专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006004191A1 PYRROLOPYRIDAZINE DERIVATIVES WHICH INHIBIT PDE IV AND TNF ALFA 审中-公开
标题翻译：抑制PDE IV和TNF ALFA的吡咯并吡啶衍生物
公开(公告)号：WO2006004191A1
公开(公告)日：2006-01-12
申请号：PCT/JP2005/012622
申请日：2005-07-01
申请人： ASTELLAS PHARMA INC. , ABE, Yoshito , INOUE, Makoto , OKUMURA, Mitsuaki , OHNE, Kazuhiko , SATO, Kentaro
发明人： ABE, Yoshito , INOUE, Makoto , OKUMURA, Mitsuaki , OHNE, Kazuhiko , SATO, Kentaro
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R 1 , R 2 , R 3 and R 4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R

2. 发明申请

WO2006004188A1 PYRAZOLOPYRIDINE DERIVATIVES 审中-公开
标题翻译：吡唑并吡啶衍生物
公开(公告)号：WO2006004188A1
公开(公告)日：2006-01-12
申请号：PCT/JP2005/012618
申请日：2005-07-01
申请人： ASTELLAS PHARMA INC. , ABE, Yoshito , OHNE, Kazuhiko , SATO, Kentaro , INOUE, Makoto , OKUMURA, Mitsuaki
发明人： ABE, Yoshito , OHNE, Kazuhiko , SATO, Kentaro , INOUE, Makoto , OKUMURA, Mitsuaki
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R 1 , R 2 , R 3 and R 4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病。

3. 发明申请

WO2004063197A1 PYRROLOPYRIDAZINE DERIVATIVES 审中-公开
标题翻译：吡咯烷酮衍生物
公开(公告)号：WO2004063197A1
公开(公告)日：2004-07-29
申请号：PCT/JP2003/017091
申请日：2003-12-26
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , ABE, Yoshito , INOUE, Makoto , MIZUTANI, Tsuyoshi , SAWADA, Kozo , OHNE, Kazuhiko , OKUMURA, Mitsuaki , SAWADA, Yuki , IMAMURA, Kenichiro
发明人： ABE, Yoshito , INOUE, Makoto , MIZUTANI, Tsuyoshi , SAWADA, Kozo , OHNE, Kazuhiko , OKUMURA, Mitsuaki , SAWADA, Yuki , IMAMURA, Kenichiro
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R 1 , R 2 , R 3 and R 4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 4如说明书中所定义，它们作为药物的用途，其制备和用途用于治疗PDE-IV或TNF-α介导的疾病。

4. 发明申请

WO2003022842A1 THIOPHENYLTHIOPYRANE DIOXIDES AS MMP OR TNF-ALPHA INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶或TNF-ALPHA抑制剂的十二烷基二甲氧基硅氧烷
公开(公告)号：WO2003022842A1
公开(公告)日：2003-03-20
申请号：PCT/JP2002/008895
申请日：2002-09-02
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , NEYA, Masahiro , SAWADA, Akihiko , OHNE, Kazuhiko , ABE, Yoshito , MIZUTANI, Tsuyoshi , ISHIBASHI, Naoki , INOUE, Makoto
发明人： NEYA, Masahiro , SAWADA, Akihiko , OHNE, Kazuhiko , ABE, Yoshito , MIZUTANI, Tsuyoshi , ISHIBASHI, Naoki , INOUE, Makoto
IPC分类号： C07D409/04
CPC分类号： C07D409/04 , C07D409/14 , C07D413/14 , C07D417/14 , C07F7/0812
摘要： A compound of the formula : in which R 1 is optionally substituted phenyl, optionally substituted naphthyl, optionally substituted bicyclic heterocyclic group, optionally substituted lower alkenyl or optionally substituted lower alkynyl, and R 2 is carboxy or protected carboxy, or a salt thereof, useful for treating and/or preventing MMP- or TNF-α mediated diseases.
摘要翻译：下式的化合物：其中R 1是任选取代的苯基，任选取代的萘基，任选取代的双环杂环基，任选取代的低级烯基或任选取代的低级炔基，R 2是羧基或保护的羧基，或其盐，其可用于治疗和/或预防MMP-或TNF-α介导的疾病。

5. 发明申请

WO2012054510A1 OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF 审中-公开
标题翻译：抑制β-分泌酶活性的OXADIAZOLE化合物及其使用方法
公开(公告)号：WO2012054510A1
公开(公告)日：2012-04-26
申请号：PCT/US2011/056747
申请日：2011-10-18
申请人： COMENTIS, INC. , ASTELLAS PHARMA INC. , BILCER, Geoffrey, M. , DEVASAMUDRAM, Thippeswamy , LILLY, John, C. , ANKALA, Sudha, V. , MOSKALEV, Nikolai, V. , LIU, Chunfeng , INOUE, Makoto , KAWAKAMI, Shimpei , MUNAKATA, Ryosuke , HAMAJIMA, Toshihiro
发明人： BILCER, Geoffrey, M. , DEVASAMUDRAM, Thippeswamy , LILLY, John, C. , ANKALA, Sudha, V. , MOSKALEV, Nikolai, V. , LIU, Chunfeng , INOUE, Makoto , KAWAKAMI, Shimpei , MUNAKATA, Ryosuke , HAMAJIMA, Toshihiro
IPC分类号： C07D417/14 , A61K31/427 , C07D413/12 , A61K31/422 , A61K31/4439 , C07D413/14 , A61K31/4245 , A61P25/28
CPC分类号： C07D413/12 , C07D413/14 , C07D417/14
摘要： The invention provides novel beta-secretase inhibitors and methods for their including methods of treating Alzheimer's disease.
摘要翻译：本发明提供新颖的β-分泌酶抑制剂及其包括治疗阿尔茨海默氏病的方法。

6. 发明申请

WO2010042892A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF 审中-公开
标题翻译：抑制β-分泌酶活性的吡咯烷类化合物及其使用方法
公开(公告)号：WO2010042892A1
公开(公告)日：2010-04-15
申请号：PCT/US2009/060273
申请日：2009-10-09
申请人： COMENTIS, INC. , PURDUE RESEARCH FOUNDATION , ASTELLAS PHARMA INC. , BILCER, Geoffrey, M. , DEVASAMUDRAM, Thippeswamy , ANKALA, Sudha, V. , LILLY, John, C. , LIU, Chunfeng , LEI, Hui , GHOSH, Arun, K. , INOUE, Makoto
发明人： BILCER, Geoffrey, M. , DEVASAMUDRAM, Thippeswamy , ANKALA, Sudha, V. , LILLY, John, C. , LIU, Chunfeng , LEI, Hui , GHOSH, Arun, K. , INOUE, Makoto
IPC分类号： A61K31/16
CPC分类号： C07D417/14 , A61K31/16 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
摘要翻译：本文描述了新的β-分泌酶抑制剂及其用途，包括治疗阿尔茨海默氏病的方法。

7. 发明申请

WO2010110817A1 PYRROLIDINE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF 审中-公开
标题翻译：抑制β-分泌酶活性的吡咯烷酮化合物及其使用方法
公开(公告)号：WO2010110817A1
公开(公告)日：2010-09-30
申请号：PCT/US2009/060269
申请日：2009-10-09
申请人： COMENTIS, INC. , PURDUE RESEARCH FOUNDATION , ASTELLAS PHARMA INC. , BILCER, Geoffrey, M. , DEVASAMUDRAM, Thippeswamy , ANKALA, Sudha, V. , LILLY, John, C. , LIU, Chunfeng , LEI, Hui , GHOSH, Arun, K. , INOUE, Makoto
发明人： BILCER, Geoffrey, M. , DEVASAMUDRAM, Thippeswamy , ANKALA, Sudha, V. , LILLY, John, C. , LIU, Chunfeng , LEI, Hui , GHOSH, Arun, K. , INOUE, Makoto
IPC分类号： A61K31/16 , A61K31/40 , A61K31/195
CPC分类号： A61K31/16 , A61K31/195 , A61K31/40 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： Described herein are novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
摘要翻译：本文描述的是新型β-分泌酶抑制剂及其使用方法，包括治疗阿尔茨海默氏病的方法。

8. 发明申请

WO2013181202A2 CHROMANE COMPOUNDS 审中-公开
标题翻译： CHROMANE化合物
公开(公告)号：WO2013181202A2
公开(公告)日：2013-12-05
申请号：PCT/US2013/043016
申请日：2013-05-29
申请人： ASTELLAS PHARMA INC. , COMENTIS, INC.
发明人： MUNAKATA, Ryosuke , INOUE, Makoto , TOMINAGA, Hiroaki , YAMASAKI, Shingo , SHIINA, Yasuhiro , SAMIZU, Kiyohiro , HAMAGUCHI, Hisao , HONG, Lin
IPC分类号： A61K31/497
CPC分类号： C07D413/14 , C07D263/52 , C07D498/10 , C07D498/20 , C07D519/00
摘要： The present invention provides a compound which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by β-secretase activity, hydrolysis of a β-secretase site of a β -amyloid precursor protein, and/or β -amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.
摘要翻译：本发明提供了可用作药物组合物的活性成分的化合物，特别是用于预防或治疗与β-分泌酶活性相关和/或介导的疾病或病症的药物组合物，β-分泌酶位点的水解 β-淀粉样蛋白前体蛋白和/或β-淀粉样蛋白积聚，包括用于预防或治疗疾病的药物组合物，包括但不限于青光眼，MCI（轻度认知障碍）或阿尔茨海默病，特别是阿尔茨海默氏病。

9. 发明申请

WO2004048899A2 DEVICE AND METHOD OF DETECTING ROTATION ANGLE 审中-公开
标题翻译：检测旋转角度的装置和方法
公开(公告)号：WO2004048899A2
公开(公告)日：2004-06-10
申请号：PCT/JP2003/014872
申请日：2003-11-21
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. , INOUE, Makoto
发明人： INOUE, Makoto
IPC分类号： G01D5/00
CPC分类号： G01D5/24461 , G01D5/04 , G01D5/145
摘要： The rotation-angle detecting device of the present invention contains two rotators having the same number of teeth, which engage with a gear fixed to a rotation-detecting axle as a detected object. The detecting device further includes a controller. Receiving a rotation-angle signal from the rotators, the controller amplifies the signal, performs calculations, and stores the results. The controller converts each rotation-angle signal from each rotator into each periodic waveform output having the same crest value, and stores an initial phase difference value at initial setting. In driving operations, monitoring an evaluation value calculated with reference to the initial phase difference value, the controller determines that abnormalities occurred, if the evaluation value exceeds a predetermined abnormality-evaluation threshold.
摘要翻译：本发明的旋转角度检测装置包括具有相同齿数的两个旋转器，所述两个旋转器与固定到作为检测对象的旋转检测轴的齿轮啮合。该检测装置还包括控制器。从旋转器接收旋转角度信号，控制器放大信号，执行计算并存储结果。控制器将来自每个旋转器的每个旋转角度信号转换为具有相同峰值的每个周期性波形输出，并且在初始设置时存储初始相位差值。在驾驶操作中，监视参考初始相位差值计算的评估值，如果评估值超过预定的异常评估阈值，则控制器确定发生了异常。

10. 发明申请

WO2008018268A1 AIR CONDITIONING REGISTER 审中-公开
标题翻译：空调注册
公开(公告)号：WO2008018268A1
公开(公告)日：2008-02-14
申请号：PCT/JP2007/064048
申请日：2007-07-10
申请人： TOYOTA JIDOSHA KABUSHIKI KAISHA , SAKAKIBARA, Kimio , NONOYAMA, Michiyo , TANAKA, Keiko , INOUE, Makoto
发明人： SAKAKIBARA, Kimio , NONOYAMA, Michiyo , TANAKA, Keiko , INOUE, Makoto
IPC分类号： B60H1/34
CPC分类号： B60H1/3421 , B60H2001/3464 , B60H2001/3478
摘要： There is provided an air conditioning register which can prevent or effectively suppress a reduction in an effective opening surface area at an air-conditioned air blow-out portion, and which has good blow-out efficiency of air-conditioned air. A first flow path 42 and a second flow path 44, whose directions toward a blow-out bezel 26 differ, are formed within a retainer 12 of an air conditioning register 10. A first damper 52 and plural second dampers 58, which are interlocked with one another, are provided at the retainer 12. The first damper 52 opens and closes the first flow path 42, and the second dampers 58 open and close the second flow path 44. The first damper 52 and the second dampers 58 are operated such that either one of the first flow path 42 and the second flow path 44 is opened and the other is closed, and the flow path of the air-conditioned air is switched. In this way, a blow-out direction of the air-conditioned air from the blow-out bezel 26 is controlled, while a reduction in an effective opening surface area at the blow-out bezel 26 is prevented or effectively suppressed.
摘要翻译：提供了一种能够防止或有效地抑制空调吹风部的有效开口面积的空调调节装置，并且具有良好的空气调节空气的吹出效率。在空调装置10的保持器12内形成有朝向吹出边框26的方向不同的第一流路42和第二流路44.第一阻尼器52和多个第二阻尼器58，其与彼此设置在保持器12上。第一阻尼器52打开和关闭第一流动路径42，并且第二阻尼器58打开和关闭第二流动路径44.第一阻尼器52和第二阻尼器58被操作使得第一流路42和第二流路44中的任一个被打开，另一个闭合，并且空调空气的流路被切换。以这种方式，控制来自吹出框架26的空调空气的吹出方向，同时防止或有效地抑制吹出框架26处的有效开口表面积的减小。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式