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1. 发明授权

US5093531A Polyethylene glycol substituted phenyl glyoxals 失效
标题翻译：聚乙二醇取代苯甲酸
公开(公告)号：US5093531A
公开(公告)日：1992-03-03
申请号：US347902
申请日：1989-05-05
申请人： Akihiko Sano , Hiroo Maeda , Yoshiyuki Kai , Keiichi Ono
发明人： Akihiko Sano , Hiroo Maeda , Yoshiyuki Kai , Keiichi Ono
IPC分类号： C12N9/00 , A61K38/00 , C07K1/02 , C07K1/06 , C07K1/107 , C07K1/113 , C07K7/23 , C07K14/00 , C07K14/52 , C07K14/53 , C07K14/535 , C07K14/575 , C07K14/58 , C07K14/60 , C07K14/65 , C08G65/32 , C08G65/323 , C08G65/329 , C08G65/334 , C08G65/48
CPC分类号： C08G65/323 , C07K1/064 , C07K1/1077 , C08G65/329 , C08G65/3346
摘要： A polyethylene glycol derivative of the formula ##STR1## wherein R represents a lower alkyl and n represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by said polyethylene glycol derivative and a method for production thereof.The polyethylene glycol derivative (I) is capable of modifying the guanidino groups in peptides. The peptides modified by the polyethylene glycol derivative (I) are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.

2. 发明授权

US5214131A Polyethylene glycol derivatives, modified peptides and production thereof 失效
标题翻译：聚乙二醇衍生物，修饰肽及其制备
公开(公告)号：US5214131A
公开(公告)日：1993-05-25
申请号：US798138
申请日：1991-11-26
申请人： Akihiko Sano , Hiroo Maeda , Yoshiyuki Kai , Keiichi Ono
发明人： Akihiko Sano , Hiroo Maeda , Yoshiyuki Kai , Keiichi Ono
IPC分类号： C07K1/06 , C07K1/107 , C08G65/323 , C08G65/329 , C08G65/334
CPC分类号： C07K1/064 , C07K1/1077 , C08G65/323 , C08G65/329 , C08G65/3346
摘要： A polyethylene glycol derivative of the formula ##STR1## wherein R represents a lower alkyl and n represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by said polyethylene glycol derivative and a method for production thereof. The polyethylene glycol derivative (I) is capable of modifying the guanidino groups in peptides. The peptides modified by the polyethylene glycol derivative (I) are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.
摘要翻译：式（I）的聚乙二醇衍生物，其中R表示低级烷基，n表示任选的正整数，其使得聚乙二醇部分的平均分子量为约1,000至12,000，由所述聚乙二醇衍生物修饰的肽及其制造方法。聚乙二醇衍生物（I）能够改变肽中的胍基。由聚乙二醇衍生物（I）改性的肽是非常稳定的，生物清除率（即耐久性延长）显着延迟，并且在长时间内有效地表现出其生理活性。

3. 发明授权

US4774319A Synthesis of a derivative of GRF and intermediate peptides 失效
标题翻译： GRF和中间体肽衍生物的合成
公开(公告)号：US4774319A
公开(公告)日：1988-09-27
申请号：US119279
申请日：1987-11-09
申请人： Keiichi Ono , Yoshiyuki Kai , Yoshiaki Takebayashi , Akihiko Sano , Kazushi Suwa
发明人： Keiichi Ono , Yoshiyuki Kai , Yoshiaki Takebayashi , Akihiko Sano , Kazushi Suwa
IPC分类号： A61K38/00 , C07K14/60 , C07K7/06 , C07K7/08 , C07K7/10
CPC分类号： C07K14/60 , A61K38/00 , Y02P20/55 , Y10S930/12
摘要： A process for the manufacture of a polypeptide (I) having the formula: ##STR1## which comprises steps of: (a) coupling, successively and in the order of the sequence of the polypeptide (I), the four protected fragments A, B, C and D or five protected fragments A, B, C, E and F,said fragment A by the formula, Leu-Gin-Asp-Ile-Met-Ser-Arg-NH.sub.2said fragment B by the formula, Gln-Leu-Ser-Ala-Arg-Lys-Leusaid fragment C by the formula, Arg-Lys-Val-Leu-Glysaid fragment D by the formula, Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyrsaid fragment E by the formula, Ile-Phe-Thr-Asn-Ser-Tyrand said fragment F by the formula, Tyr-Ala-Asp-Ala being represented, respectively, and(b) eliminating, at the end of sequence, all the protecting groups to provide the polypeptide (I) which is active on the stimulation of the release of the growth hormone and thus is very useful as medicine for treatment of growth hormone deficiency disease and the like.
摘要翻译：一种制备具有下式的多肽（I）的方法：其包括以下步骤：（a）依次和按照多肽（I ），四个保护的片段A，B，C和D或五个保护的片段A，B，C，E和F，所述片段A通过式Leu-Gin-Asp-Ile-Met-Ser-Arg-NH2表示片段B由式Gln-Leu-Ser-Ala-Arg-Lys-Leu表示，由式Arg-Lys-Val-Leu-Gly表示的片段C表示下式的Tyr-Ala-Asp-Ala- Ile-Phe-Thr-Asn-Ser-Tyr分别表示分子式为Ile-Phe-Thr-Asn-Ser-Tyr的片段E和由式Tyr-Ala-Asp-Ala表示的所述片段F，以及（b）在序列结束时，除去所有保护基以提供在刺激生长激素释放方面具有活性的多肽（I），因此作为治疗生长激素缺乏症的药物非常有用，类似。

4. 发明授权

US06756048B1 Long time drug-sustained release preparation 有权
标题翻译：长时间药物缓释制剂
公开(公告)号：US06756048B1
公开(公告)日：2004-06-29
申请号：US09786746
申请日：2001-04-18
申请人： Akihiko Sano , Hiroo Maeda , Masako Kajihara , Shunsuke Tani , Toshihiko Sugie
发明人： Akihiko Sano , Hiroo Maeda , Masako Kajihara , Shunsuke Tani , Toshihiko Sugie
IPC分类号： A61F200
CPC分类号： A61K9/0087 , A61K31/00 , A61K47/30
摘要： The present invention relates to a sustained release preparation of a lipophilic drug, comprising a drug dispersion wherein the lipophilic drug and a water-soluble substance are dispersed, in a solid state at the body temperature of an animal or a human being to which the preparation is to be administered, in a water-impermeable and biocompatible material.
摘要翻译：本发明涉及亲脂性药物的持续释放制剂，其包含药物分散体，其中所述亲脂性药物和水溶性物质以固体状态分散在动物或人的体温，所述制剂将在不透水和生物相容的材料中施用。

5. 发明授权

US07601363B2 Sustained-release drug formulations 失效
标题翻译：持续释放药物制剂
公开(公告)号：US07601363B2
公开(公告)日：2009-10-13
申请号：US11688082
申请日：2007-03-19
申请人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
发明人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
IPC分类号： A61K9/14 , A61F2/00 , A61F13/00
CPC分类号： A61K9/0024 , A61K47/02
摘要： The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.
摘要翻译：本发明涉及具有实现活性成分控制释放的新颖结构的植入制剂。制剂包含组合（a），（b）和（c）中的一种，以及包含疏水性聚合物的载体，其中所述颗粒组合分散在载体中：（a）包含活性成分的颗粒，碳酸盐和包含与碳酸盐在水溶液中反应产生二氧化碳（物质如酸）的物质的颗粒; （b）包含活性成分和碳酸酯的颗粒，以及包含物质如酸的颗粒; 和（c）包含碳酸盐的颗粒和包含活性成分和物质如酸的颗粒。

6. 发明授权

US07247312B1 Sustained-release drug formulations for implantation 失效
标题翻译：用于植入的持续释放药物制剂
公开(公告)号：US07247312B1
公开(公告)日：2007-07-24
申请号：US10089694
申请日：2000-10-31
申请人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
发明人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
IPC分类号： A61F13/00 , A61F2/00 , A61K9/14
CPC分类号： A61K9/0024 , A61K47/02
摘要： The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.
摘要翻译：本发明涉及具有实现活性成分控制释放的新颖结构的植入制剂。制剂包含组合（a），（b）和（c）中的一种，以及包含疏水性聚合物的载体，其中所述颗粒组合分散在载体中：（a）包含活性成分的颗粒，碳酸盐和包含与碳酸盐在水溶液中反应产生二氧化碳（物质如酸）的物质的颗粒; （b）包含活性成分和碳酸酯的颗粒，以及包含物质如酸的颗粒; 和（c）包含碳酸盐的颗粒和包含活性成分和物质如酸的颗粒。

7. 发明申请

US20070166377A1 SUSTAINED-RELEASE DRUG FORMULATIONS 失效
标题翻译：持续释放药物制剂
公开(公告)号：US20070166377A1
公开(公告)日：2007-07-19
申请号：US11688082
申请日：2007-03-19
申请人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
发明人： Akihiko Sano , Masako Kajihara , Hiroo Maeda
IPC分类号： A61K39/00 , A61K9/46
CPC分类号： A61K9/0024 , A61K47/02
摘要： The present invention relates to a formulation for implantation having a novel constitution, which accomplishes controlled releases of active ingredients. The formulation comprises one of combinations (a), (b) and (c), as well as a carrier comprising a hydrophobic polymer, wherein the particle combination is dispersed into the carrier: (a) particles comprising an active ingredient, particles comprising a carbonate, and particles comprising a substance which is reacted with the carbonate in an aqueous solution to generate carbon dioxide (substance such as an acid); (b) particles comprising an active ingredient and a carbonate, and particles comprising a substance such as an acid; and (c) particles comprising a carbonate, and particles comprising an active ingredient and a substance such as an acid.
摘要翻译：本发明涉及具有实现活性成分控制释放的新颖结构的植入制剂。制剂包含组合（a），（b）和（c）中的一种，以及包含疏水性聚合物的载体，其中所述颗粒组合分散在载体中：（a）包含活性成分的颗粒，碳酸盐和包含与碳酸盐在水溶液中反应产生二氧化碳（物质如酸）的物质的颗粒; （b）包含活性成分和碳酸酯的颗粒，以及包含物质如酸的颗粒; 和（c）包含碳酸盐的颗粒和包含活性成分和物质如酸的颗粒。

8. 发明申请

US20140202838A1 ELECTRONIC COMPONENT 审中-公开
标题翻译：电子元件
公开(公告)号：US20140202838A1
公开(公告)日：2014-07-24
申请号：US14236639
申请日：2012-07-18
申请人： Akihiko Sano , Takeshi Fujiwara , Hidenori Maruyama , Tomonori Seki
发明人： Akihiko Sano , Takeshi Fujiwara , Hidenori Maruyama , Tomonori Seki
IPC分类号： H01H59/00
CPC分类号： H01H59/0009 , B81B2201/018 , B81B2207/012 , B81B2207/095 , B81C1/00238 , B81C2203/035 , H01H2001/0078
摘要： An electronic component has a first member in which an electrostatic actuator is provided, a second member in which a drive integrated circuit for driving the electrostatic actuator is provided, and join parts that joins the first member and the second member while a surface on which the electrostatic actuator is provided in the first member and a surface on which the drive integrated circuit is provided in the second member are opposed to each other. The electrostatic actuator and the drive integrated circuit are disposed in a space surrounded by the first member, the second member, and the join parts.
摘要翻译：电子部件具有设置有静电致动器的第一部件，设置有用于驱动静电致动器的驱动集成电路的第二部件和与第一部件和第二部件连接的接合部，静电致动器设置在第一构件中，并且在第二构件中设置有驱动集成电路的表面彼此相对。静电致动器和驱动集成电路设置在由第一构件，第二构件和接合部包围的空间中。

9. 发明授权

US08742091B2 Method of promoting nucleic acid transfer 有权
标题翻译：促进核酸转运的方法
公开(公告)号：US08742091B2
公开(公告)日：2014-06-03
申请号：US10481511
申请日：2002-06-20
申请人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
发明人： Masaaki Terada , Takahiro Ochiya , Yu Aso , Kimi Honma , Akihiko Sano , Shunji Nagahara
IPC分类号： C07H21/02 , A61K38/17 , C12N15/11
CPC分类号： A61K48/0008 , A61K47/6435 , A61K48/00 , C12N15/87
摘要： Means for transferring efficiently a desired nucleic acid into a cell is provided.The present invention comprises using a complex comprising a collagen or a collagen derivative, and a desired nucleic acid.
摘要翻译：提供了将期望的核酸有效转移到细胞中的方法。本发明包括使用包含胶原蛋白或胶原衍生物和所需核酸的复合物。

10. 发明授权

US08696216B2 Optical module, method of producing optical module, optical transmission module, and electronic apparatus 失效
标题翻译：光模块，光模块生产方法，光传输模块和电子设备
公开(公告)号：US08696216B2
公开(公告)日：2014-04-15
申请号：US12296495
申请日：2007-04-12
申请人： Akihiko Sano , Hiroto Nozawa , Toshiaki Okuno , Junichi Tanaka , Naru Yasuda , Hayami Hosokawa
发明人： Akihiko Sano , Hiroto Nozawa , Toshiaki Okuno , Junichi Tanaka , Naru Yasuda , Hayami Hosokawa
IPC分类号： G02B6/36
CPC分类号： G02B6/4214 , G02B6/4253 , G02B6/4255
摘要： An optical module has a support board, an optical transmission path, and at least a single optical element having a light receiving function or a light emitting function provided on the support board. A light emission surface of the optical transmission path or a light incidence surface of the optical transmission path is arranged such that the optical element and the optical transmission path are optically coupled to each other, with respect to a light receiving surface or a light emitting surface of the optical element. The optical element is sealed by a sealing agent. A gap is provided between the optical transmission path and the surface of the sealing agent on the light receiving surface or the light emitting surface of the optical element.
摘要翻译：光学模块具有支撑板，光传输路径和至少一个光学元件，其具有设置在支撑板上的光接收功能或发光功能。光传输路径的光发射表面或光传输路径的光入射表面被布置成使得光学元件和光传输路径相对于光接收表面或发光表面彼此光学耦合的光学元件。光学元件由密封剂密封。在光传输路径和光学元件的光接收表面或发光表面上的密封剂的表面之间设置间隙。

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