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1. 发明授权

US5498602A Oligosaccharide aromatic glycoside and sulfate thereof 失效
标题翻译：寡糖芳香糖苷及其硫酸盐
公开(公告)号：US5498602A
公开(公告)日：1996-03-12
申请号：US944077
申请日：1992-09-11
申请人： Tadao Shoji , Nahoko Takahashi , Naoya Ikushima , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima , Kaname Katsuraya , Koichiro Adachi , Fusayo Kataoka
发明人： Tadao Shoji , Nahoko Takahashi , Naoya Ikushima , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima , Kaname Katsuraya , Koichiro Adachi , Fusayo Kataoka
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61P31/12 , A61P31/18 , C07H15/203 , C08B37/00 , C07G3/00 , C07H11/00
CPC分类号： C07H15/203 , C08B37/006
摘要： Oligosaccharide aromatic glycoside sulfates and physiologically acceptable salts thereof, are disclosed. Further, antiviral agents having these sulfate compounds as the active components, and particularly an antiviral agent, wherein the virus is one which causes AIDS (Acquired Immune Deficiency Syndrome), are disclosed. The active components or the glycoside sulfates, and the salts thereof, are characterized by an oligosaccharide aromatic glycoside sulfate in which the hydrogen of the position-1 hydroxyl group of the terminal sugar of an oligosaccharide is substituted with a specified formula having an alkyl group consisting of 1 to 18 carbons, an oxygen or no oxygen, and an allylene group. The number of constituent monosaccharides in the oligosaccharide portion is preferably within a range of 2 to 20. Further, 10% or more of the remaining hydroxyl groups of the sugar subunits are subjected to sulfated esterification. In addition the antiviral agent exhibits low toxicity and is useful in the treatment of AIDS. Furthermore, an oligosaccharide is also disclosed as described above with the exception that it is the hydrogen atom of the position 1 hydrogen group at the terminal sugar residue which is substituted with the specified formula, also described above. However, in addition the remaining hydroxyl groups of the sugar portion of this oligosaccharide are protected by acyl groups or are present in an unprotected form. Also disclosed is a method for the production of an oligosaccharide aromatic glycoside sulfate synthesized by sulfation using a sulfating agent.
摘要翻译：公开了寡糖芳香糖苷硫酸盐及其生理上可接受的盐。此外，公开了具有这些硫酸盐化合物作为活性成分的抗病毒剂，特别是其中病毒是引起AIDS（获得性免疫缺陷综合征）的抗病毒剂。活性成分或糖苷硫酸盐及其盐的特征在于寡糖芳香糖苷硫酸盐，其中寡糖末端糖的位置1羟基的氢被具有烷基的特定式所取代， 1至18个碳，氧或无氧，以及烯丙基。寡糖部分中的构成单糖的数量优选在2〜20的范围内。此外，将糖亚基的剩余羟基的10％以上进行硫酸化酯化。此外，抗病毒剂的毒性低，可用于治疗艾滋病。此外，还公开了如上所述的寡糖，不同之处在于它是上述也被指定式取代的末端糖残基上的1位氢原子的氢原子。然而，此外，该寡糖的糖部分的剩余羟基由酰基保护或以未保护的形式存在。还公开了通过使用硫酸化剂硫酸化合成的寡糖芳香族糖苷硫酸盐的制造方法。

2. 发明授权

US5268461A Alkylated oligosaccharides and acetyl derivatives of the same 失效
标题翻译：烷基化低聚糖及其乙酰衍生物
公开(公告)号：US5268461A
公开(公告)日：1993-12-07
申请号：US834305
申请日：1992-02-25
申请人： Tadao Shoji , Nahoko Takahashi , Koichiro Adachi , Naoya Ikushima , Kaname Katsuraya , Toshiyuki Uryu , Takashi Yoshida
发明人： Tadao Shoji , Nahoko Takahashi , Koichiro Adachi , Naoya Ikushima , Kaname Katsuraya , Toshiyuki Uryu , Takashi Yoshida
IPC分类号： C07H3/06 , C07H15/04 , C07H13/06
CPC分类号： C07H15/04 , C07H3/06
摘要： An alkylated oligosaccharide and the acetyl derivative of the same, both useful as the raw material for producing lowly toxic surfactants or medicines. The alkylated oligosaccharide is prepared by substituting with an alkyl group having a linear or branched chain the hydrogen atom of the hydroxy group at the 1-position of a terminal sugar moiety of an oligosaccharide in which glucose moieties are .beta.(1.fwdarw.3)-glucoside-linked, or of an oligosaccharide in which galactose is .beta.(1.fwdarw.4)-glycoside-linked at the 4-position in the galactose moiety of lactose and in which galactose moieties are .beta.(1.fwdarw.4)-glycoside-linked in succession to the newly formed terminal galactose moieties. The invention also includes an acetyl derivative of the oligosaccharide, wherein the hydroxy groups excluding the 2-positional hydroxy group adjacent to the alkyl-ether-linking position in the terminal sugar moiety are acetylated, and a mixture thereof. In addition, an acetylated oligosaccharide is allowed to react with an alcohol using a heteropolyacid as the reacting agent.
摘要翻译： PCT No.PCT / JP91 / 00867 Sec。 371日期：1992年2月25日 102（e）1992年2月25日PCT PCT 1991年6月27日PCT公布。出版物WO92 / 0031020 日本1992年1月9日。烷基化低聚糖及其乙酰衍生物，均可用作生产低毒性表面活性剂或药物的原料。烷基化的寡糖通过用直链或支链的烷基取代，其中葡萄糖部分为β（1-> 3） - 寡糖的寡糖的末端糖部分的1-位羟基的氢原子，葡萄糖苷连接的寡糖或寡聚糖，其中半乳糖是在乳糖的半乳糖部分的4-位上是β（1-> 4） - 糖苷连接的，其中半乳糖部分是β（1-> 4） - 糖苷 - 连接到新形成的末端半乳糖部分。本发明还包括寡糖的乙酰衍生物，其中不包括与末端糖部分中的烷基 - 醚连接位置相邻的2-位羟基的羟基被乙酰化，以及它们的混合物。此外，使用杂多酸作为反应剂，使乙酰化寡糖与醇反应。

3. 发明授权

US5280111A Sulfated tocopheryl oligosaccharides and antiviral agents including the same as active ingredients 失效
标题翻译：硫酸化生育酚低聚糖和包括与活性成分相同的抗病毒剂
公开(公告)号：US5280111A
公开(公告)日：1994-01-18
申请号：US856710
申请日：1992-03-24
申请人： Tadao Shoji , Naoya Ikushima , Kaname Katsuraya , Nahoko Takahashi , Fusayo Kobayashi , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima
发明人： Tadao Shoji , Naoya Ikushima , Kaname Katsuraya , Nahoko Takahashi , Fusayo Kobayashi , Toshiyuki Uryu , Takashi Yoshida , Naoki Yamamoto , Hideki Nakashima
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7048 , A61P31/12 , A61P31/18 , C07H17/065 , C07H15/20 , A61K31/72 , C07H11/00 , C07H13/02 , C07H17/04
CPC分类号： C07H17/065 , A61K31/70
摘要： The present invention relates to novel tocopheryl oligosaccharides, acylated tocopheryl oligosaccharides, sulfated tocopheryl oligosaccharides, and antiviral agents including the sulfated tocopheryl oligosaccharides as active ingredients. In the tocopheryl oligosaccharide, the hydrogen atom of the hydroxy group at the 1-position in the terminal sugar moiety of an oligosaccharide which consists of 3.about.20 of identical or different repeating monosaccharide units selected from the group consisting of glucose, galactose, mannose, talose, idose, altrose, allose, glucose, xylose, arabinose, rhamnose, fucose, and fructose, which are glycoside-linked, is substituted by a tocopherol group. In the acylated tocopheryl oligosaccharides, each of any hydroxy group of the sugar moiety, other than the hydroxy group at the 1-position in the terminal sugar moiety of the oligosaccharide described above, is protected by an acyl group. The antiviral agents including the sulfated tocopheryl oligosaccharides or the biologically acceptable salt of the same as active ingredients have low toxicities and exhibit improved antiviral action, especially against the Human Immunodeficiency Virus.
摘要翻译：本发明涉及新的生育酚低聚糖，酰化生育酚低聚糖，硫酸生育酚寡糖，以及包含硫酸生育酚寡糖作为活性成分的抗病毒剂。在生育酚低聚糖中，低聚糖的末端糖部分的1位的羟基的氢原子由3〜20个相同或不同的重复单糖单元组成，所述重复单糖单元选自葡萄糖，半乳糖，甘露糖，与糖生成酚基取代的与糖苷连接的谷氨酸，阿糖，阿卓糖，阿洛糖，葡萄糖，木糖，阿拉伯糖，鼠李糖，岩藻糖和果糖。在酰化的生育酚低聚糖中，除了上述寡糖的末端糖部分的1位以外的除了羟基以外的糖部分的任何羟基都被酰基保护。包括硫酸生育酚寡糖或与生物活性成分相同的生物学上可接受的盐的抗病毒剂具有低毒性，并且表现出改善的抗病毒作用，特别是针对人类免疫缺陷病毒。

4. 发明授权

US5512672A Curdlan sulfate 失效
标题翻译：硫酸曲霉素
公开(公告)号：US5512672A
公开(公告)日：1996-04-30
申请号：US76174
申请日：1993-06-14
申请人： Naoki Yamamoto , Hideki Nakashima , Toshiyuki Uryu , Takashi Yoshida , Kei Matsuzaki , Yutaro Kaneko , Toru Mimura
发明人： Naoki Yamamoto , Hideki Nakashima , Toshiyuki Uryu , Takashi Yoshida , Kei Matsuzaki , Yutaro Kaneko , Toru Mimura
IPC分类号： C08B37/00 , C07B37/00 , A61K31/70
CPC分类号： C08B37/0024
摘要： A beta-1,3-glucan of sulfated curdlan having a sulfur content of 12.4 to 17% and an average molecular weight of 27,000 to 330,000 daltons. Sulfate curdlan exhibits strong HIV inhibitory activity with little anticoagulant activity and little toxicity.
摘要翻译：硫酸凝乳糖的β-1,3-葡聚糖，硫含量为12.4〜17％，平均分子量为27,000〜33万道尔顿。硫酸凝乳蛋白具有强烈的HIV抑制活性，抗凝血活性很小，毒性小。

5. 发明授权

US5573589A Cement compositions containing a sulfated polysaccharide and method 失效
标题翻译：含有硫酸化多糖的水泥组合物及方法
公开(公告)号：US5573589A
公开(公告)日：1996-11-12
申请号：US402452
申请日：1995-03-09
申请人： Yoshio Tanaka , Toshiyuki Uryu , Minoru Yaguchi
发明人： Yoshio Tanaka , Toshiyuki Uryu , Minoru Yaguchi
IPC分类号： C04B24/16 , C04B24/38 , C08B5/14 , C08B37/00 , C04B24/20
CPC分类号： C08B37/0024 , C04B24/168 , C04B24/38 , C08B5/14
摘要： An additive for cementitious compositions comprises at least one sulfated polysaccharide obtained by the sulfation of a polysaccharide, preferably under moderate conditions. The additive enhances the fluidity and workability of cementitious mixes, and gives higher final compressive strength.
摘要翻译：用于水泥组合物的添加剂包含至少一种通过多糖的硫酸化获得的硫酸化多糖，优选在中等条件下。添加剂增加了水泥混合料的流动性和可加工性，并提供了更高的最终抗压强度。

6. 发明授权

US4885369A Photoconductive material for electrophotography comprising rhodanine derivative charge complex 失效
标题翻译：包含绕丹宁衍生物电荷复合物的电子照相用光导材料
公开(公告)号：US4885369A
公开(公告)日：1989-12-05
申请号：US278237
申请日：1988-11-30
申请人： Toshiyuki Uryu , Toshihiko Nishiguchi
发明人： Toshiyuki Uryu , Toshihiko Nishiguchi
IPC分类号： C09B23/01 , C09B23/10 , G03G5/06
CPC分类号： G03G5/067 , C09B23/0091 , C09B23/105
摘要： A photoconductive material for use in electrophotography comprising a rhodanine derivative and a halogen-containing polymer. The marked feature of the invention is to use a compound of the following formula ##STR1## wherein X represents ##STR2## and R represents a substituent such as an alkyl, aryl or amino group.
摘要翻译：一种用于电子照相术的光导材料，其包含绕丹宁衍生物和含卤聚合物。本发明的显着特征是使用下式的化合物，其中X表示 + TR ，R表示取代基，例如烷基，芳基或氨基。

7. 发明授权

US4710547A Process for producing three-dimensionally crosslinked polyester having the liquid crystal structure 失效
标题翻译：具有液晶结构的三维交联聚酯的制造方法
公开(公告)号：US4710547A
公开(公告)日：1987-12-01
申请号：US867997
申请日：1986-05-29
申请人： Toshiyuki Uryu , Takashi Kato
发明人： Toshiyuki Uryu , Takashi Kato
IPC分类号： C08G63/00 , C08G63/20 , C08G63/60 , C08G63/91 , C09K19/38 , C08G63/76
CPC分类号： C08G63/60 , C08G63/20 , C09K19/3809
摘要： A polyester, being capable of the anisotropic property in the molten state and a thermotropic liquid crystals, or a composition comprising a low molecular weight polyester and a thermotropic crosslinked, while having the structure of liquid crystals, by a crosslinking reaction with a compound having at least three reactive groups. The reactive group preferably includes hydroxy, carboxyl, amino, amide, carbodiimide, isocyanate, carbamate, epoxy and ester.

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