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1. 发明申请

WO2006004191A1 PYRROLOPYRIDAZINE DERIVATIVES WHICH INHIBIT PDE IV AND TNF ALFA 审中-公开
标题翻译：抑制PDE IV和TNF ALFA的吡咯并吡啶衍生物
公开(公告)号：WO2006004191A1
公开(公告)日：2006-01-12
申请号：PCT/JP2005/012622
申请日：2005-07-01
申请人： ASTELLAS PHARMA INC. , ABE, Yoshito , INOUE, Makoto , OKUMURA, Mitsuaki , OHNE, Kazuhiko , SATO, Kentaro
发明人： ABE, Yoshito , INOUE, Makoto , OKUMURA, Mitsuaki , OHNE, Kazuhiko , SATO, Kentaro
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R 1 , R 2 , R 3 and R 4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R

2. 发明申请

WO2006004188A1 PYRAZOLOPYRIDINE DERIVATIVES 审中-公开
标题翻译：吡唑并吡啶衍生物
公开(公告)号：WO2006004188A1
公开(公告)日：2006-01-12
申请号：PCT/JP2005/012618
申请日：2005-07-01
申请人： ASTELLAS PHARMA INC. , ABE, Yoshito , OHNE, Kazuhiko , SATO, Kentaro , INOUE, Makoto , OKUMURA, Mitsuaki
发明人： ABE, Yoshito , OHNE, Kazuhiko , SATO, Kentaro , INOUE, Makoto , OKUMURA, Mitsuaki
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R 1 , R 2 , R 3 and R 4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病。

3. 发明申请

WO0040576A3 THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP 审中-公开
标题翻译：作为MMP的抑制剂的噻咯化合物
公开(公告)号：WO0040576A3
公开(公告)日：2001-03-22
申请号：PCT/JP0000018
申请日：2000-01-06
申请人： FUJISAWA PHARMACEUTICAL CO , TANIGUCHI KIYOSHI , NEYA MASAHIRO , TERASAWA TAKESHI , YAMAZAKI HITOSHI , SATO KENTARO , HOSOI KUMI , TOMISHIMA YASUYO , YOSHIDA NORIKO , IMAMURA YOSHIMASA , TAKASUGI HISASHI , SETOI HIROYUKI
发明人： TANIGUCHI KIYOSHI , NEYA MASAHIRO , TERASAWA TAKESHI , YAMAZAKI HITOSHI , SATO KENTARO , HOSOI KUMI , TOMISHIMA YASUYO , YOSHIDA NORIKO , IMAMURA YOSHIMASA , TAKASUGI HISASHI , SETOI HIROYUKI
IPC分类号： C07D333/28 , A61K31/381 , A61K31/382 , A61K31/385 , A61K31/4166 , A61K31/4436 , A61K31/4725 , A61K31/5355 , A61P1/02 , A61P9/10 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P35/04 , A61P37/00 , A61P43/00 , C07D333/48 , C07D335/02 , C07D339/08 , C07D409/04 , C07D409/12 , C07D409/14 , A61K31/38 , A61K31/44
CPC分类号： C07D333/48 , C07D335/02 , C07D339/08 , C07D409/04 , C07D409/12 , C07D409/14
摘要： A compound of formula (I) in which R is lower alkyl, halogen, optionally substituted heterocyclic group or optionally substituted aryl, R is carboxy, protected carboxy or amidated carboxy, Ar is optionally substituted aryl or optionally substituted heterocyclic group, A is lower alkylene, X is oxa or a single bond, Y is thia, sulfinyl or sulfonyl, Z is methylene, thia, sulfinyl or sulfonyl, m and n are each an integer of 0 to 6, and 1
摘要翻译：式（I）化合物，其中R 1是低级烷基，卤素，任选取代的杂环基或任选取代的芳基，R 2是羧基，保护的羧基或酰胺基羧基，Ar是任选取代的芳基或任选取代的杂环基团，A是低级亚烷基，X是氧杂或单键，Y是硫杂，亚磺酰基或磺酰基，Z是亚甲基，硫杂，亚磺酰基或磺酰基，m和n各自是0-6的整数， m + n = 6或其盐，其可用作基质金属蛋白酶（MMP）或肿瘤坏死因子α（TNFα）的抑制剂。

4. 发明申请

WO2006046683A1 THIAZOLYLBENZOFURAN DERIVATIVES AS LEUKOTRIENE AND PROSTAGLANDIN D2 RECEPTOR ANTAGONISTS 审中-公开
标题翻译：噻吗啉衍生物作为白介素和前列腺素D2受体拮抗剂
公开(公告)号：WO2006046683A1
公开(公告)日：2006-05-04
申请号：PCT/JP2005/019854
申请日：2005-10-24
申请人： ASTELLAS PHARMA INC. , SHIGENAGA, Shinji , HIGUCHI, Koichi , MUKOYOSHI, Koichiro , TANABE, Daisuke , INOUE, Takayuki , SATO, Kentaro , TENDA, Yoshiyuki , TSUJIMOTO, Susumu
发明人： SHIGENAGA, Shinji , HIGUCHI, Koichi , MUKOYOSHI, Koichiro , TANABE, Daisuke , INOUE, Takayuki , SATO, Kentaro , TENDA, Yoshiyuki , TSUJIMOTO, Susumu
IPC分类号： C07D417/14 , A61K31/425
CPC分类号： C07D417/14
摘要： There is provided a compound of the formula (I): wherein R 1 is lower alkyl, R 2 is lower alkyl substituted with a substituent selected from the group consisting of carboxy and esterified carboxy, and R 3 is lower alkoxy substituted with lower alkylcarbamoyl, or a pharmaceutically acceptable salt thereof, which are useful as a medicament.
摘要翻译：提供式（I）化合物：其中R 1为低级烷基，R 2为被选自下组的取代基取代的低级烷基：羧基和酯化的羧基，R 3是用作药物的低级烷基氨基甲酰基或其药学上可接受的盐取代的低级烷氧基。

5. 发明申请

WO1998027069A1 PIPERAZINE COMPOUNDS AS INHIBITORS OF MMP OR TNF 审中-公开
标题翻译：作为MMP或TNF的抑制剂的哌嗪化合物
公开(公告)号：WO1998027069A1
公开(公告)日：1998-06-25
申请号：PCT/JP1997004613
申请日：1997-12-15
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , NEYA, Masahiro , YAMAZAKI, Hitoshi , KAYAKIRI, Natsuko , SATO, Kentaro , OKU, Teruo
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07D241/04
CPC分类号： C07D405/12 , C07D241/04 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A compound of formula (I) wherein A is a sulfonyl or a carbonyl; R is an optionally substituted aryl, an optionally substituted heterocyclic group, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; R is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R is an optionally substituted lower alkyl, an optionally substituted lower alkoxy, an optionally substituted aryloxy, an optionally substitued lower alkenyl, an optionally substituted aryl, an optionally substituted heterocyclic group or an optionally substitued amino; R is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; R is a hydrogen, an optionally substituted lower alkyl, an optionally substituted aryl or an optionally substituted heterocyclic group; and R is a hydroxy or a protected hydroxy, and a pharmaceutically acceptable salt thereof. The compound of the present invention is useful as a medicament for prophylactic and therapeutic treatment of MMP- or TNF alpha -mediated diseases.
摘要翻译：式（I）的化合物，其中A是磺酰基或羰基; R 1是任选取代的芳基，任选取代的杂环基，任选取代的低级烷基或任选取代的低级烯基; R 2是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R 3是任选取代的低级烷基，任选取代的低级烷氧基，任选取代的芳氧基，任选取代的低级烯基，任选取代的芳基，任选取代的杂环基或任选取代的氨基; R 4是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R 5是氢，任选取代的低级烷基，任选取代的芳基或任选取代的杂环基; R 10为羟基或保护的羟基及其药学上可接受的盐。本发明的化合物可用作用于预防和治疗MMP或TNFα介导的疾病的药物。

6. 发明申请

WO02055541A3 PEPTIDES HAVING INHIBITING ACTIVITY ON THE PRODUCTION OF NITRIC OXIDE 审中-公开
标题翻译：具有抑制生产氧化氮的活性的肽
公开(公告)号：WO02055541A3
公开(公告)日：2003-08-07
申请号：PCT/JP0111067
申请日：2001-12-18
申请人： FUJISAWA PHARMACEUTICAL CO , SHIMA ICHIRO , OHKAWA TAKEHIKO , SATO KENTARO , ISHIBASHI NAOKI , IMAMURA KENICHIRO
发明人： SHIMA ICHIRO , OHKAWA TAKEHIKO , SATO KENTARO , ISHIBASHI NAOKI , IMAMURA KENICHIRO
IPC分类号： A61K38/00 , A61K31/436 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/10 , A61P17/00 , A61P17/04 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P27/10 , A61P27/12 , A61P27/14 , A61P29/00 , A61P31/04 , A61P31/12 , A61P31/22 , A61P35/00 , A61P35/04 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K5/06 , C07K5/078 , A61K38/05
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06191
摘要： The present invention relates to a compound of the formula (I)wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (I) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals.
摘要翻译：本发明涉及式（I）化合物，其中R 1为被卤素取代的苯并呋喃基或被卤素取代的苯乙烯基; R2是取代的羟基，取代的巯基或取代的磺酰基; X是其药学上可接受的盐。本发明的化合物（I）及其药学上可接受的盐对一氧化氮（NO）的产生具有很强的抑制活性，可用于预防和/或治疗人和动物中NO介导的疾病。

7. 发明申请

WO1996041795A1 BENZAMIDE DERIVATIVES AND THEIR USE AS VASOPRESSIN ANTAGONISTS 审中-公开
标题翻译：苯并咪唑衍生物及其作为VASOPRESSIN ANTAGONISTS的用途
公开(公告)号：WO1996041795A1
公开(公告)日：1996-12-27
申请号：PCT/JP1996001533
申请日：1996-06-06
申请人： FUJISAWA PHARMACEUTICAL CO., LTD. , SETOI, Hiroyuki , OHKAWA, Takehiko , ZENKOH, Tatsuya , SAWADA, Hitoshi , SATO, Kentaro , TANAKA, Hirokazu
发明人： FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： C07C237/42
CPC分类号： C07D209/48 , C07C235/42 , C07C237/42 , C07C237/44 , C07C243/28 , C07C255/54 , C07C271/16 , C07C271/22 , C07C271/48 , C07C279/08 , C07C279/24 , C07D211/46 , C07D211/58 , C07D211/74 , C07D213/30 , C07D213/75 , C07D213/80 , C07D239/26 , C07D295/185 , C07D295/192 , C07D295/205 , C07D295/215 , C07D295/26 , C07D295/32
摘要： This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc., and represented by general formula (I), wherein R is aryl optionally substituted with lower alkoxy, etc., R is lower alkyl, etc., R is hydrogen, etc., R is lower alkoxy, etc., R is hydrogen, etc., A is NH, etc., E is (a), etc., X is -CH=CH-, -CH=N-, or S, and Y is CH or N, and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.
摘要翻译：本发明涉及具有加压素拮抗作用的新型苯甲酰胺衍生物等，由通式（I）表示，其中R 1为任选被低级烷氧基取代的芳基等，R 2为低级烷基等 R 3为氢等，R 4为低级烷氧基等，R 5为氢等，A为NH等，E为（a）等，X 是-CH = CH-，-CH = N-或S，Y是CH或N及其药学上可接受的盐，其制备方法和包含其的药物组合物。

8. 发明专利

JP2000159000A CARGO LOADING MECHANISM FOR WORK VEHICLE 失效
公开(公告)号：JP2000159000A
公开(公告)日：2000-06-13
申请号：JP33324498
申请日：1998-11-24
申请人： NISHIATSU KK , SATO KENTARO
发明人： SATO KENTARO , SHIBATA TSUGIO
IPC分类号： B60P1/48 , B60P3/00 , H02G1/06
摘要： PROBLEM TO BE SOLVED: To provide a cargo loading mechanism capable of mechanically and efficiently performing a series of work from loading and unloading work of a cargo such as a cable drum to carrying work and unreeling work of a cable on a laying site. SOLUTION: In this cargo loading mechanism, an operation unit 4 is disposed on a table 3 of a work vehicle to reciprocate in the longitudinal direction. The operation unit 4 has a pair of traveling frames 5 for traveling along main frames 2 disposed at the width directional side edges of a cargo bed; a pair of swing arms 7 joined to the respective traveling frames 5 capable of vertical ascent/descent operation and capable of variable operation of a distance between them; sleeves 7c projected from surfaces facing to each other near the tips of the swing arms 7 and capable of suspending a cargo with the sleeves 7c inserted in holes formed in side faces of the cargo; and a centering mechanism for centering the middle position between the swing arms 7 on the center in a vehicle width direction of the table 3.

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