专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004110982A1 PROCESSES FOR PREPARING (2S)-3-(4-{2-[AMINO]-2-OXOETHOXY}PHENYL)-2-ETHOXYPROPANOIC ACID DERIVATIVES 审中-公开
标题翻译：制备（2S）-3-（4- {2- [氨基] -2-氧代乙基}苯基）-2-乙氧基丙酸衍生物的方法
公开(公告)号：WO2004110982A1
公开(公告)日：2004-12-23
申请号：PCT/SE2004/000966
申请日：2004-06-16
申请人： ASTRAZENECA AB , AURELL, Carl-Johan , MACEDO, Emmanuel , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail
发明人： AURELL, Carl-Johan , MACEDO, Emmanuel , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail
IPC分类号： C07C231/08
CPC分类号： C07C235/20 , C07C231/08 , Y02P20/55
摘要： The present invention provides a process for the preparation of a compound of formula I [Chemical formula should be inserted here. Please see paper copy] in which a compound of formula II [Chemical formula should be inserted here. Please see paper copy] in which R is H or OR represents a protecting group for a carboxylic hydroxy group is reacted with a compound of formula III C 6 H 13 X wherein X is a leaving group, in the presence of a base in the presence of an inert solvent at a temperature in the range -25°C to 150°C and optionally, when OR represents a protecting group, removal of the protecting group.
摘要翻译：本发明提供了制备式I化合物的方法[化学式应在此插入。请参见纸质文件]，其中应将式Ⅱ化合物[化学式在此插入。请参见纸张文件]，其中R为H或OR表示羧基羟基的保护基团与式III的化合物C6H13X（其中X为离去基团）在碱存在下，在惰性溶剂在-25℃至150℃的温度范围内，任选地，当OR表示保护基时，除去保护基。

2. 发明申请

WO2004056748A1 THERAPEUTIC AGENTS 审中-公开
标题翻译：治疗药剂
公开(公告)号：WO2004056748A1
公开(公告)日：2004-07-08
申请号：PCT/GB2003/005602
申请日：2003-12-19
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , LINDSTEDT ALSTERMARK, Eva-Lotte , OLSSON, Anna, Christina , LI, Lanna , AURELL, Carl-Johan , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail , DAHLSTROM, Mikael, Ulf, Johan
发明人： LINDSTEDT ALSTERMARK, Eva-Lotte , OLSSON, Anna, Christina , LI, Lanna , AURELL, Carl-Johan , MINIDIS, Anna , YOUSEFI-SALAKDEH, Esmail , DAHLSTROM, Mikael, Ulf, Johan
IPC分类号： C07C235/20
CPC分类号： A61K31/16 , C07C235/20
摘要： The present invention provides the S enantiomer of a compound of formula (I) wherein R 1 represents chloro, trifluoromethyl or trifluoromethoxy, R 2 represents H or fluoro and R 3 represents a C 2-4 alkyl group as well as pharmaceutically acceptable salts, solvates and prodrugs thereof, to processes for preparing such compounds, to their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
摘要翻译：本发明提供式（I）化合物的S对映异构体，其中R 1表示氯，三氟甲基或三氟甲氧基，R 2表示H或氟，R 3表示C 2-4烷基，用于制备此类化合物的方法，用于治疗临床状况，包括不论是否与胰岛素抵抗相关的脂质紊乱（血脂异常），其治疗用途的方法和含有它们的药物组合物。

3. 发明申请

WO2004110984A1 PHARMACEUTICALLY USEFUL SALTS OF CARBOXYLIC ACID DERIVATES 审中-公开
标题翻译：羧甲酸衍生物的药用有效的盐
公开(公告)号：WO2004110984A1
公开(公告)日：2004-12-23
申请号：PCT/SE2004/000964
申请日：2004-06-16
申请人： ASTRAZENECA AB , AURELL, Carl-Johan , DAHLSTRÖM, Mikael , LINDSTEDT-ALSTERMARK, Eva-Lotte , MINIDIS, Anna , OHLSSON, Bengt , STÅHLE, Erica
发明人： AURELL, Carl-Johan , DAHLSTRÖM, Mikael , LINDSTEDT-ALSTERMARK, Eva-Lotte , MINIDIS, Anna , OHLSSON, Bengt , STÅHLE, Erica
IPC分类号： C07C235/20
CPC分类号： C07C235/20 , C07B2200/07
摘要： A compound selected from one or more of the following: a ( 1 R ,2 S )-2-hydroxyindan-1-amine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an L-arginine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a tert -butylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino-2-oxoethoxyphenyl)propanoic acid; a choline salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; an adamantylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N -benzyl-2-phenylethanaminium salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; a N -benzyl-2-(benzylamino) ethanaminium salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid; or a tris(hydroxymethyl)methylamine salt of (2 S )-2-ethoxy-3-(4-{2-[hexyl(2-phenylethyl)amino]-2-oxoethoxy}phenyl)propanoic acid.
摘要翻译：选自下列一种或多种的化合物：（2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基-2-氧代乙氧基苯基）丙酸的L-精氨酸盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基-2-氧代乙氧基苯基）丙酸的叔丁基胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的胆碱盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的金刚烷基胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的N-苄基-2-苯基乙胺盐; （2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的N-苄基-2-（苄基氨基）乙胺盐; 或（2S）-2-乙氧基-3-（4- {2- [己基（2-苯基乙基）氨基] -2-氧代乙氧基}苯基）丙酸的三（羟甲基）甲胺盐。

4. 发明申请

WO2012044243A1 CRYSTALLINE NALOXOL-PEG CONJUGATE 审中-公开
标题翻译：结晶NALOXOL-PEG结合物
公开(公告)号：WO2012044243A1
公开(公告)日：2012-04-05
申请号：PCT/SE2011/051161
申请日：2011-09-29
申请人： ASTRAZENECA AB , NEKTAR THERAPEUTICS , ÅSLUND, Bengt Leonard , AURELL, Carl-Johan , BOHLIN, Martin Hans , SEBHATU, Tesfai , YMÉN, Bo Ingvar , HEALY, Eric Thomas , JENSEN, David Richard , JONAITIS, David Thomas , PARENT, Stephan
发明人： ÅSLUND, Bengt Leonard , AURELL, Carl-Johan , BOHLIN, Martin Hans , SEBHATU, Tesfai , YMÉN, Bo Ingvar , HEALY, Eric Thomas , JENSEN, David Richard , JONAITIS, David Thomas , PARENT, Stephan
IPC分类号： A61K31/485 , A61K31/765 , A61P25/04 , A61K31/194 , A61K33/42
CPC分类号： A61K47/48215 , A61K47/60 , C07B2200/13 , C07C51/41 , C07C55/07 , C07D489/04
摘要： Naloxol-polyethlyene glycol conjugates of the formula:are provided in oxalate or phosphate salt forms including crystalline forms. Methods of preparing the salt forms and pharmaceutical compositions comprising the salt forms are also provided.
摘要翻译：下式的纳洛酮 - 聚乙二醇共轭物以草酸盐或磷酸盐形式提供，包括结晶形式。还提供了制备盐形式的方法和包含盐形式的药物组合物。

5. 发明申请

WO2012039657A1 NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS 审中-公开
标题翻译：用于治疗疼痛病症的新型色素化合物
公开(公告)号：WO2012039657A1
公开(公告)日：2012-03-29
申请号：PCT/SE2010/051021
申请日：2010-09-22
申请人： ASTRAZENECA AB , AURELL, Carl-Johan , BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin
发明人： AURELL, Carl-Johan , BESIDSKI, Yevgeni , KERS, Inger , NYLÖF, Martin
IPC分类号： C07D405/14 , A61K31/497 , A61P29/00
CPC分类号： C07D405/14 , C07D311/62 , C07D405/04 , C07F5/025
摘要： The present invention relates to the compound N-[(3S)-5-(5-methoxypyrazin-2-yl)-3,4- dihydro-2H-chromen-3-yl]-6-[(2,2,2-trifluoroethoxy)methyl]pyridine-3-carboxamide, or a pharmaceutical composition comprising said compound and to the use of said compounds in therapy.
摘要翻译：本发明涉及化合物N - [（3S）-5-（5-甲氧基吡嗪-2-基）-3,4-二氢-2H-色烯-3-基] -6 - [（2,2,2 - 三氟乙氧基）甲基]吡啶-3-甲酰胺，或包含所述化合物的药物组合物和所述化合物在治疗中的用途。

6. 发明申请

WO2008004945A1 NOVEL CRYSTALLINE FORMS I AND II 审中-公开
标题翻译：新一代晶体I和II
公开(公告)号：WO2008004945A1
公开(公告)日：2008-01-10
申请号：PCT/SE2007/000645
申请日：2007-07-02
申请人： ASTRAZENECA AB , ANDERSEN, Soren , AURELL, Carl-Johan , ERIKSSON, Caroline , SIGFRIDSSON, Carl-Gustav , ZETTERBERG, Fredrik
发明人： ANDERSEN, Soren , AURELL, Carl-Johan , ERIKSSON, Caroline , SIGFRIDSSON, Carl-Gustav , ZETTERBERG, Fredrik
IPC分类号： C07D401/04 , A61K31/455 , A61P7/02
CPC分类号： C07D401/04
摘要： The present invention relates to 6-(4-{[(benzylsulfonyl)amino]carbonyl}piperidin-1-yl)-5-cyano-2-methylnicotinic acid ethyl ester, form I and II, to processes for preparing such compounds, to their utility as P2Y 12 inhibitors and as anti-thrombotic agents etc, their use as medicaments in cardiovascular diseases as well as pharmaceutical compositions containing them.
摘要翻译：本发明涉及6-（4 - {[（苄基磺酰基）氨基]羰基}哌啶-1-基）-5-氰基-2-甲基烟酸乙酯I和II型，用于制备这些化合物，它们作为P2Y 12抑制剂的用途和作为抗血栓形成剂等，其作为心血管疾病中的药物的用途以及含有它们的药物组合物。

7. 发明申请

WO2002053617A1 LINEAR BLOCK POLYMER 审中-公开
标题翻译：线性块聚合物
公开(公告)号：WO2002053617A1
公开(公告)日：2002-07-11
申请号：PCT/SE2001/002902
申请日：2001-12-27
申请人： ARTIMPLANT AB , AURELL, Carl-Johan , FLODIN, Per
发明人： AURELL, Carl-Johan , FLODIN, Per
IPC分类号： C08G18/10
CPC分类号： A61K9/0024 , A61K47/34 , A61L15/26 , A61L27/18 , C08G18/10 , C08G18/4277 , C08G18/797 , C08G2101/00 , C08L75/00 , C08G18/3271
摘要： The present invention relates to a linear block polymer having a molecular weight of at least 10 4 Dalton, which linear block polymer is comprised of internally linearly connected sequences, which sequences may be described according to formula (I), wherein 1 to 100 % of R 1 , which 1 to 100 % of R 1 may be the same or different, comprise a functional group Z and each Z, which Z may be the same or different, is a protected or unprotected functional group such as hydroxyl, amino, carboxyl, thiol, cyano, or nitro group; and, each R 2 , which R 2 may be same or different, may be derived from a diisocyanate and comprises no, one or more ester groups; each R 3 , which R 3 may be same or different, comprises no, one or more ester groups and may be derived from one or more of polyesterdiol, polyetherdiol or monodiol; method for preparation and fractional precipitation, implants, material for promotion of wound healing, pharmaceutical compositions, microencapsules, suspensions and emulsions.
摘要翻译：本发明涉及分子量为至少10 -4道尔顿的线性嵌段聚合物，该线性嵌段聚合物由内部线性连接的序列组成，该序列可以根据式（1）描述，其中1至100 R1的1至100％可以相同或不同的R1包含官能团Z，Z可以相同或不同，Z是被保护或未被保护的官能团，例如羟基，氨基，羧基，硫醇，氰基或硝基; 并且R 2可以相同或不同，各个R 2可以衍生自二异氰酸酯并且不包括一个或多个酯基; 每个R 3可以相同或不同，R 3包括一个或多个酯基，并且可以衍生自聚酯二醇，聚醚二醇或单二醇中的一种或多种; 制备和分级沉淀的方法，植入物，促进伤口愈合的材料，药物组合物，微胶囊，悬浮液和乳液。

8. 发明申请

WO2020016302A1 A XINAFOATE SALT OF A JAK INHIBITING COMPOUND 审中-公开
公开(公告)号：WO2020016302A1
公开(公告)日：2020-01-23
申请号：PCT/EP2019/069252
申请日：2019-07-17
申请人： ASTRAZENECA AB
发明人： PETTERSEN, Anna, Matilda, Angelica , MCCABE, James , AURELL, Carl-Johan
IPC分类号： C07D403/04 , A61P11/06 , A61K31/506
摘要： The present disclosure relates to salts of compounds of Formula (I) prepared as a xinafoate (1-hydroxy-2-naphthoate) salt (Formula (Ia)), pharmaceutically acceptable compositions comprising same and methods of using the same.

9. 发明申请

WO2015110826A1 (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS 审中-公开
标题翻译：（2S）-N - [（1S）-1-氰基-2-苯基] -1,4-氧杂环己烷-2-羧酰胺作为DIPEPTIDYL PEPTIDASE I抑制剂
公开(公告)号：WO2015110826A1
公开(公告)日：2015-07-30
申请号：PCT/GB2015/050155
申请日：2015-01-23
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED
发明人： LÖNN, Hans, Roland , CONNOLLY, Stephen , SWALLOW, Steven , KARLSSON, Staffan PO , AURELL, Carl-Johan , PONTÉN, John Fritiof , DOYLE, Kevin, James , VAN DE POËL, Amanda, Jane , JONES, Graham, Peter , WATSON, David, Wyn , MACRITCHIE, Jaqueline, Anne , PALMER, Nicholas, John
IPC分类号： C07D267/10 , C07D413/14 , C07D413/12 , C07D417/12 , A61K31/553 , A61P11/00
CPC分类号： C07D267/10 , A61K31/553 , A61K45/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The present disclosure relates to certain (2 S )- N -[(1 S )-1-cyano-2-phenylethyl]-1,4- oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof), (Formula (I)) that inhibit dipeptidyl peptidase 1(DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.
摘要翻译：本公开内容涉及某些（2S）-N - [（1S）-1-氰基-2-苯基乙基] -1,4-氧氮杂环庚烷-2-甲酰胺化合物（包括其药学上可接受的盐），（式（I））抑制二肽基肽酶1（DPP1）活性在治疗和/或预防包括呼吸系统疾病如哮喘和慢性阻塞性肺疾病（COPD）在内的临床病症中的用途，用于治疗，包含它们的药物组合物和制备这些化合物的方法。

10. 发明公开

EP3323814A1 (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES AS DIPEPTIDYL PEPTIDASE I INHIBITORS 有权转让
公开(公告)号：EP3323814A1
公开(公告)日：2018-05-23
申请号：EP17195612.1
申请日：2015-01-23
申请人： AstraZeneca AB
发明人： LÖNN, Hans, Roland , CONNOLLY, Stephen , SWALLOW, Steven , KARLSSON, Staffan PO , AURELL, Carl-Johan , PONTÉN, John Fritiof , DOYLE, Kevin, James , VAN DE POËL, Amanda, Jane , JONES, Graham, Peter , WATSON, David, Wyn , MACRITCHIE, Jaqueline, Anne , PALMER, Nicholas, John
IPC分类号： C07D267/10 , C07D413/14 , C07D413/12 , C07D417/12 , A61K31/553 , A61P11/00
摘要： The present disclosure relates to certain (2 S )- N -[(1 S )-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamide compounds (including pharmaceutically acceptable salts thereof),

that inhibit dipeptidyl peptidase 1 (DPP1) activity, to their utility in treating and/or preventing clinical conditions including respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), to their use in therapy, to pharmaceutical compositions containing them and to processes for preparing such compounds.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式