（其中R表示木糖残基或阿拉伯糖残基，环D部分表示以下部分a至f中的任一个（其中R 1表示氢原子或甲基，R 2表示氢原子或乙酰基，R 3表示氢原子或羟基，R 4表示氢原子或羟基，Ac表示乙酰基））。

8. 发明申请

US20130102549A1 VEGF Production Promoter 有权
标题翻译： VEGF生产启动子
公开(公告)号：US20130102549A1
公开(公告)日：2013-04-25
申请号：US13805798
申请日：2011-07-01
申请人： Akiyo Kameyama , Sachie Ueda
发明人： Akiyo Kameyama , Sachie Ueda
IPC分类号： A61K31/704
CPC分类号： A61K31/704 , A61K8/63 , A61K31/7048 , A61K2800/78 , A61Q5/00 , A61Q19/00 , C07J53/004 , C07J71/00 , C07J71/0005 , C07J71/0026
摘要： Provided are a VEGF production promoter, a hair quality improver, and an external preparation for skin, each of which has a VEGF production promoting activity and can be used as a pharmaceutical agent, a cosmetic, a food, or a material therefor.The VEGF production promoter, the hair quality improver, and the external preparation for skin each comprises, as an active ingredient, a cycloartane-type glycoside represented by the following general formula (1) (where R represents a xylose residue or an arabinose residue, and the ring D moiety represents any one of the following moieties a to f (where R1 represents a hydrogen atom or a methyl group, R2 represents a hydrogen atom or an acetyl group, R3 represents a hydrogen atom or a hydroxyl, group, R4 represents a hydrogen atom or a hydroxyl group, and Ac represents an acetyl group)).
摘要翻译：提供了VEGF生产促进剂，毛发质量改良剂和皮肤外用剂，其各自具有VEGF生产促进活性，并且可以用作药剂，化妆品，食品或其材料。 VEGF生成促进剂，毛发质量改良剂，皮肤外用剂均含有作为活性成分的由以下通式（1）表示的环阿糖型糖苷（其中R表示木糖残基或阿拉伯糖残基，环D部分表示以下部分a至f中的任一个（其中R 1表示氢原子或甲基，R 2表示氢原子或乙酰基，R 3表示氢原子或羟基，R 4表示氢原子或羟基，Ac表示乙酰基））。

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