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1. 发明授权

US08816102B2 Compounds 有权
标题翻译：化合物
公开(公告)号：US08816102B2
公开(公告)日：2014-08-26
申请号：US13378257
申请日：2010-06-24
申请人： Abdelmajid Kaouas , Harry Renes , Alexander P. Tondeur , Cornelis Winkel
发明人： Abdelmajid Kaouas , Harry Renes , Alexander P. Tondeur , Cornelis Winkel
IPC分类号： C07D317/44 , A24B15/30 , A24B15/36 , A23L1/226 , C07D317/60 , C07C235/34 , C07C235/78
CPC分类号： A23L1/22671 , A23L27/204 , A23L27/2052 , C07C235/34 , C07C235/78 , C07D317/60
摘要： A method of modulating the flavor of an orally-receivable product, such as a foodstuff, beverage, dentifrice or medicine, comprising the addition thereto of a flavor-modulating proportion of at least one compound of the formula I in which X is selected from CHOH, C═O, CH2—CO and CH═C(OH), Y is selected from C1-C7 linear and branched alkyl and CH2CH2OH, Z is selected from CH3 and a moiety of the formula II in which the wavy bond represents bond linking Z to X and R1 and R2 are selected from the possibilities (i) both hydrogen; (ii) independently OH and OCH3; and (iii) R1 and R2 together with their bonds to the phenyl ring form a ring of the formula —O—CH2—O—; such that, when Z is CH3, X is C═O and Y is CH2CH2OH.
摘要翻译：一种调节口服应用产品如食品，饮料，洁齿剂或药物的风味的方法，包括向其中加入风味调节比例的至少一种式I化合物，其中X选自CHOH ，C = O，CH 2 -CO和CH = C（OH），Y选自C 1 -C 7直链和支链烷基和CH 2 CH 2 OH，Z选自CH 3和式II的部分，其中波状键表示键连接 Z至X和R1和R2选自以下可能性（i）氢; （ii）独立地是OH和OCH 3; 和（iii）R1和R2以及它们与苯环的键形成式-O-CH 2 -O-的环; 使得当Z为CH 3时，X为C = O且Y为CH 2 CH 2 OH。

2. 发明申请

US20120093742A1 Compounds 有权
标题翻译：化合物
公开(公告)号：US20120093742A1
公开(公告)日：2012-04-19
申请号：US13378257
申请日：2010-06-24
申请人： Abdelmajid Kaouas , Harry Renes , Alexander P. Tondeur , Cornelis Winkel
发明人： Abdelmajid Kaouas , Harry Renes , Alexander P. Tondeur , Cornelis Winkel
IPC分类号： A61K8/44 , C07D317/60 , A23L1/226 , C07C233/11 , A61Q11/00 , A61K8/49 , C07C233/22 , C07C233/18
CPC分类号： A23L1/22671 , A23L27/204 , A23L27/2052 , C07C235/34 , C07C235/78 , C07D317/60
摘要： A method of modulating the flavour of an orally-receivable product, such as a foodstuff, beverage, dentifrice or medicine, comprising the addition thereto of a flavour-modulating proportion of at least one compound of the formula I in which X is selected from CHOH, C═O, CH2—CO and CH═C(OH), Y is selected from C1-C7 linear and branched alkyl and CH2CH2OH, Z is selected from CH3 and a moiety of the formula II in which the wavy bond represents bond linking Z to X and R1 and R2 are selected from the possibilities (i) both hydrogen; (ii) independently OH and OCH3; and (iii) R1 and R2 together with their bonds to the phenyl ring form a ring of the formula —O—CH2—O—; such that, when Z is CH3, X is C═O and Y is CH2CH2OH.
摘要翻译：一种调节口服应用产品如食品，饮料，洁齿剂或药物的风味的方法，包括向其中加入风味调节比例的至少一种式I化合物，其中X选自CHOH ，C = O，CH 2 -CO和CH = C（OH），Y选自C 1 -C 7直链和支链烷基和CH 2 CH 2 OH，Z选自CH 3和式II的部分，其中波状键表示键连接 Z至X和R1和R2选自以下可能性（i）氢; （ii）独立地是OH和OCH 3; 和（iii）R1和R2以及它们与苯环的键形成式-O-CH 2 -O-的环; 使得当Z为CH 3时，X为C = O且Y为CH 2 CH 2 OH。

3. 发明授权

US08815321B2 Geranylamine derivatives as flavouring agents 有权
标题翻译：香叶基胺衍生物作为调味剂
公开(公告)号：US08815321B2
公开(公告)日：2014-08-26
申请号：US13202194
申请日：2010-02-16
申请人： Abdelmajid Kaouas , Harry Renes , Cornelis Winkel
发明人： Abdelmajid Kaouas , Harry Renes , Cornelis Winkel
IPC分类号： A23L1/226 , A23L2/56 , C07C235/06
CPC分类号： A23L1/226 , A23L2/56 , A23L27/20 , A23L27/202 , C07C235/06
摘要： Compounds of the formula (I) A is OH or a carbonyl group, n is 0 or 1, R is an alkyl radical having from 1 to 4 carbon atoms, in particular methyl, ethyl, n-propyl, iso-propyl, n-butyl or t-butyl; or a residue of a hydroxy carboxylic acid, in particular the residue —CH(OH)COOH, —CH(OH)CH2COOH, —CH2CH(OH)COOH or —CH(OH)CH(OH)COOH; and R′ is independently selected from H or OH.
摘要翻译：式（I）的化合物是OH或羰基，n为0或1，R为具有1至4个碳原子的烷基，特别是甲基，乙基，正丙基，异丙基，丁基或叔丁基; 或羟基羧酸的残基，特别是残基-CH（OH）COOH，-CH（OH）CH 2 COOH，-CH 2 CH（OH）COOH或-CH（OH）CH（OH）COOH; 和R'独立地选自H或OH。

4. 发明申请

US20120015089A1 Geranylamine Derivatives As Flavouring Agents 有权
标题翻译：香叶基胺衍生物作为调味剂
公开(公告)号：US20120015089A1
公开(公告)日：2012-01-19
申请号：US13202194
申请日：2010-02-16
申请人： Abdelmajid Kaouas , Harry Renes , Cornelis Winkel
发明人： Abdelmajid Kaouas , Harry Renes , Cornelis Winkel
IPC分类号： A23L1/22 , C07C233/05
CPC分类号： A23L1/226 , A23L2/56 , A23L27/20 , A23L27/202 , C07C235/06
摘要： Compounds of the formula (I) A is OH or a carbonyl group, n is 0 or 1, R is an alkyl radical having from 1 to 4 carbon atoms, in particular methyl, ethyl, n-propyl, iso-propyl, n-butyl or t-butyl; or a residue of a hydroxy carboxylic acid, in particular the residue —CH(OH)COOH, —CH(OH)CH2COOH, —CH2CH(OH)COOH or —CH(OH)CH(OH)COOH; and R′ is independently selected from H or OH.
摘要翻译：式（I）的化合物是OH或羰基，n为0或1，R为具有1至4个碳原子的烷基，特别是甲基，乙基，正丙基，异丙基，丁基或叔丁基; 或羟基羧酸的残基，特别是残基-CH（OH）COOH，-CH（OH）CH 2 COOH，-CH 2 CH（OH）COOH或-CH（OH）CH（OH）COOH; 和R'独立地选自H或OH。

5. 发明申请

US20100129515A1 FLAVOUR MODULATING SUBSTANCES 审中-公开
标题翻译：挥发性调节物质
公开(公告)号：US20100129515A1
公开(公告)日：2010-05-27
申请号：US11995336
申请日：2006-07-28
申请人： Chris Winkel , Abdelmajid Kaouas , Sylvia N. Noomen , Harry Renes
发明人： Chris Winkel , Abdelmajid Kaouas , Sylvia N. Noomen , Harry Renes
IPC分类号： A23L1/22 , A23L2/56
CPC分类号： C07C335/12 , A23L27/00 , A23L27/204 , A23L27/88
摘要： The present invention in a first aspect relates to flavour modulation in foodstuffs, beverages, tobacco products and oral care products, using a flavour modulating substance selected from the group represented by formula (I), edible salts thereof and edible esters thereof. It has been found that these substances are capable imparting highly desirable taste attributes in the products they are incorporated in. In addition said flavour modulating substances are capable of modulating and complementing, the sensory impact of other, taste imparting, substances. Thus, the present substances are advantageously applied in flavour compositions, foodstuffs, tobacco products and oral care products. Typical examples of flavour modulating substances according to the present invention include N-vanillyl urea, N-vanillyl thiourea, N-vanillyl guanidine, N-isovanillyl urea, N-(3-ethoxy-4-hydroxybenzyl) urea, N-(3,4 dimethoxybenzyl) urea, N,N′-divanillyl urea, N,N′-divanillyl thiourea, N-octyl-N′-vanillyl urea, N-octyl-N′-vanillyl thiourea, N-hexyl-N′-vanillyl urea, N-hexyl-N′-vanillyl thiourea, N-decyl-N′-vanillyl urea, N-decyl-N′-vanillyl thiourea, N-benzyl-N′-vanillyl urea, N-benzyl-N′-vanillyl thiourea, edible salts thereof and edible esters thereof.
摘要翻译：本发明的第一方面涉及使用选自式（I）所示的调味剂的物质，食用盐和其食用酯的食品，饮料，烟草制品和口腔护理产品中的风味调节剂。已经发现，这些物质能够赋予它们所掺入的产品中非常理想的味道特性。此外，所述风味调节物质能够调节和补充其它味道赋予物质的感官影响。因此，本发明的物质有利地应用于风味组合物，食品，烟草制品和口腔护理产品中。根据本发明的风味调节物质的典型实例包括N-香草基脲，N-香草基硫脲，N-香兰基胍，N-异钒酰脲，N-（3-乙氧基-4-羟基苄基）脲，N-（3， 4-二甲氧基苄基）脲，N，N'-二苯乙烯基脲，N，N'-二苯乙烯基硫脲，N-辛基-N'-香草基脲，N-辛基-N'-香草基硫脲，N-己基-N'-香草基脲，N-己基-N'-香草基硫脲，N-癸基-N'-香草基脲，N-癸基-N'-香草基硫脲，N-苄基-N'-香草基脲，N-苄基-N'-香草基硫脲，其食用盐和其食用酯。

6. 发明申请

US20080199584A1 Flavour Compositions 审中-公开
标题翻译：香精组合物
公开(公告)号：US20080199584A1
公开(公告)日：2008-08-21
申请号：US12065189
申请日：2006-09-04
申请人： Abdelmajid Kaouas , Harry Renes , Chris Winkel
发明人： Abdelmajid Kaouas , Harry Renes , Chris Winkel
IPC分类号： A23L1/226
CPC分类号： A24B15/00 , A23L2/56 , A23L27/202 , A23L27/2022 , A23V2002/00
摘要： The present invention in a first aspect relates to flavour modulation in foodstuffs, beverages, pharmaceutics, tobacco products and oral care products, using a flavour modulating substance selected from the group of substances represented by formula (I) or formula (II), edible salts thereof and edible esters thereof: It has been found that these substances are capable imparting highly desirable taste attributes in the products they are incorporated in. In addition said flavour modulating substances are capable of modulating and complementing, the sensory impact of other, taste imparting, substances. Thus, the present substances are advantageously applied in flavour compositions, foodstuffs, pharmaceutics, tobacco products and oral care products. Typical examples of flavour modulating substances according to the present invention include 2-hydroxy-N-(2-hydroxy-2-methylpropyl)-propanamide, N-lactoyl 1-amino-2-propanol, N-lactoyl 2-amino-1-propanol, N-lactoyl 2-amino-2-methylpropanol, N-gluconyl 1-amino-2-methyl-2-propanol, N-gluconyl 1-amino-2-propanol, N-gluconyl 2-amino-1-propanol, N-gluconyl 2-amino-2-methylpropanol, N-(2-mercaptopropyl)lactamide, edible salts thereof and edible esters thereof.
摘要翻译：第一方面的本发明涉及使用选自式（I）或式（II）所示的物质的组中的调味物质的食品，饮料，制药，烟草制品和口腔护理产品中的风味调节剂，食用盐和它们的食用酯：已经发现，这些物质能够赋予它们所掺入的产品中高度理想的味道特性。此外，所述风味调节物质能够调节和补充其它味道赋予的感官影响，物质因此，本发明的物质有利地应用于风味组合物，食品，药物，烟草制品和口腔护理产品中。根据本发明的风味调节物质的典型实例包括2-羟基-N-（2-羟基-2-甲基丙基） - 丙酰胺，N-乳酰基-1-氨基-2-丙醇，N-乳酰基2-氨基-1- 丙醇，N-乳酰基2-氨基-2-甲基丙醇，N-葡萄糖酸1-氨基-2-甲基-2-丙醇，N-葡萄糖基1-氨基-2-丙醇，N-葡萄糖基-2-氨基-1-丙醇， N-葡萄糖基2-氨基-2-甲基丙醇，N-（2-巯基丙基）乳酰胺，其食用盐和其食用酯。

7. 发明授权

US09596874B2 Bitter taste masking compositions and method of masking bitter taste 有权
公开(公告)号：US09596874B2
公开(公告)日：2017-03-21
申请号：US13989107
申请日：2011-11-30
申请人： Gesa Haseleu , Elisabetta Lubian , Harry Renes , Cornelis Winkel
发明人： Gesa Haseleu , Elisabetta Lubian , Harry Renes , Cornelis Winkel
IPC分类号： A23L1/22
CPC分类号： A23C9/1544 , A23L27/202 , A23L27/2026 , A23L27/40 , A23L27/86 , A23L27/88
摘要： A composition for masking the bitter taste of potassium chloride or other potassium salt used in a consumable product as a substitute, in whole or in part, for common table salt, said composition comprising a sugar alcohol and a compound of formula (I) CH2OH—(CHOH)4—CO—NH—CH2—CH2—X; a compound of the formula (II): R1—CR2(OR3)—CO—Y; or a mixture thereof.

8. 发明申请

US20130309381A1 Organic Compounds 有权
标题翻译：有机化合物
公开(公告)号：US20130309381A1
公开(公告)日：2013-11-21
申请号：US13989107
申请日：2011-11-30
申请人： Gesa Haseleu , Elisabetta Lubian , Harry Renes , Cornelis Winkel
发明人： Gesa Haseleu , Elisabetta Lubian , Harry Renes , Cornelis Winkel
IPC分类号： A23L1/22
CPC分类号： A23C9/1544 , A23L27/202 , A23L27/2026 , A23L27/40 , A23L27/86 , A23L27/88
摘要： A composition for masking the bitter taste of potassium chloride or other potassium salt used in a consumable product as a substitute, in whole or in part, for common table salt, said composition comprising a sugar alcohol and a compound of formula (I) CH2OH—(CHOH)4—CO—NH—CH2—CH2—X; a compound of the formula (II): R1—CR2(OR3)—CO—Y; or a mixture thereof
摘要翻译：一种用于将消耗品中使用的氯化钾或其它钾盐的苦味全部或部分地用于普通餐盐的组合物，所述组合物包含糖醇和式（I）化合物，CH 2 OH- （CHOH）4-CO-NH-CH 2 -CH 2 -X; 式（II）化合物：R1-CR2（OR3）-CO-Y; 或其混合物

9. 发明授权

US08778437B2 Taste improving substances 有权
标题翻译：滋味改善物质
公开(公告)号：US08778437B2
公开(公告)日：2014-07-15
申请号：US11578846
申请日：2005-04-06
申请人： Harry Renes , Chris Winkel , Caroline De Lamarliere , Thorsten König , Esther Van Ommeren , Sander Tondeur
发明人： Harry Renes , Chris Winkel , Caroline De Lamarliere , Thorsten König , Esther Van Ommeren , Sander Tondeur
IPC分类号： A23L1/226
CPC分类号： A23L27/21 , A23L27/202
摘要： The present invention in a first aspect relates to taste improvement of foodstuffs, beverages, pharmaceutics, tobacco products and oral care products, using a substance according to formula (I) or formula (II), or edible salts thereof: R1—CR7(OR4)—CO—NR2—CR8R3—X—OR5 (I) R6—CR7(OR4)—CO-Az (II) It was found that substances represented by formula (I) and/or formula (II) are capable of modulating and complementing the sensory impact of taste imparting substances. Thus, the present taste improving substances are advantageously applied in flavor compositions, foodstuffs, beverages, pharmaceutics, tobacco products and oral care products. Typical examples of flavor improving substances according to the present invention include N-lactoyl ethanolamine, N-lactoyl ethanolamine phosphate, N-α-hydroxy-butanoyl ethanolamine, N-lactoyl diethanolamine, N-lactoyl-2-amino-1,3-propanediol, N-lactoyl-3-amino-1,2-propanediol, N-lactoyl-3-amino-1-propanol, N-gluconyl-2-amino-1,3-propanediol, N-gluconyl-3-amino-1,2-propanediol, N-mannonyl ethanolamine, N-glycolyl ethanolamine, 2-hydroxyethyl-N-tartaramide, 2-hydroxyethyl-N-malamide, 2-hydroxyethyl-N-citramide and N-gluconyl-Az.
摘要翻译：本发明的第一方面涉及使用根据式（I）或式（II）的物质或其可食用盐的食品，饮料，药物，烟草制品和口腔护理产品的味道改善：R1-CR7（OR4 ）-CO-NR2-CR8R3-X-OR5（I）R6-CR7（OR4）-CO-Az（II）发现由式（I）和/或式（II）表示的物质能够调节和补充味道赋予物质的感官影响。因此，本发明的味道改善物质有利地用于风味组合物，食品，饮料，药物，烟草制品和口腔护理产品中。根据本发明的风味改良物质的典型实例包括N-乳酰乙醇胺，N-乳酰乙醇胺磷酸盐，N-α-羟基丁酰乙醇胺，N-乳酰二乙醇胺，N-乳酰-2-氨基-1,3-丙二醇，N-乳酰基-3-氨基-1,2-丙二醇，N-乳酰-3-氨基-1-丙醇，N-葡糖基-2-氨基-1,3-丙二醇，N-葡糖基-3-氨基-1 2-丙二醇，N-甘露糖醇乙醇胺，N-乙醇酰乙醇胺，2-羟乙基-N-苯甲酰胺，2-羟乙基-N-异丙酰胺，2-羟乙基-N-乙酰丙酰胺和N-葡萄糖基-Za。

10. 发明授权

US08293215B2 Flavour modulating derivative of a carboxylic acid and a purine, pyrimidine, nucleoside, or nucleotide 有权
标题翻译：调节羧酸和嘌呤，嘧啶，核苷或核苷酸的调味衍生物
公开(公告)号：US08293215B2
公开(公告)日：2012-10-23
申请号：US12517335
申请日：2007-12-13
申请人： Adri De Klerk , Marieke Baalbergen , Harry Renes , Chris Winkel
发明人： Adri De Klerk , Marieke Baalbergen , Harry Renes , Chris Winkel
IPC分类号： A61K8/18 , A61K8/00 , A23L1/22 , A23L2/56 , C07H19/167 , C07H19/04
CPC分类号： C07H19/04 , A23L27/202 , A23L27/23 , C07H19/16
摘要： The present invention relates to the field of improving the flavor of foodstuffs, beverages, tobacco products, pharmaceutics and oral care products. More particularly, the present invention provides flavor modulating substances selected from the group represented by formula (I): and edible salts thereof and edible esters thereof, which can advantageously be used for modulating the flavor of foodstuffs, beverages, tobacco products, pharmaceutics and oral care products. These flavor modulating substances can be used to impart desirable taste attributes in a wide variety of applications and products. In addition, the present flavor modulating substances are capable of modulating the taste and/or aroma impact of other, flavor imparting, substances contained within these same products, thereby improving the overall flavor quality of these products.
摘要翻译：本发明涉及改善食品，饮料，烟草制品，药物和口腔护理产品的风味的领域。更具体地，本发明提供了选自由式（I）表示的基团的风味调节物质及其食用盐和其食用酯，其可有利地用于调节食品，饮料，烟草制品，药物和口服的风味护理产品。这些风味调节物质可用于在各种应用和产品中赋予理想的味道特性。此外，本发明的风味调节物质能够调节这些相同产品中所含的其它赋香味物质的味道和/或香气的影响，从而提高这些产品的整体风味品质。

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