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    • 1. 发明授权
    • Controlled release preparations having multi-layer structure
    • 具有多层结构的控制释放制剂
    • US07101567B1
    • 2006-09-05
    • US09701303
    • 1999-05-19
    • Akihiko SanoMasako KajiharaToshihiko Sugie
    • Akihiko SanoMasako KajiharaToshihiko Sugie
    • A61F2/00
    • A61K9/209A61K9/0024
    • Preparations whereby two or more drugs can be released separately at appropriate speeds depending on the disease or the release behaviors of one or more drugs can be precisely controlled, which consist of an outer layer wherein a water-soluble drug is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and one or more inner layers wherein a water-soluble drug, differing in kind or concentration from the one contained in the outer layer, is dispersed in a carrier made of a biologically non-degradable and hydrophobic polymer material, and in which the outer and inner layers are concentrically located in diametral direction of rod-like preparations and both or one of the ends in the axial direction are opened so as to directly come into contact with the environment.
    • 可以精确地控制两种或更多种药物以适当的速度单独释放的制剂,这取决于一种或多种药物的疾病或释放行为,其由外层组成,其中水溶性药物分散在由 生物不可降解和疏水的聚合物材料,以及一种或多种内层,其中与外层中所含的不同种类或浓度的水溶性药物分散在由生物不可降解的载体制成的载体中, 疏水性聚合物材料,并且其中外层和内层同心地位于棒状制剂的直径方向上,并且两个或一个端部沿轴向方向打开以直接与环境接触。