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1. 发明申请

WO2006008575A2 CONSTRUCTION OF A COMPARATIVE DATABASE AND IDENTIFICAITON OF VIRULENCE FACTORS THROUGH COMPARISON OF POLYMORPHIC REGIONS IN CLINICAL ISOLATES OF INFECTIOUS ORGANISMS 审中-公开
标题翻译：通过对感染性有机体临床分离株中多态性区域的比较，构建比较数据库和鉴定因子的鉴定
公开(公告)号：WO2006008575A2
公开(公告)日：2006-01-26
申请号：PCT/IB2004/002598
申请日：2004-07-12
申请人： AVESTHA GENGRAINE TECHNOLOGIES PVT. LTD. , BIOMERIEUX SA , PATELL, Villoo, Morawala , RAJYASHRI, K., R. , RODRIGUE, Marc , VERNET, Guy
发明人： PATELL, Villoo, Morawala , RAJYASHRI, K., R. , RODRIGUE, Marc , VERNET, Guy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is directed to novel nucleotide sequences to be used for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency for all infectious diseases more particularly tuberculosis. The present invention also includes method for the identification and selection of polymorphisms associated with the virulence' and /or infectivity in infectious diseases more particularly in tuberculosis by a comparative genomic analysis of the sequences of different clinical isolates/strains of infectious organisms. The regions of polymorphisms, can also act as potential drug targets and vaccine targets. More particularly, the invention also relates to identifying virulence factors of M. tuberculosis strains and other infectious organisms to be included in a diagnostic DNA chip allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence. Although the present invention has been illustrated with specific reference to the polymorphic region in the Mycobacterium tuberculosis, the said invention is not to be understood and construed as being limited to Tuberculosis but is applicable to all infectious diseases.
摘要翻译：本发明涉及新的核苷酸序列，用于诊断，鉴定菌株，分型和赋予其潜在的毒性程度，感染性和/或所有感染性疾病特别是结核病的潜伏期的方向。本发明还包括通过对不同临床分离株/感染性生物菌株的序列的比较基因组分析来鉴定和选择与感染性疾病相关的多态性和/或感染性疾病更特别地在结核病中的方法。多态性区域也可以作为潜在的药物靶点和疫苗靶点。更具体地，本发明还涉及鉴定要包括在诊断DNA芯片中的结核分枝杆菌菌株和其他感染性生物体的毒力因子，其允许鉴定菌株，分选菌株并最终给出其潜在的毒力程度。虽然已经具体参考结核分枝杆菌中的多态性区域来说明了本发明，但是本发明不被理解为并且被解释为限于结核病，而是适用于所有感染性疾病。

2. 发明公开

EP1789577A2 CONSTRUCTION OF A COMPARATIVE DATABASE AND IDENTIFICAITON OF VIRULENCE FACTORS THROUGH COMPARISON OF POLYMORPHIC REGIONS IN CLINICAL ISOLATES OF INFECTIOUS ORGANISMS 审中-公开
标题翻译：建筑的对比数据库和毒力通过对比多态区在临床分离株鉴定传染性生物体
公开(公告)号：EP1789577A2
公开(公告)日：2007-05-30
申请号：EP04744233.0
申请日：2004-07-12
申请人： AVESTHA GENGRAINE TECHNOLOGIES PVT. LTD. , bioMérieux S.A.
发明人： PATELL, Villoo, Avestha Gengraine Tech. Pvt. Ltd. , RAJYASHRI, K., Avestha Gengraine Tech. Pvt. Ltd. , RODRIGUE, Marc , VERNET, Guy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156

3. 发明申请

WO2007010110A2 PROCEDE DE DETECTION DES FPCA UTILISANT UN AGENT D'AGREGATION DES FPCA ET UN AGENT DE CAPTURE DES AGREGATS FORMES 审中-公开
标题翻译： FPCA检测方法使用FPCA聚合剂和FORM AGEGEGATE CAPTURING AGENT
公开(公告)号：WO2007010110A2
公开(公告)日：2007-01-25
申请号：PCT/FR2006/001641
申请日：2006-07-07
申请人： BIOMERIEUX S.A. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE CLAUDE BERNARD LYON 1 , CECILLON, Sébastien , COLEMAN, Anthony, William , EVENO-NOBILE, Anne , PERRON, Hervé , RODRIGUE, Marc
发明人： CECILLON, Sébastien , COLEMAN, Anthony, William , EVENO-NOBILE, Anne , PERRON, Hervé , RODRIGUE, Marc
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/4709 , G01N2800/2821 , G01N2800/2835
摘要： La présente invention concerne un procédé de détection des FPCA dans un échantillon biologique d'origine humaine susceptible de contenir desdites FPCA, caractérisé en ce qu'il met en oeuvre un agent I non protéique produisant l'agrégation des formes circulantes des protéines non infectieuses impliquées dans des processus d'agrégation pathologique du système nerveux central et/ou un agent II non protéique de capture des agrégats naturels de FPCA ou induits par lesdits agents I.
摘要翻译：解码方法技术领域本发明涉及一种解码方法 FPCA在可能含有FPCA的人类生物样品中的特征因为它使用非保护性试剂I，其产生参与中枢神经系统的病理性聚集过程的非感染性蛋白质的循环形式的聚集和/或或用于捕获FPCA的天然聚集物或由所述制剂I诱导的非保护剂II。

4. 发明申请

WO2001044510A3 NUCLEIC ACID AMPLIFICATION AND DETECTION OF MYCOBACTERIUM SPECIES 审中-公开
公开(公告)号：WO2001044510A3
公开(公告)日：2001-06-21
申请号：PCT/US1999/030346
申请日：1999-12-17
申请人： GEN-PROBE INCORPORATED , BIOMERIEUX S.A. , BRENTANO, Steven, T. , JUCKER, Markus, T. , DELGADO, Francisco, D. , CLEUZIAT, Philippe , RODRIGUE, Marc
发明人： BRENTANO, Steven, T. , JUCKER, Markus, T. , DELGADO, Francisco, D. , CLEUZIAT, Philippe , RODRIGUE, Marc
IPC分类号： C12Q1/68
摘要： Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.

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