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1. 发明申请

WO2009128789A1 VESICLES FOR INTRACELLULAR DRUG DELIVERY 审中-公开
标题翻译：用于细胞内药物输送的药剂
公开(公告)号：WO2009128789A1
公开(公告)日：2009-10-22
申请号：PCT/SG2009/000142
申请日：2009-04-17
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YUE, Zhilian , YU, Hanry
发明人： YUE, Zhilian , YU, Hanry
IPC分类号： A61K9/127 , A61K9/133 , A61K47/34 , A61K47/48 , C08G81/00
CPC分类号： A61K47/6919
摘要： The present invention is directed to a composition comprising a pegylated amphiphilic polymer, wherein the pegylated amphiphilic polymer is comprised of at least one polymerizable carboxylic acid and at least one amino acid; wherein the degree of pegylation is adapted to cause the amphiphilic polymer to form a vesicle; wherein the polyethyleneglycol moiety is linked to a cleavable linkage; and wherein the cleavable linkage is cleavable by an external stimulus to cause a conformational change of the vesicle form of the polymer into its linear form. The present invention also describes the manufacture of such compositions and the use as pharmaceutical and in scaffolds.
摘要翻译：本发明涉及包含聚乙二醇化两亲性聚合物的组合物，其中所述聚乙二醇化两亲性聚合物由至少一种可聚合羧酸和至少一种氨基酸组成; 其中聚乙二醇化程度适于使两亲性聚合物形成囊泡; 其中所述聚乙二醇部分连接到可切割键; 并且其中所述可切割连接可通过外部刺激来切割，以使所述聚合物的小泡形式的构象变化为其线性形式。本发明还描述了这种组合物的制造以及作为药物和支架的用途。

2. 发明申请

WO2009078819A1 FORMING POROUS SCAFFOLD FROM CELLULOSE DERIVATIVES 审中-公开
标题翻译：从纤维素衍生物形成多孔的SCAFF
公开(公告)号：WO2009078819A1
公开(公告)日：2009-06-25
申请号：PCT/SG2008/000491
申请日：2008-12-18
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , YUE, Zhilian , WEN, Feng , YU, Hanry
发明人： YUE, Zhilian , WEN, Feng , YU, Hanry
IPC分类号： A61L27/20 , A61L27/56 , C08F6/14 , C08L1/08
CPC分类号： B32B3/26 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08J2201/024 , C08J2201/026 , C08J2201/0484 , C08J2201/0524 , C08J2205/044 , C08J2207/10 , C08J2301/28 , C08L1/14 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , C08L1/28
摘要： Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
摘要翻译：脚手架包含限定大孔的聚合物，并且包含部分被包含通过自交联基团交联的自交联基团的取代基取代的羟丙基纤维素。大孔具有大于50微米的平均孔径并且至少部分互连。在一种方法中，形成包含连续水相和连续聚合物相的双连续乳液。聚合物相包含部分由包含自交联基团的取代基取代的羟丙基纤维素，并且通过自交联基团交联以形成限定至少部分互连的孔的聚合物。在另一种方法中，在包含聚合物前体和水的溶液中诱导相分离以形成包含连续聚合物相和连续水相的双连续乳液。聚合物前体包含自交联基团，并且通过乳液中的自交联基团交联以形成限定至少部分互连的大孔的聚合物。

3. 发明公开

EP2234655A1 FORMING POROUS SCAFFOLD FROM CELLULOSE DERIVATIVES 有权
标题翻译： BILDUNG EINESPORÖSENGERÜSTSAUS CELLULOSE-DERIVATEN
公开(公告)号：EP2234655A1
公开(公告)日：2010-10-06
申请号：EP08863269.0
申请日：2008-12-18
申请人： Agency for Science, Technology And Research
发明人： YUE, Zhilian , WEN, Feng , YU, Hanry
IPC分类号： A61L27/20 , A61L27/56 , C08F6/14 , C08L1/08
CPC分类号： B32B3/26 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08J2201/024 , C08J2201/026 , C08J2201/0484 , C08J2201/0524 , C08J2205/044 , C08J2207/10 , C08J2301/28 , C08L1/14 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , C08L1/28
摘要： Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.
摘要翻译：脚手架包含限定大孔的聚合物，并且包含部分由包含通过自交联基团交联的自交联基团的取代基取代的羟丙基纤维素。大孔具有大于50微米的平均孔径并且至少部分互连。在一种方法中，形成包含连续水相和连续聚合物相的双连续乳液。聚合物相包含部分由包含自交联基团的取代基取代的羟丙基纤维素，并且通过自交联基团交联以形成限定至少部分互连的孔的聚合物。在另一种方法中，在包含聚合物前体和水的溶液中诱导相分离，以形成包含连续聚合物相和连续水相的双连续乳液。聚合物前体包含自交联基团，并且通过乳液中的自交联基团交联以形成限定至少部分互连的大孔的聚合物。

4. 发明授权

EP2234655B1 FORMING POROUS SCAFFOLD FROM CELLULOSE DERIVATIVES 有权
公开(公告)号：EP2234655B1
公开(公告)日：2018-12-12
申请号：EP08863269.0
申请日：2008-12-18
申请人： Agency for Science, Technology And Research
发明人： YUE, Zhilian , WEN, Feng , YU, Hanry
IPC分类号： C08L1/14 , C08B11/20 , C08J9/28 , A61L27/20 , A61L27/56
CPC分类号： B32B3/26 , A61L27/20 , A61L27/56 , C08B11/20 , C08J9/28 , C08J2201/024 , C08J2201/026 , C08J2201/0484 , C08J2201/0524 , C08J2205/044 , C08J2207/10 , C08J2301/28 , C08L1/14 , Y10T428/249921 , Y10T428/249978 , Y10T428/249979 , C08L1/28
摘要： Scaffold comprises a polymer defining macropores and comprising hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, which is crosslinked through the self-crosslinkable group. The macropores have an average pore size larger than 50 microns and are at least partially interconnected. In one method, bicontinuous emulsion comprising a continuous aqueous phase and a continuous polymer phase is formed. The polymer phase comprises hydroxypropylcellulose partially substituted by a substituent comprising a self-crosslinkable group, and is crosslinked through the self-crosslinkable group to form a polymer defining at least partially interconnected pores. In another method, phase separation is induced in a solution comprising a polymer precursor and water to form a bicontinuous emulsion comprising a continuous polymer phase and a continuous aqueous phase. The polymer precursor comprises a self-crosslinkable group and is crosslinked through the self-crosslinkable group in the emulsion to form a polymer defining at least partially interconnected macropores.

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