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1. 发明授权

US07858337B2 Process for the manufacture of a composite material 有权
标题翻译：制造复合材料的方法
公开(公告)号：US07858337B2
公开(公告)日：2010-12-28
申请号：US12074329
申请日：2008-03-03
申请人： Achim Müller , Monika Knuth , Katharina Schmid , Ralf Pasternack , Jens Zotzel , Kai Oertel , Christine Reiff, geb. Schmitt , Hans-Lothar Fuchsbauer
发明人： Achim Müller , Monika Knuth , Katharina Schmid , Ralf Pasternack , Jens Zotzel , Kai Oertel , Christine Reiff, geb. Schmitt , Hans-Lothar Fuchsbauer
IPC分类号： C07K7/00 , C12P1/00 , C12P21/04
CPC分类号： C08J7/047 , A61F2/14 , A61L27/28 , A61L27/34 , A61L27/50 , C08J2489/00 , G02C7/04 , C08L89/00
摘要： The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking the water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.
摘要翻译：本发明涉及一种制备复合材料的方法，包括以下步骤：（a）提供疏水性有机体材料，和（b）通过首先非共价连接到疏水性有机大块材料本体材料的表面是包含疏水部分的水溶性肽; 然后化学或酶促交联水溶性肽。根据本发明的方法制造的复合材料具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此特别适用于眼科装置。

2. 发明申请

US20090029413A1 Process for the manufacture of a composite material 有权
标题翻译：制造复合材料的方法
公开(公告)号：US20090029413A1
公开(公告)日：2009-01-29
申请号：US12074329
申请日：2008-03-03
申请人： Achim Muller , Monika Knuth , Katharina Schmid , Ralf Pasternack , Jens Zotzel , Kai Oertel , Christine Reiff, geb. Schmitt , Hans-Lothar Fuchsbauer
发明人： Achim Muller , Monika Knuth , Katharina Schmid , Ralf Pasternack , Jens Zotzel , Kai Oertel , Christine Reiff, geb. Schmitt , Hans-Lothar Fuchsbauer
IPC分类号： C12P21/04 , C12P1/00 , C07K7/00
CPC分类号： C08J7/047 , A61F2/14 , A61L27/28 , A61L27/34 , A61L27/50 , C08J2489/00 , G02C7/04 , C08L89/00
摘要： The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking said water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.
摘要翻译：本发明涉及一种制备复合材料的方法，包括以下步骤：（a）提供疏水性有机体材料，和（b）通过首先非共价连接到疏水性有机大块材料本体材料的表面是包含疏水部分的水溶性肽; 然后化学或酶促交联所述水溶性肽。根据本发明的方法制造的复合材料具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此特别适用于眼科装置。

3. 发明授权

US07429465B2 Process for analyzing tear fluid 有权
标题翻译：撕裂液分析方法
公开(公告)号：US07429465B2
公开(公告)日：2008-09-30
申请号：US10653866
申请日：2003-09-03
申请人： Achim Müller , Roland Schmieder , Katharina Schmid
发明人： Achim Müller , Roland Schmieder , Katharina Schmid
IPC分类号： G01N33/00 , A61B5/00
CPC分类号： G01N33/487 , A61B2010/0067
摘要： The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up the contact lens and (b) feeding the analyte obtained according to step (a) into an analyzer. The process of the invention provides a new concept for noninvasively measuring various analytes occurring in the tear fluid that is comfortable to the user.
摘要翻译：本发明涉及一种用于分析水凝胶隐形眼镜在眼睛上的磨损后的分析物的方法，包括以下步骤：（a）物理或化学诱导水凝胶隐形眼镜的体积减少，从而将分析物挤出聚合物构成隐形眼镜的材料和（b）将根据步骤（a）获得的分析物进料到分析器中。本发明的方法提供了用于非侵入性地测量在用户舒适的泪液中出现的各种分析物的新概念。

4. 发明授权

US08206622B2 Process for production of ionically crosslinked polysaccharide microspheres 有权
标题翻译：离子交联多糖微球的制备方法
公开(公告)号：US08206622B2
公开(公告)日：2012-06-26
申请号：US10590316
申请日：2005-02-22
申请人： Stefan Kammermeier , Till Merkel , Katharina Schmid , Achim Müller
发明人： Stefan Kammermeier , Till Merkel , Katharina Schmid , Achim Müller
IPC分类号： B29B9/00
CPC分类号： B01J13/046 , A61K9/5036 , B01J13/14
摘要： The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.
摘要翻译：本发明涉及一种制备包含离子交联聚合物的微球的方法，所述方法包括：（a）通过使用超声波将由含离子交联性聚离子聚合物的溶液（3）制成液体气溶胶微滴（13）至连续气流中喷雾器; （b）将气流转移到包含二价，多价或多价离子的胶凝溶液（10）中，由此形成交联的聚合物微球体（14），（c）从胶凝溶液中分离出微球体，和（d）任选地，通过筛网过滤微球。

5. 发明授权

US08460743B2 Coating process for ophthalmic lenses 有权
公开(公告)号：US08460743B2
公开(公告)日：2013-06-11
申请号：US12381694
申请日：2009-03-16
申请人： Achim Müller , Katharina Schmid
发明人： Achim Müller , Katharina Schmid
IPC分类号： B05D1/36 , B05D3/04 , G02C7/04
CPC分类号： B29D11/00865 , G02B1/043 , C08L83/04
摘要： The present invention generally relates to a method for coating ophthalmic lenses, preferably contact lenses, more preferably silicone hydrogel contact lenses. In particular, the present invention is directed to a method for forming a coating comprising a polyionic material on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user.

6. 发明授权

US08147897B2 Cross-linkable polyionic coatings for medical devices 有权
标题翻译：用于医疗器械的可交联聚离子涂层
公开(公告)号：US08147897B2
公开(公告)日：2012-04-03
申请号：US12012870
申请日：2008-02-06
申请人： Maria Gonzalez Ferreiro , Lutz Kröhne , Achim Müller , Katharina Schmid , Andreas Voigt
发明人： Maria Gonzalez Ferreiro , Lutz Kröhne , Achim Müller , Katharina Schmid , Andreas Voigt
IPC分类号： A61L33/00 , B05D5/06 , G02B1/04 , A61K9/00
CPC分类号： G02B1/043 , C08J7/04 , Y10T428/31511
摘要： A method for making an article comprising a core material and a coating thereon, the method comprising the steps of:(a) providing the core material;(b) applying one or more layers of a crosslinkable polycationic material, wherein the polycationic material is a reaction product of:(i) an epoxide of formula (I) wherein X equals bromo, chloro, iodo, or cyano, and R1, R2, R3, R4, independently of one another, are selected from the group consisting of hydrogen, linear or branched C1-C6-alkyl, and linear or branched C1-C6-alkyl which is substituted with halogen, and (ii) a polymer having repeating units comprising one or more secondary or tertiary amine group(s); (c) applying one or more layers of a polyanionic material; and (d) cross-linking the layers of polyelectrolytes formed by steps (b) and (c). The articles obtainable by the method of the invention have desirable characteristics regarding adherence to the core material, durability, hydrophilicity, and wettability and are thus useful for the manufacture of medical articles such as ophthalmic devices.
摘要翻译：一种用于制造包括芯材料和其上的涂层的制品的方法，所述方法包括以下步骤：（a）提供所述芯材料; （b）施加一层或多层可交联聚阳离子材料，其中聚阳离子材料是以下物质的反应产物：（i）式（I）的环氧化物，其中X等于溴，氯，碘或氰基，R1，R2 ，R 3，R 4彼此独立地选自氢，直链或支链C 1 -C 6烷基和被卤素取代的直链或支链C 1 -C 6烷基，和（ii）具有包含一个或多个仲胺或叔胺基团的重复单元; （c）施加一层或多层聚阴离子材料; 和（d）交联由步骤（b）和（c）形成的聚电解质层。通过本发明的方法可获得的制品具有关于对芯材的粘附性，耐久性，亲水性和润湿性的所需特性，因此可用于制造医疗制品如眼科装置。

7. 发明授权

US07772286B2 Polyvinyl alcohol copolymers comprising biomolecules 有权
标题翻译：包含生物分子的聚乙烯醇共聚物
公开(公告)号：US07772286B2
公开(公告)日：2010-08-10
申请号：US10544725
申请日：2004-02-27
申请人： Achim Müller , Roland Schmieder , Katharina Schmid
发明人： Achim Müller , Roland Schmieder , Katharina Schmid
IPC分类号： C08F8/00 , C08F116/06 , C08F299/00
CPC分类号： G02B1/043 , C08F8/30 , C08F8/48 , C08F2810/30 , C08L29/04 , C08F16/06
摘要： The present invention relates to a copolymer, which is the reaction product of (a) a first prepolymer, comprising a bioactive moiety and at least one radically polymerizable group, and (b) a second prepolymer which is a polyvinyl alcohol having a weight average molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprises from 0.5 to 80% structural units of formula (I) wherein: R is alkylene having up to 8 carbon atoms, R1 is hydrogen or alkyl having up to seven carbon atoms, and R2 is an olefinically unsaturated, electron-attracting copolymerizable radical.
摘要翻译：本发明涉及一种共聚物，它是（a）包含生物活性部分和至少一个可自由基聚合基团的第一预聚物的反应产物，和（b）第二预聚物，其是具有重均分子量至少约2000重量，基于聚乙烯醇的羟基数，包含0.5至80％的式（I）结构单元，其中：R是具有至多8个碳原子的亚烷基，R 1是氢或烷基具有至多7个碳原子，并且R 2是烯属不饱和的吸电子共聚基团。

8. 发明申请

US20070178162A1 Process for production of ionically crosslinked polysaccharide microspheres 有权
标题翻译：离子交联多糖微球的制备方法
公开(公告)号：US20070178162A1
公开(公告)日：2007-08-02
申请号：US10590316
申请日：2005-02-22
申请人： Stefan Kammermeier , Till Merkel , Katharina Schmid , Achim Muller
发明人： Stefan Kammermeier , Till Merkel , Katharina Schmid , Achim Muller
IPC分类号： B29B9/00 , A61K9/14
CPC分类号： B01J13/046 , A61K9/5036 , B01J13/14
摘要： The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the micro-spheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.
摘要翻译：本发明涉及一种制备包含离子交联聚合物的微球的方法，所述方法包括：（a）通过使用超声波将由含离子交联性聚离子聚合物的溶液（3）制成液体气溶胶微滴（13）至连续气流中喷雾器; （b）将气流转移到包含二价，多价或多价离子的胶凝溶液（10）中，由此形成交联聚合物微球体（14），（c）将微球体与胶凝溶液分离，和（d ）任选地，通过筛网过滤微球。

9. 发明申请

US20060148983A1 Copolymers comprising biomolecules 有权
标题翻译：包含生物分子的共聚物
公开(公告)号：US20060148983A1
公开(公告)日：2006-07-06
申请号：US10544725
申请日：2004-02-27
申请人： Achim Muller , Roland Schmieder , Katharina Schmid
发明人： Achim Muller , Roland Schmieder , Katharina Schmid
IPC分类号： C08F116/06
CPC分类号： G02B1/043 , C08F8/30 , C08F8/48 , C08F2810/30 , C08L29/04 , C08F16/06
摘要： The present invention relates to a copolymer, which is the reaction product of (a) a first prepolymer, comprising a bioactive moiety and at least one radically polymerizable group, and (b) a second prepolymer which is a polyvinyl alcohol having a weight average molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprises from 0.5 to 80% structural units of formula (I) wherein: R is alkylene having up to 8 carbon atoms, R1 is hydrogen or alkyl having up to seven carbon atoms, and R2 is an olefinically unsaturated, electron-attracting copolymerizable radical.
摘要翻译：本发明涉及一种共聚物，它是（a）包含生物活性部分和至少一个可自由基聚合基团的第一预聚物的反应产物，和（b）第二预聚物，其是具有重均分子量至少约2000重量，基于聚乙烯醇的羟基数，包含0.5至80％的式（I）结构单元，其中：R是具有至多8个碳原子的亚烷基，R 1 H 2是具有至多7个碳原子的氢或烷基，R 2是烯属不饱和的吸电子共聚基团。

10. 发明申请

US20080152800A1 Process for the coating of biomedical articles 有权
标题翻译：生物医学制品涂层工艺
公开(公告)号：US20080152800A1
公开(公告)日：2008-06-26
申请号：US12004002
申请日：2007-12-19
申请人： Harald Bothe , Yasuo Matsuzawa , Bernhard Seiferling , Katharina Schmid , Heike Arndt
发明人： Harald Bothe , Yasuo Matsuzawa , Bernhard Seiferling , Katharina Schmid , Heike Arndt
IPC分类号： B05D5/00 , G02C7/04
CPC分类号： A61L27/34 , C08L33/08
摘要： The invention relates to a process for the manufacture of a hydrophilic coating on a biomedical article, which comprises treating the biomedical article for a time period of ≦5 minutes with a solution of an organic solvent comprising a polyanionic compound with a number average molecular weight Mn of >5000, wherein the solution comprises less than 10% by weight of water, and wherein the solution is devoid of a cationic polymer. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.
摘要翻译：本发明涉及在生物医学制品上制造亲水性涂层的方法，该方法包括用含有数均分子量的聚阴离子化合物的有机溶剂溶液处理生物医药制品<= 5分钟的时间其中溶液包含小于10重量％的水，并且其中该溶液没有阳离子聚合物。通过本发明的方法可获得的涂覆的生物医学制品具有关于对基底的粘附，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此在眼科装置领域中特别有用。

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