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1. 发明申请

WO2009013562A2 ABSORBABLE SOLID COMPOSITIONS FOR THE TOPICAL TREATMENT OF ORAL MUCOSAL DISORDERS 审中-公开
标题翻译：用于局部治疗口腔粘膜病的可吸收固体组合物
公开(公告)号：WO2009013562A2
公开(公告)日：2009-01-29
申请号：PCT/IB2007/004665
申请日：2007-12-14
申请人： AXIOMEDIC, LTD. , DOMB, Abraham, J. , WOLNERMAN, Joseph, S.
发明人： DOMB, Abraham, J. , WOLNERMAN, Joseph, S.
CPC分类号： A61K9/006 , A61K9/2086 , A61K31/045 , A61K31/56 , A61K33/18 , A61K36/18 , A61K45/06
摘要： Bioadhesive sticker tablets which are applied directly to vaginal,, rectal and/or oral mucosa are described herein. In one embodiment, the sticker tablets are applied directly to ulcers or lesions in the oral cavity. The compositions adhere immediately upon administration, swell over time, and remain adherent to the ulcer or lesion for at least 60 minutes. The compositions can be in the form of single layer, double layer, or multilayer sticker tablets. The compositions provide immediate pain relief to the patient and promote rapid healing of the ulcer or lesion. The sticker tablet compositions contain one or more bioadhesive polymers. In one embodiment, the polymers are crosslinked polycarboxylic acids and polyols. The compositions contain at least one herbal agent and/or irritating compound, and optionally, a non-herbal active agent. The compositions can deliver a non-irritating effective dose of the agent for at least 60 minutes. The compositions described herein are stable upon storage for six months or longer.
摘要翻译：本文描述了直接施用于阴道，直肠和/或口腔粘膜的生物粘附贴剂片剂。在一个实施方案中，将贴纸片剂直接施用于口腔中的溃疡或病灶。施用后立即粘附组合物，随着时间膨胀并且保持粘附至溃疡或损伤至少60分钟。组合物可以是单层，双层或多层贴纸片剂的形式。该组合物为患者提供即时的疼痛缓解并促进溃疡或病变的快速愈合。贴纸片组合物含有一种或多种生物粘附聚合物。在一个实施方案中，聚合物是交联的聚羧酸和多元醇。该组合物含有至少一种草药和/或刺激性化合物，以及任选的非草药活性剂。该组合物可以递送非刺激性有效剂量的试剂至少60分钟。本文所述的组合物在储存六个月或更长时间后是稳定的。

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