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1. 发明申请

WO2012009438A2 ANTI-APPETITE ADHESIVE COMPOSITIONS 审中-公开
标题翻译：防胶粘组合物
公开(公告)号：WO2012009438A2
公开(公告)日：2012-01-19
申请号：PCT/US2011/043853
申请日：2011-07-13
申请人： AXIOMEDIC LTD. , MIZRAHI, Boaz , BRAMA, Benny , DOMB, Abraham, J.
发明人： MIZRAHI, Boaz , BRAMA, Benny , DOMB, Abraham, J.
IPC分类号： A61K36/00 , A61K9/28 , A61K36/82 , A61K36/27 , A61K36/48 , A61K36/906 , A61K36/258 , A61P3/00
CPC分类号： A61K36/258 , A61K9/006 , A61K9/2086 , A61K36/27 , A61K36/48 , A61K36/82 , A61K36/906 , A61K2300/00
摘要： Compositions for appetite suppression and methods of making and using thereof are disclosed herein. The compositions are typically in the form of a tablet, such as a single or multi-layer sticker tablet. The compositions adhere to a buccal surface or mucosal surface in the oral cavity for at least 15 minutes, preferably for at least 30 minutes. In a preferred embodiment, the compositions contain herbal agents that are anti-appetite agents. The composition is generally effective for suppressing appetite for a time period ranging from at least 30 minutes up to eight hours following administration to the buccal or oral mucosa.
摘要翻译：本文公开了食欲抑制的组合物及其制备和使用方法。组合物通常为片剂的形式，例如单层或多层贴片片剂。组合物粘附在口腔中的口腔表面或粘膜表面至少15分钟，优选至少30分钟。在优选的实施方案中，组合物含有作为抗食欲剂的草药。该组合物通常对于抑制食欲在给药至颊或口腔粘膜后至少30分钟至8小时的时间段内是有效的。

2. 发明申请

WO2009013562A2 ABSORBABLE SOLID COMPOSITIONS FOR THE TOPICAL TREATMENT OF ORAL MUCOSAL DISORDERS 审中-公开
标题翻译：用于局部治疗口腔粘膜病的可吸收固体组合物
公开(公告)号：WO2009013562A2
公开(公告)日：2009-01-29
申请号：PCT/IB2007/004665
申请日：2007-12-14
申请人： AXIOMEDIC, LTD. , DOMB, Abraham, J. , WOLNERMAN, Joseph, S.
发明人： DOMB, Abraham, J. , WOLNERMAN, Joseph, S.
CPC分类号： A61K9/006 , A61K9/2086 , A61K31/045 , A61K31/56 , A61K33/18 , A61K36/18 , A61K45/06
摘要： Bioadhesive sticker tablets which are applied directly to vaginal,, rectal and/or oral mucosa are described herein. In one embodiment, the sticker tablets are applied directly to ulcers or lesions in the oral cavity. The compositions adhere immediately upon administration, swell over time, and remain adherent to the ulcer or lesion for at least 60 minutes. The compositions can be in the form of single layer, double layer, or multilayer sticker tablets. The compositions provide immediate pain relief to the patient and promote rapid healing of the ulcer or lesion. The sticker tablet compositions contain one or more bioadhesive polymers. In one embodiment, the polymers are crosslinked polycarboxylic acids and polyols. The compositions contain at least one herbal agent and/or irritating compound, and optionally, a non-herbal active agent. The compositions can deliver a non-irritating effective dose of the agent for at least 60 minutes. The compositions described herein are stable upon storage for six months or longer.
摘要翻译：本文描述了直接施用于阴道，直肠和/或口腔粘膜的生物粘附贴剂片剂。在一个实施方案中，将贴纸片剂直接施用于口腔中的溃疡或病灶。施用后立即粘附组合物，随着时间膨胀并且保持粘附至溃疡或损伤至少60分钟。组合物可以是单层，双层或多层贴纸片剂的形式。该组合物为患者提供即时的疼痛缓解并促进溃疡或病变的快速愈合。贴纸片组合物含有一种或多种生物粘附聚合物。在一个实施方案中，聚合物是交联的聚羧酸和多元醇。该组合物含有至少一种草药和/或刺激性化合物，以及任选的非草药活性剂。该组合物可以递送非刺激性有效剂量的试剂至少60分钟。本文所述的组合物在储存六个月或更长时间后是稳定的。

3. 发明公开

EP1233795A1 ELECTROPOLYMERIZABLE MONOMERS AND POLYMERIC COATINGS ON IMPLANTABLE DEVICES 无效
标题翻译：可电单体和聚合物涂层ON的可植入装置
公开(公告)号：EP1233795A1
公开(公告)日：2002-08-28
申请号：EP00979913.1
申请日：2000-11-30
申请人： Efrat Biopolymers Ltd. , Domb, Abraham J.
发明人： DOMB, Abraham, J.
IPC分类号： A61L31/16 , A61L31/10 , A61L33/00
CPC分类号： C09D5/4476 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/416 , A61L2300/42 , A61L2300/602 , A61L2300/606 , A61L2300/62
摘要： The invention provides an electropolymerizable monomer comprising a chemically bound active agent, said agent being capable of affecting animal tissue.

4. 发明授权

EP1339776B1 POLYANHYDRIDES 有权
标题翻译：聚酸酐
公开(公告)号：EP1339776B1
公开(公告)日：2011-07-13
申请号：EP01998571.2
申请日：2001-11-29
申请人： Efrat Biopolymers Ltd. , Domb, Abraham J.
发明人： DOMB, Abraham, J.
IPC分类号： C08G67/04 , A61K9/00
CPC分类号： C08G67/02 , A61K9/2031 , A61K9/204
摘要： The invention provides polyanhydrides with aliphatic hydrocarbon terminals having ester or amide bonds.

5. 发明公开

EP1339776A2 POLYANHYDRIDES 有权
标题翻译：聚酸酐
公开(公告)号：EP1339776A2
公开(公告)日：2003-09-03
申请号：EP01998571.2
申请日：2001-11-29
申请人： Efrat Biopolymers Ltd. , Domb, Abraham J.
发明人： DOMB, Abraham, J.
IPC分类号： C08G67/04 , A61K9/00
CPC分类号： C08G67/02 , A61K9/2031 , A61K9/204
摘要： The invention provides polyanhydrides with aliphatic hydrocarbon terminals having ester or amide bonds.

6. 发明申请

WO2007010536A2 ELECTROPOLYMERIZABLE MONOMERS AND POLYMERIC COATINGS ON IMPLANTABLE DEVICES PREPARED THEREFROM 审中-公开
标题翻译：可塑性单体和聚合物涂料在其制备的可植入装置上
公开(公告)号：WO2007010536A2
公开(公告)日：2007-01-25
申请号：PCT/IL2006/000839
申请日：2006-07-19
申请人： ELUTEX LTD. , DOMB, Abraham, J.
发明人： DOMB, Abraham, J.
IPC分类号： A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： C07D207/327 , A61L27/042 , A61L27/34 , A61L31/022 , A61L31/10 , A61L31/16 , A61L33/0088 , A61L2300/80 , A61L2400/12 , A61L2420/02 , C08F2/58 , C08F226/06 , C09D5/4476 , C08L39/06
摘要： Conductive surfaces of e.g., implantable devices, coated with electropolymerized polymers having active substances attached thereto are disclosed. Electropolymerizable monomers designed and used for obtaining such conductive surfaces and processes, devices and methods for attaching the electropolymerized polymers to conductive surfaces are also disclosed. The polymers, processes and devices presented herein can be beneficially used in the preparation of implantable medical devices.
摘要翻译：公开了涂覆有附着有活性物质的电聚合聚合物的例如可植入装置的导电表面。还公开了设计并用于获得这种导电表面的电聚合单体和用于将电聚合聚合物附着到导电表面的方法，装置和方法。本文提出的聚合物，方法和装置可有利地用于可植入医疗装置的制备。

7. 发明申请

WO2006008739A2 MODIFIED CONDUCTIVE SURFACES HAVING ACTIVE SUBSTANCES ATTACHED THERETO AND USES THEREOF 审中-公开
标题翻译：带有活性物质的改性导电表面及其用途
公开(公告)号：WO2006008739A2
公开(公告)日：2006-01-26
申请号：PCT/IL2005/000769
申请日：2005-07-19
申请人： ELUTEX LTD. , DOMB, Abraham, J. , MANDLER, Daniel , DANZIGER, Ishaiahu , OROM, Miriam , OKNER, Regina , SHUSTAK, Galit , SWED, Avi , TAL, Noam
发明人： DOMB, Abraham, J. , MANDLER, Daniel , DANZIGER, Ishaiahu , OROM, Miriam , OKNER, Regina , SHUSTAK, Galit , SWED, Avi , TAL, Noam
IPC分类号： A61L27/00
CPC分类号： C09D5/4476 , A61L27/34 , A61L27/54 , A61L31/10 , A61L31/16 , A61L2300/62 , B82Y30/00
摘要： Novel processes for coating metal surfaces and/or for attaching active substances to metal surfaces, objects having coated metal surfaces and/or active substances attached thereto and uses thereof in the preparation of implantable devices are disclosed.
摘要翻译：公开了用于将金属表面和/或用于将活性物质附着到金属表面，具有涂覆的金属表面的物体和/或附着于其上的活性物质的新方法及其在可植入装置的制备中的用途。

8. 发明申请

WO2006001009A3 DEVICE SYSTEM AND METHOD FOR TISSUE DISPLACEMENT OR SEPARATION 审中-公开
公开(公告)号：WO2006001009A3
公开(公告)日：2006-01-05
申请号：PCT/IL2005/000672
申请日：2005-06-23
申请人： BIOPROTECT LTD. , PAZ, Adrian , DOMB, Abraham, J.
发明人： PAZ, Adrian , DOMB, Abraham, J.
IPC分类号： A61B17/02
摘要： A tissue displacement/separation device is provided. The device includes a bladder which is expandable between a first tissue and a second tissue of a body. The bladder has an expanded shape which is selected capable of displacing or separating the first tissue from the second tissue in a manner suitable for protecting the first tissue from an effect of a treatment applied to the second tissue.

9. 发明申请

WO2007110694A3 GELLING HYDROPHOBIC INJECTABLE POLYMER COMPOSITIONS 审中-公开
公开(公告)号：WO2007110694A3
公开(公告)日：2007-10-04
申请号：PCT/IB2006/003540
申请日：2006-09-27
申请人： EFRAT BIOPOLYMERS LTD. , DOMB, Abraham, J.
发明人： DOMB, Abraham, J.
IPC分类号： A61K47/34 , A61K9/08 , A61K31/337
摘要： Biodegradable carriers synthesized from ricinoleic acid oligoesters and aliphatic molecules having at least one carboxylic acid and at least one hydroxy or carboxylic acid group that are liquids or pastes at temperatures below 370C and methods of making and using thereof are described herein. These polymers can be used as hydrophobic biomedical sealants, temporary barriers to prevent adhesions, such as organ to organ adhesion, cell supports, carriers for drug delivery, and coatings on implantable medical devices, such as stents.

10. 发明申请

WO2006071813A2 DISPOSABLE MEDICAL SUPPLIES FROM HYDROLYTICALLY BIODEGRADABLE PLASTICS 审中-公开
标题翻译：一次性水性生物降解塑料的一次性医疗用品
公开(公告)号：WO2006071813A2
公开(公告)日：2006-07-06
申请号：PCT/US2005/046922
申请日：2005-12-22
申请人： DOMB, Abraham, J. , LANGER, Robert, S.
发明人： DOMB, Abraham, J. , LANGER, Robert, S.
IPC分类号： A61F13/53
CPC分类号： A61L29/148 , Y10T428/1352 , Y10T428/2913 , Y10T428/2915 , Y10T428/31786
摘要： Hydrolytically degradable polymers in the form of biodegradable disposable medical devices for use in medicine and laboratories such as syringes, test tubes, catheters, tubing, trays, medical fabrics, and gloves are described. The devices are formed in whole or in part of a hydrolytically degradable polymer. In the preferred embodiment, the devices or structural components thereof degrade in a period of weeks to months, preferably within a year and more preferably within six months of exposure to aqueous solutions. Conventional hydrolytically degradable polymers may be utilized or these may be modified to increase mechanical or processing characteristics, for example, using a polyfunctional branching agent and/or a chain extending agent. In one embodiment, the hydrolytically degradable polymer is a member of a class of polyesters comprising an aliphatic dicarboxylic acid, an aliphatic diol and optionally, one or more bifunctional fatty acids, such as ricinoleic acid and/or castor oil. The devices are prepared using standard techniques, such as by injection molding, extrusion or melt spinning. The devices can be formed entirely of the degradable polymer, or they can be coated with a polymer coating, optionally formed of a non-biodegradable polymer, in order to increase the compatibility of and reduce the possibility for interaction between the surface of the device and liquids that may come in contact with the device, or they may include core or other internal structural member formed of either the biodegradable or non-biodegradable material and a coating of either a biodegradable or non-biodegradable material.
摘要翻译：描述了用于医学和实验室的生物可降解一次性医疗装置形式的水解可降解聚合物，例如注射器，试管，导管，管道，托盘，医用织物和手套。该装置全部或部分由可水解降解的聚合物形成。在优选实施方案中，所述装置或其结构组分在暴露于水溶液的数周至数月内，优选在一年内，更优选在六个月内降解。可以使用常规的可水解降解的聚合物，或者可以对这些聚合物进行改性以增加机械或加工特性，例如使用多官能支化剂和/或扩链剂。在一个实施方案中，可水解降解的聚合物是包含脂族二羧酸，脂族二醇和任选地一种或多种双官能脂肪酸如蓖麻油酸和/或蓖麻油的一类聚酯的成员。这些装置使用标准技术制备，例如通过注塑，挤出或熔融纺丝。这些装置可以完全由可降解聚合物形成，或者它们可以涂覆有聚合物涂层，任选地由不可生物降解的聚合物形成，以便提高装置表面的相容性并降低装置表面与可能与设备接触的液体，或者它们可以包括由生物可降解或不可生物降解材料和可生物降解或不可生物降解材料的涂层形成的芯或其他内部结构构件。

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