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    • 9. 发明申请
    • Method and Apparatus for Assaying Test Substance in Sample
    • 样品中测试物质的测定方法和装置
    • US20090305254A1
    • 2009-12-10
    • US12162008
    • 2007-01-24
    • Koji SodeKazunori IkebukuroHiroki Yamazaki
    • Koji SodeKazunori IkebukuroHiroki Yamazaki
    • C12Q1/68C12M1/34
    • G01N33/5308C12Q1/6825G01N33/58C12Q2565/628C12Q2565/518C12Q2525/205
    • Disclosed are a method for assaying a target substance in a sample and an apparatus for the method. The method can specifically assay the target substance in the sample without using any antibody against the target substance. The assaying method includes simultaneously or successively bringing a labeled aptamer, the target substance in the sample and a solid phase into contact together, and then measuring the label of the aptamer which has not been bound on the solid phase. The labeled aptamer has a property of binding to the target substance. The solid phase carries an oligonucleotide immobilized on it in an excess amount relative to the target substance. The oligonucleotide is hybridizable with the labeled aptamer when the labeled aptamer is in a state that it is not bound to the target substance, but is not hybridizable with the labeled aptamer when the labeled aptamer is in a state that it is bound to the target substance.
    • 公开了用于测定样品中的目标物质的方法和该方法的装置。 该方法可以特异性地测定样品中的目标物质,而不使用针对目标物质的任何抗体。 测定方法包括同时或连续地将标记的适体,样品中的目标物质和固相接触在一起,然后测量未结合在固相上的适体的标记。 标记的适体具有与靶物质结合的性质。 固相携带相对于目标物质过量固定在其上的寡核苷酸。 当标记的适体处于与靶物质不结合的状态下,当标记的适体处于与靶物质结合的状态时,寡核苷酸可与标记的适配子杂交,但与标记的适体不可杂交 。