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1. 发明申请

US20110001929A1 Fundus photographing apparatus 有权
标题翻译：眼底摄影设备
公开(公告)号：US20110001929A1
公开(公告)日：2011-01-06
申请号：US12801913
申请日：2010-07-01
申请人： Akira Tawada
发明人： Akira Tawada
IPC分类号： A61B3/15
CPC分类号： A61B3/12
摘要： A fundus photographing apparatus has an optical system including a movable focusing lens and photographing a fundus, an optical system photo-receiving by a first image pickup element a target from an alignment target projection optical system and detect an alignment state of the photographing optical system with respect to an eye based on a result by the first element, a detection optical system photo-receiving by a second image pickup element a target from a focus target projection optical system and detect a focus state adjusted by moving the lens based on a photo-receiving result by the second element, a unit controlling a light source to successively emit flash light at predetermined intervals in a predetermined period to perform fluorescent photographing, and a unit controlling movement of the photographing optical system with respect to the eye based on a result by the alignment detection optical system during the predetermined period.
摘要翻译：眼底摄影装置具有包括可移动聚焦透镜和拍摄眼底的光学系统，由对准目标投影光学系统的第一图像拾取元件对目标进行光学接收的光学系统，并且检测拍摄光学系统的对准状态，基于第一元素的结果，基于由第二图像拾取元件从聚焦目标投影光学系统对目标进行光接收的检测光学系统，并且检测通过基于光电转换器移动透镜而调整的聚焦状态，通过第二元件接收结果，控制光源的单元在预定周期内以预定间隔连续地发射闪光，以执行荧光拍摄;以及单元，基于结果，控制摄影光学系统相对于眼睛的移动在预定时段内的对准检测光学系统。

2. 发明授权

US06365733B1 Lactosamine oligosaccharide and method for producing the same 有权
标题翻译：乳糖胺寡糖及其制造方法
公开(公告)号：US06365733B1
公开(公告)日：2002-04-02
申请号：US09616341
申请日：2000-07-14
申请人： Akira Tawada , Keiichi Yoshida
发明人： Akira Tawada , Keiichi Yoshida
IPC分类号： C08B3700
CPC分类号： C12P19/26 , C07H13/06
摘要： A method for producing an N-acetyllactosamine oligosaccharide, comprising the steps of: adjusting a sulfate group content of keratan sulfate; allowing an enzyme having an ability to cleave a glycosidic linkage of keratan sulfate to act on the keratan sulfate with the adjusted sulfate group content to obtain a sulfated N-acetyllactosamine oligosaccharide; and completely desulfating said sulfated N-acetyllactosamine oligosaccharide.
摘要翻译：一种N-乙酰基乳糖胺寡糖的制造方法，其特征在于，包括：调整硫酸角质素的硫酸基含量;使具有切割硫酸角质素糖苷键的能力的酶作用于硫酸角质素，调节硫酸根基含量得到硫酸化N-乙酰乳糖胺寡糖; 并完全脱硫所述硫酸化N-乙酰乳糖胺寡糖。

3. 发明授权

US5939403A Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same 失效
$Keratan sulfate oligosaccharide fraction and pharmaceutical containing the same$
标题翻译：硫酸角质素寡糖部分和含有相同的药物
公开(公告)号：US5939403A
公开(公告)日：1999-08-17
申请号：US849925
申请日：1997-06-02
申请人： Hiroshi Maruyama , Kiyoshi Morikawa , Akira Tawada , Satoshi Miyauchi , Keiichi Yoshida , Akira Asari
发明人： Hiroshi Maruyama , Kiyoshi Morikawa , Akira Tawada , Satoshi Miyauchi , Keiichi Yoshida , Akira Asari
IPC分类号： A61K31/737 , C07H11/00 , C07H13/04 , C08B37/00 , C12P19/26 , A61K31/73 , A61K31/725 , C08B3/04 , C08B3/06
CPC分类号： A61K31/7024 , A61K31/702 , A61K31/737 , C07H11/00 , C07H13/04 , C08B37/0063 , C12P19/26 , Y10S514/885
摘要： A keratan sulfate oligosaccharide which comprises from two to five sugar units and has sulfated N-acetylglucosamine at the reducing end and in a molecule of which at least two hydroxyl groups are sulfated, preferably, which contains at least disaccharide represented by the formula Gal(6S)-GlcNAc(6S) (in the formula, Gal, GlcN, Ac, and 6S represent a galactose, a glucosamine, an acetyl group, and a 6-O-sulfate ester, respectively) as a constitutional ingredient, and/or pharmaceutically acceptable salt thereof are used as active ingredients of anti-inflammatory agents, antiallergic agents, immunomodulators, cell differentiation inducers, and apoptosis inducers.
摘要翻译： PCT No.PCT / JP95 / 02386 Sec。 371日期：1997年6月2日 102（e）日期1997年6月2日PCT提交1995年11月22日PCT公布。公开号WO96 / 16973 日期：1996年6月6日硫酸角质素寡糖，其包含2至5个糖单元并且在还原端具有硫酸化的N-乙酰葡糖胺，并且其至少两个羟基被硫酸化的分子中，优选至少含有由配方Gal（6S）-GlcNAc（6S）（在分子式中，Gal，GlcN，Ac和6S分别代表半乳糖，葡糖胺，乙酰基和6-O-硫酸酯）作为构成成分，和/或其药学上可接受的盐用作抗炎剂，抗过敏剂，免疫调节剂，细胞分化诱导剂和凋亡诱导剂的活性成分。

4. 发明授权

US08646912B2 Fundus photographing apparatus 有权
标题翻译：眼底摄影设备
公开(公告)号：US08646912B2
公开(公告)日：2014-02-11
申请号：US12801913
申请日：2010-07-01
申请人： Akira Tawada
发明人： Akira Tawada
IPC分类号： A61B3/14 , A61B3/10
CPC分类号： A61B3/12
摘要： A fundus photographing apparatus has an optical system including a movable focusing lens and photographing a fundus, an optical system photo-receiving by a first image pickup element a target from an alignment target projection optical system and detect an alignment state of the photographing optical system with respect to an eye based on a result by the first element, a detection optical system photo-receiving by a second image pickup element a target from a focus target projection optical system and detect a focus state adjusted by moving the lens based on a photo-receiving result by the second element, a unit controlling a light source to successively emit flash light at predetermined intervals in a predetermined period to perform fluorescent photographing, and a unit controlling movement of the photographing optical system with respect to the eye based on a result by the alignment detection optical system during the predetermined period.
摘要翻译：眼底摄影装置具有包括可移动聚焦透镜和拍摄眼底的光学系统，由对准目标投影光学系统的第一图像拾取元件对目标进行光学接收的光学系统，并且检测拍摄光学系统的对准状态，基于第一元素的结果，基于由第二图像拾取元件从聚焦目标投影光学系统对目标进行光接收的检测光学系统，并且检测通过基于光电转换器移动透镜而调整的聚焦状态，通过第二元件接收结果，控制光源的单元在预定周期内以预定间隔连续地发射闪光，以执行荧光拍摄;以及单元，基于结果，控制摄影光学系统相对于眼睛的移动在预定时段内的对准检测光学系统。

5. 发明授权

US07507723B2 Hyaluronic acid oligosaccharide fractions and drugs containing the same 有权
$Hyaluronic acid oligosaccharide fractions and drugs containing the same$
标题翻译：透明质酸寡糖组分和含有相同的药物
公开(公告)号：US07507723B2
公开(公告)日：2009-03-24
申请号：US10312879
申请日：2001-07-06
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A61K31/702 , A61K31/728
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.
摘要翻译：具有选自尺寸为4至60个糖的大小的透明质酸寡糖，含有透明质酸寡糖的部分并且具有特定的理化性质，以及含有该物质的药物。本发明的透明质酸寡糖是非常有用的，因为它们作为热休克蛋白表达启动子，细胞死亡抑制剂，细胞损伤抑制剂和细胞和组织保护剂（例如器官保存剂，抗溃疡剂）的活性成分发挥优异的药物作用药物，抗肝病，IL-10生产促进剂或IL-8产生抑制剂），并表现出高安全性。

6. 发明申请

US20060114412A1 Fundus camera 失效
标题翻译：眼底相机
公开(公告)号：US20060114412A1
公开(公告)日：2006-06-01
申请号：US11289431
申请日：2005-11-30
申请人： Akira Tawada
发明人： Akira Tawada
IPC分类号： A61B3/10 , A61B3/14
CPC分类号： A61B3/0041 , A61B3/0091 , A61B3/14
摘要： A fundus camera, of which usability is enhanced while offering an excellent combination of automatic and manual photographing, includes a photographing optical system having a photographing optical axis, a movable focusing lens and an image-pickup element, alignment-state detection means, focusing-state detection means, a fixation target presenting unit where a presenting position of a fixation target is changeable between a reference position for photographing a central portion and a peripheral position for photographing a peripheral portion, a photographing starting switch, means for switching between a manual mode in which photographing is performed based on a signal from the switch and an automatic mode in which photographing is automatically performed based on results detected by the alignment-state and the focusing-state detection means, and fixation target presentation control means for controlling the unit to bring the presenting position to the reference position when switching from the manual mode to the automatic mode.
摘要翻译：提供了自动和手动拍摄的优异组合的可用性增强的眼底相机包括具有拍摄光轴的拍摄光学系统，可移动聚焦透镜和图像拾取元件，对准状态检测装置，状态检测装置，其中固定目标的呈现位置在用于拍摄中心部分的基准位置与用于拍摄周边部分的周边位置之间可改变的定影目标呈现单元，拍摄启动开关，用于在手动模式基于来自开关的信号执行拍摄，以及基于由对准状态和聚焦状态检测装置检测到的结果自动执行拍摄的自动模式，以及用于控制单元的定影目标呈现控制装置在转换时将演示位置置于参考位置 g从手动模式到自动模式。

7. 发明授权

US07837329B2 Fundus camera 有权
标题翻译：眼底相机
公开(公告)号：US07837329B2
公开(公告)日：2010-11-23
申请号：US12415547
申请日：2009-03-31
申请人： Masayuki Yoshino , Yoshiaki Mimura , Akira Tawada , Naoki Ichikawa
发明人： Masayuki Yoshino , Yoshiaki Mimura , Akira Tawada , Naoki Ichikawa
IPC分类号： A61B3/14
CPC分类号： A61B3/14
摘要： A fundus camera favorably performing focusing on a fundus of an examinee's eye without a black dot plate in a target projection optical system comprises an illumination optical system comprising a light source and an objective lens, a photographing optical system comprising a focusing lens movable in the optical axis direction and a diopter correction lens to correct a diopter of severe ametropia, a first moving mechanism comprising a first driving unit moving the focusing lens, a focus detection optical system comprising a projection optical system comprising a light source and a photo-receiving optical system comprising a photodetector, a second moving mechanism comprising a second driving unit moving a part of the detection optical system including at least one of the projection light source and the photodetector in the optical axis direction, a monitor, and a control unit controlling the second unit in conjunction with movement of the focusing lens.
摘要翻译：在目标投影光学系统中没有黑点板的情况下，有利地执行聚焦在受检者的眼底的眼底相机包括包括光源和物镜的照明光学系统，包括可在光学器件中移动的聚焦透镜的拍摄光学系统以及用于校正严重屈光度的屈光度的屈光度校正透镜，包括移动聚焦透镜的第一驱动单元的第一移动机构，包括投影光学系统的焦点检测光学系统，所述投影光学系统包括光源和光接收光学系统包括光电检测器，第二移动机构，包括第二驱动单元，其将包括所述投影光源和所述光电检测器中的至少一个在所述光轴方向上移动的所述检测光学系统的一部分移动;监视器，以及控制所述第二单元结合聚焦透镜的移动。

8. 发明授权

US07601488B2 Hyaluronic acid oligosaccharide fractions and drugs containing the same 失效
$Hyaluronic acid oligosaccharide fractions and drugs containing the same$
标题翻译：透明质酸寡糖组分和含有相同的药物
公开(公告)号：US07601488B2
公开(公告)日：2009-10-13
申请号：US11622673
申请日：2007-01-12
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A01N1/02 , A61K31/702
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译：用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示，通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分，或通过施用有效量的分离和基本上纯的本申请中描述的式（1）四糖。保存器官的方法

9. 发明申请

US20070134646A1 HYALURONIC ACID OLIGOSACCHARIDE FRACTIONS AND DRUGS CONTAINING THE SAME 失效
标题翻译：羟丙酸低聚糖和含有其的药物
公开(公告)号：US20070134646A1
公开(公告)日：2007-06-14
申请号：US11622673
申请日：2007-01-12
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A01N1/02 , A61K31/728
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译：用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示，通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分，或通过施用有效量的分离和基本上纯的本申请中描述的式（1）四糖。保存器官的方法

10. 发明申请

US20050225722A1 Fundus camera 失效
标题翻译：眼底相机
公开(公告)号：US20050225722A1
公开(公告)日：2005-10-13
申请号：US11063840
申请日：2005-02-23
申请人： Akira Tawada , Setsuo Saito
发明人： Akira Tawada , Setsuo Saito
IPC分类号： A61B3/14 , A61B3/15
CPC分类号： A61B3/156 , A61B3/152
摘要： A fundus camera capable of favorably obtaining a photographed fundus image and an observation fundus image, has an optical system having an objective lens and a diaphragm at a conjugate position with a pupil relative to the lens, for performing visible photographing and infrared observation via the lens and an aperture of the diaphragm, an optical system for illumination with visible and infrared light via the lens, a first plate, with a first black dot to cover an aperture image and at a conjugate position on an optical path with a position where a virtual image is formed relative to a lens surface reflecting the visible light, and a second plate, with a second black dot to cover an aperture image and in the vicinity of a conjugate position on the path with a position where a virtual image is formed relative to the surface reflecting the infrared light.
摘要翻译：能够有利地获得拍摄的眼底图像和观察眼底图像的眼底照相机具有在与瞳孔相对于透镜的共轭位置处具有物镜和光阑的光学系统，用于经由透镜进行可见摄影和红外观察以及光阑的孔径，用于通过透镜可见光和红外光照明的光学系统，第一板，具有第一黑点以覆盖孔径图像，并且在光路上的共轭位置处具有虚拟相对于反射可见光的透镜表面形成图像，第二平板具有第二黑点以覆盖孔径图像并且在路径上的共轭位置附近具有相对于虚拟图像形成的位置表面反射红外光。

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