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1. 发明专利

ES2386803T3 Fragmentos proteicos poliepitópicos de las proteinas E6 y E7 de HPV , su obtencion y sus utilizaciones particularmente en vacunación 未知
公开(公告)号：ES2386803T3
公开(公告)日：2012-08-31
申请号：ES00938875
申请日：2000-05-31
申请人： ASSIST PUBL HOPITAUX DE PARIS , INST NAT SANTE RECH MED
发明人： CHOPPIN JEANNINE , BOURGAULT VILLADA ISABELLE , GUILLET JEAN-GERARD , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： C12N15/37 , A61K38/00 , A61K39/00 , A61K39/12 , A61P31/18 , C07K14/025 , C07K14/16 , C07K16/08 , C12N15/12 , C12N15/33
摘要： Utilización de fragmentos poliepitópicos que contienen 6 epítopos de la proteína E6 de HPV, elegidos entre aquellos queincluyen:- el fragmento que contiene 6 epítopos delimitados por 5 los aminoácidos situados en las posiciones 46 y 62, o en lasposiciones 46 y 67 de la secuencia peptídica de la proteína E6, este último fragmento estando caracterizado por lasecuencia peptídica siguiente:(46)RREVYDF AFRDLCIVYRDGNPY(67)dicho fragmento conteniendo los péptidos, cada péptido ligándose de manera estable a una al menos de lasmoléculas HLA de tipo A2, A3, A11, A24, A29, B7, B27, B35, B44, o B51, dichos epítopos siendo los siguientes:- (46)RREVYDFAFR(55) ligándose de manera estable a las moléculas HLA de tipo B27,- (49)VYDFAFRDL(57) ligándose de manera estable a las moléculas HLA de tipo A24,- (50)YDFAFRDL(57) ligándose de manera estable a las moléculas HLA de tipo A29, o B44,- (52)FAFRDLCIV(60) ligándose de manera estable a las moléculas HLA de tipo A2, B35, B51, o B7;- (54)FRDLCIVYR(62) ligándose de manera estable a las moléculas HLA de tipo A3, o A11,- (59)IVYRDGNPY(67) ligándose de manera estable a las moléculas HLA de tipo A3, o A11y las secuencias peptídicas derivadas de los fragmentos poliepitópicos anteriormente mencionados,- por sustitución y/o adición de uno o varios aminoácidos, de los fragmentos anteriormente mencionados, y/o- por modificación de al menos un enlace peptídico -CO-NH- de la cadena peptídica de los fragmentos anteriormente mencionados, particularmente por introducción de un enlace del tipo retro, o retro-inverso, y/o- por sustitución de al menos un aminoácido de la cadena peptídica de la secuencia o del fragmento anteriormentemencionado, por un aminoácido no proteinogénico, dichas secuencias derivadas conteniendo los péptidos opseudopéptidos, cada péptido ligándose específicamente a la o a las mismas moléculas del CMH que aquellasligándose a los péptidos contenidos en los fragmentos poliepitópicos anteriormente mencionados de los cuales éstasderivan, para la preparación de un medicamento o vacuna destinado a la prevención o al tratamiento de patologíasligadas a la infección de individuos por los papillomavirus humanos; tales como las neoplasias cervicalesintraepiteliales (CIN), el cáncer invasivo del cuello del útero, las neoplasias vulvares intraepiteliales (VIN).

2. 发明专利

AT554172T 未知
公开(公告)号：AT554172T
公开(公告)日：2012-05-15
申请号：AT00938875
申请日：2000-05-31
申请人： ASSIST PUBL HOPITAUX DE PARIS , INST NAT SANTE RECH MED
发明人： CHOPPIN JEANNINE , BOURGAULT VILLADA ISABELLE , GUILLET JEAN-GERARD , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： C12N15/37 , A61K38/00 , A61K39/00 , A61K39/12 , A61P31/18 , C07K14/025 , C07K14/16 , C07K16/08 , C12N15/12 , C12N15/33
摘要： Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. (I) is contained within any of the sequences: PheProValThrProGluValProLeuArgProMetThrTyrLysAlaAlaValAspLeuSer- HisPheLeuLysGluLysGlyGlyLeu; ArgArgGlnAspIleLeuAspLeuTrpIleTyrHisThrGlnGlyTyrPheProAspTrpGln- AsnTyrThrProGlyProGlyValArgTyrProLeuThrPheGlyTrpCysTyrLysLeu; ValLeuGluTrpArgPheAspSerArgLeuAlaPheHisHisValAlaArgGluLeuHisPro- GluTyr. These represent, respectively, amino acids 68-97, 105-145 or 180-202 of Nef, and bind stably to, respectively, the human leukocyte antigen (HLA) type molecules A2, A3, A11, B7, B8, B14, B35, B62 or Cw8; A1, A2, A24, A32, B7, B18, B27, B35, B49, B57/58 or B62; or A1, A2, A3, B8, B35, or B52. Alternatively, (I) comprises their derivatives which bind to the same HLA molecules as the parent compounds, formed by substitution, deletion and/or addition of one or more amino acids, modification of at least one peptide bond (particularly replacement by retro or retro-inverso bonds) and/or substitution of at least one amino acid by a non-proteinogenic amino acid. Independent claims are also included for the following: (1) a nucleic acid (II) that encodes (I) or its derivatives; (2) mono- or poly-clonal antibodies (Ab) directed against (I) or its derivatives; and (3) pharmaceutical composition or vaccine containing at least one (I), or its derivative, (II) or Ab. ACTIVITY : Antiviral. No biological data is given. MECHANISM OF ACTION : (I) induce a specific immune response; particularly they induce cytolysis, by cytotoxic T cells (CTL), of cells that express (I) associated with appropriate HLA molecules and induce secretion of cytokines (particularly interleukins -2 and -4, and gamma -interferon) by these CTL; vaccine.

3. 发明申请

WO0075336A3 POLYEPITOPIC PROTEINIC FRAGMENTS OF E6 AND E7 HPV PROTEINS, PRODUCTION AND USE THEREOF IN VACCINES 审中-公开
标题翻译： E6和E7 HPV蛋白的多肽蛋白质片段，其在疫苗中的生产和使用
公开(公告)号：WO0075336A3
公开(公告)日：2001-07-26
申请号：PCT/FR0001513
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED , CHOPPIN JEANNINE , BOURGAULT VILLADA ISABELLE , GUILLET JEAN GERARD , CONNAN FRANCINE , FERRIES ESTELLE
发明人： CHOPPIN JEANNINE , BOURGAULT VILLADA ISABELLE , GUILLET JEAN-GERARD , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , A61K39/12 , C07K16/08
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2710/20022 , C12N2740/16322
摘要： The invention relates to the use of polyepitopic fragments of a determined protein in the production of medicaments for preventing or treating pathologies in which said protein is recognized by the cellular immune system. Said fragments are chosen from E6 and E7 HPV proteins. The invention also relates to polyepitopic proteinic fragments of E6 and E7 HPV proteins, a method for the production and the use thereof in the field of vaccination.
摘要翻译：本发明涉及确定的蛋白质的多表位片段在生产药物中用于预防或治疗所述蛋白质被细胞免疫系统识别的病理学的用途。所述片段选自E6和E7 HPV蛋白。本发明还涉及E6和E7 HPV蛋白的多表位蛋白质片段，其在疫苗接种领域的制备及其应用的方法。

4. 发明专利

CA2375602A1 FRAGMENTS PROTEIQUES POLYEPITOPIQUES DE LA PROTEINE NEF DE HIV, LEUR OBTENTION ET LEURS UTILISATIONS NOTAMMENT EN VACCINATION 未知
公开(公告)号：CA2375602A1
公开(公告)日：2000-12-14
申请号：CA2375602
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED
发明人： BOURGAULT VILLADA ISABELLE , GUILLET JEAN-GERARD , CHOPPIN JEANNINE , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , C12N15/11 , C07K16/10 , A61K39/21 , C12N15/31 , A61K39/395
摘要： La présente invention a pour objet l'utilisation de fragments polyépitopique s d'une protéine déterminée pour la préparation de médicaments destinés à la prévention ou au traitement de pathologies dans lesquelles ladite protéine e st reconnue par le système immunitaire cellulaire, lesdits fragments polyépitopiques étant choisis parmi ceux de la protéine Nef d'HIV. L'inventi on a également pour objet des fragments protéiques polyépitopiques de la protéi ne Nef d'HIV, leur procédé d'obtention, et leurs utilisations, notamment dans l e domaine de la vaccination.

5. 发明专利

AU5411000A Polyepitopic proteinic fragments of e6 and e7 hpv proteins, production and use thereof in vaccines 未知
公开(公告)号：AU5411000A
公开(公告)日：2000-12-28
申请号：AU5411000
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED
发明人： CHOPPIN JEANNINE , BOURGAULT-VILLADA ISABELLE , GUILLET JEAN-GERARD , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , A61K39/12 , C07K16/08
摘要： Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. (I) is contained within any of the sequences: PheProValThrProGluValProLeuArgProMetThrTyrLysAlaAlaValAspLeuSer- HisPheLeuLysGluLysGlyGlyLeu; ArgArgGlnAspIleLeuAspLeuTrpIleTyrHisThrGlnGlyTyrPheProAspTrpGln- AsnTyrThrProGlyProGlyValArgTyrProLeuThrPheGlyTrpCysTyrLysLeu; ValLeuGluTrpArgPheAspSerArgLeuAlaPheHisHisValAlaArgGluLeuHisPro- GluTyr. These represent, respectively, amino acids 68-97, 105-145 or 180-202 of Nef, and bind stably to, respectively, the human leukocyte antigen (HLA) type molecules A2, A3, A11, B7, B8, B14, B35, B62 or Cw8; A1, A2, A24, A32, B7, B18, B27, B35, B49, B57/58 or B62; or A1, A2, A3, B8, B35, or B52. Alternatively, (I) comprises their derivatives which bind to the same HLA molecules as the parent compounds, formed by substitution, deletion and/or addition of one or more amino acids, modification of at least one peptide bond (particularly replacement by retro or retro-inverso bonds) and/or substitution of at least one amino acid by a non-proteinogenic amino acid. Independent claims are also included for the following: (1) a nucleic acid (II) that encodes (I) or its derivatives; (2) mono- or poly-clonal antibodies (Ab) directed against (I) or its derivatives; and (3) pharmaceutical composition or vaccine containing at least one (I), or its derivative, (II) or Ab. ACTIVITY : Antiviral. No biological data is given. MECHANISM OF ACTION : (I) induce a specific immune response; particularly they induce cytolysis, by cytotoxic T cells (CTL), of cells that express (I) associated with appropriate HLA molecules and induce secretion of cytokines (particularly interleukins -2 and -4, and gamma -interferon) by these CTL; vaccine.

6. 发明专利

AU5229400A Polyepitopic proteinic fragments of the hiv nef protein, production and use thereof in vaccinations 未知
公开(公告)号：AU5229400A
公开(公告)日：2000-12-28
申请号：AU5229400
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED
发明人： CHOPPIN JEANNINE , BOURGAULT-VILLADA ISABELLE , GUILLET JEAN-GERARD , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , A61K39/21 , C07K16/10 , A61K39/395
摘要： Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. (I) is contained within any of the sequences: PheProValThrProGluValProLeuArgProMetThrTyrLysAlaAlaValAspLeuSer- HisPheLeuLysGluLysGlyGlyLeu; ArgArgGlnAspIleLeuAspLeuTrpIleTyrHisThrGlnGlyTyrPheProAspTrpGln- AsnTyrThrProGlyProGlyValArgTyrProLeuThrPheGlyTrpCysTyrLysLeu; ValLeuGluTrpArgPheAspSerArgLeuAlaPheHisHisValAlaArgGluLeuHisPro- GluTyr. These represent, respectively, amino acids 68-97, 105-145 or 180-202 of Nef, and bind stably to, respectively, the human leukocyte antigen (HLA) type molecules A2, A3, A11, B7, B8, B14, B35, B62 or Cw8; A1, A2, A24, A32, B7, B18, B27, B35, B49, B57/58 or B62; or A1, A2, A3, B8, B35, or B52. Alternatively, (I) comprises their derivatives which bind to the same HLA molecules as the parent compounds, formed by substitution, deletion and/or addition of one or more amino acids, modification of at least one peptide bond (particularly replacement by retro or retro-inverso bonds) and/or substitution of at least one amino acid by a non-proteinogenic amino acid. Independent claims are also included for the following: (1) a nucleic acid (II) that encodes (I) or its derivatives; (2) mono- or poly-clonal antibodies (Ab) directed against (I) or its derivatives; and (3) pharmaceutical composition or vaccine containing at least one (I), or its derivative, (II) or Ab. ACTIVITY : Antiviral. No biological data is given. MECHANISM OF ACTION : (I) induce a specific immune response; particularly they induce cytolysis, by cytotoxic T cells (CTL), of cells that express (I) associated with appropriate HLA molecules and induce secretion of cytokines (particularly interleukins -2 and -4, and gamma -interferon) by these CTL; vaccine.

7. 发明专利

CA2375627A1 FRAGMENT PROTEIQUES POLYEPITOPIQUES DES PROTEINES E6 ET E7 DE HPV, LEUR OBTENTION ET LEURS UTILISATIONS NOTAMMENT EN VACCINATION 未知
公开(公告)号：CA2375627A1
公开(公告)日：2000-12-14
申请号：CA2375627
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED
发明人： BOURGAULT VILLADA ISABELLE , GUILLET JEAN-GERARD , CHOPPIN JEANNINE , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , C07K16/08 , A61K39/12
摘要： La présente invention a pour objet l'utilisation de fragments polyépitopique s d'une protéine déterminée pour la préparation de médicaments destinés à la prévention ou au traitement de pathologies dans lesquelles ladite protéine e st reconnue par le système immunitaire cellulaire, lesdits fragments polyépitopiques étant choisis parmi ceux des protéines E6 et E7 de HPV. L'invention a également pour objet des fragments protéiques polyépitopiques des protéines E6 et E7 de HPV, leur procédé d'obtention, et leurs utilisations, notamment dans le domaine de la vaccination.

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