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1. 发明授权

US07507723B2 Hyaluronic acid oligosaccharide fractions and drugs containing the same 有权
$Hyaluronic acid oligosaccharide fractions and drugs containing the same$
标题翻译：透明质酸寡糖组分和含有相同的药物
公开(公告)号：US07507723B2
公开(公告)日：2009-03-24
申请号：US10312879
申请日：2001-07-06
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A61K31/702 , A61K31/728
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.
摘要翻译：具有选自尺寸为4至60个糖的大小的透明质酸寡糖，含有透明质酸寡糖的部分并且具有特定的理化性质，以及含有该物质的药物。本发明的透明质酸寡糖是非常有用的，因为它们作为热休克蛋白表达启动子，细胞死亡抑制剂，细胞损伤抑制剂和细胞和组织保护剂（例如器官保存剂，抗溃疡剂）的活性成分发挥优异的药物作用药物，抗肝病，IL-10生产促进剂或IL-8产生抑制剂），并表现出高安全性。

2. 发明授权

US08314079B2 Hyaluronic acid oligosaccharide fractions and drugs containing the same 失效
$Hyaluronic acid oligosaccharide fractions and drugs containing the same$
标题翻译：透明质酸寡糖组分和含有相同的药物
公开(公告)号：US08314079B2
公开(公告)日：2012-11-20
申请号：US13115435
申请日：2011-05-25
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A61K31/702
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译：用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示，通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分，或通过施用有效量的分离和基本上纯的本申请中描述的式（1）四糖。保存器官的方法

3. 发明申请

US20110224169A1 HYALURONIC ACID OLIGOSACCHARIDE FRACTIONS AND DRUGS CONTAINING THE SAME 失效
标题翻译：羟丙酸低聚糖和含有其的药物
公开(公告)号：US20110224169A1
公开(公告)日：2011-09-15
申请号：US13115435
申请日：2011-05-25
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A61K31/702 , A61P1/16 , A61P1/04
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译：用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示，通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分，或通过施用有效量的分离和基本上纯的本申请中描述的式（1）四糖。保存器官的方法

4. 发明授权

US07601488B2 Hyaluronic acid oligosaccharide fractions and drugs containing the same 失效
$Hyaluronic acid oligosaccharide fractions and drugs containing the same$
标题翻译：透明质酸寡糖组分和含有相同的药物
公开(公告)号：US07601488B2
公开(公告)日：2009-10-13
申请号：US11622673
申请日：2007-01-12
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A01N1/02 , A61K31/702
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译：用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示，通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分，或通过施用有效量的分离和基本上纯的本申请中描述的式（1）四糖。保存器官的方法

5. 发明申请

US20070134646A1 HYALURONIC ACID OLIGOSACCHARIDE FRACTIONS AND DRUGS CONTAINING THE SAME 失效
标题翻译：羟丙酸低聚糖和含有其的药物
公开(公告)号：US20070134646A1
公开(公告)日：2007-06-14
申请号：US11622673
申请日：2007-01-12
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A01N1/02 , A61K31/728
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： A method for promoting expression of a heat shock protein, or for inhibiting cell injury or cell death, or for treating a disease for which cell or tissue protection is desired, or for promoting production of IL-10, or for inhibiting production of IL-8, by administering an effective amount of a fraction containing a hyaluronic acid tetrasaccharide comprising four saccharide residues and having certain physicochemical properties or by administering an effective amount of an isolated and substantially pure tetrasaccharide of formula (1) described in the application. Methods for preserving an organ.
摘要翻译：用于促进热休克蛋白的表达或用于抑制细胞损伤或细胞死亡或用于治疗需要细胞或组织保护的疾病或用于促进IL-10的产生或用于抑制IL- 如图8所示，通过施用有效量的含有包含四个糖残基并具有一定物理化学性质的透明质酸四糖的级分，或通过施用有效量的分离和基本上纯的本申请中描述的式（1）四糖。保存器官的方法

6. 发明申请

US20080182983A1 HYALURONIC ACID OLIGOSACCHARIDE FRACTIONS AND DRUGS CONTAINING THE SAME 审中-公开
标题翻译：羟丙酸低聚糖和含有其的药物
公开(公告)号：US20080182983A1
公开(公告)日：2008-07-31
申请号：US11928833
申请日：2007-10-30
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： C08B37/00 , C07H1/00
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.
摘要翻译：具有选自尺寸为4至60个糖的大小的透明质酸寡糖，含有透明质酸寡糖的部分并且具有特定的理化性质，以及含有该物质的药物。本发明的透明质酸寡糖是非常有用的，因为它们作为热休克蛋白表达启动子，细胞死亡抑制剂，细胞损伤抑制剂和细胞和组织保护剂（例如器官保存剂，抗溃疡剂）的活性成分发挥优异的药物作用药物，抗肝病，IL-10生产促进剂或IL-8产生抑制剂），并表现出高安全性。

7. 发明申请

US20050090661A1 Hyaluronic acid oligosaccharide fractions and drugs containing the same 有权
$Hyaluronic acid oligosaccharide fractions and drugs containing the same$
标题翻译：透明质酸寡糖组分和含有相同的药物
公开(公告)号：US20050090661A1
公开(公告)日：2005-04-28
申请号：US10312879
申请日：2001-07-06
申请人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
发明人： Akira Asari , Hitoshi Kurihara , Tomomi Shibata , Yuka Miyazaki , Hiroko Yamanokuchi , Akira Tawada , Takahiro Masa , Yuji Matsuzaki
IPC分类号： A61K31/702 , A61K31/728 , A61P1/04 , A61P1/16 , A61P43/00 , C07H7/033 , C08B37/08 , C08B37/00
CPC分类号： C08B37/0072 , A61K31/702 , A61K31/728 , C07H7/033
摘要： Hyaluronic acid oligosaccharides having a size selected from sizes of 4 to 60 saccharides, fractions containing the hyaluronic acid oligosaccharides and having particular physicochemical properties, and drugs containing the same. The hyaluronic acid oligosaccharides of the present invention are extremely useful, because they exert superior pharmaceutical effects as active ingredients of a heat shock protein expression promoter, cell death inhibitor, cell injury inhibitor and cell and tissue protecting agent (e.g., organ preservation agent, antiulcer agent, antihepatopathic agent, IL-10 production promoter or IL-8 production inhibitor) and exhibit high safety.
摘要翻译：具有选自尺寸为4至60个糖的大小的透明质酸寡糖，含有透明质酸寡糖的部分并且具有特定的理化性质，以及含有该物质的药物。本发明的透明质酸寡糖是非常有用的，因为它们作为热休克蛋白表达启动子，细胞死亡抑制剂，细胞损伤抑制剂和细胞和组织保护剂（例如器官保存剂，抗溃疡剂）的活性成分发挥优异的药物作用药物，抗肝病，IL-10生产促进剂或IL-8产生抑制剂），并表现出高安全性。

8. 发明授权

US06436911B1 IL-12 production inhibitor 有权
标题翻译： IL-12生产抑制剂
公开(公告)号：US06436911B1
公开(公告)日：2002-08-20
申请号：US09620747
申请日：2000-07-21
申请人： Akira Asari , Hitoshi Kurihara , Heping Xu , Satoshi Miyauchi , Toshikazu Minamisawa
发明人： Akira Asari , Hitoshi Kurihara , Heping Xu , Satoshi Miyauchi , Toshikazu Minamisawa
IPC分类号： A01N4304
CPC分类号： A61K31/7024
摘要： An IL-12 production inhibitor which comprises, as an active ingredient, a keratan sulfate oligosaccharide or a derivative thereof, for example, a keratan sulfate oligosaccharide comprising at least one repeating unit of either one of the disaccharides represented by the following formulas: Gal (6s)-GlcNAc (6s) and Gal (6s)-GlcNAc wherein Gal represents a galactose residue, GlcNAc represents an N-acetylglucosamine residue, 6s indicates that 6-0-sulfate ester is formed at a Hydroxyl group at the 6-position, and - represents a glycosidic linkage.
摘要翻译：作为活性成分的含有硫酸角质素寡糖或其衍生物的IL-12产生抑制剂，例如硫酸角质素寡糖，其包含由下式表示的二糖中的至少一个重复单元：Gal（ 6s）-GlcNAc（6s）和Gal（6s）-GlcNAc，其中Gal表示半乳糖残基，GlcNAc表示N-乙酰葡糖胺残基，6s表示6位羟基上形成6-0-硫酸酯，和 - 表示糖苷键。

9. 发明授权

US08845156B2 Vehicle lamp 有权
标题翻译：车灯
公开(公告)号：US08845156B2
公开(公告)日：2014-09-30
申请号：US12450038
申请日：2008-03-07
申请人： Yosuke Fukasawa , Yasushi Kawaji , Hitoshi Kurihara , Tatsuya Sugamoto
发明人： Yosuke Fukasawa , Yasushi Kawaji , Hitoshi Kurihara , Tatsuya Sugamoto
IPC分类号： F21V9/00 , B60R1/12 , B60Q1/26 , F21V8/00
CPC分类号： B60R1/1207 , B60Q1/2665 , G02B6/002
摘要： A vehicle lamp includes a long solid-core shaped light guide; a first light source that irradiates an end portion of the long solid-core shaped light guide in a longitudinal direction such that light is radiated long from an end side of the vehicle lamp toward another end side of the vehicle lamp; and a second light source that irradiates the another end side of the vehicle lamp to a lateral outer side.
摘要翻译：车灯包括长实心芯导光体; 第一光源，其沿长度方向照射长实芯形光导的端部，使得光从车灯的端侧向车灯的另一端侧照射长; 以及向车外灯的另一端侧照射的第二光源。

10. 发明申请

US20100238015A1 DOOR MIRROR 有权
标题翻译：门镜
公开(公告)号：US20100238015A1
公开(公告)日：2010-09-23
申请号：US12682794
申请日：2008-10-07
申请人： Yosuke Fukasawa , Yasushi Kawaji , Hitoshi Kurihara
发明人： Yosuke Fukasawa , Yasushi Kawaji , Hitoshi Kurihara
IPC分类号： B60Q1/34 , B60R1/12
CPC分类号： B60R1/1207 , B60Q1/2665 , F21S43/14 , F21S43/235 , F21V31/005
摘要： A door mirror has a turn lamp that can be mounted easily and without an increased size. The turn lamp (2) has a housing (3) and an outer lens (4) that are formed by molding. A light emitting diode (6) is mounted in the housing (3), and the outer lens (4) covers the housing (3). The housing (3) and the outer lens (4) are integrated by a joint (7) produced by injection molding and placed at a butt section at which the housing (3) and the outer lens (4) are butted together. Steps (7c, 7d) are formed at the butt section integrated by the joint (7) of the turn lamp (2), and a lower end edge section (1c) and a left end edge section (1e) that form an opening (1b) of a body (1) of the door mirror (DM) are butted to the steps (7c, 7d).
摘要翻译：门镜具有可以容易地安装并且没有增加尺寸的转向灯。转向灯（2）具有通过模制形成的壳体（3）和外部透镜（4）。发光二极管（6）安装在壳体（3）中，外透镜（4）覆盖壳体（3）。壳体（3）和外透镜（4）通过注射成型制成的接头（7）一体化，并且放置在壳体（3）和外透镜（4）对接在一起的对接部分处。步骤（7c，7d）形成在由转向灯（2）的接头（7）一体化的对接部分和形成开口的下端边缘部分（1c）和左端边缘部分（1e）将门镜（DM）的主体（1）的上表面（1b）对接到台阶（7c，7d）。

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