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1. 发明授权

US11897927B2 Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof 有权
公开(公告)号：US11897927B2
公开(公告)日：2024-02-13
申请号：US16348274
申请日：2017-11-30
申请人： Advaxis, Inc.
发明人： Robert Petit , Michael F. Princiotta , Brandon Coder , David Balli
IPC分类号： C07K14/47 , A61K35/74 , A61K39/00 , C12N15/74
CPC分类号： C07K14/4748 , A61K35/74 , A61K39/0011 , A61K39/00115 , A61K39/001103 , A61K39/001104 , A61K39/001107 , A61K39/001157 , A61K39/001186 , A61K39/001188 , A61K39/001189 , A61K39/001194 , A61K39/001195 , C12N15/74 , A61K2039/523 , A61K2039/55544 , A61K2039/55594 , A61K2039/645 , C07K2319/43 , C07K2319/95
摘要： Provided herein are recombinant fusion polypeptides comprising one or more antigenic peptides (e.g., fused to a PEST-containing peptide) from cancer-associated proteins. The antigenic peptides can comprise one or more or all of an antigenic peptide comprising a recurrent cancer mutation, an antigenic peptide comprising a heteroclitic mutation, or an antigenic peptide fused to a ubiquitin protein. For example, provided herein are recombinant fusion polypeptides comprising two or more antigenic peptides (e.g., fused to a PEST-containing peptide), wherein each antigenic peptide comprises a recurrent cancer mutation, and wherein at least two of the antigenic peptides are fragments of the same cancer-associated protein. Also provided are nucleic acids encoding such fusion polypeptides, recombinant bacteria or Listeria strains comprising such fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such recombinant fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.

2. 发明申请

US20210246457A1 Listeria-Based Compositions Comprising a Peptide Minigene Expression System and Methods of Use Thereof 有权
公开(公告)号：US20210246457A1
公开(公告)日：2021-08-12
申请号：US17127530
申请日：2020-12-18
申请人： ADVAXIS, INC.
发明人： Robert Petit , Michael F. Princiotta
IPC分类号： C12N15/74 , A61P35/00 , A61K39/00 , A61K35/74 , C07K14/00 , C12P21/02 , C07K14/195 , C07K14/82
摘要： This disclosure provides compositions, including Listeria delivery vectors comprising minigene expression constructs, and methods of using the same for inducing an immune response against an antigen-expressing tumor and for treating the same, and vaccinating against the same in subjects bearing the tumors.

3. 发明公开

US20230357781A1 LISTERIA-BASED COMPOSITIONS COMPRISING A PEPTIDE MINIGENE EXPRESSION SYSTEM AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20230357781A1
公开(公告)日：2023-11-09
申请号：US18316539
申请日：2023-05-12
申请人： Advaxis, Inc.
发明人： Robert Petit , Michael F. Princiotta
IPC分类号： C12N15/74 , A61P35/00 , A61K39/00 , A61K35/74 , C07K14/00 , C12P21/02 , C07K14/195 , C07K14/82
CPC分类号： C12N15/74 , A61P35/00 , A61K39/001106 , A61K35/74 , C07K14/00 , C12P21/02 , C07K14/195 , C07K14/82 , C07K2319/036 , A61K2039/522 , A61K2039/523 , A61K38/00
摘要： This disclosure provides compositions, including Listeria delivery vectors comprising minigene expression constructs, and methods of using the same for inducing an immune response against an antigen-expressing tumor and for treating the same, and vaccinating against the same in subjects bearing the tumors.

4. 发明申请

US20190322714A1 Immunogenic Compositions Targeting Recurrent Cancer Mutations And Methods Of Use Thereof 审中-公开
公开(公告)号：US20190322714A1
公开(公告)日：2019-10-24
申请号：US16348274
申请日：2017-11-30
申请人： Advaxis, Inc.
发明人： Robert Petit , Michael F. Princiotta , Brandon Coder , David Balli
IPC分类号： C07K14/47 , A61K35/74 , A61K39/00 , C12N15/74
摘要： Provided herein are recombinant fusion polypeptides comprising one or more antigenic peptides (e.g., fused to a PEST-containing peptide) from cancer-associated proteins. The antigenic peptides can comprise one or more or all of an antigenic peptide comprising a recurrent cancer mutation, an antigenic peptide comprising a heteroclitic mutation, or an antigenic peptide fused to a ubiquitin protein. For example, provided herein are recombinant fusion polypeptides comprising two or more antigenic peptides (e.g., fused to a PEST-containing peptide), wherein each antigenic peptide comprises a recurrent cancer mutation, and wherein at least two of the antigenic peptides are fragments of the same cancer-associated protein. Also provided are nucleic acids encoding such fusion polypeptides, recombinant bacteria or Listeria strains comprising such fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such recombinant fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.

5. 发明申请

US20190002891A1 Listeria-Based Compositions Comprising A Peptide Minigene Expression System And Methods Of Use Thereof 审中-公开
公开(公告)号：US20190002891A1
公开(公告)日：2019-01-03
申请号：US15553507
申请日：2016-03-03
申请人： Advaxis, Inc.
发明人： Robert Petit , Michael F. Princiotta
IPC分类号： C12N15/74 , C07K14/195 , C07K14/82 , A61K39/00 , A61P35/00
摘要： This disclosure provides compositions, including Listeria delivery vectors comprising minigene expression constructs, and methods of using the same for inducing an immune response against an antigen-expressing tumor and for treating the same, and vaccinating against the same in subjects bearing the tumors.

6. 发明公开

US20240124540A1 IMMUNOGENIC COMPOSITIONS TARGETING RECURRENT CANCER MUTATIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20240124540A1
公开(公告)日：2024-04-18
申请号：US18516360
申请日：2023-11-21
申请人： Advaxis, Inc.
发明人： Robert Petit , Michael F. Princiotta , Brandon Coder , David Balli
IPC分类号： C07K14/47 , A61K35/74 , A61K39/00 , C12N15/74
CPC分类号： C07K14/4748 , A61K35/74 , A61K39/0011 , A61K39/001103 , A61K39/001104 , A61K39/001107 , A61K39/00115 , A61K39/001157 , A61K39/001186 , A61K39/001188 , A61K39/001189 , A61K39/001194 , A61K39/001195 , C12N15/74 , A61K2039/523 , A61K2039/55544 , A61K2039/55594 , A61K2039/645 , C07K2319/43 , C07K2319/95
摘要： Provided herein are recombinant fusion polypeptides comprising one or more antigenic peptides (e.g., fused to a PEST-containing peptide) from cancer-associated proteins. The antigenic peptides can comprise one or more or all of an antigenic peptide comprising a recurrent cancer mutation, an antigenic peptide comprising a heteroclitic mutation, or an antigenic peptide fused to a ubiquitin protein. For example, provided herein are recombinant fusion polypeptides comprising two or more antigenic peptides (e.g., fused to a PEST-containing peptide), wherein each antigenic peptide comprises a recurrent cancer mutation, and wherein at least two of the antigenic peptides are fragments of the same cancer-associated protein. Also provided are nucleic acids encoding such fusion polypeptides, recombinant bacteria or Listeria strains comprising such fusion polypeptides or such nucleic acids, and cell banks comprising such recombinant bacteria or Listeria strains. Also provided herein are methods of generating such fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. Also provided are methods of inducing an anti-tumor-associated-antigen immune response in a subject, methods of inducing an anti-tumor or anti-cancer immune response in a subject, methods of treating a tumor or cancer in a subject, methods of preventing a tumor or cancer in a subject, and methods of protecting a subject against a tumor or cancer using such recombinant fusion polypeptides, nucleic acids, recombinant bacteria or Listeria strains, immunogenic compositions, pharmaceutical compositions, or vaccines.

7. 发明授权

US11702664B2 Listeria-based compositions comprising a peptide minigene expression system and methods of use thereof 有权
公开(公告)号：US11702664B2
公开(公告)日：2023-07-18
申请号：US17127530
申请日：2020-12-18
申请人： ADVAXIS, INC.
发明人： Robert Petit , Michael F. Princiotta
IPC分类号： C12N15/74 , A61P35/00 , A61K39/00 , A61K35/74 , C07K14/00 , C12P21/02 , C07K14/195 , C07K14/82 , A61K38/00 , A61K39/12
CPC分类号： C12N15/74 , A61K35/74 , A61K39/001106 , A61P35/00 , C07K14/00 , C07K14/195 , C07K14/82 , C12P21/02 , A61K38/00 , A61K39/12 , A61K2039/522 , A61K2039/523 , A61K2039/572 , A61K2039/585 , C07K2319/02 , C07K2319/036 , C12N2710/20034 , C12N2710/20071
摘要： This disclosure provides compositions, including Listeria delivery vectors comprising minigene expression constructs, and methods of using the same for inducing an immune response against an antigen-expressing tumor and for treating the same, and vaccinating against the same in subjects bearing the tumors.

8. 发明授权

US10900044B2 Listeria-based compositions comprising a peptide minigene expression system and methods of use thereof 有权
公开(公告)号：US10900044B2
公开(公告)日：2021-01-26
申请号：US15553507
申请日：2016-03-03
申请人： Advaxis, Inc.
发明人： Robert Petit , Michael F. Princiotta
IPC分类号： C12N15/74 , A61P35/00 , A61K39/00 , A61K35/74 , C07K14/00 , C12P21/02 , C07K14/195 , C07K14/82 , A61K38/00 , A61K39/12
摘要： This disclosure provides compositions, including Listeria delivery vectors comprising minigene expression constructs, and methods of using the same for inducing an immune response against an antigen-expressing tumor and for treating the same, and vaccinating against the same in subjects bearing the tumors.

9. 发明申请

US20180305702A1 Listeria-Based Immunogenic Compositions And Methods Of Use Thereof in Cancer Prevention And Treatment 审中-公开
公开(公告)号：US20180305702A1
公开(公告)日：2018-10-25
申请号：US15563447
申请日：2016-09-14
申请人： Advaxis, Inc.
发明人： Robert Petit , Michael F. Princiotta , Kyle Perry
IPC分类号： C12N15/74 , C07K14/195 , C12N9/64 , C07K14/47 , C12N9/90 , C12N9/10
CPC分类号： C12N15/74 , A61K39/00 , A61K39/0011 , A61K2039/522 , A61K2039/523 , A61K2039/585 , C07K14/195 , C07K14/4747 , C07K14/4748 , C07K14/705 , C07K2319/00 , C07K2319/03 , C12N9/1096 , C12N9/6424 , C12N9/6445 , C12N9/90 , C12Y206/01021 , C12Y304/21077 , C12Y304/21106 , C12Y501/01001
摘要： Disclosed herein are recombinant Listeria strains comprising nucleotides encoding two or more heterologous antigens each fused to a truncated LLO, an N-terminal ActA or a PEST-sequence, methods of preparing same, and methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering same.

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