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1. 发明授权

US08709364B2 Heat retaining device 有权
标题翻译：保温装置
公开(公告)号：US08709364B2
公开(公告)日：2014-04-29
申请号：US13502271
申请日：2010-10-20
申请人： Akimasa Osaka , Minoru Sano , Hideo Kanno , Akiyuki Nemoto , Yoshiyuki Shoji
发明人： Akimasa Osaka , Minoru Sano , Hideo Kanno , Akiyuki Nemoto , Yoshiyuki Shoji
IPC分类号： B01L9/06 , C12M1/02 , B01L3/00 , C12M3/00
CPC分类号： G01N35/025 , G01N2035/00346
摘要： The present invention provides a heat retaining device for solving problematic adhesion of a container to the heat retaining device. The heat retaining device includes a supporting rod, a top plate, a bottom plate, a heat retaining body, and a supporting spring. A pressing force applied to the container contained in the hole of the heat retaining body compresses the supporting spring to move the heat retaining body downward along the supporting rod. Release of the pressing force moves the heat retaining body upward by an elastic force of the supporting spring until the heat retaining body comes into contact with the top plate.
摘要翻译：本发明提供一种用于解决容器对保温装置的有问题的粘附的保温装置。保温装置包括支撑杆，顶板，底板，保温体和支撑弹簧。施加到容纳在保温体的孔中的容器的按压力压缩支撑弹簧，以沿着支撑杆向下移动保温体。按压力的释放通过支撑弹簧的弹力使保温体向上移动，直到保温体与顶板接触。

2. 发明申请

US20120207646A1 HEAT INSULATOR 有权
标题翻译：热绝缘子
公开(公告)号：US20120207646A1
公开(公告)日：2012-08-16
申请号：US13502271
申请日：2010-10-20
申请人： Akimasa Osaka , Minoru Sano , Hideo Kanno , Akiyuki Nemoto , Yoshiyuki Shoji
发明人： Akimasa Osaka , Minoru Sano , Hideo Kanno , Akiyuki Nemoto , Yoshiyuki Shoji
IPC分类号： B65D81/00 , G01N31/00
CPC分类号： G01N35/025 , G01N2035/00346
摘要： The present invention provides a heat retaining device for solving problematic adhesion of a container to the heat retaining device. The heat retaining device includes a supporting rod, a top plate, a bottom plate, a heat retaining body, and a supporting spring. A pressing force applied to the container contained in the hole of the heat retaining body compresses the supporting spring to move the heat retaining body downward along the supporting rod. Release of the pressing force moves the heat retaining body upward by an elastic force of the supporting spring until the heat retaining body comes into contact with the top plate.
摘要翻译：本发明提供一种用于解决容器对保温装置的有问题的粘附的保温装置。保温装置包括支撑杆，顶板，底板，保温体和支撑弹簧。施加到容纳在保温体的孔中的容器的按压力压缩支撑弹簧，以沿着支撑杆向下移动保温体。按压力的释放通过支撑弹簧的弹力使保温体向上移动，直到保温体与顶板接触。

3. 发明申请

US20130017595A1 ANALYTICAL APPARATUS AND DETECTION METHOD EMPLOYED IN ANALYTICAL APPARATUS 有权
标题翻译：分析仪器中采用的分析仪器和检测方法
公开(公告)号：US20130017595A1
公开(公告)日：2013-01-17
申请号：US13519228
申请日：2010-12-22
申请人： Shuhei Yamamoto , Minoru Sano , Akiyuki Nemoto , Michiru Fujioka
发明人： Shuhei Yamamoto , Minoru Sano , Akiyuki Nemoto , Michiru Fujioka
IPC分类号： C12M1/34 , G01B11/14
CPC分类号： G01N35/02 , B65B7/2821 , G01N35/04 , G01N2035/0405 , G01N2035/0491
摘要： Disclosed is an analytical apparatus wherein a container is automatically transferred and the container is automatically closed with a cap member, said analytical apparatus being provided with a suitable mechanism that reliably closes the container. The analytical apparatus is provided with an optical sensor composed of at least one pair of a light source (4) and a light detector (5), which face each other with the container disposing position therebetween, and which are disposed such that the container disposing position is irradiated with light, and the analytical apparatus detects whether the container (1) is disposed or not or the absence/presence of the cap of the container, corresponding to a transmitted light quantity detected by means of the optical sensor. Thus, cap closing is prevented from being performed if there is no container, and the container is prevented from being transferred without the cap.
摘要翻译：公开了一种分析装置，其中容器被自动转移并且容器被盖构件自动关闭，所述分析装置设置有可靠地关闭容器的适当机构。分析装置设置有由至少一对光源（4）和光检测器（5）组成的光学传感器，所述至少一对光源（4）和光检测器（5）在其间具有容器设置位置彼此面对，并且被布置成使得容器设置位置被照射，并且分析装置检测容器（1）是否被放置，或者与通过光学传感器检测到的透射光量相对应的容器的盖子的存在/不存在。因此，如果没有容器，则防止盖子关闭，并且防止容器在没有盖子的情况下传送。

4. 发明授权

US08842280B2 Analytical apparatus and detection method employed in analytical apparatus 有权
标题翻译：分析仪器中使用的分析仪器和检测方法
公开(公告)号：US08842280B2
公开(公告)日：2014-09-23
申请号：US13519228
申请日：2010-12-22
申请人： Shuhei Yamamoto , Minoru Sano , Akiyuki Nemoto , Michiru Fujioka
发明人： Shuhei Yamamoto , Minoru Sano , Akiyuki Nemoto , Michiru Fujioka
IPC分类号： G01N21/00
CPC分类号： G01N35/02 , B65B7/2821 , G01N35/04 , G01N2035/0405 , G01N2035/0491
摘要： Disclosed is an analytical apparatus wherein a container is automatically transferred and the container is automatically closed with a cap member, said analytical apparatus being provided with a suitable mechanism that reliably closes the container. The analytical apparatus is provided with an optical sensor composed of at least one pair of a light source (4) and a light detector (5), which face each other with the container disposing position therebetween, and which are disposed such that the container disposing position is irradiated with light, and the analytical apparatus detects whether the container (1) is disposed or not or the absence/presence of the cap of the container, corresponding to a transmitted light quantity detected by means of the optical sensor. Thus, cap closing is prevented from being performed if there is no container, and the container is prevented from being transferred without the cap.
摘要翻译：公开了一种分析装置，其中容器被自动转移并且容器被盖构件自动关闭，所述分析装置设置有可靠地关闭容器的适当机构。分析装置设置有由至少一对光源（4）和光检测器（5）组成的光学传感器，所述至少一对光源（4）和光检测器（5）在其间具有容器设置位置彼此面对，并且被布置成使得容器设置位置被照射，并且分析装置检测容器（1）是否被放置，或者与通过光学传感器检测到的透射光量相对应的容器的盖子的存在/不存在。因此，如果没有容器，则防止盖子关闭，并且防止容器在没有盖子的情况下传送。

5. 发明授权

US09714455B2 Method for detecting nucleic acid amplification in sample and device therefor 有权
公开(公告)号：US09714455B2
公开(公告)日：2017-07-25
申请号：US13810954
申请日：2011-07-04
申请人： Kimikazu Sugiyama , Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Kimikazu Sugiyama , Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： C12Q1/68 , B01L7/00 , C12Q3/00 , G01N35/02 , G01N35/04 , G01N35/00
CPC分类号： C12Q3/00 , B01L7/52 , G01N35/0092 , G01N35/026 , G01N35/04
摘要： A device for detecting nucleic acid amplification in a sample, comprising: a loading unit (thermoregulation unit) which is provided with a plurality of holes for loading reaction containers and capable of arbitrarily controlling a measurement unit for measuring samples in the containers that are loaded in the holes. The loading unit and the measurement unit, which are placed opposite to each other, can be operated independently from each other. In a transfer operation, the operation speeds of the thermoregulation unit and measurement unit are controlled so that the sum of these speeds amounts to an arbitrary constant value.

6. 发明授权

US09440235B2 Genetic testing method and testing apparatus 有权
标题翻译：遗传检测方法及检测仪器
公开(公告)号：US09440235B2
公开(公告)日：2016-09-13
申请号：US13883612
申请日：2011-11-04
申请人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： B01L7/00 , C12Q1/68 , G01N35/00
CPC分类号： B01L7/52 , C12Q1/686 , G01N35/00623 , G01N2035/00346 , G01N2035/00366 , G01N2035/009
摘要： A genetic testing method and an apparatus therefor are provided, in which temperatures of a plurality of reaction tubes are independently controlled using a thermostat, a temperature detecting device, and a heating and cooling device provided on each of the reaction tubes, the reaction tubes each accommodate an amplification liquid and a component necessary for amplification, temperature is controlled at individual positions to hold the reaction tubes and at a predetermined temperature set at the individual positions according to an analysis and testing protocol predetermined at individual positions of the reaction tubes, a controlled temperature value is monitored in a reaction tube unit and a corrected value of controlled temperature is computed and stored on a reaction tube unit, a temperature of the reaction tube is controlled based on the computed value, and light emission of the amplification liquid accommodated in the reaction tube is measured.
摘要翻译：提供了一种基因检测方法及其装置，其中使用在每个反应管上设置的恒温器，温度检测装置和加热和冷却装置独立地控制多个反应管的温度，每个反应管适应放大液体和扩增所需的成分，根据在反应管的各个位置预先确定的分析和测试方案，在各个位置控制温度以保持反应管并在设定在各个位置的预定温度，受控的在反应管单元中监测温度值，并计算控制温度的校正值并将其存储在反应管单元上，基于计算值控制反应管的温度，并将容纳在该反应管中的扩增液的发光测量反应管。

7. 发明授权

US09211541B2 Nucleic acid amplification apparatus and nucleic acid analysis apparatus 有权
标题翻译：核酸扩增仪和核酸分析仪
公开(公告)号：US09211541B2
公开(公告)日：2015-12-15
申请号：US14123824
申请日：2012-05-31
申请人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
发明人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
IPC分类号： C12M3/00 , B01L7/00
CPC分类号： B01L7/52 , B01L2200/148 , B01L2300/024 , B01L2300/0829 , B01L2300/1822
摘要： According to a conventional technique, when a calibrated temperature measuring probe is used for correcting the temperature absolute values of individually temperature-controllable thermal control blocks, a temperature difference of a maximum of 0.5° C. remains between the thermal control blocks. According to the present invention, the melting temperature of a temperature calibration sample housed in a reaction vessel corresponding to each of the temperature control blocks is measured as a measured melting temperature. The measured melting temperature corresponding to each of the thermal control blocks and the reference melting temperature of the temperature calibration sample are compared, and the temperature absolute value of each of the thermal control blocks is corrected based on respective difference values.
摘要翻译：根据常规技术，当使用校准的温度测量探针来校正单独的温度可控热控制块的温度绝对值时，在热控制块之间保留最大值为0.5℃的温差。根据本发明，测量容纳在对应于每个温度控制块的反应容器中的温度校准样品的熔融温度作为测量的熔融温度。比较对应于每个热控制块的测量的熔化温度和温度校准样品的参考熔融温度，并且基于各自的差值来校正每个热控制块的温度绝对值。

8. 发明申请

US20140093947A1 NUCLEIC ACID AMPLIFICATION APPARATUS AND NUCLEIC ACID ANALYSIS APPARATUS 有权
标题翻译：核酸扩增装置和核酸分析装置
公开(公告)号：US20140093947A1
公开(公告)日：2014-04-03
申请号：US14123824
申请日：2012-05-31
申请人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
发明人： Kohshi Maeda , Chie Sugiyama , Yoshiyuki Shoji , Masato Ishizawa , Minoru Sano
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , B01L2200/148 , B01L2300/024 , B01L2300/0829 , B01L2300/1822
摘要： According to a conventional technique, when a calibrated temperature measuring probe is used for correcting the temperature absolute values of individually temperature-controllable thermal control blocks, a temperature difference of a maximum of 0.5° C. remains between the thermal control blocks. According to the present invention, the melting temperature of a temperature calibration sample housed in a reaction vessel corresponding to each of the temperature control blocks is measured as a measured melting temperature. The measured melting temperature corresponding to each of the thermal control blocks and the reference melting temperature of the temperature calibration sample are compared, and the temperature absolute value of each of the thermal control blocks is corrected based on respective difference values.
摘要翻译：根据常规技术，当使用校准的温度测量探针来校正单独的温度可控热控制块的温度绝对值时，在热控制块之间保留最大值为0.5℃的温差。根据本发明，测量容纳在对应于每个温度控制块的反应容器中的温度校准样品的熔融温度作为测量的熔融温度。比较对应于每个热控制块的测量的熔化温度和温度校准样品的参考熔融温度，并且基于各自的差值来校正每个热控制块的温度绝对值。

9. 发明授权

US08679421B2 Dispensing device and analyzer 有权
标题翻译：点胶装置和分析仪
公开(公告)号：US08679421B2
公开(公告)日：2014-03-25
申请号：US13388451
申请日：2010-07-15
申请人： Minoru Sano , Kazutoshi Onuki , Yoshiyuki Shoji , Isao Yamazaki
发明人： Minoru Sano , Kazutoshi Onuki , Yoshiyuki Shoji , Isao Yamazaki
IPC分类号： B01L3/02 , G01L21/00
CPC分类号： G01N35/10 , G01N2035/103
摘要： A dispensing device and an analyzer capable of improving dispensing accuracy as well as improving jamming detection accuracy can be realized by having a short distance between a syringe and a suction tip. The dispensing device 10 includes an upper fixed unit 10A, a lower movable unit 10B which is connected to the upper fixed unit 10A, the movable unit being relatively movable with respect to the upper fixed unit 10A, and a Z-axis movement mechanism 55Z which moves the upper fixed unit to and fro. A syringe 4 and a plunger 13 are held by the upper fixed unit 10A. A tip nozzle 8 is attached to the lower movable unit 10B. An interior space of the syringe 4 and an interior space of the tip nozzle 8 are connected with each other by a connection tube 1 having flexibility.
摘要翻译：可以通过在注射器和吸嘴之间具有短距离来实现能够提高分配精度以及提高卡住检测精度的分配装置和分析器。分配装置10包括上固定单元10A，连接到上固定单元10A的下可移动单元10B，可移动单元相对于上固定单元10A相对移动;以及Z轴移动机构55Z，Z轴运动机构55Z 上下固定单元来回移动。注射器4和柱塞13由上固定单元10A保持。尖端喷嘴8附接到下部可移动单元10B。注射器4的内部空间和尖端喷嘴8的内部空间通过具有柔性的连接管1相互连接。

10. 发明申请

US20130224753A1 GENETIC TESTING METHOD AND TESTING APPARATUS 有权
标题翻译：遗传测试方法和测试装置
公开(公告)号：US20130224753A1
公开(公告)日：2013-08-29
申请号：US13883612
申请日：2011-11-04
申请人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
发明人： Masato Ishizawa , Yoshiyuki Shoji , Minoru Sano
IPC分类号： B01L7/00
CPC分类号： B01L7/52 , C12Q1/686 , G01N35/00623 , G01N2035/00346 , G01N2035/00366 , G01N2035/009
摘要： A genetic testing method and an apparatus therefor are provided, in which temperatures of a plurality of reaction tubes are independently controlled using a thermostat, a temperature detecting device, and a heating and cooling device provided on each of the reaction tubes, the reaction tubes each accommodate an amplification liquid and a component necessary for amplification, temperature is controlled at individual positions to hold the reaction tubes and at a predetermined temperature set at the individual positions according to an analysis and testing protocol predetermined at individual positions of the reaction tubes, a controlled temperature value is monitored in a reaction tube unit and a corrected value of controlled temperature is computed and stored on a reaction tube unit, a temperature of the reaction tube is controlled based on the computed value, and light emission of the amplification liquid accommodated in the reaction tube is measured.
摘要翻译：提供了一种基因检测方法及其装置，其中使用在每个反应管上设置的恒温器，温度检测装置和加热和冷却装置独立地控制多个反应管的温度，每个反应管适应放大液体和扩增所需的成分，根据在反应管的各个位置预先确定的分析和测试方案，在各个位置控制温度以保持反应管并在设定在各个位置的预定温度，受控的在反应管单元中监测温度值，并计算控制温度的校正值并将其存储在反应管单元上，基于计算值控制反应管的温度，并将容纳在该反应管中的扩增液的发光测量反应管。

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