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1. 发明申请

US20090029413A1 Process for the manufacture of a composite material 有权
标题翻译：制造复合材料的方法
公开(公告)号：US20090029413A1
公开(公告)日：2009-01-29
申请号：US12074329
申请日：2008-03-03
申请人： Achim Muller , Monika Knuth , Katharina Schmid , Ralf Pasternack , Jens Zotzel , Kai Oertel , Christine Reiff, geb. Schmitt , Hans-Lothar Fuchsbauer
发明人： Achim Muller , Monika Knuth , Katharina Schmid , Ralf Pasternack , Jens Zotzel , Kai Oertel , Christine Reiff, geb. Schmitt , Hans-Lothar Fuchsbauer
IPC分类号： C12P21/04 , C12P1/00 , C07K7/00
CPC分类号： C08J7/047 , A61F2/14 , A61L27/28 , A61L27/34 , A61L27/50 , C08J2489/00 , G02C7/04 , C08L89/00
摘要： The invention relates to a process for the manufacture of a composite materials comprising the steps of (a) providing a hydrophobic organic bulk material, and (b) applying a hydrophilic surface coating on the hydrophobic organic bulk material by first non-covalently attaching to the surface of the bulk material a water-soluble peptide comprising a hydrophobic moiety; and then chemically or enzymatically crosslinking said water-soluble peptide. The composite materials manufactured according to the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus particularly useful as ophthalmic devices.
摘要翻译：本发明涉及一种制备复合材料的方法，包括以下步骤：（a）提供疏水性有机体材料，和（b）通过首先非共价连接到疏水性有机大块材料本体材料的表面是包含疏水部分的水溶性肽; 然后化学或酶促交联所述水溶性肽。根据本发明的方法制造的复合材料具有关于对基材的粘附性，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此特别适用于眼科装置。

2. 发明申请

US20090186229A1 Method for coating silicone hydrogels 有权
标题翻译：硅胶水凝胶涂层方法
公开(公告)号：US20090186229A1
公开(公告)日：2009-07-23
申请号：US12321443
申请日：2009-01-21
申请人： Achim Muller , Monika Knuth , Ralf Pasternack , Jens Zotzel , Christine Reiff
发明人： Achim Muller , Monika Knuth , Ralf Pasternack , Jens Zotzel , Christine Reiff
IPC分类号： A61L33/00 , B32B13/04
CPC分类号： B29D11/00865 , G02B1/043 , Y10S514/839
摘要： The invention relates to a process for producing biomedical articles, in particular, silicone hydrogel contact lenses having durable hydrophilic chitosan coating. The chitosan coating is covalently attached to the medical device by performing a crosslinking reaction between chitosan and the carboxylic groups on the surface of a medical device directly in a sealed package during autoclave. The coated biomedical articles obtainable by the process of the invention have desirable characteristics regarding adherence to the substrate, durability, hydrophilicity, wettability, biocompatibility and permeability and are thus especially useful in the field of ophthalmic devices.
摘要翻译：本发明涉及一种用于生产生物医学制品的方法，特别是具有持久的亲水性壳聚糖涂层的硅酮水凝胶隐形眼镜。壳聚糖涂层通过在高压釜中直接在密封包装中在壳聚糖和医疗器械表面上的羧基之间进行交联反应而共价连接到医疗装置上。通过本发明的方法可获得的涂覆的生物医学制品具有关于对基底的粘附，耐久性，亲水性，润湿性，生物相容性和渗透性的期望特性，因此在眼科装置领域中特别有用。

3. 发明申请

US20050176158A1 Process for analyzing the tear fluid 有权
标题翻译：泪液分析方法
公开(公告)号：US20050176158A1
公开(公告)日：2005-08-11
申请号：US10653866
申请日：2003-09-03
申请人： Achim Muller , Roland Schmieder , Katharina Schmid
发明人： Achim Muller , Roland Schmieder , Katharina Schmid
IPC分类号： G02C7/04 , A61B3/10 , A61B10/00 , G01N33/487 , G01N33/543
CPC分类号： G01N33/487 , A61B2010/0067
摘要： The present invention concerns a process for analyzing an analyte in a hydrogel contact lens following its wear on the eye, comprising the steps of (a) physically or chemically inducing a volume reduction of the hydrogel contact lens and thereby squeezing the analyte out of the polymer material making up the contact lens and (b) feeding the analyte obtained according to step (a) into an analyzer. The process of the invention provides a new concept for noninvasively measuring various analytes occurring in the tear fluid that is comfortable to the user.
摘要翻译：本发明涉及一种用于分析水凝胶隐形眼镜在眼睛上的磨损后的分析物的方法，包括以下步骤：（a）物理或化学诱导水凝胶隐形眼镜的体积减少，从而将分析物挤出聚合物构成隐形眼镜的材料和（b）将根据步骤（a）获得的分析物进料到分析器中。本发明的方法提供了用于非侵入性地测量在用户舒适的泪液中出现的各种分析物的新概念。

4. 发明申请

US20070178162A1 Process for production of ionically crosslinked polysaccharide microspheres 有权
标题翻译：离子交联多糖微球的制备方法
公开(公告)号：US20070178162A1
公开(公告)日：2007-08-02
申请号：US10590316
申请日：2005-02-22
申请人： Stefan Kammermeier , Till Merkel , Katharina Schmid , Achim Muller
发明人： Stefan Kammermeier , Till Merkel , Katharina Schmid , Achim Muller
IPC分类号： B29B9/00 , A61K9/14
CPC分类号： B01J13/046 , A61K9/5036 , B01J13/14
摘要： The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the micro-spheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.
摘要翻译：本发明涉及一种制备包含离子交联聚合物的微球的方法，所述方法包括：（a）通过使用超声波将由含离子交联性聚离子聚合物的溶液（3）制成液体气溶胶微滴（13）至连续气流中喷雾器; （b）将气流转移到包含二价，多价或多价离子的胶凝溶液（10）中，由此形成交联聚合物微球体（14），（c）将微球体与胶凝溶液分离，和（d ）任选地，通过筛网过滤微球。

5. 发明申请

US20060148983A1 Copolymers comprising biomolecules 有权
标题翻译：包含生物分子的共聚物
公开(公告)号：US20060148983A1
公开(公告)日：2006-07-06
申请号：US10544725
申请日：2004-02-27
申请人： Achim Muller , Roland Schmieder , Katharina Schmid
发明人： Achim Muller , Roland Schmieder , Katharina Schmid
IPC分类号： C08F116/06
CPC分类号： G02B1/043 , C08F8/30 , C08F8/48 , C08F2810/30 , C08L29/04 , C08F16/06
摘要： The present invention relates to a copolymer, which is the reaction product of (a) a first prepolymer, comprising a bioactive moiety and at least one radically polymerizable group, and (b) a second prepolymer which is a polyvinyl alcohol having a weight average molecular weight of at least about 2000 that, based on the number of hydroxy groups of the polyvinyl alcohol, comprises from 0.5 to 80% structural units of formula (I) wherein: R is alkylene having up to 8 carbon atoms, R1 is hydrogen or alkyl having up to seven carbon atoms, and R2 is an olefinically unsaturated, electron-attracting copolymerizable radical.
摘要翻译：本发明涉及一种共聚物，它是（a）包含生物活性部分和至少一个可自由基聚合基团的第一预聚物的反应产物，和（b）第二预聚物，其是具有重均分子量至少约2000重量，基于聚乙烯醇的羟基数，包含0.5至80％的式（I）结构单元，其中：R是具有至多8个碳原子的亚烷基，R 1 H 2是具有至多7个碳原子的氢或烷基，R 2是烯属不饱和的吸电子共聚基团。

6. 发明申请

US20090238948A1 Coating process for ophthalmic lenses 有权
标题翻译：眼科镜片涂层工艺
公开(公告)号：US20090238948A1
公开(公告)日：2009-09-24
申请号：US12381694
申请日：2009-03-16
申请人： Achim Muller , Katharina Schmid
发明人： Achim Muller , Katharina Schmid
IPC分类号： B05D7/24
CPC分类号： B29D11/00865 , G02B1/043 , C08L83/04
摘要： The present invention generally relates to a method for coating ophthalmic lenses, preferably contact lenses, more preferably silicone hydrogel contact lenses. In particular, the present invention is directed to a method for forming a coating comprising a polyionic material on a contact lens, preferably a silicone hydrogel contact lens, directly in the primary package and maintaining the coated contact lens within said primary package until insertion of the coated contact lens in the eye of the contact lens user.
摘要翻译：本发明总体上涉及一种用于涂覆眼镜片，优选隐形眼镜，更优选硅酮水凝胶隐形眼镜的方法。特别地，本发明涉及一种在隐形眼镜，优选硅酮水凝胶隐形眼镜，直接在初级包装中形成包含聚离子材料的涂层的方法，并将涂覆的隐形眼镜保持在所述初级包装中，直到插入在隐形眼镜用户的眼睛中涂覆隐形眼镜。

7. 发明申请

US20080226922A1 Cross-linkable polyionic coatings for medical devices 有权
标题翻译：用于医疗器械的可交联聚离子涂层
公开(公告)号：US20080226922A1
公开(公告)日：2008-09-18
申请号：US12012870
申请日：2008-02-06
申请人： Maria Gonzalez Ferreiro , Lutz Krohne , Achim Muller , Katharina Schmid , Andreas Voigt
发明人： Maria Gonzalez Ferreiro , Lutz Krohne , Achim Muller , Katharina Schmid , Andreas Voigt
IPC分类号： B32B27/38 , B05D5/06
CPC分类号： G02B1/043 , C08J7/04 , Y10T428/31511
摘要： A method for making an article comprising a core material and a coating thereon, the method comprising the steps of:(a) providing the core material; (b) applying one or more layers of a crosslinkable polycationic material, wherein the polycationic material is a reaction product of: (i) an epoxide of formula (I) wherein X equals bromo, chloro, iodo, or cyano, and R1, R2, R3, R4, independently of one another, are selected from the group consisting of hydrogen, linear or branched C1-C6-alkyl, and linear or branched C1-C6-alkyl which is substituted with halogen, and (ii) a polymer having repeating units comprising one or more secondary or tertiary amine group(s); (c) applying one or more layers of a polyanionic material; and (d) cross-linking the layers of polyelectrolytes formed by steps (b) and (c). The articles obtainable by the method of the invention have desirable characteristics regarding adherence to the core material, durability, hydrophilicity, and wettability and are thus useful for the manufacture of medical articles such as ophthalmic devices.
摘要翻译：一种用于制造包括芯材料和其上的涂层的制品的方法，所述方法包括以下步骤：（a）提供所述芯材料; （b）施加一层或多层可交联聚阳离子材料，其中聚阳离子材料是以下物质的反应产物：（i）式（I）的环氧化物，其中X等于溴，氯，碘或氰基，R 0 R 1，R 2，R 3，R 4和R 4彼此独立地选自氢直链或支链C 1 -C 6 - 烷基，以及直链或支链C 1 -C 6 - 被卤素取代的烷基，和（ii）具有包含一个或多个仲胺或叔胺基团的重复单元的聚合物; （c）施加一层或多层聚阴离子材料; 和（d）交联由步骤（b）和（c）形成的聚电解质层。通过本发明的方法可获得的制品具有关于对芯材的粘附性，耐久性，亲水性和润湿性的所需特性，因此可用于制造医疗制品如眼科装置。

8. 发明申请

US20080249381A1 Combined Apparatus For Measuring the Blood Glucose Level From an Ocular Fluid 审中-公开
标题翻译：用于从眼液测量血糖水平的组合仪器
公开(公告)号：US20080249381A1
公开(公告)日：2008-10-09
申请号：US11570628
申请日：2005-06-13
申请人： Achim Muller , Peter Herbrechtsmeier , Bernhard Seiferling , Wolfgang Hofmann
发明人： Achim Muller , Peter Herbrechtsmeier , Bernhard Seiferling , Wolfgang Hofmann
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/0071 , A61B5/1455 , A61B5/1486 , A61B5/6821
摘要： A combined apparatus for measuring the blood glucose level from an ocular fluid comprises a hand-held fluorescence photometer (D1) for determining the glucose level of the ocular fluid and a device (D2) for the amperometric or photometric determination of the blood glucose level. The fluorescence photometer (D1) comprises: first irradiating means (7,8,10) for providing a pilot beam (1) for irradiation of the eye (3) in order to excite a first fluorescence comprising a first wavelength band; first detecting means (8,9,12,13) for measuring the intensity of the of the pupil fluorescence within the first wavelength band; second irradiating means (17,18,21) for providing a measurement beam (5) for irradiation of the eye in order to excite an ocular sensor (4) to emit a second fluorescence comprising a second wavelength band; second detecting means (18,19,20,22,23,24,25) for measuring the intensity of the second fluorescence within the second wavelength band. The first and second irradiating means are arranged such that the measurement beam irradiates the eye under a predetermined angle (a) between 0° and 90° and at a predetermined distance from the pilot beam.
摘要翻译：用于测量来自眼液的血糖水平的组合装置包括用于确定眼液的葡萄糖水平的手持荧光光度计（D 1）和用于血糖的电流或光度测定的装置（D 2）水平。荧光光度计（D 1）包括：第一照射装置（7,8,10），用于提供用于照射眼睛（3）的引导光束（1），以便激发包括第一波长带的第一荧光; 第一检测装置（8,9,12,13），用于测量第一波长带内的瞳孔荧光的强度; 第二照射装置（17,18,21），用于提供用于照射眼睛的测量光束（5），以激发眼睛传感器（4）以发射包括第二波长带的第二荧光; 用于测量第二波长带内的第二荧光的强度的第二检测装置（18,19,20,22,23,24,25）。第一和第二照射装置被布置成使得测量光束以0°至90°之间的预定角度（a）照射眼睛并且距离导向光束预定距离。

9. 发明授权

US6149842A Methods and compositions for manufacturing tinted ophthalmic lenses 有权
标题翻译：用于制造有色眼镜的方法和组合物
公开(公告)号：US6149842A
公开(公告)日：2000-11-21
申请号：US191063
申请日：1998-11-12
申请人： John Martin Lally , Friedrich Stockinger , Charlotte Lynn Cooper , Achim Muller , Deborah Jean Mulcahy , Bernhard Seiferling
发明人： John Martin Lally , Friedrich Stockinger , Charlotte Lynn Cooper , Achim Muller , Deborah Jean Mulcahy , Bernhard Seiferling
IPC分类号： B29C35/02 , B29D11/00
CPC分类号： B29D11/00317 , B29C35/02
摘要： The invention relates to a process for the manufacture of tinted ophthalmic moldings comprising the steps of(a) providing a water soluble polymer precursor having crosslinkable or polymerizable groups;(b) providing a pigment dispersion comprising an inorganic or organic pigment and a dispersing agent;(c) mixing the metal phthalocyanine dye or pigment with the polymer precursor to form a tinted prepolymerization mixture,(d) dispensing the tinted prepolymerization mixture into a mold,(e) applying radiation to the tinted prepolymerization mixture in the mold, thereby crosslinking or polymerizing the polymer precursor and entrapping the dye or pigment within the polymeric network of the resultant ophthalmic molding, and(f) opening the mold so that the ophthalmic molding can be removed from the mold.According to the process, tinted ophthalmic moldings, particularly full-body tinted soft contact lenses having improved properties, are prepared with an improved efficiency.
摘要翻译：本发明涉及一种制造有色眼用模制品的方法，包括以下步骤：（a）提供具有可交联或可聚合基团的水溶性聚合物前体; （b）提供包含无机或有机颜料和分散剂的颜料分散体; （c）将金属酞菁染料或颜料与聚合物前体混合以形成着色的预聚合混合物，（d）将着色的预聚合混合物分配到模具中，（e）向模具中的着色预聚合混合物施加辐射，从而交联或使聚合物前体聚合并将染料或颜料捕获到所得眼用模制品的聚合物网络内，和（f）打开模具，使得可以将模具从模具中移出。根据该方法，以提高的效率制备着色眼用模制品，特别是具有改进性能的全身有色软触角镜。

10. 发明授权

US5650720A Rotational speed-detecting device with rod-shaped sensor 失效
标题翻译：带棒状传感器的转速检测装置
公开(公告)号：US5650720A
公开(公告)日：1997-07-22
申请号：US552793
申请日：1995-11-03
申请人： Uwe Brockmuller , Achim Muller
发明人： Uwe Brockmuller , Achim Muller
IPC分类号： B60T8/171 , B60T8/32 , G01P1/00 , G01P3/481 , G01P3/44
CPC分类号： G01P3/481 , B60T8/171 , B60T8/329 , G01P1/00
摘要： In a device for detecting the rotational speed of a motor vehicle wheel, a sensor and a sensor bracket. The bracket is mounted on a non-rotating part of the vehicle chassis such as an axle journal. The sensor bracket (1) has a tubular socket for the sensor (13) with a locking clip (3), which can be flipped open around a hinge (4), and a latching element (8, 9), which holds the locking clip (3) in a closed position.
摘要翻译：在用于检测机动车辆车轮，传感器和传感器支架的转速的装置中。支架安装在诸如轴颈的车辆底盘的非旋转部分上。传感器支架（1）具有用于传感器（13）的管状插座，其具有可绕铰链（4）翻转的锁定夹（3），以及锁定元件（8,9），其保持锁定夹子（3）处于关闭位置。

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