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    • 7. 发明授权
    • Method for the preparation of .beta.-ketothioamide compound
    • β-酮硫代酰胺化合物的制备方法
    • US5677444A
    • 1997-10-14
    • US530402
    • 1995-09-15
    • Tohru TsuchiyaIsao ShibuyaYoichi TaguchiAkihiro OishiKazumasa Honda
    • Tohru TsuchiyaIsao ShibuyaYoichi TaguchiAkihiro OishiKazumasa Honda
    • C07D223/08C07C327/42C07C327/44C07D223/02C07D223/06C07D225/02
    • C07C327/44C07C327/42C07D223/06C07D225/02
    • A novel and simple method is proposed for the synthetic preparation of an N,N-disubstituted .beta.-ketothioamide compound represented by the general formula R.sup.1 R.sup.2 N--CS--CH.sub.2 --CO--R.sup.3, in which R.sup.1 and R.sup.2 are each a monovalent hydrocarbon group or each a divalent hydrocarbon group jointly forming a cyclic structure together with the nitrogen atom and R.sup.3 is a hydrogen atom, a monovalent hydrocarbon group or a divalent hydrocarbon group forming a cyclic structure jointly with R.sup.1, R.sup.1 being a divalent hydrocarbon group and R.sup.2 being a monovalent hydrocarbon group. The method comprises:(a) mixing an N,N-disubstituted amide compound represented by the general formula R.sup.1 R.sup.2 N--CO--R.sup.3, and a bis(trialkylsilyl)thioketene compound represented by the general formula (R.sub.3 Si).sub.2 C.dbd.C.dbd.S, in which each R is an alkyl group, to effect an addition reaction therebetween forming an intermediate compound; and (b) dissolving the intermediate compound obtained in step (a) in an alcohol.
    • 提出了一种简单的方法,用于合成制备由通式R 1 R 2 N-CS-CH 2 -CO-R 3表示的N,N-二取代的β-酮硫代酰胺化合物,其中R 1和R 2各自是一价烃基, 二价烃基与氮原子一起形成环状结构,R 3为氢原子,一价烃基或二价烃基,与R 1一起形成环状结构,R 1为二价烃基,R 2为一价烃基 。 该方法包括:(a)将由通式R 1 R 2 N -CO-R 3表示的N,N-二取代酰胺化合物和由通式(R3Si)2C = C = S表示的双(三烷基甲硅烷基)硫代烯酮化合物混合,其中 每个R是烷基,以形成中间体化合物之间的加成反应; 和(b)将步骤(a)中获得的中间体化合物溶解在醇中。