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1. 发明申请

WO0202811B1 METHOD FOR CONTROLLING THE MICROBIOLOGICAL QUALITY OF AN AQUEOUS MEDIUM AND KIT THEREFOR 审中-公开
标题翻译：用于控制水性中等微量元素及其制品的微生物学质量的方法
公开(公告)号：WO0202811B1
公开(公告)日：2004-03-04
申请号：PCT/FR0102191
申请日：2001-07-06
申请人： BIO MERIEUX , RENAUD PATRICIA , GUILLOT EMMANUELLE , MABILAT CLAUDE , VACHON CAROLE , LACROIX BRUNO , VERNET GUY , ARMAND MARIE-ASTRID , LAFFAIRE PHILIPPE
发明人： RENAUD PATRICIA , GUILLOT EMMANUELLE , MABILAT CLAUDE , VACHON CAROLE , LACROIX BRUNO , VERNET GUY , ARMAND MARIE-ASTRID , LAFFAIRE PHILIPPE
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , C12Q1/70 , C12R1/19 , G01N33/18 , G01N33/569 , G01N37/00
CPC分类号： C12Q1/701 , C12Q1/689 , C12Q1/6893
摘要： The invention concerns a method for controlling the microbiological quality of an environmental aqueous medium, suspected of containing various micro-organisms, comprising the following steps: selecting a reference set, consisting of at least three micro-organisms, representing jointly or separately, a microbiological quality level; providing a microbiological detection kit, consisting of at least three probes specifically and respectively identifying said three micro-organisms; after treating the medium to be analysed, contacting said micro-organisms, or any fraction thereof derived from the medium to be analysed therefrom, with said detection kit, whereby a multiple determination of said micro-organisms is carried out, said determination representing the microbiological quality level of the medium. The invention also concerns an appropriate microbiological detection kit for implementing said method.
摘要翻译：本发明涉及一种用于控制怀疑含有各种微生物的环境水性介质的微生物学质量的方法，其包括以下步骤：选择由至少三种微生物组成的参考文献，其共同或分别表示微生物质量水平; 提供微生物检测试剂盒，由至少三个探针组成，分别鉴定所述三种微生物; 在处理要分析的培养基之后，将所述微生物或其衍生自待分析培养基的任何部分与所述检测试剂盒接触，由此进行所述微生物的多重测定，所述测定代表微生物质量水平的介质。本发明还涉及用于实施所述方法的合适的微生物检测试剂盒。

2. 发明申请

WO0202811A3 METHOD FOR CONTROLLING THE MICROBIOLOGICAL QUALITY OF AN AQUEOUS MEDIUM AND KIT THEREFOR 审中-公开
标题翻译：用于控制水性中等微量元素及其制品的微生物学质量的方法
公开(公告)号：WO0202811A3
公开(公告)日：2003-03-20
申请号：PCT/FR0102191
申请日：2001-07-06
申请人： BIO MERIEUX , RENAUD PATRICIA , GUILLOT EMMANUELLE , MABILAT CLAUDE , VACHON CAROLE , LACROIX BRUNO , VERNET GUY , ARMAND MARIE-ASTRID , LAFFAIRE PHILIPPE
发明人： RENAUD PATRICIA , GUILLOT EMMANUELLE , MABILAT CLAUDE , VACHON CAROLE , LACROIX BRUNO , VERNET GUY , ARMAND MARIE-ASTRID , LAFFAIRE PHILIPPE
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , C12Q1/70 , C12R1/19 , G01N33/18 , G01N33/569 , G01N37/00
CPC分类号： C12Q1/701 , C12Q1/689 , C12Q1/6893
摘要： The invention concerns a method for controlling the microbiological quality of an environmental aqueous medium, suspected of containing various micro-organisms, comprising the following steps: selecting a reference set, consisting of at least three micro-organisms, representing jointly or separately, a microbiological quality level; providing a microbiological detection kit, consisting of at least three probes specifically and respectively identifying said three micro-organisms; after treating the medium to be analysed, contacting said micro-organisms, or any fraction thereof derived from the medium to be analysed therefrom, with said detection kit, whereby a multiple determination of said micro-organisms is carried out, said determination representing the microbiological quality level of the medium. The invention also concerns an appropriate microbiological detection kit for implementing said method.
摘要翻译：本发明涉及一种用于控制怀疑含有各种微生物的环境水性介质的微生物学质量的方法，包括以下步骤：选择由至少三种微生物组成的参考文献，所述微生物共同或分别代表微生物质量水平; 提供微生物检测试剂盒，由至少三个探针组成，分别鉴定所述三种微生物; 在处理要分析的培养基之后，将所述微生物或其衍生自待分析培养基的任何部分与所述检测试剂盒接触，由此进行所述微生物的多重测定，所述测定代表微生物质量水平的介质。本发明还涉及用于实施所述方法的合适的微生物检测试剂盒。

3. 发明申请

WO2007060366A1 OLIGONUCLEOTIDES, UTILISATION, METHODE DE DETECTION ET KIT PERMETTANT DE DIAGNOSTIQUER LA PRESENCE DES GENES H5 ET N1 DU VIRUS D'INFLUENZA A 审中-公开
标题翻译：寡核苷酸，其用途，用于诊断流感病毒H5和N1基因存在的检测方法和试剂盒
公开(公告)号：WO2007060366A1
公开(公告)日：2007-05-31
申请号：PCT/FR2006/051218
申请日：2006-11-23
申请人： BIOMÉRIEUX , LEFEUVRE, Aurélie , TELLES, Jean-Noël , VERNET, Guy
发明人： LEFEUVRE, Aurélie , TELLES, Jean-Noël , VERNET, Guy
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701
摘要： La présente invention concerne une double paire d'oligonucléotides destinée à permettre l'amplification de deux séquences cibles localisées respectivement dans les gènes H5 et N1 du génome du virus d' Influenza A, ces oligonucléotides étant d'une longueur comprise entre 10 et 50 nucléotides et comprenant au moins un fragment de 10 nucléotides consécutifs issus des séquences suivantes : SEQ ID No. 1 : TGTATGTTGTGGAATGGCA, SEQ ID No. 2 : GCCGAATGATGCCATCAA, SEQ ID No. 3 : CGTGGATTGTCTCCGAAA, et SEQ ID No. 4 : GGAATGCTCCTGTTATCCTGA, ou leur séquence complémentaire. L'invention concerne également des oligonucléotides permettant la détections des amplicons, l'utilisation de toutes ces séquences, une méthode de détection et un kit afin de diagnostiquer la présence des gènes H5 et N1 du virus d' Influenza A. L'invention trouve une application préférentielle dans le domaine du diagnostic.
摘要翻译：本发明涉及用于扩增分别位于甲型流感病毒基因组的H5和N1基因中的两个靶序列的双对寡核苷酸，所述寡核苷酸的长度范围在10至50个核苷酸之间并且包含至少10个片段衍生自以下序列的连续核苷酸：SEQ ID No.1：TGTATGTTGTGGAATGGCA，SEQ ID No.2：GCCGAATGATGCCATCAA，SEQ ID No.3：CGTGGATTGTCTCCGAAA和SEQ ID No.4：GGAATGCTCCTGTTATCCTGA或其互补序列。本发明还涉及用于检测扩增子的寡核苷酸，所有这些序列的使用，用于检测甲型流感病毒基因H5和N1的方法。本发明特别适用于诊断领域。

4. 发明申请

WO2006008575A9 CONSTRUCTION OF A COMPARATIVE DATABASE AND IDENTIFICAITON OF VIRULENCE FACTORS THROUGH COMPARISON OF POLYMORPHIC REGIONS IN CLINICAL ISOLATES OF INFECTIOUS ORGANISMS 审中-公开
标题翻译：通过对感染性有机体临床分离株中多态性区域的比较，构建比较数据库和维生素因子的鉴定
公开(公告)号：WO2006008575A9
公开(公告)日：2010-08-12
申请号：PCT/IB2004002598
申请日：2004-07-12
申请人： AVESTHA GENGRAINE TECH PVT LTD , BIOMERIEUX SA , PATELL VILLOO MORAWALA , RAJYASHRI K R , RODRIGUE MARC , VERNET GUY
发明人： PATELL VILLOO MORAWALA , RAJYASHRI K R , RODRIGUE MARC , VERNET GUY
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156

5. 发明申请

WO0220852A9 AMPLIFICATION OF HIV-1 SEQUENCES FOR DETECTION OF SEQUENCES ASSOCIATED WITH DRUG-RESISTANCE MUTATIONS 审中-公开
标题翻译：用于检测与药物耐药突变相关的序列的HIV-1序列的扩增
公开(公告)号：WO0220852A9
公开(公告)日：2008-04-03
申请号：PCT/US0024117
申请日：2000-09-01
申请人： GEN PROBE INC , BIOMERIEUX SA , YANG YEASING Y , BRENTANO STEVEN T , BABOLA ODILE , TRAN NATHALIE , VERNET GUY
发明人： YANG YEASING Y , BRENTANO STEVEN T , BABOLA ODILE , TRAN NATHALIE , VERNET GUY
IPC分类号： C12N15/09 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/703 , C12Q1/6865
摘要： Sequences of nucleic acid oligonucleotides for amplifying different portions of gag and pol genes of HIV-1 and for detecting such amplified nucleic acid sequences are disclosed. Methods of amplifying and detecting HIV-1 nucleic acid in a biological sample using theamplification oligonucleotides specific forgag and pol target sequences are disclosed.
摘要翻译：公开了用于扩增HIV-1的gag和pol基因的不同部分的核酸寡核苷酸的序列和用于检测这种扩增的核酸序列的序列。公开了使用扩增寡核苷酸特异性forgag和pol靶序列扩增和检测生物样品中HIV-1核酸的方法。

6. 发明申请

WO2006008575A2 CONSTRUCTION OF A COMPARATIVE DATABASE AND IDENTIFICAITON OF VIRULENCE FACTORS THROUGH COMPARISON OF POLYMORPHIC REGIONS IN CLINICAL ISOLATES OF INFECTIOUS ORGANISMS 审中-公开
标题翻译：通过对感染性有机体临床分离株中多态性区域的比较，构建比较数据库和鉴定因子的鉴定
公开(公告)号：WO2006008575A2
公开(公告)日：2006-01-26
申请号：PCT/IB2004/002598
申请日：2004-07-12
申请人： AVESTHA GENGRAINE TECHNOLOGIES PVT. LTD. , BIOMERIEUX SA , PATELL, Villoo, Morawala , RAJYASHRI, K., R. , RODRIGUE, Marc , VERNET, Guy
发明人： PATELL, Villoo, Morawala , RAJYASHRI, K., R. , RODRIGUE, Marc , VERNET, Guy
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The present invention is directed to novel nucleotide sequences to be used for diagnosis, identification of the strain, typing of the strain and giving orientation to its potential degree of virulence, infectivity and/or latency for all infectious diseases more particularly tuberculosis. The present invention also includes method for the identification and selection of polymorphisms associated with the virulence' and /or infectivity in infectious diseases more particularly in tuberculosis by a comparative genomic analysis of the sequences of different clinical isolates/strains of infectious organisms. The regions of polymorphisms, can also act as potential drug targets and vaccine targets. More particularly, the invention also relates to identifying virulence factors of M. tuberculosis strains and other infectious organisms to be included in a diagnostic DNA chip allowing identification of the strain, typing of the strain and finally giving orientation to its potential degree of virulence. Although the present invention has been illustrated with specific reference to the polymorphic region in the Mycobacterium tuberculosis, the said invention is not to be understood and construed as being limited to Tuberculosis but is applicable to all infectious diseases.
摘要翻译：本发明涉及新的核苷酸序列，用于诊断，鉴定菌株，分型和赋予其潜在的毒性程度，感染性和/或所有感染性疾病特别是结核病的潜伏期的方向。本发明还包括通过对不同临床分离株/感染性生物菌株的序列的比较基因组分析来鉴定和选择与感染性疾病相关的多态性和/或感染性疾病更特别地在结核病中的方法。多态性区域也可以作为潜在的药物靶点和疫苗靶点。更具体地，本发明还涉及鉴定要包括在诊断DNA芯片中的结核分枝杆菌菌株和其他感染性生物体的毒力因子，其允许鉴定菌株，分选菌株并最终给出其潜在的毒力程度。虽然已经具体参考结核分枝杆菌中的多态性区域来说明了本发明，但是本发明不被理解为并且被解释为限于结核病，而是适用于所有感染性疾病。

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