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1. 发明申请

US20140128562A1 RADICAL POLYMERIZABLE COMPOSITION, CURED PRODUCT, AND PLASTIC LENS 有权
标题翻译：光学可聚合组合物，固化产品和塑料镜片
公开(公告)号：US20140128562A1
公开(公告)日：2014-05-08
申请号：US14125628
申请日：2012-03-12
申请人： Nobuo Kobayashi , Akihiro Kondo , Atsuhisa Miyawaki , Naoya Ikushima , Kazuaki Hatsusaka
发明人： Nobuo Kobayashi , Akihiro Kondo , Atsuhisa Miyawaki , Naoya Ikushima , Kazuaki Hatsusaka
IPC分类号： G02B1/04
CPC分类号： G02B1/041 , C08F24/00 , C08F212/02 , C08F212/04 , C08F212/06 , C08F212/14 , C08F212/145 , C08F212/32 , C08F212/34 , C08F220/06 , C08F220/10 , C08F220/18 , C08F220/68 , C08F224/00 , C08F234/02 , C08F283/10 , C08F283/105 , C08F290/064 , C08L51/08 , G02B1/04 , Y10S526/937 , C08L33/10 , C08L33/08 , C08F220/16
摘要： There are provided a radical polymerizable composition having a low viscosity suitable for coating and a cured product and a plastic lens each obtained by curing the composition, the cured product having a high refractive index, good adhesiveness to a plastic film substrate, and good adhesiveness kept even under high-temperature and high-humidity conditions. The radical polymerizable composition includes phenylbenzyl (meth)acrylate (A), an epoxy (meth)acrylate (X) having an aromatic ring in its molecular structure, and a radical polymerization initiator (Y) as essential components.
摘要翻译：本发明提供一种适用于涂料的低粘度的可自由基聚合的组合物，以及通过固化组合物获得的固化产物和塑料透镜，固化产物具有高折射率，对塑料膜基材的良好粘合性，并且保持良好的粘合性甚至在高温高湿条件下。可自由基聚合的组合物包括（甲基）丙烯酸苯基酯（A），分子结构中具有芳环的环氧（甲基）丙烯酸酯（X）和作为必需成分的自由基聚合引发剂（Y）。

2. 发明授权

US09156931B2 Radical polymerizable composition, cured product, and plastic lens 有权
标题翻译：可自由基聚合的组合物，固化产物和塑料透镜
公开(公告)号：US09156931B2
公开(公告)日：2015-10-13
申请号：US13822076
申请日：2012-03-12
申请人： Nobuo Kobayashi , Akihiro Kondo , Atsuhisa Miyawaki , Naoya Ikushima , Kazuaki Hatsusaka
发明人： Nobuo Kobayashi , Akihiro Kondo , Atsuhisa Miyawaki , Naoya Ikushima , Kazuaki Hatsusaka
IPC分类号： C08F212/34 , C08F220/10 , C08F220/36 , G02B1/04 , C08F220/18 , C08G18/04 , C08F283/10 , C08F212/32 , C08G71/04 , C08F212/04 , C08F220/68 , C08F220/06
CPC分类号： C08F220/36 , C08F212/04 , C08F212/32 , C08F212/34 , C08F220/06 , C08F220/10 , C08F220/18 , C08F220/68 , C08F283/10 , C08F283/105 , C08G18/04 , C08G71/04 , G02B1/04 , C08L33/10 , C08L33/08 , C08L75/16
摘要： There are provided a radical polymerizable composition having a low viscosity suitable for coating, a cured product obtained by curing the composition, the cured product having a high refractive index and high toughness and being not easily cracked or chipped when cutting, and a plastic lens obtained by curing the composition. A radical polymerizable composition includes phenylbenzyl(meth)acrylate (A), a urethane(meth)acrylate (X) having an aromatic ring in its molecular structure, and a radical polymerization initiator (Y) as essential components.
摘要翻译：本发明提供一种适用于涂布的低粘度的自由基聚合性组合物，通过固化该组合物得到的固化物，具有高折射率，高韧性的固化物，切断时不容易破裂或切片，得到的塑料透镜通过固化组合物。可自由基聚合组合物包括（甲基）苯基苄基酯（A），分子结构中具有芳环的氨基甲酸酯（甲基）丙烯酸酯（X）和作为必需成分的自由基聚合引发剂（Y）。

3. 发明申请

US20150057422A1 RADICALLY POLYMERIZABLE COMPOSITION, CURED PRODUCT THEREOF, AND PLASTIC LENS 有权
标题翻译：无机聚合物，其固化产品和塑料镜片
公开(公告)号：US20150057422A1
公开(公告)日：2015-02-26
申请号：US14384060
申请日：2012-03-12
申请人： Akihiro Kondo , Atsuhisa Miyawaki , Nobuo Kobayashi , Naoya Ikushima , Kazuaki Hatsusaka
发明人： Akihiro Kondo , Atsuhisa Miyawaki , Nobuo Kobayashi , Naoya Ikushima , Kazuaki Hatsusaka
IPC分类号： C08F220/18 , C08F222/14 , G02B1/04 , C08F222/20
CPC分类号： C08F220/18 , C08F222/1006 , C08F222/14 , C08F222/20 , C08K5/101 , C08K2201/014 , G02B1/041 , C08L33/10 , C08L33/08
摘要： There are provided a radically polymerizable composition that has a low viscosity suitable for use in coating and that forms a cured product having a high refractive index, a cured product formed by curing the composition, and plastic lens formed by curing the composition. The radically polymerizable composition includes, as essential components, phenylbenzyl acrylate (A); and bis[(meth)acryloylmethyl]biphenyl (B) or biphenyl compound (C) having a molecular structure in which biphenyl structures are bonded to each other through a methylene.
摘要翻译：本发明提供一种自由基聚合性组合物，其具有适用于涂布的低粘度，并且形成具有高折射率的固化产物，通过固化该组合物形成的固化产物和通过固化该组合物而形成的塑料透镜。可自由基聚合的组合物包括作为必需组分的丙烯酸苯酯（A）; 和具有其中联苯结构通过亚甲基彼此键合的分子结构的双[（甲基）丙烯酰甲基]联苯（B）或联苯化合物（C）。

4. 发明授权

US09150680B2 Radically polymerizable composition, cured product thereof, and plastic lens 有权
标题翻译：可自由基聚合的组合物，其固化产物和塑料透镜
公开(公告)号：US09150680B2
公开(公告)日：2015-10-06
申请号：US14384060
申请日：2012-03-12
申请人： Akihiro Kondo , Atsuhisa Miyawaki , Nobuo Kobayashi , Naoya Ikushima , Kazuaki Hatsusaka
发明人： Akihiro Kondo , Atsuhisa Miyawaki , Nobuo Kobayashi , Naoya Ikushima , Kazuaki Hatsusaka
IPC分类号： C08F220/18 , G02B1/04 , C08F222/10 , C08F222/14 , C08F222/20 , C08K5/101
CPC分类号： C08F220/18 , C08F222/1006 , C08F222/14 , C08F222/20 , C08K5/101 , C08K2201/014 , G02B1/041 , C08L33/10 , C08L33/08
摘要： There are provided a radically polymerizable composition that has a low viscosity suitable for use in coating and that forms a cured product having a high refractive index, a cured product formed by curing the composition, and plastic lens formed by curing the composition. The radically polymerizable composition includes, as essential components, phenylbenzyl acrylate (A); and bis[(meth)acryloylmethyl]biphenyl (B) or biphenyl compound (C) having a molecular structure in which biphenyl structures are bonded to each other through a methylene.
摘要翻译：本发明提供一种自由基聚合性组合物，其具有适用于涂布的低粘度，并且形成具有高折射率的固化产物，通过固化该组合物形成的固化产物，以及通过固化该组合物而形成的塑料透镜。作为必要成分，自由基聚合性组合物含有丙烯酸苯甲酯（A）; 和具有其中联苯结构通过亚甲基彼此键合的分子结构的双[（甲基）丙烯酰甲基]联苯（B）或联苯化合物（C）。

5. 发明授权

US08912300B2 Radical polymerizable composition, cured product, and plastic lens 有权
标题翻译：可自由基聚合的组合物，固化产物和塑料透镜
公开(公告)号：US08912300B2
公开(公告)日：2014-12-16
申请号：US14125628
申请日：2012-03-12
申请人： Nobuo Kobayashi , Akihiro Kondo , Atsuhisa Miyawaki , Naoya Ikushima , Kazuaki Hatsusaka
发明人： Nobuo Kobayashi , Akihiro Kondo , Atsuhisa Miyawaki , Naoya Ikushima , Kazuaki Hatsusaka
IPC分类号： C08F232/06 , C08F220/06 , C08F220/30 , C08F220/32 , C08F290/06 , C08F224/00 , C08F220/18 , G02B1/04 , C08F212/32 , C08F234/02 , C08F220/10 , C08L51/08 , C08F212/06 , C08F212/14 , C08F24/00 , C08F212/02 , C08F212/34 , C08F220/68 , C08F212/04 , C08F283/10
CPC分类号： G02B1/041 , C08F24/00 , C08F212/02 , C08F212/04 , C08F212/06 , C08F212/14 , C08F212/145 , C08F212/32 , C08F212/34 , C08F220/06 , C08F220/10 , C08F220/18 , C08F220/68 , C08F224/00 , C08F234/02 , C08F283/10 , C08F283/105 , C08F290/064 , C08L51/08 , G02B1/04 , Y10S526/937 , C08L33/10 , C08L33/08 , C08F220/16
摘要： There are provided a radical polymerizable composition having a low viscosity suitable for coating and a cured product and a plastic lens each obtained by curing the composition, the cured product having a high refractive index, good adhesiveness to a plastic film substrate, and good adhesiveness kept even under high-temperature and high-humidity conditions. The radical polymerizable composition includes phenylbenzyl (meth)acrylate (A), an epoxy (meth)acrylate (X) having an aromatic ring in its molecular structure, and a radical polymerization initiator (Y) as essential components.
摘要翻译：本发明提供一种适用于涂料的低粘度的可自由基聚合的组合物，以及通过固化组合物获得的固化产物和塑料透镜，固化产物具有高折射率，对塑料膜基材的良好粘合性，并且保持良好的粘合性甚至在高温高湿条件下。可自由基聚合的组合物包括（甲基）丙烯酸苯基酯（A），分子结构中具有芳香环的环氧（甲基）丙烯酸酯（X）和作为必需成分的自由基聚合引发剂（Y）。

6. 发明申请

US20140054227A1 SUGAR-IMMOBILIZED POLYMER SUBSTRATE FOR REMOVING VIRUS AND METHOD FOR REMOVING VIRUS 审中-公开
标题翻译：用于去除病毒的糖固定聚合物底物和用于移除病毒的方法
公开(公告)号：US20140054227A1
公开(公告)日：2014-02-27
申请号：US14003092
申请日：2012-02-29
申请人： Naoto Sakurai , Naoya Ikushima , Tetsuro Suzuki
发明人： Naoto Sakurai , Naoya Ikushima , Tetsuro Suzuki
IPC分类号： A61M1/34
CPC分类号： A61M1/34 , A61M1/3679 , A61M2202/206 , A61M2205/3306 , B01J20/28023 , B01J20/321 , B01J20/3212 , B01J20/3219 , B01J20/3274 , B01J20/328 , B01J20/3293
摘要： The present invention provides a sugar-immobilized polymer substrate for removing a virus, the polymer substrate allowing efficient removal of a hepatitis virus or the like in a fluid, and a method for removing a virus. In particular, the present invention provides a sugar-immobilized polymer substrate for removing a hepatitis virus or the like, the polymer substrate allowing, in the case of an application to blood of a living body, reduction in the amount of blood taken out of the body, reduction in the removal amount of blood useful components, low invasiveness, and shortening of the operation cycle; and a method for removing a virus. A hollow fiber membrane according to the present invention can be used as a module having a function of effectively removing a virus and a function of not removing useful plasma components.
摘要翻译：本发明提供了用于除去病毒的糖固定化聚合物底物，允许有效去除流体中的肝炎病毒等的聚合物底物和用于除去病毒的方法。特别地，本发明提供了用于除去肝炎病毒等的糖固定化聚合物底物，所述聚合物基材在施用于生物体的血液的情况下，可以减少从减少血液有用成分的去除量，低侵入性，缩短手术周期; 以及用于去除病毒的方法。根据本发明的中空纤维膜可以用作具有有效去除病毒的功能的模块和不去除有用的血浆成分的功能。

7. 发明授权

US5498602A Oligosaccharide aromatic glycoside and sulfate thereof 失效
标题翻译：寡糖芳香糖苷及其硫酸盐
公开(公告)号：US5498602A
公开(公告)日：1996-03-12
申请号：US944077
申请日：1992-09-11
申请人： Tadao Shoji , Nahoko Takahashi , Naoya Ikushima , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima , Kaname Katsuraya , Koichiro Adachi , Fusayo Kataoka
发明人： Tadao Shoji , Nahoko Takahashi , Naoya Ikushima , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima , Kaname Katsuraya , Koichiro Adachi , Fusayo Kataoka
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61P31/12 , A61P31/18 , C07H15/203 , C08B37/00 , C07G3/00 , C07H11/00
CPC分类号： C07H15/203 , C08B37/006
摘要： Oligosaccharide aromatic glycoside sulfates and physiologically acceptable salts thereof, are disclosed. Further, antiviral agents having these sulfate compounds as the active components, and particularly an antiviral agent, wherein the virus is one which causes AIDS (Acquired Immune Deficiency Syndrome), are disclosed. The active components or the glycoside sulfates, and the salts thereof, are characterized by an oligosaccharide aromatic glycoside sulfate in which the hydrogen of the position-1 hydroxyl group of the terminal sugar of an oligosaccharide is substituted with a specified formula having an alkyl group consisting of 1 to 18 carbons, an oxygen or no oxygen, and an allylene group. The number of constituent monosaccharides in the oligosaccharide portion is preferably within a range of 2 to 20. Further, 10% or more of the remaining hydroxyl groups of the sugar subunits are subjected to sulfated esterification. In addition the antiviral agent exhibits low toxicity and is useful in the treatment of AIDS. Furthermore, an oligosaccharide is also disclosed as described above with the exception that it is the hydrogen atom of the position 1 hydrogen group at the terminal sugar residue which is substituted with the specified formula, also described above. However, in addition the remaining hydroxyl groups of the sugar portion of this oligosaccharide are protected by acyl groups or are present in an unprotected form. Also disclosed is a method for the production of an oligosaccharide aromatic glycoside sulfate synthesized by sulfation using a sulfating agent.
摘要翻译：公开了寡糖芳香糖苷硫酸盐及其生理上可接受的盐。此外，公开了具有这些硫酸盐化合物作为活性成分的抗病毒剂，特别是其中病毒是引起AIDS（获得性免疫缺陷综合征）的抗病毒剂。活性成分或糖苷硫酸盐及其盐的特征在于寡糖芳香糖苷硫酸盐，其中寡糖末端糖的位置1羟基的氢被具有烷基的特定式所取代， 1至18个碳，氧或无氧，以及烯丙基。寡糖部分中的构成单糖的数量优选在2〜20的范围内。此外，将糖亚基的剩余羟基的10％以上进行硫酸化酯化。此外，抗病毒剂的毒性低，可用于治疗艾滋病。此外，还公开了如上所述的寡糖，不同之处在于它是上述也被指定式取代的末端糖残基上的1位氢原子的氢原子。然而，此外，该寡糖的糖部分的剩余羟基由酰基保护或以未保护的形式存在。还公开了通过使用硫酸化剂硫酸化合成的寡糖芳香族糖苷硫酸盐的制造方法。

8. 发明授权

US5280111A Sulfated tocopheryl oligosaccharides and antiviral agents including the same as active ingredients 失效
标题翻译：硫酸化生育酚低聚糖和包括与活性成分相同的抗病毒剂
公开(公告)号：US5280111A
公开(公告)日：1994-01-18
申请号：US856710
申请日：1992-03-24
申请人： Tadao Shoji , Naoya Ikushima , Kaname Katsuraya , Nahoko Takahashi , Fusayo Kobayashi , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima
发明人： Tadao Shoji , Naoya Ikushima , Kaname Katsuraya , Nahoko Takahashi , Fusayo Kobayashi , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/12 , A61P31/18 , C07H17/065 , C07H15/20 , A61K31/72 , C07H11/00 , C07H13/02 , C07H17/04
CPC分类号： C07H17/065 , A61K31/70
摘要： The present invention relates to novel tocopheryl oligosaccharides, acylated tocopheryl oligosaccharides, sulfated tocopheryl oligosaccharides, and antiviral agents including the sulfated tocopheryl oligosaccharides as active ingredients. In the tocopheryl oligosaccharide, the hydrogen atom of the hydroxy group at the 1-position in the terminal sugar moiety of an oligosaccharide which consists of 3.about.20 of identical or different repeating monosaccharide units selected from the group consisting of glucose, galactose, mannose, talose, idose, altrose, allose, glucose, xylose, arabinose, rhamnose, fucose, and fructose, which are glycoside-linked, is substituted by a tocopherol group. In the acylated tocopheryl oligosaccharides, each of any hydroxy group of the sugar moiety, other than the hydroxy group at the 1-position in the terminal sugar moiety of the oligosaccharide described above, is protected by an acyl group. The antiviral agents including the sulfated tocopheryl oligosaccharides or the biologically acceptable salt of the same as active ingredients have low toxicities and exhibit improved antiviral action, especially against the Human Immunodeficiency Virus.
摘要翻译：本发明涉及新的生育酚低聚糖，酰化生育酚低聚糖，硫酸生育酚寡糖，以及包含硫酸生育酚寡糖作为活性成分的抗病毒剂。在生育酚低聚糖中，低聚糖的末端糖部分的1位的羟基的氢原子由3〜20个相同或不同的重复单糖单元组成，所述重复单糖单元选自葡萄糖，半乳糖，甘露糖，与糖生成酚基取代的与糖苷连接的谷氨酸，阿糖，阿卓糖，阿洛糖，葡萄糖，木糖，阿拉伯糖，鼠李糖，岩藻糖和果糖。在酰化的生育酚低聚糖中，除了上述寡糖的末端糖部分的1位以外的除了羟基以外的糖部分的任何羟基都被酰基保护。包括硫酸生育酚寡糖或与生物活性成分相同的生物学上可接受的盐的抗病毒剂具有低毒性，并且表现出改善的抗病毒作用，特别是针对人类免疫缺陷病毒。

9. 发明授权

US5459257A Sulfated oligoglycoside acylate and antiviral agent containing the same as active ingredient 失效
标题翻译：硫酸低聚糖苷酰化物和含有与活性成分相同的抗病毒剂
公开(公告)号：US5459257A
公开(公告)日：1995-10-17
申请号：US179623
申请日：1994-01-07
申请人： Tadao Shoji , Akira Kasai , Osamu Misumi , Naoya Ikushima , Naoki Yamamoto , Hideki Nakashima , Kazuhiko Inazawa , Nahoko Takahashi
发明人： Tadao Shoji , Akira Kasai , Osamu Misumi , Naoya Ikushima , Naoki Yamamoto , Hideki Nakashima , Kazuhiko Inazawa , Nahoko Takahashi
IPC分类号： C07H15/04 , C07H15/203 , C07H17/065 , C07H13/12 , C07H11/00
CPC分类号： C07H15/203 , C07H15/04 , C07H17/065
摘要： A sulfated oligoglycoside acylate comprising monosaccharides of a single or two kinds as the constituents, wherein the hydrogen in the hydroxyl group at the 1-position of a reducing end sugar of the oligosaccharide formed via the glycoside bond of these monosaccharides has been substituted with an aglycon selected from a group consisting of alkyl groups, aromatic alkyl groups, aromatic alkoxy groups and tocopheryl groups; from 12 to 80% of the residual hydroxyl groups have been acylated with an acyl group selected from a group consisting of aliphatic acyl groups and aromatic acyl groups; and 88 to 20% thereof have been sulfated; or a physiologically acceptable salt thereof provided that compounds wherein the aglycon is an alkyl group and the acyl group is an aliphatic acyl group are excluded is disclosed. Further, an antiviral agent, which exerts a long-lasting antiviral action particularly on HIV, containing said compound as an active ingredient is disclosed.
摘要翻译：一种包含单一或两种单糖作为组分的硫酸化寡糖苷酰化物，其中通过这些单糖的糖苷键形成的寡糖的还原性末端糖在1位羟基中的氢被aglycon取代选自烷基，芳族烷基，芳族烷氧基和生育酚基; 残余羟基的12至80％已经用选自脂族酰基和芳族酰基的酰基酰化; 88％〜20％已被硫酸化; 或其生理学上可接受的盐，其中排除了糖苷配基是烷基和酰基是脂族酰基的化合物。此外，公开了以含有所述化合物作为有效成分的对HIV特别施加长效抗病毒作用的抗病毒剂。

10. 发明授权

US5268461A Alkylated oligosaccharides and acetyl derivatives of the same 失效
标题翻译：烷基化低聚糖及其乙酰衍生物
公开(公告)号：US5268461A
公开(公告)日：1993-12-07
申请号：US834305
申请日：1992-02-25
申请人： Tadao Shoji , Nahoko Takahashi , Koichiro Adachi , Naoya Ikushima , Kaname Katsuraya , Toshiyuki Uryu , Takashi Yoshida
发明人： Tadao Shoji , Nahoko Takahashi , Koichiro Adachi , Naoya Ikushima , Kaname Katsuraya , Toshiyuki Uryu , Takashi Yoshida
IPC分类号： C07H3/06 , C07H15/04 , C07H13/06
CPC分类号： C07H15/04 , C07H3/06
摘要： An alkylated oligosaccharide and the acetyl derivative of the same, both useful as the raw material for producing lowly toxic surfactants or medicines. The alkylated oligosaccharide is prepared by substituting with an alkyl group having a linear or branched chain the hydrogen atom of the hydroxy group at the 1-position of a terminal sugar moiety of an oligosaccharide in which glucose moieties are .beta.(1.fwdarw.3)-glucoside-linked, or of an oligosaccharide in which galactose is .beta.(1.fwdarw.4)-glycoside-linked at the 4-position in the galactose moiety of lactose and in which galactose moieties are .beta.(1.fwdarw.4)-glycoside-linked in succession to the newly formed terminal galactose moieties. The invention also includes an acetyl derivative of the oligosaccharide, wherein the hydroxy groups excluding the 2-positional hydroxy group adjacent to the alkyl-ether-linking position in the terminal sugar moiety are acetylated, and a mixture thereof. In addition, an acetylated oligosaccharide is allowed to react with an alcohol using a heteropolyacid as the reacting agent.
摘要翻译： PCT No.PCT / JP91 / 00867 Sec。 371日期：1992年2月25日 102（e）1992年2月25日PCT PCT 1991年6月27日PCT公布。出版物WO92 / 0031020 日本1992年1月9日。烷基化低聚糖及其乙酰衍生物，均可用作生产低毒性表面活性剂或药物的原料。烷基化的寡糖通过用直链或支链的烷基取代，其中葡萄糖部分为β（1-> 3） - 寡糖的寡糖的末端糖部分的1-位羟基的氢原子，葡萄糖苷连接的寡糖或寡聚糖，其中半乳糖是在乳糖的半乳糖部分的4-位上是β（1-> 4） - 糖苷连接的，其中半乳糖部分是β（1-> 4） - 糖苷 - 连接到新形成的末端半乳糖部分。本发明还包括寡糖的乙酰衍生物，其中不包括与末端糖部分中的烷基 - 醚连接位置相邻的2-位羟基的羟基被乙酰化，以及它们的混合物。此外，使用杂多酸作为反应剂，使乙酰化寡糖与醇反应。

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