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1. 发明申请

WO2011162820A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011162820A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/001127
申请日：2011-06-23
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/48 , G01N33/53
CPC分类号： G01N33/6893 , G01N33/6854 , G01N33/6863 , G01N33/74 , G01N2333/4725 , G01N2333/4745 , G01N2333/495 , G01N2333/521 , G01N2333/5431 , G01N2333/7155 , G01N2333/96472 , G01N2333/96494 , G01N2800/347 , G01N2800/50 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cancer antigen CA 15-3, C-C Motif chemokine 18, C-C Motif chemokine 24, Cathepsin D, C-X-C Motif chemokine 13, C-C motif chemokine 8, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, Interleukin-11, Matrix Metalloproteinase-8, Transforming growth factor alpha, IgG1, and IgG2 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自下组的肾损伤标记：癌抗原CA 15-3，CC基序趋化因子18，CC基序趋化因子24，组织蛋白酶D，CXC基序趋化因子13 ，CC基序趋化因子8，白细胞介素-2受体α链，胰岛素样生长因子结合蛋白3，白细胞介素-11，基质金属蛋白酶-8，转化生长因子α，IgG1和IgG2作为肾损伤中的诊断和预后生物标志物。

2. 发明申请

WO2011097541A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011097541A2
公开(公告)日：2011-08-11
申请号：PCT/US2011/023832
申请日：2011-02-04
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/4737 , G01N2333/524 , G01N2333/5409 , G01N2333/585 , G01N2333/70525 , G01N2333/7155 , G01N2333/745 , G01N2333/75 , G01N2333/775 , G01N2333/8107 , G01N2333/96486 , G01N2800/00 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Interleukin-5, Interleukin-6 receptor subunit beta, Tissue factor, Sex hormone-binding globulin, Alpha-2-macroglobulin, Apolipoprotein A-I, Calcitonin, Thrombopoietin, C-reactive protein, Intercellular adhesion molecule 3, Macrophage metalloelastase, Apolipoprotein B-100, and Fibrinogen as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自白细胞介素-5，白细胞介素-6受体亚单位β，组织因子，性激素结合球蛋白，α-2- 巨球蛋白，载脂蛋白AI，降钙素，血小板生成素，C-反应蛋白，细胞间粘附分子3，巨噬细胞金属弹性蛋白酶，载脂蛋白B-100和纤维蛋白原作为肾损伤的诊断和预后生物标志物。

3. 发明申请

WO2011097539A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011097539A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023830
申请日：2011-02-04
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： C12Q1/68 , G01N33/567
CPC分类号： G01N33/6893 , G01N33/6863 , G01N33/86 , G01N2333/4745 , G01N2333/522 , G01N2333/96447 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Coagulation factor VII, CA 19-9, Insulin-like growth factor-binding protein 7, C-X-C motif chemokine 6, and C-C motif chemokine 13 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自凝血因子VII，CA19-9，胰岛素样生长因子结合蛋白7，CXC基序趋化因子6，和CC基序趋化因子13作为肾损伤的诊断和预后生物标志物。

4. 发明申请

WO2011057147A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011057147A1
公开(公告)日：2011-05-12
申请号：PCT/US2010/055730
申请日：2010-11-05
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6842 , G01N33/6893 , G01N2333/96413 , G01N2800/347 , G01N2800/56 , Y02A90/26
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Cathepsin B, Renin, Dipeptidyl Peptidase IV, Neprilysin, Beta-2- microglobulin, Carbonic anhydrase IX, and C-X-C motif chemokine 2 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自组织蛋白酶B，肾素，二肽基肽酶IV，Neprilysin，β-2-微球蛋白，碳酸酐酶IX和CXC基序的肾损伤标记趋化因子2作为肾损伤的诊断和预后生物标志物。

5. 发明申请

WO2013043310A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2013043310A1
公开(公告)日：2013-03-28
申请号：PCT/US2012/052298
申请日：2012-08-24
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/50 , G01N2800/60
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Heat shock 70 kDa protein 1, Alpha-1-antitrypsin Neutrophil elastase complex, Stromelysin-1 :Metalloproteinase inhibitor 2 complex, 72 kDa type IV collagenase: Metalloproteinase inhibitor 2 complex, Insulin-like growth factor 1 receptor, Myeloid differentiation primary response protein MyD88, Neuronal cell adhesion molecule, and Tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自热休克70kDa蛋白1，α-1-抗胰蛋白胨中性粒细胞弹性蛋白酶复合物，溶血素蛋白酶-1：金属蛋白酶抑制剂2复合物的肾损伤标记物，72kDa IV型胶原酶：金属蛋白酶抑制剂2复合物，胰岛素样生长因子1受体，骨髓分化初级应答蛋白MyD88，神经元细胞粘附分子和肿瘤坏死因子配体超家族成员10作为肾损伤中的诊断和预后生物标志物。

6. 发明申请

WO2012094658A3 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
公开(公告)号：WO2012094658A3
公开(公告)日：2012-07-12
申请号：PCT/US2012/020572
申请日：2012-01-08
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/53 , G01N33/00 , G01N33/48 , G01N33/543
摘要： The disclosure relates to methods and compositions (or monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the disclosure relates to using one or more assays configure to detect a kidney Injury marker selected from the group consisting of Proheparin-binding EGF-like growth factor, Tenascin C, Anglopoietinrelated protein 4, Fibroblast growth factor 19, Fibroblast growth factor 21, Heparlnbinding growth factor 1, Angiopoietin- related protein 6, Proepiregulin, Probetacellulln, Amphiregulin, Angiogenln, Thrombospondin-2, and Collagen alpha-1 (XVIII) chain as diagnostic and prognostic biomarker in renal injuries.

7. 发明申请

WO2012094657A1 METHOD AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2012094657A1
公开(公告)日：2012-07-12
申请号：PCT/US2012/020571
申请日：2012-01-08
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/20
CPC分类号： G01N33/6893 , A61B10/007 , G01N2333/47 , G01N2800/347
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect Trefoil factor 3 as diagnostic and prognostic biomarker assays in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用检测Trefoil因子3作为肾损伤中的诊断和预后生物标志物测定的测定法。

8. 发明申请

WO2011075744A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011075744A1
公开(公告)日：2011-06-23
申请号：PCT/US2010/061377
申请日：2010-12-20
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2800/347 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a plurality of assays, one or more of which is configured to detect a kidney injury marker selected from the group consisting of Hyaluronic acid, Immunoglobulin A, Immunoglobulin Gl, Immunoglobulin G2, Insulin-like growth factor-binding protein 7, Alpha- 1 antitrypsin, Serum amyloid P component, Metalloproteinase inhibitor 2, Hepatocyte growth factor, Intercellular adhesion molecule 1, Beta-2-glycoprotein 1, Interleukin-1 beta, Neutrophil Elastase, Tumor necrosis factor receptor superfamily member HB, Interleukin-11, Cathepsin D, C-C motif chemokine 24, C-X-C motif chemokine 6, C-C motif chemokine 13, C-X-C motif chemokines -1, -2, and -3, Matrilysin, Interleukin-2 receptor alpha chain, Insulin-like growth factor-binding protein 3, and Macrophage colony-stimulating factor 1 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用多个测定，其中一个或多个测定被配置为检测选自透明质酸，免疫球蛋白A，免疫球蛋白G1，免疫球蛋白G2，胰岛素样生长因子 - 结合蛋白7，α-1抗胰蛋白酶，血清淀粉样蛋白P成分，金属蛋白酶抑制剂2，肝细胞生长因子，细胞间粘附分子1，β-2-糖蛋白1，白细胞介素-1β，嗜中性粒细胞弹性蛋白酶，肿瘤坏死因子受体超家族成员HB，白细胞介素-11，组织蛋白酶D，CC基序趋化因子24，CXC基序趋化因子6，CC基序趋化因子13，CXC基序趋化因子-1，-2和-3，Matrilysin，白细胞介素-2受体α链，胰岛素样生长因子 - 结合蛋白3和巨噬细胞集落刺激因子1作为肾损伤中的诊断和预后生物标志物。

9. 发明申请

WO2012103450A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2012103450A2
公开(公告)日：2012-08-02
申请号：PCT/US2012/022926
申请日：2012-01-27
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/515 , G01N2333/705 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Angiopoietin-related protein 3, Soluble Lymphatic vessel endothelial hyaluronic acid receptor 1, and Vascular endothelial growth factor D as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自以下的肾损伤标志物：血管生成素相关蛋白3，可溶性淋巴管内皮透明质酸受体1和血管内皮生长因子D作为诊断和肾损伤的预后生物标志物。

10. 发明申请

WO2011097540A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
公开(公告)号：WO2011097540A1
公开(公告)日：2011-08-11
申请号：PCT/US2011/023831
申请日：2011-02-04
申请人： ASTUTE MEDICAL, INC. , ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： C12Q1/68 , G01N33/567
CPC分类号： G01N33/6863 , G01N33/74 , G01N2333/5437 , G01N2333/5754 , G01N2333/61 , G01N2800/347 , G01N2800/50 , G01N2800/52
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Endothelin-1, Somatotropin, and Interleukin-13 as diagnostic and prognostic biomarkers in renal injuries.
摘要翻译：本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自由内皮素-1，生长激素和白细胞介素-13组成的组的肾损伤标志物，作为肾损伤中的诊断和预后生物标志物。

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