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1. 发明公开

KR20180042391A 신장 전구 세포를 제조하는 방법 审中-公开
公开(公告)号：KR20180042391A
公开(公告)日：2018-04-25
申请号：KR20187008288
申请日：2016-09-09
申请人： ASTELLAS PHARMA INC , UNIV KYOTO
发明人： KAWAMOTO TATSUYA , YAMAGISHI YUKIKO , OSAFUNE KENJI
IPC分类号： C12N5/071 , G01N33/569
CPC分类号： A61K35/22 , C12N5/10 , C12N15/09 , C12Q1/04
摘要： 본발명의과제는, 신장전구세포특이적인세포표면항원마커를동정함으로써, 다능성줄기세포로부터신장전구세포로분화유도된세포집단으로부터, 순도가높은신장전구세포를취득하고제조하는방법을제공하는데 있다. 다능성줄기세포로부터분화유도된신장전구세포를제조하는방법이며, (i) 다능성줄기세포를신장전구세포로의분화를유도하는조건하에서배양하는공정; 및 (ⅱ) 공정 (i)에서얻어진세포로부터, CD9(-), CD55(-), CD106(+), CD140a(+), CD140b(+), CD165(+), CD271(+) 및 CD326(-)로이루어지는군에서선택되는적어도 1개의세포표면마커를사용하여세포집단을선별하는공정을포함하는방법.

2. 发明公开

EP3020803A4 METHOD FOR PRODUCING RENAL PRECURSOR CELLS, AND DRUG CONTAINING RENAL PRECURSOR CELLS 有权
标题翻译：用于生产肾及药物祖细胞CARDIOID祖细胞
公开(公告)号：EP3020803A4
公开(公告)日：2017-02-22
申请号：EP14811223
申请日：2014-06-11
申请人： UNIV KYOTO , ASTELLAS PHARMA INC
发明人： OSAFUNE KENJI , TOYOHARA TAKAFUMI , YAMAGISHI YUKIKO
IPC分类号： C12N5/07 , A61K35/22 , A61K38/18 , A61L27/00 , A61P13/12 , A61P31/12 , C12N5/077
CPC分类号： C12N5/0687 , A61K35/22 , A61K35/545 , A61K38/1841 , C12N5/0686 , C12N2501/15 , C12N2501/155 , C12N2501/999 , C12N2506/45
摘要： The present invention provides: a method for producing renal progenitor cells from intermediate mesoderm cells, which comprises a step of culturing intermediate mesoderm cells in a medium containing a TGF² signaling activator(s) and a BMP inhibitor(s); the renal progenitor cells produced by the method; a pharmaceutical composition comprising the renal progenitor cells; and a therapeutic drug for kidney diseases comprising the renal progenitor cells.

3. 发明专利

PL1957518T3 Nowe cykliczne związki peptydowe 未知
公开(公告)号：PL1957518T3
公开(公告)日：2016-07-29
申请号：PL06822844
申请日：2006-10-26
申请人： ASTELLAS PHARMA INC
发明人： NEYA MASAHIRO , YOSHIMURA SEIJI , KAMIJYO KAZUNORI , MAKINO TAKUYA , YASUDA MINORU , YAMANAKA TOSHIO , TSUJII EISAKU , YAMAGISHI YUKIKO
IPC分类号： C07K7/64 , A61P31/12

4. 发明专利

AU2006306974A1 New cyclic peptide compounds 未知
公开(公告)号：AU2006306974A1
公开(公告)日：2007-05-03
申请号：AU2006306974
申请日：2006-10-26
申请人： ASTELLAS PHARMA INC
发明人： NEYA MASAHIRO , YASUDA MINORU , YAMAGISHI YUKIKO , YOSHIMURA SEIJI , MAKINO TAKUYA , TSUJII EISAKU , YAMANAKA TOSHIO , KAMIJYO KAZUNORI
IPC分类号： C07K7/64 , A61P31/12
摘要： The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

5. 发明专利

RU2730861C2 СПОСОБ ПРОДУЦИРОВАНИЯ ПОЧЕЧНЫХ КЛЕТОК-ПРЕДШЕСТВЕННИКОВ 未知
公开(公告)号：RU2730861C2
公开(公告)日：2020-08-26
申请号：RU2018112687
申请日：2016-09-09
申请人： ASTELLAS PHARMA INC
发明人： KAWAMOTO TATSUYA , YAMAGISHI YUKIKO , OSAFUNE KENJI
IPC分类号： C12N5/071
摘要： Изобретениеотноситсяк областибиотехнологии, аименнок продуцированиюпочечныхклеток-предшественников, вкоторыедифференцируютсяиндуцированныеплюрипотентныестволовыеклетки (иПС-клетки) иотборуклеточнойпопуляцииизклеточнойпопуляции, содержащейпочечныеклетки-предшественники. СпособвключаеткультивированиеиПС-клетокв условиях, индуцирующихдифференцировкув почечныеклетки-предшественникии разделениеклеточнойпопуляцииизклеток, полученныхнастадии (i), путемотборапомаркерамклеточнойповерхности: CD9(-), CD140a(+), CD140b(+) и CD271(+). Способвключаетиспользованиепоменьшеймередвухмаркеровклеточнойповерхности, включающихкомбинациюодногомаркеранегативногоотбора, выбранногоизгруппы, состоящейиз CD9(-), CD55(-) и CD326(-), иодногомаркерапозитивногоотбора, выбранногоизгруппы, состоящейиз CD106(+), CD140a(+), CD140b(+), CD165(+) и CD271(+) илитрехмаркеровклеточнойповерхности, включающихкомбинациюодногомаркеранегативногоотбора, выбранногоизгруппы, состоящейиз CD9(-), CD55(-) и CD326(-), идвухмаркеровположительногоотбора, выбранныхизгруппы, состоящейиз CD106(+), CD140a(+), CD140b(+), CD165(+) и CD271(+), илитрехмаркеровположительногоотбора, выбранныхизгруппы, состоящейиз CD106(+), CD140a(+), CD140b(+), CD165(+) и CD271(+). Способвключаетиспользованиедвухмаркеровклеточнойповерхности, выбранныхизгруппы, состоящейиз CD9(-), CD140a(+), CD140b(+) и CD271(+). Изобретениепозволяетрасширитьарсеналтехническихсредств. 4 н. и 5 з.п. ф-лы, 7 ил., 7 пр.

6. 发明专利

PT1957518E NOVOS COMPOSTOS PEPTÍDICOS CÍCLICOS 未知
公开(公告)号：PT1957518E
公开(公告)日：2016-02-26
申请号：PT06822844
申请日：2006-10-26
申请人： ASTELLAS PHARMA INC
发明人： NEYA MASAHIRO , YOSHIMURA SEIJI , KAMIJYO KAZUNORI , MAKINO TAKUYA , YASUDA MINORU , YAMANAKA TOSHIO , TSUJII EISAKU , YAMAGISHI YUKIKO
IPC分类号： C07K7/64 , A61P31/12

7. 发明专利

SG11201801970XA METHOD FOR PRODUCING RENAL PROGENITOR CELLS 未知
公开(公告)号：SG11201801970XA
公开(公告)日：2018-04-27
申请号：SG11201801970X
申请日：2016-09-09
申请人： ASTELLAS PHARMA INC , UNIV KYOTO
发明人： KAWAMOTO TATSUYA , YAMAGISHI YUKIKO , OSAFUNE KENJI
IPC分类号： C12N5/071 , A61K35/22 , C12N5/10 , C12N15/09 , C12Q1/04
摘要： An object of the present invention resides in providing a method for acquiring and producing high-purity renal progenitor cells from a renal progenitor cell population into which pluripotent stem cells are induced to differentiate, by identifying a cell surface antigen marker specific to renal progenitor cells. A method for producing renal progenitor cells into which pluripotent stem cells are induced to differentiate, the method comprising the steps of: (i) culturing the pluripotent stem cells under conditions that induce differentiation into renal progenitor cells; and (ii) sorting a cell population from the cells obtained at step (i), by using at least one cell surface marker selected from the group consisting of CD9(-), CD55(-), CD106(+), CD140a(+), CD140b(+), CD165(+), CD271(+) and CD326(-).

8. 发明专利

CA2998096A1 METHOD FOR PRODUCING KIDNEY PROGENITOR CELLS 未知
公开(公告)号：CA2998096A1
公开(公告)日：2017-03-16
申请号：CA2998096
申请日：2016-09-09
申请人： ASTELLAS PHARMA INC , UNIV KYOTO
发明人： KAWAMOTO TATSUYA , YAMAGISHI YUKIKO , OSAFUNE KENJI
IPC分类号： C12N5/071 , A61K35/22 , C12N5/10 , C12N15/09 , C12Q1/04
摘要： The present invention addresses the problem of providing a method for acquiring and producing kidney progenitor cells having a high degree of purity from a cell population obtained by inducing differentiation of pluripotent stem cells into kidney progenitor cells by identifying a kidney progenitorspecific cell surface antigen marker. A method for preparing kidney progenitor cells obtained by inducing differentiation of pluripotent stem cells, which includes: (i) a step for cultivating pluripotent stem cells under conditions that induce differentiation into kidney progenitor cells; and (ii) a step for sorting a cell population from the cells obtained in step (i) by using at least one cell surface marker selected from the group consisting of CD9(-), CD55(-), CD106(+), CD140a(+), CD140b(+), CD165(+), CD271(+), and CD326(-).

9. 发明专利

BRPI0617781A2 未知
公开(公告)号：BRPI0617781A2
公开(公告)日：2011-08-09
申请号：BRPI0617781
申请日：2006-10-26
申请人： ASTELLAS PHARMA INC
发明人： NEYA MASAHIRO , YOSHIMURA SEIJI , KAMIJYO KAZUNORI , MAKINO TAKUYA , YASUDA MINORU , YAMANAKA TOSHIO , TSUJII EISAKU , YAMAGISHI YUKIKO
IPC分类号： C07K7/64 , A61P31/12
摘要： The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

10. 发明专利

NO20082354L 未知
公开(公告)号：NO20082354L
公开(公告)日：2008-07-01
申请号：NO20082354
申请日：2008-05-23
申请人： ASTELLAS PHARMA INC
发明人： NEYA MASAHIRO , YOSHIMURA SEIJI , KAMIJYO KAZUNORI , MAKINO TAKUYA , YASUDA MINORU , YAMANAKA TOSHIO , TSUJII EISAKU , YAMAGISHI YUKIKO
IPC分类号： C07K7/64 , A61K38/12 , A61P31/12
摘要： The present invention relates to a new cyclic peptide compound or a salt thereof, which has anti-hepatitis C virus activities based on inhibitory activity against the RNA replication of hepatitis C virus replicon, to a process for preparation thereof comprising a rearrangement reaction under a mild acidic condition and the following amino acid changing reactions etc., to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of hepatitis C in a human being or an animal.

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