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1. 发明授权

US5460715A Apparatus for filtering plasma 失效
标题翻译：用于过滤等离子体的装置
公开(公告)号：US5460715A
公开(公告)日：1995-10-24
申请号：US202262
申请日：1994-02-25
申请人： Akio Kawamura , Motoki Yonekawa , Eiji Sakashita , Hiroshi Kamogawa
发明人： Akio Kawamura , Motoki Yonekawa , Eiji Sakashita , Hiroshi Kamogawa
IPC分类号： C07C22/00 , A61M1/34 , A61M1/36 , B01D29/62 , B01D29/66 , C07C22/02 , C07C22/04 , C07C22/08 , C07C25/24 , C07C43/172 , C07C43/176 , C07C43/184 , C07C43/192 , C07C43/20 , C07C43/225 , C07C43/257 , C07C69/75 , C07C69/753 , C07C69/757 , C07C69/76 , C07C255/46 , C07C255/49 , C07C255/50 , C07C323/04 , C07C323/07 , C07D213/26 , C07D213/30 , C07D213/65 , C07D239/26 , C07D239/34 , C07D319/06 , C07D339/08 , C09K19/04 , C09K19/30 , C09K19/34 , C09K19/42 , B01D36/00
CPC分类号： A61M1/3472 , A61M1/3482 , A61M2205/7554
摘要： In a process for filtering plasma by separating blood into blood cells and plasma by a primary filter and filtering the separated plasma by a secondary filter to remove macromolecules from the plasma as harmful components, the loss of plasma to be discarded from the system by a procedure for eliminating plugging of the secondary filter can be diminished by opening an inner chamber of the secondary filter to the atmosphere to thereby lower the internal pressure of the chamber every time increase of the pressure to an upper limit value due to an increasing plugging tendency of the secondary filter is detected, and washing the interior of the secondary filter from the inner and outer chamber sides after the internal pressure has lowered.
摘要翻译：在通过初级过滤器将血液分离成血细胞和血浆以过滤等离子体并通过二次过滤器过滤分离的血浆以从血浆中除去大分子作为有害成分的过程中，通过程序从体系中丢弃等离子体的损失通过将二次过滤器的内部室打开到大气中，可以减少二次过滤器的堵塞，从而由于压力增加到上限值，从而降低室内部压力，这是由于增加的堵塞趋势检测到二次过滤器，并且在内部压力降低之后从内室侧和外室侧洗涤二次过滤器的内部。

2. 发明授权

US5516431A Method of washing secondary filter in process for filtering plasma 失效
标题翻译：在过滤等离子体过程中清洗二次过滤器的方法
公开(公告)号：US5516431A
公开(公告)日：1996-05-14
申请号：US302774
申请日：1994-09-19
申请人： Akio Kawamura , Motoki Yonekawa , Osamu Kaneko , Hiroshi Kamogawa
发明人： Akio Kawamura , Motoki Yonekawa , Osamu Kaneko , Hiroshi Kamogawa
IPC分类号： A61M1/02 , A61M1/34 , B01D11/00 , B01D61/00 , C02F1/44
CPC分类号： A61M1/3472 , A61M1/02 , A61M1/3482 , A61M2205/707 , A61M2205/7554
摘要： In a plasma filtration process including a treatment with a primary filter for separating blood into blood cells and plasma and a treatment with a secondary filter for removing harmful macromolecules from the separated plasma for purification, the secondary filter is washed by passing a washing liquid through an inner chamber of the filter, an outer chamber thereof or both the chambers in an amount corresponding to 5 to 50% of the priming volume of the filter every time the filtration pressure has reached 70 to 100% of the withstanding pressure of the secondary filter. This washing procedure reduces the time required for the filtration of plasma to about 60 to 70% of the time conventionally needed, shortens the patient restraining time, and decreases the amount of washing liquid to be used to consequently diminish the disposal loss of plasma from the system.
摘要翻译： PCT No.PCT / JP94 / 00085 Sec。 371日期1994年9月19日 102（e）1994年9月19日PCT 1994年1月21日PCT PCT。公开号WO94 / 16751 日期为1905年8月4日。在等离子体过滤方法中，包括用初级过滤器将血液分离成血细胞和血浆，并用二级过滤器处理，从分离的血浆中除去有害的大分子以进行纯化，将二次过滤器洗涤通过将过滤器的内部室，其外部室或两个室中的洗涤液通过，每当过滤压力达到过滤压力的70％至100％时，其量相当于过滤器的起动体积的5％至50％二级过滤器承受压力。这种洗涤方法将血浆过滤所需的时间减少到常规需要时间的约60-70％，缩短了患者的约束时间，并减少了使用的洗涤液的量，从而减少了等离子体的处置损失系统。

3. 发明授权

US5859626A Display circuit which automatically deciphers different video formats and optimizes the horizontal and vertical centering of the image on the display 失效
标题翻译：显示电路，自动解码不同的视频格式，并优化图像在显示屏上的水平和垂直居中
公开(公告)号：US5859626A
公开(公告)日：1999-01-12
申请号：US604746
申请日：1996-02-23
申请人： Akio Kawamura
发明人： Akio Kawamura
IPC分类号： G02F1/133 , G09G3/20 , G09G3/36 , G09G5/00 , H04N3/27 , H04N5/46
CPC分类号： G09G5/008 , G09G5/005 , H04N3/27 , G09G2340/0421 , G09G2340/0471 , G09G2340/0478 , G09G2340/0485 , G09G5/006 , H04N5/46
摘要： A display device that is automatically operable with various types of standards of video signals has a display panel, a controller, and a timing generator. The display panel includes pixels arranged in the form of a matrix to form an image. The display panel also contains a built-in vertical scanning circuit that is operable in response to input timing signals and sequentially selects the respective rows of the pixels. Additionally, the display panel contains a built-in horizontal scanning circuit that is operable in response to input timing signals and distributes the various types of standards of the video signals provided from the exterior to the selected rows of the pixels, thereby displaying the image. The controller deciphers the standard of the video signal provided from the exterior and automatically supplies the adjustment information required for optimizing the picture. The timing generator generates the timing signals in accordance with the adjustment information and inputs them into the display panel, whereby the image that has been optimally adjusted based on the standard of the video signal is displayed.
摘要翻译：可以利用各种类型的视频信号标准自动操作的显示装置具有显示面板，控制器和定时发生器。显示面板包括以矩阵形式布置以形成图像的像素。显示面板还包括内置垂直扫描电路，其可响应于输入定时信号而可操作并顺序地选择像素的相应行。此外，显示面板包含内置水平扫描电路，其可响应于输入定时信号而操作，并将从外部提供的视频信号的各种类型的标准分配给所选择的像素行，从而显示图像。控制器解码从外部提供的视频信号的标准，并自动提供优化图像所需的调整信息。定时发生器根据调整信息生成定时信号并将其输入显示面板，由此显示基于视频信号的标准被最佳调整的图像。

4. 发明授权

US4987921A Method of fabricating frozen fine liver piece for artificial liver, apparatus for freezing the same and freezing vessel 失效
标题翻译：制造用于人造肝的冷冻细肝片的方法，用于冷冻其的冷冻装置和冷冻容器
公开(公告)号：US4987921A
公开(公告)日：1991-01-29
申请号：US408111
申请日：1989-09-15
申请人： Yoichi Kasai, deceased , Akio Kawamura , Yoshimi Nakanishi , Akira Kakita , Toshihiko Tsuburaya , Yasuo Kuraoka , Nobuo Sakao
发明人： Yoichi Kasai, deceased , Akio Kawamura , Yoshimi Nakanishi , Akira Kakita , Toshihiko Tsuburaya , Yasuo Kuraoka , Nobuo Sakao
IPC分类号： A01N1/02 , F25D3/10 , A61B19/00 , F25D25/00
CPC分类号： F25D3/10 , A01N1/02 , A01N1/0257 , Y10T137/8593
摘要： A method of fabricating frozen fine liver pieces for an artificial liver which comprises cutting a liver removed from a human being or an animal, from which blood is removed into fine pieces of square shape and freezing the liver pieces with helium gas. A freezing apparatus for an artificial liver which has gas phase pressurizing means for pressurizing liquid helium coupled to a chamber for storing the liquid helium, a helium gas conduit dipped in the liquid helium passed through the chamber to be closed and contained, in which the liver fine pieces are telescopically received and an exhaust conduit provided with a control valve coupled to the freezing chamber. And, a freezing vessel for an artificial liver which has a flow conduit capable of being coupled to an upper portion and a lower portion of a unit, an upper coupling port and a lower coupling port respectively formed therethrough with closing plugs, two or more mesh plates laterally laid elevationally in the unit, and exit opening in to a containing chamber thus formed.

5. 发明授权

US06495874B1 Semiconductor device and production process thereof 有权
标题翻译：半导体装置及其制造方法
公开(公告)号：US06495874B1
公开(公告)日：2002-12-17
申请号：US09443007
申请日：1999-11-18
申请人： Akio Kawamura , Takahiro Tsuchida
发明人： Akio Kawamura , Takahiro Tsuchida
IPC分类号： H01L27108
CPC分类号： H01L28/40 , H01L21/76838
摘要： A semiconductor device comprises a first insulating film which is formed on a semiconductor substrate and has a groove whose bottom does not reach said semiconductor substrate, and a capacitive element which is composed of a lower electrode of a first metal layer which is embedded in said groove, a capacitive insulating film of a second insulating film formed on said lower electrode, and an upper electrode of a second metal layer formed in a region where both said lower electrode and said capacitive insulating film are formed.
摘要翻译：一种半导体器件包括：第一绝缘膜，其形成在半导体衬底上，并且具有底部未到达所述半导体衬底的沟槽;以及电容元件，其由嵌入所述沟槽中的第一金属层的下电极形成在所述下电极上的第二绝缘膜的电容绝缘膜和形成在所述下电极和所述电容绝缘膜两者的区域中的第二金属层的上电极。

6. 发明授权

US5629744A Active matrix display device and timing generator 失效
标题翻译：主动矩阵显示装置和定时发生器
公开(公告)号：US5629744A
公开(公告)日：1997-05-13
申请号：US424058
申请日：1995-04-19
申请人： Akio Kawamura
发明人： Akio Kawamura
IPC分类号： G02F1/133 , G09G3/20 , G09G3/36 , H04N3/12 , H04N5/66 , H04N5/68 , H04N3/14 , H04N5/46 , H04N9/30
CPC分类号： H04N7/0122 , G09G3/3611 , G09G3/3648 , G09G3/3677 , H04N3/127 , G09G2310/0232 , G09G2340/0414 , G09G2340/0442 , G09G2340/0471 , G09G3/2011 , H04N5/68
摘要： an active matrix display device comprises a plurality of pixels, a vertical scanning circuit, a horizontal scanning circuit and a thinning-out circuit. The plurality of pixels are arranged in a matrix on a normal standard screen. The vertical scanning circuit is for sequentially selecting pixels every line. The horizontal scanning circuit is for writing single horizontal period portions of a wide standard image signal for selected lines of pixels and the thinning-out circuit is for controlling timing of the vertical scanning circuit sequential selection and thinning-out a prescribed number of horizontal period portions from a wide standard image signal in such a manner that wide displaying compressed in the longitudinal direction of the screen is carried out. It is therefore possible for a normal standard screen to change over to displaying a wide standard image.
摘要翻译：有源矩阵显示装置包括多个像素，垂直扫描电路，水平扫描电路和稀疏电路。多个像素在正常标准屏幕上以矩阵形式布置。垂直扫描电路用于每行顺序选择像素。水平扫描电路用于为所选择的像素行写入宽标准图像信号的单个水平周期部分，并且该稀疏电路用于控制垂直扫描电路顺序选择的定时和将规定数量的水平周期部分从广泛的标准图像信号，使得在屏幕的纵向被压缩的宽显示被执行。因此，通常的标准画面可以转换成显示宽标准图像。

7. 发明授权

US5173444A Method for forming a semiconductor device isolation region 失效
标题翻译：形成半导体器件隔离区的方法
公开(公告)号：US5173444A
公开(公告)日：1992-12-22
申请号：US760131
申请日：1991-09-16
申请人： Akio Kawamura
发明人： Akio Kawamura
IPC分类号： H01L21/76 , H01L21/316 , H01L21/32 , H01L21/762
CPC分类号： H01L21/32 , H01L21/76205
摘要： A method for forming a semiconductor device isolation region including steps of forming a first silicon oxide film on a silicon substrate, depositing a first silicon nitride film over the first silicon oxide film, and removing the first silicon oxide film and first silicon nitride film in a device isolation region by using a resist pattern, which is formed by a one-time photolithographic step, as a mask so as to expose the surface of the silicon substrate, removing the resist pattern, and oxidizing the exposed surface of the silicon substrate so as to form a second silicon oxide film having a smaller thickness than the first silicon oxide film and to deposit a second silicon nitride film, removing the second silicon nitride film by anisotropic etching until the second silicon oxide film is exposed in the device isolation region so as to make the second silicon nitride film remain as the side wall portion of the silicon nitride film in only the opening side wall portion of the first silicon nitride film, etching the second silicon oxide film in the opening of the first silicon nitride film on a self-aligning basis by using as etching masks the first silicon nitride film and the side wall portion of the second silicon nitride film remaining on the opening side wall portion of the first silicon nitride film, and selectively carrying out oxidation so as to form a thick silicon oxide film in the device isolation region.

8. 发明授权

US09420769B2 Chimeric non-human animal carrying human hepatocyte 有权
标题翻译：携带人肝细胞的嵌合非人动物
公开(公告)号：US09420769B2
公开(公告)日：2016-08-23
申请号：US14351481
申请日：2012-10-12
申请人： Mitsuo Oshimura , Yasuhiro Kazuki , Chise Mukaidani , Takashi Shimada , Masakazu Kakuni , Satoko Hamamura , Hidetaka Kamimura , Akio Kawamura , Naoyuki Nakada , Masato Ohbuchi , Kota Kato
发明人： Mitsuo Oshimura , Yasuhiro Kazuki , Chise Mukaidani , Takashi Shimada , Masakazu Kakuni , Satoko Hamamura , Hidetaka Kamimura , Akio Kawamura , Naoyuki Nakada , Masato Ohbuchi , Kota Kato
IPC分类号： A01K67/027 , C12N9/02 , G01N33/50
CPC分类号： A01K67/0271 , A01K2207/12 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N9/0042 , G01N33/5067 , G01N33/5088
摘要： A chimeric non-human animal having an in vivo human hepatocyte population, wherein the effects of non-human animal cells on drug metabolism are suppressed or deleted is provided. A method for producing a chimeric non-human animal that lacks a drug-metabolizing system or has a suppressed drug-metabolizing system and is provided with a drug-metabolizing system driven by human hepatocytes, is provided. The method comprises transplanting human hepatocytes into a non-human animal characterized by (i) being immunodeficient, (ii) having liver damage, and (iii) lacking the functions of an endogenous Cyp3a gene.
摘要翻译：提供具有体内人肝细胞群体的嵌合非人动物，其中非人动物细胞对药物代谢的作用被抑制或缺失。提供了一种制备缺乏药物代谢系统或具有抑制药物代谢系统并具有由人肝细胞驱动的药物代谢系统的嵌合非人动物的方法。该方法包括将人肝细胞移植到非人动物中，其特征在于：（i）免疫缺陷，（ii）具有肝损伤，和（iii）缺乏内源性Cyp3a基因的功能。

9. 发明授权

US06524273B2 No-needle blood access device for hemodialysis 失效
标题翻译：用于血液透析的无针入血装置
公开(公告)号：US06524273B2
公开(公告)日：2003-02-25
申请号：US09851326
申请日：2001-05-09
申请人： Akio Kawamura
发明人： Akio Kawamura
IPC分类号： A61M3700
CPC分类号： A61M39/0247 , A61M1/3655 , A61M2039/0258 , A61M2039/0264
摘要： A no-needle blood access device for hemodialysis including a cylindrical external body (20), the lower portion of the external body being provided with openings (28) at diametrically facing locations. Pipe members (30) are mounted in the respective openings. First and second artificial conduits (12, 14) are fitted into the respective pipe member, each of the artificial conduits being anastomosed to a targeted artery or vein; and a columnar internal body (40) fitted into the external body so as to be rotated in the external body. The device is arranged such that, when the internal body is rotated so that a first through-hole (42) communicates with the openings (28), the first artificial conduit (12) is in communication with the second artificial conduit (14) through the first through-hole (42), and when the internal body is rotated so that a first position (44) mates with one of the openings and a third position (50) mates with the other of the openings, a second through-hole is in communication with the first artificial conduit (12) and the third through-hole is in communication with the second artificial conduit (14).
摘要翻译：一种用于血液透析的无针血液进入装置，包括圆柱形外体（20），外部本体的下部在直径方向的位置设有开口（28）。管件（30）安装在相应的开口中。将第一和第二人造管道（12,14）装配到相应的管件中，每个人造管道与目标动脉或静脉吻合; 以及嵌合到所述外部主体中以在所述外部主体中旋转的柱状内部主体（40）。所述装置被布置成使得当所述内部主体旋转以使得第一通孔（42）与所述开口（28）连通时，所述第一人造管道（12）与所述第二人造管道（14）连通第一通孔（42），并且当内体旋转使得第一位置（44）与其中一个开口相配合，并且第三位置（50）与另一个开口配合时，第二通孔与第一人造管道（12）连通，第三通孔与第二人造管道（14）连通。

10. 发明授权

US5278082A Method for electrically connecting an electrode and impurity-diffused layer formed on a semiconductor substrate 失效
标题翻译：用于电连接形成在半导体衬底上的电极和杂质扩散层的方法
公开(公告)号：US5278082A
公开(公告)日：1994-01-11
申请号：US36621
申请日：1993-03-24
申请人： Akio Kawamura
发明人： Akio Kawamura
IPC分类号： H01L21/336 , H01L21/8244 , H01L27/11 , H01L29/78 , H01L21/265
CPC分类号： H01L27/11 , Y10S257/903 , Y10S438/965
摘要： A method for producing a semiconductor device in which an electrode and an impurity-diffused layer formed on a semiconductor substrate are electrically connected to each other, includes the following steps: forming a first insulating film on the semiconductor substrate; forming a first mask layer on the first insulating film, and forming a second mask layer on the first mask layer, the first mask layer comprising a first opening for exposing a part of the surface of the semiconductor substrate, the second mask layer comprising a second opening, at least the exposed part of the surface of the semiconductor substrate being exposed by the second opening; removing at least a part of the first insulating film exposed through the first opening; implanting a first impurity into the semiconductor substrate using the second mask layer as a mask and employing an acceleration energy at which the first impurity can pass through the first mask layer; removing the second mask layer, and forming the electrode doped with a second impurity so as to entirely cover the first opening; implanting a third impurity into the semiconductor substrate using the electrode as a mask; and activating the first impurity and the third impurity by annealing the semiconductor substrate, and diffusing the second impurity from the electrode to the semiconductor substrate by annealing the semiconductor substrate by annealing the semiconductor substrate, thereby forming the impurity-diffused layer.
摘要翻译：其中形成在半导体衬底上的电极和杂质扩散层彼此电连接的半导体器件的制造方法包括以下步骤：在半导体衬底上形成第一绝缘膜; 在所述第一绝缘膜上形成第一掩模层，以及在所述第一掩模层上形成第二掩模层，所述第一掩模层包括用于暴露所述半导体衬底的一部分表面的第一开口，所述第二掩模层包括第二掩模层，至少所述半导体衬底的所述表面的暴露部分被所述第二开口暴露; 去除通过所述第一开口暴露的所述第一绝缘膜的至少一部分; 使用所述第二掩模层作为掩模将第一杂质注入到所述半导体衬底中，并采用所述第一杂质可以通过所述第一掩模层的加速能; 去除所述第二掩模层，以及形成掺杂有第二杂质的电极，以便完全覆盖所述第一开口; 使用所述电极作为掩模将第三杂质注入所述半导体衬底; 以及通过退火所述半导体衬底来激活所述第一杂质和所述第三杂质，以及通过使所述半导体衬底退火来使所述半导体衬底退火从而将所述第二杂质从所述电极扩散到所述半导体衬底，从而形成所述杂质扩散层。

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