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1. 发明申请

US20130150721A1 ULTRASOUND DIAGNOSTIC APPARATUS AND ULTRASOUND DIAGNOSTIC APPARATUS CONTROL METHOD 审中-公开
标题翻译：超声诊断设备和超声诊断设备控制方法
公开(公告)号：US20130150721A1
公开(公告)日：2013-06-13
申请号：US13817975
申请日：2011-12-22
申请人： Akihiro Kawabata , Yoshihiko Itoh , Takao Suzuki
发明人： Akihiro Kawabata , Yoshihiko Itoh , Takao Suzuki
IPC分类号： A61B8/00 , A61B8/08 , A61B8/14
CPC分类号： A61B8/54 , A61B8/0891 , A61B8/145 , A61B8/4444 , A61B8/4488 , A61B8/461 , A61B8/483 , A61B8/5207 , A61B8/5223
摘要： An ultrasonic diagnostic apparatus according to the present invention is an apparatus to which a probe with transducers is connectible. The apparatus includes a controller 100 which performs transmission processing for sending out an ultrasonic wave toward a subject by driving the probe 1 and reception processing for generating a received signal based on the ultrasonic wave that has been reflected from the subject and received at the probe and which performs, if a predetermined condition based on the received signal is satisfied, automatic freeze processing for stopping at least one of the transmission processing and the reception processing. The controller 100 restricts the automatic freeze processing for a predetermined period of time after having accepted a predetermined operating event.
摘要翻译：根据本发明的超声波诊断装置是具有换能器的探针可连接的装置。该装置包括控制器100，其执行通过驱动探头1向受检者发送超声波的发送处理和基于从被检体反射并在探头接收的超声波产生接收信号的接收处理，以及如果满足基于接收信号的预定条件，则执行用于停止发送处理和接收处理中的至少一个的自动冻结处理。控制器100在接受预定的操作事件之后，将自动冻结处理限制预定时间段。

2. 发明申请

US20120310086A1 ULTRASONIC DIAGNOSTIC DEVICE, AND METHOD FOR MEASURING INTIMA-MEDIA THICKNESS 有权
标题翻译：超声波诊断装置及测量介质厚度的方法
公开(公告)号：US20120310086A1
公开(公告)日：2012-12-06
申请号：US13520214
申请日：2010-11-12
申请人： Takenori Fukumoto , Kazuya Takagi , Takao Suzuki , Akihiro Kawabata
发明人： Takenori Fukumoto , Kazuya Takagi , Takao Suzuki , Akihiro Kawabata
IPC分类号： A61B8/00
CPC分类号： A61B8/0858 , A61B8/0891 , G06T7/12 , G06T7/62 , G06T2207/10132 , G06T2207/30048 , G06T2207/30101
摘要： The present invention provides a method for detecting lumen and adventitia boundaries and measuring an intima-media thickness without depending on the magnitudes of echo intensity variations on the lumen and adventitia sides.The ultrasonic diagnostic apparatus transmits an ultrasonic wave toward a body and obtains biological information based on an echo signal received and includes: an intensity distribution generating section that generates an echo intensity distribution in a depth direction about a vascular wall based on the echo signal; a template generating section that generates a template to detect a boundary based on template data provided in advance to represent a reference pattern of the intensity distribution; a pattern similarity calculating section that changes the depth and intima-media thickness pattern of the template to calculate similarity between the template and the intensity distribution on any change made; and a boundary defining section that defines lumen and adventitia boundaries based on the degree of similarity calculated on any change made.
摘要翻译：本发明提供一种用于检测内腔和外膜边界并测量内膜 - 中膜厚度的方法，而不依赖于内腔和外膜侧的回波强度变化的大小。所述超声波诊断装置向身体发送超声波，并且基于所接收的回波信号获得生物信息，并且包括：强度分布生成部，其基于所述回波信号生成围绕血管壁的深度方向的回波强度分布; 模板生成部，其基于预先提供的表示强度分布的参照图案的模板数据，生成检测边界的模板; 模式相似度计算部分，改变模板的深度和中内层厚度模式，以计算模板与强度分布之间的相似性; 以及基于根据任何改变而计算出的相似程度来定义腔和外膜边界的边界限定部分。

3. 发明授权

US09179889B2 Ultrasonic diagnostic device, and method for measuring initma-media complex thickness 有权
标题翻译：超声波诊断装置以及测量初始 - 媒体复合物厚度的方法
公开(公告)号：US09179889B2
公开(公告)日：2015-11-10
申请号：US13496832
申请日：2010-11-12
申请人： Takenori Fukumoto , Akihiro Kawabata , Makiko Urabe , Takao Suzuki , Yushi Nishimura
发明人： Takenori Fukumoto , Akihiro Kawabata , Makiko Urabe , Takao Suzuki , Yushi Nishimura
IPC分类号： A61B8/02 , A61B8/08
CPC分类号： A61B8/0858 , A61B8/0891 , A61B8/5284
摘要： An ultrasonic diagnostic apparatus according to the present invention includes: an ultrasonic signal processing section, which performs transmission processing for transmitting an ultrasonic wave toward a subject's blood vessel by driving a probe and reception processing for generating a received signal based on the ultrasonic wave reflected from the subject's blood vessel and received at the probe; a tomographic image processing section, which generates a tomographic image based on the received signal; a boundary detecting section, which detects the lumen-intima and media-adventitia boundaries of the blood vessel based on the received signal or the tomographic image; a vascular wall thickness calculating section, which calculates, as a vascular wall thickness value, the interval between the lumen-intima and media-adventitia boundaries detected by the boundary detecting section; a reliability determining section, which determines the reliability of the vascular wall thickness value by a signal feature of the received signal or an image information feature of the tomographic image at a location on the lumen-intima and/or media-adventitia boundaries detected; and a control section, which decides, in accordance with the decision made by the reliability determining section, that the vascular wall thickness value be defined as an intima-media thickness.
摘要翻译：根据本发明的超声波诊断装置包括：超声波信号处理部，其进行用于通过驱动探头向被检者的血管发送超声波的发送处理和基于从所述超声波反射的超声波生成接收信号的接收处理受试者的血管并在探头处接受; 断层图像处理部，其基于所接收的信号生成断层图像; 边界检测部，其基于所接收的信号或断层图像检测血管的内腔和介质 - 外膜边界; 血管壁厚计算部，其计算由所述边界检测部检测出的所述内腔和介质 - 外膜边界之间的间隔作为血管壁厚度值; 可靠性确定部，其通过接收信号的信号特征或者在检测到的管腔内膜和/或介质外膜边界上的位置处的断层图像的图像信息特征来确定血管壁厚值的可靠性; 以及控制部，其根据所述可靠性判定部的判定，判断为血管壁厚值被定义为内膜中间厚度。

4. 发明申请

US20120179042A1 ULTRASONIC DIAGNOSTIC DEVICE, AND METHOD FOR MEASURING INITMA-MEDIA COMPLEX THICKNESS 有权
标题翻译：超声波诊断装置及测量复合材料厚度的方法
公开(公告)号：US20120179042A1
公开(公告)日：2012-07-12
申请号：US13496832
申请日：2010-11-12
申请人： Takenori Fukumoto , Akihiro. Kawabata , Makiko Urabe , Takao Suzuki , Yushi Nishimura
发明人： Takenori Fukumoto , Akihiro. Kawabata , Makiko Urabe , Takao Suzuki , Yushi Nishimura
IPC分类号： A61B8/02 , A61B8/14
CPC分类号： A61B8/0858 , A61B8/0891 , A61B8/5284
摘要： An ultrasonic diagnostic apparatus according to the present invention includes: an ultrasonic signal processing section, which performs transmission processing for transmitting an ultrasonic wave toward a subject's blood vessel by driving a probe and reception processing for generating a received signal based on the ultrasonic wave reflected from the subject's blood vessel and received at the probe; a tomographic image processing section, which generates a tomographic image based on the received signal; a boundary detecting section, which detects the lumen-intima and media-adventitia boundaries of the blood vessel based on the received signal or the tomographic image; a vascular wall thickness calculating section, which calculates, as a vascular wall thickness value, the interval between the lumen-intima and media-adventitia boundaries detected by the boundary detecting section; a reliability determining section, which determines the reliability of the vascular wall thickness value by a signal feature of the received signal or an image information feature of the tomographic image at a location on the lumen-intima and/or media-adventitia boundaries detected; and a control section, which decides, in accordance with the decision made by the reliability determining section, that the vascular wall thickness value be defined as an intima-media thickness.
摘要翻译：根据本发明的超声波诊断装置包括：超声波信号处理部，其进行用于通过驱动探头向被检者的血管发送超声波的发送处理和基于从所述超声波反射的超声波生成接收信号的接收处理受试者的血管并在探头处接受; 断层图像处理部，其基于所接收的信号生成断层图像; 边界检测部，其基于所接收的信号或断层图像检测血管的内腔和介质 - 外膜边界; 血管壁厚计算部，其计算由所述边界检测部检测出的所述内腔和介质 - 外膜边界之间的间隔作为血管壁厚度值; 可靠性确定部，其通过接收信号的信号特征或者在检测到的管腔内膜和/或介质外膜边界上的位置处的断层图像的图像信息特征来确定血管壁厚值的可靠性; 以及控制部，其根据所述可靠性判定部的判定，判断为血管壁厚值被定义为内膜中间厚度。

5. 发明授权

US08740796B2 Ultrasonic diagnostic device, and method for measuring intima-media thickness 有权
标题翻译：超声诊断装置以及内膜厚度测定方法
公开(公告)号：US08740796B2
公开(公告)日：2014-06-03
申请号：US13520214
申请日：2010-11-12
申请人： Takenori Fukumoto , Kazuya Takagi , Takao Suzuki , Akihiro Kawabata
发明人： Takenori Fukumoto , Kazuya Takagi , Takao Suzuki , Akihiro Kawabata
IPC分类号： A61B8/00 , G06K9/00
CPC分类号： A61B8/0858 , A61B8/0891 , G06T7/12 , G06T7/62 , G06T2207/10132 , G06T2207/30048 , G06T2207/30101
摘要： An ultrasonic diagnostic apparatus transmits an ultrasonic wave toward a body and obtains biological information based on an echo signal received and includes: an intensity distribution generating section that generates an echo intensity distribution in a depth direction about a vascular wall based on the echo signal; a template generating section that generates a template to detect a boundary based on template data provided in advance to represent a reference pattern of the intensity distribution; a pattern similarity calculating section that changes the depth and intima-media thickness pattern of the template to calculate similarity between the template and the intensity distribution on any change made; and a boundary defining section that defines lumen and adventitia boundaries based on the degree of similarity calculated on any change made. The intima-media thickness is thus determined without depending on the magnitudes of echo intensity variations on the lumen and adventitia sides.
摘要翻译：超声波诊断装置向身体发送超声波，并且基于接收到的回波信号获取生物信息，并且包括：强度分布生成部，其基于回波信号，在血管壁周围的深度方向生成回波强度分布; 模板生成部，其基于预先提供的表示强度分布的参照图案的模板数据，生成检测边界的模板; 模式相似度计算部分，改变模板的深度和中内层厚度模式，以计算模板与强度分布之间的相似性; 以及基于根据任何改变而计算出的相似程度来定义腔和外膜边界的边界限定部分。因此确定内膜 - 中膜厚度，而不依赖于内腔和外膜侧的回波强度变化的大小。

6. 发明申请

US20220081403A1 OXAZOLIDINONE COMPOUNDS AND METHODS OF USE THEREOF AS ANTIBACTERIAL AGENTS 有权
公开(公告)号：US20220081403A1
公开(公告)日：2022-03-17
申请号：US17422308
申请日：2019-12-19
申请人： Randall R. MILLER , Joseph A. KOZLOWSKI , Philippe NANTERMET , David B. OLSEN , Jing SU , Uihu YANG , Takao SUZUKI , Brendan M. CROWLEY , Nengxue WANG , Lanying YOU , Merck Sharp & Dohme Corp.
发明人： Randall R. Miller , Joseph A. Kozlowski , Philippe Nantermet , David B. Olsen , Jing Su , Lihu Yang , Takao Suzuki , Brendan Crowley , Negxue Wang , Lanying You
IPC分类号： C07D263/06 , C07D471/04 , C07D413/12 , C07D495/04 , C07F9/653 , C07F9/6553 , A61K31/422 , A61K31/421 , A61K31/437 , A61K31/498 , A61K31/4439 , A61K31/541 , A61P31/06 , A61K45/06
摘要： The present invention discloses oxazolidinone compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A and E, are as defined herein. The present invention also relates to compositions which comprise at least one oxazolidinone compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of an oxazolidinone of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

7. 发明申请

US20170283416A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL 有权
公开(公告)号：US20170283416A1
公开(公告)日：2017-10-05
申请号：US15505620
申请日：2015-10-26
申请人： Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Takao Suzuki , Joseph P. Vacca , Shouning Xu , Merck Sharp & Dohme Corp.
发明人： Fa-Xiang Ding , Shuzhi Dong , Jinlong Jiang , Takao Suzuki , Joseph P. Vacca , Shouning Xu
IPC分类号： C07D471/10 , A61K31/444 , A61K31/501 , A61K31/435
CPC分类号： C07D471/10 , A61K31/401 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/435 , A61K31/4422 , A61K31/444 , A61K31/501 , A61K31/55 , A61K2300/00
摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

8. 发明授权

US09650375B2 Indole derivatives useful as anti-diabetic agents 有权
公开(公告)号：US09650375B2
公开(公告)日：2017-05-16
申请号：US14769159
申请日：2014-03-10
申请人： Merck Sharp & Dohme Corp. , John J. Acton, III , Rajan Anand , Ashok Arasappan , Qun Dang , Iyassu Sebhat , Zhifa Pu , Takao Suzuki
发明人： John J. Acton, III , Rajan Anand , Ashok Arasappan , Qun Dang , Iyassu Sebhat , Zhifa Pu , Takao Suzuki
IPC分类号： C07D209/04 , C07D471/04 , A61K31/404 , C07D209/12 , C07D209/30 , A61K31/366 , A61K31/397 , A61K31/437 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/10 , C07D413/04 , C07D413/10 , C07D493/04 , C07D209/18 , C07D519/00 , C07D209/08
CPC分类号： C07D471/04 , A61K31/366 , A61K31/397 , A61K31/404 , A61K31/437 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/4985 , A61K31/5377 , A61K31/541 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/30 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/04 , C07D405/04 , C07D405/06 , C07D405/10 , C07D413/04 , C07D413/10 , C07D493/04 , C07D519/00 , A61K2300/00
摘要： Novel compounds of the structural formula (I) are activators of AMP-protein kinase and may be useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention may be useful in the treatment of Type 2 diabetes, hyperglycemia, metabolic syndrome, obesity, hypercholesterolemia, and hypertension.

9. 发明申请

US20160248919A1 NON-TRANSITORY RECORDING MEDIUM, INFORMATION PROCESSING APPARATUS, AND INFORMATION PROCESSING METHOD 有权
标题翻译：非传输记录介质，信息处理设备和信息处理方法
公开(公告)号：US20160248919A1
公开(公告)日：2016-08-25
申请号：US15044362
申请日：2016-02-16
申请人： Toshiyuki Haginoya , Takao Suzuki
发明人： Toshiyuki Haginoya , Takao Suzuki
IPC分类号： H04N1/00
CPC分类号： H04N1/0044 , H04N1/00411
摘要： A non-transitory recording medium has a program recorded therein that is executable by a computer. The program causes the computer to implement functions of a preview image generation condition creation unit configured to create a condition for generating a preview image, a determination unit configured to determine whether a preview image of output data should be generated based on the condition for generating the preview image and attribution information of the output data, the output data being stored in an output data storage unit, and a preview image generation unit configured to generate the preview image of the output data which is determined that the preview image of the output data should be generated.
摘要翻译：非瞬时记录介质具有记录在其中的可由计算机执行的程序。该程序使计算机实现预览图像生成条件创建单元的功能，该预览图像生成条件创建单元被配置为创建用于生成预览图像的条件;确定单元，被配置为基于用于生成预览图像的条件来确定是否应当生成输出数据的预览图像预览图像和输出数据的属性信息，输出数据存储在输出数据存储单元中，以及预览图像生成单元，其被配置为生成被确定为输出数据的预览图像应该被输出的输出数据的预览图像生成。

10. 发明授权

US08526141B2 Magnetic disk device and guide member for guiding a flexible wiring board 有权
标题翻译：用于引导柔性布线板的磁盘装置和导向件
公开(公告)号：US08526141B2
公开(公告)日：2013-09-03
申请号：US12967043
申请日：2010-12-13
申请人： Satoshi Matsumura , Takao Suzuki , Tomoki Hiramatsu , Kohji Takahashi
发明人： Satoshi Matsumura , Takao Suzuki , Tomoki Hiramatsu , Kohji Takahashi
IPC分类号： G11B5/55
CPC分类号： G11B5/4846
摘要： A disk drive comprising a guide member configured to guide a strip-shaped flexible wiring board, wherein the strip-shaped flexible wiring board has one end attached to a side portion of a carriage that is rotatably supported, in such a way that another end thereof is oriented toward a mounting position. A U-shaped component of the guide member comprises a pair of edge components and is formed into a U-shape, wherein the U-shaped component is inserted between two projecting components comprising a front-side projecting component and a rear-side projecting component which are arranged to a front and a rear portion of the carriage respectively and are provided on a side portion of the carriage, and the pair of edge components come into contact with the two projecting components, respectively, wherein the U-shaped components is elastically deformed in such a way that the pair of edge components come closer together.
摘要翻译：一种盘驱动器，包括构造成引导条状柔性布线板的引导构件，其中所述条形柔性布线板的一端附接到可旋转地支撑的托架的侧部，使得其另一端面向安装位置。引导构件的U形部件包括一对边缘部件并且形成为U形，其中U形部件插入在两个突出部件之间，包括前侧突出部件和后侧突出部件它们分别布置在托架的前部和后部，并且设置在托架的侧部上，并且一对边缘部件分别与两个突出部件接触，其中U形部件弹性地以这样的方式变形，使得该对边缘部件更靠近在一起。

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