专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0075336A3 POLYEPITOPIC PROTEINIC FRAGMENTS OF E6 AND E7 HPV PROTEINS, PRODUCTION AND USE THEREOF IN VACCINES 审中-公开
标题翻译： E6和E7 HPV蛋白的多肽蛋白质片段，其在疫苗中的生产和使用
公开(公告)号：WO0075336A3
公开(公告)日：2001-07-26
申请号：PCT/FR0001513
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED , CHOPPIN JEANNINE , BOURGAULT VILLADA ISABELLE , GUILLET JEAN GERARD , CONNAN FRANCINE , FERRIES ESTELLE
发明人： CHOPPIN JEANNINE , BOURGAULT VILLADA ISABELLE , GUILLET JEAN-GERARD , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , A61K39/12 , C07K16/08
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N2710/20022 , C12N2740/16322
摘要： The invention relates to the use of polyepitopic fragments of a determined protein in the production of medicaments for preventing or treating pathologies in which said protein is recognized by the cellular immune system. Said fragments are chosen from E6 and E7 HPV proteins. The invention also relates to polyepitopic proteinic fragments of E6 and E7 HPV proteins, a method for the production and the use thereof in the field of vaccination.
摘要翻译：本发明涉及确定的蛋白质的多表位片段在生产药物中用于预防或治疗所述蛋白质被细胞免疫系统识别的病理学的用途。所述片段选自E6和E7 HPV蛋白。本发明还涉及E6和E7 HPV蛋白的多表位蛋白质片段，其在疫苗接种领域的制备及其应用的方法。

2. 发明专利

AU5411000A Polyepitopic proteinic fragments of e6 and e7 hpv proteins, production and use thereof in vaccines 未知
公开(公告)号：AU5411000A
公开(公告)日：2000-12-28
申请号：AU5411000
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED
发明人： CHOPPIN JEANNINE , BOURGAULT-VILLADA ISABELLE , GUILLET JEAN-GERARD , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , A61K39/12 , C07K16/08
摘要： Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. (I) is contained within any of the sequences: PheProValThrProGluValProLeuArgProMetThrTyrLysAlaAlaValAspLeuSer- HisPheLeuLysGluLysGlyGlyLeu; ArgArgGlnAspIleLeuAspLeuTrpIleTyrHisThrGlnGlyTyrPheProAspTrpGln- AsnTyrThrProGlyProGlyValArgTyrProLeuThrPheGlyTrpCysTyrLysLeu; ValLeuGluTrpArgPheAspSerArgLeuAlaPheHisHisValAlaArgGluLeuHisPro- GluTyr. These represent, respectively, amino acids 68-97, 105-145 or 180-202 of Nef, and bind stably to, respectively, the human leukocyte antigen (HLA) type molecules A2, A3, A11, B7, B8, B14, B35, B62 or Cw8; A1, A2, A24, A32, B7, B18, B27, B35, B49, B57/58 or B62; or A1, A2, A3, B8, B35, or B52. Alternatively, (I) comprises their derivatives which bind to the same HLA molecules as the parent compounds, formed by substitution, deletion and/or addition of one or more amino acids, modification of at least one peptide bond (particularly replacement by retro or retro-inverso bonds) and/or substitution of at least one amino acid by a non-proteinogenic amino acid. Independent claims are also included for the following: (1) a nucleic acid (II) that encodes (I) or its derivatives; (2) mono- or poly-clonal antibodies (Ab) directed against (I) or its derivatives; and (3) pharmaceutical composition or vaccine containing at least one (I), or its derivative, (II) or Ab. ACTIVITY : Antiviral. No biological data is given. MECHANISM OF ACTION : (I) induce a specific immune response; particularly they induce cytolysis, by cytotoxic T cells (CTL), of cells that express (I) associated with appropriate HLA molecules and induce secretion of cytokines (particularly interleukins -2 and -4, and gamma -interferon) by these CTL; vaccine.

3. 发明专利

AU5229400A Polyepitopic proteinic fragments of the hiv nef protein, production and use thereof in vaccinations 未知
公开(公告)号：AU5229400A
公开(公告)日：2000-12-28
申请号：AU5229400
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED
发明人： CHOPPIN JEANNINE , BOURGAULT-VILLADA ISABELLE , GUILLET JEAN-GERARD , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , A61K39/21 , C07K16/10 , A61K39/395
摘要： Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. Polyepitopic fragments (I) from the Nef protein of human immune deficiency virus (HIV), are new. (I) is contained within any of the sequences: PheProValThrProGluValProLeuArgProMetThrTyrLysAlaAlaValAspLeuSer- HisPheLeuLysGluLysGlyGlyLeu; ArgArgGlnAspIleLeuAspLeuTrpIleTyrHisThrGlnGlyTyrPheProAspTrpGln- AsnTyrThrProGlyProGlyValArgTyrProLeuThrPheGlyTrpCysTyrLysLeu; ValLeuGluTrpArgPheAspSerArgLeuAlaPheHisHisValAlaArgGluLeuHisPro- GluTyr. These represent, respectively, amino acids 68-97, 105-145 or 180-202 of Nef, and bind stably to, respectively, the human leukocyte antigen (HLA) type molecules A2, A3, A11, B7, B8, B14, B35, B62 or Cw8; A1, A2, A24, A32, B7, B18, B27, B35, B49, B57/58 or B62; or A1, A2, A3, B8, B35, or B52. Alternatively, (I) comprises their derivatives which bind to the same HLA molecules as the parent compounds, formed by substitution, deletion and/or addition of one or more amino acids, modification of at least one peptide bond (particularly replacement by retro or retro-inverso bonds) and/or substitution of at least one amino acid by a non-proteinogenic amino acid. Independent claims are also included for the following: (1) a nucleic acid (II) that encodes (I) or its derivatives; (2) mono- or poly-clonal antibodies (Ab) directed against (I) or its derivatives; and (3) pharmaceutical composition or vaccine containing at least one (I), or its derivative, (II) or Ab. ACTIVITY : Antiviral. No biological data is given. MECHANISM OF ACTION : (I) induce a specific immune response; particularly they induce cytolysis, by cytotoxic T cells (CTL), of cells that express (I) associated with appropriate HLA molecules and induce secretion of cytokines (particularly interleukins -2 and -4, and gamma -interferon) by these CTL; vaccine.

4. 发明专利

CA2375627A1 FRAGMENT PROTEIQUES POLYEPITOPIQUES DES PROTEINES E6 ET E7 DE HPV, LEUR OBTENTION ET LEURS UTILISATIONS NOTAMMENT EN VACCINATION 未知
公开(公告)号：CA2375627A1
公开(公告)日：2000-12-14
申请号：CA2375627
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED
发明人： BOURGAULT VILLADA ISABELLE , GUILLET JEAN-GERARD , CHOPPIN JEANNINE , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , C07K16/08 , A61K39/12
摘要： La présente invention a pour objet l'utilisation de fragments polyépitopique s d'une protéine déterminée pour la préparation de médicaments destinés à la prévention ou au traitement de pathologies dans lesquelles ladite protéine e st reconnue par le système immunitaire cellulaire, lesdits fragments polyépitopiques étant choisis parmi ceux des protéines E6 et E7 de HPV. L'invention a également pour objet des fragments protéiques polyépitopiques des protéines E6 et E7 de HPV, leur procédé d'obtention, et leurs utilisations, notamment dans le domaine de la vaccination.

5. 发明专利

CA2375602A1 FRAGMENTS PROTEIQUES POLYEPITOPIQUES DE LA PROTEINE NEF DE HIV, LEUR OBTENTION ET LEURS UTILISATIONS NOTAMMENT EN VACCINATION 未知
公开(公告)号：CA2375602A1
公开(公告)日：2000-12-14
申请号：CA2375602
申请日：2000-05-31
申请人： BIOVECTOR THERAPEUTICS , INST NAT SANTE RECH MED
发明人： BOURGAULT VILLADA ISABELLE , GUILLET JEAN-GERARD , CHOPPIN JEANNINE , CONNAN FRANCINE , FERRIES ESTELLE
IPC分类号： A61K38/00 , A61K39/00 , A61P31/18 , C07K14/025 , C07K14/16 , C12N15/12 , C12N15/33 , C12N15/37 , C12N15/11 , C07K16/10 , A61K39/21 , C12N15/31 , A61K39/395
摘要： La présente invention a pour objet l'utilisation de fragments polyépitopique s d'une protéine déterminée pour la préparation de médicaments destinés à la prévention ou au traitement de pathologies dans lesquelles ladite protéine e st reconnue par le système immunitaire cellulaire, lesdits fragments polyépitopiques étant choisis parmi ceux de la protéine Nef d'HIV. L'inventi on a également pour objet des fragments protéiques polyépitopiques de la protéi ne Nef d'HIV, leur procédé d'obtention, et leurs utilisations, notamment dans l e domaine de la vaccination.

6. 发明申请

WO2005005467A2 NOVEL IMMUNE BOOSTER COMPOUND, COMPOSITIONS COMPRISING THE SAME AND METHODS USING SAID BOOSTER COMPOUND 审中-公开
标题翻译：新型免疫增强剂化合物，包含其的组合物和使用加强体化合物的方法
公开(公告)号：WO2005005467A2
公开(公告)日：2005-01-20
申请号：PCT/FR2004050308
申请日：2004-07-02
申请人： INST NAT SANTE RECH MED , CENTRE NAT RECH SCIENT , BRIAND JEAN-PAUL , BOULANGER PIERRE , BOULANGER SAW SEE , FRENKEL VALERIE , GUILLET JEAN-GERARD , BLONDEL ARMELLE , LENGAGNE RENEE
发明人： BRIAND JEAN-PAUL , BOULANGER PIERRE , BOULANGER SAW SEE , FRENKEL VALERIE , GUILLET JEAN-GERARD , BLONDEL ARMELLE , LENGAGNE RENEE
IPC分类号： A61K39/39 , A61P37/04 , C07K14/075 , C12N5/0784
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/55516 , C12N5/0639 , C12N2501/998 , C12N2710/10322
摘要： The invention relates to a peptide immune booster, comprising: a polypeptide (i) with an amino acid sequence having a length of 30 amino acids contained in the head domain of the fibre protein of the capsid of an adenovirus, said amino acid sequence comprising the sequence of amino acids forming a double ss sheet called EF , contained in said head domain, or a peptide analogue (ii) of said polypeptide (i), the amino acid sequence of which has, by comparison with the sequence of polypeptide (i), at least one substitution or at least one deletion of an amino acid, said analogue peptide conserving the double ss sheet called EF .
摘要翻译：本发明涉及肽免疫增强剂，其包含：多肽（i）具有氨基酸序列，所述氨基酸序列具有包含在腺病毒衣壳的纤维蛋白的头部结构域中的30个氨基酸长度，所述氨基酸序列包含包含在所述头结构域中的称为EF的双重片段的氨基酸序列或所述多肽（i）的肽类似物（ii），其氨基酸序列与多肽（i）的序列相比较，，氨基酸的至少一个取代或至少一个缺失，所述类似物肽保留称为EF的双片。

7. 发明申请

WO02090382A3 MIXTURE OF PEPTIDES DERIVED FROM E6 AND/OR E7 PAPILLOMAVIRUS PROTEINS AND USES THEREOF 审中-公开
标题翻译：从E6和/或E7斑马鱼蛋白衍生的肽的混合物及其用途
公开(公告)号：WO02090382A3
公开(公告)日：2003-10-02
申请号：PCT/FR0201533
申请日：2002-05-03
申请人： COMMISSARIAT ENERGIE ATOMIQUE , INST NAT SANTE RECH MED , MAILLERE BERNARD , BOURGAULT-VILLADA ISABELLE , POUVELLE-MORATILLE SANDRA , GUILLET JEAN-GERARD
发明人： MAILLERE BERNARD , BOURGAULT-VILLADA ISABELLE , POUVELLE-MORATILLE SANDRA , GUILLET JEAN-GERARD
IPC分类号： G01N33/48 , A61K39/00 , A61K39/12 , A61K48/00 , A61P31/20 , A61P35/00 , C07K14/025 , C12N5/08 , C12Q1/02 , G01N33/50
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/58 , C12N2710/20022 , C12N2710/20034 , G01N33/505 , G01N2333/025
摘要： The invention concerns a mixture of peptides derived from the E6 and/or E7 proteins of a papillomavirus involved in cervix of uterus cancer, such as HPV16, HPV18, HPV30, HPV31, HPV32, HPV33, HPV34, HPV35, HPV39, HPV40, HPV42, HPV43, HPV44, HPV45, HPV51, HPV52, HPV56, HPV57, and HPV58, for example, as well as its uses as medicine (in immunogenic compositions, capable of stimulating the production of anti-HPV T CD4+ lymphocytes in vivo and hence useful for vaccination against uterine of uterus cancer and in other cancers) or as diagnostic reagent of HPV-specific T lymphocytes, in particular for assessing the immune condition of patients. The invention also concerns a mixture of peptides derived from E6 and/or E7 proteins of a papillomavirus involved in benign skin lesions (for example warts), such as HPV10, HPV3 or HPV4 and its uses as medicine.
摘要翻译：本发明涉及衍生自参与子宫颈宫颈例如HPV16，HPV18，HPV30，HPV31，HPV32，HPV33，HPV34，HPV35，HPV39，HPV40，HPV42等的乳头瘤病毒的E6和/或E7蛋白的肽的混合物。 HPV43，HPV44，HPV45，HPV51，HPV52，HPV56，HPV57和HPV58，以及其作为药物的用途（在免疫原性组合物中，能够在体内刺激抗HPV T CD4 +淋巴细胞的产生，因此可用于针对子宫癌和其他癌症子宫的接种）或作为HPV特异性T淋巴细胞的诊断试剂，特别是用于评估患者的免疫状况。本发明还涉及衍生自涉及良性皮肤损伤（例如疣），例如HPV10，HPV3或HPV4的乳头瘤病毒的E6和/或E7蛋白的肽的混合物及其作为药物的用途。

8. 发明申请

WO03019195A2 CELLULAR IMMUNITY TEST WITH PEPTIDES FIXED ON A SOLID SUPPORT 审中-公开
标题翻译：细胞免疫测试与固定在固体支持上的肽
公开(公告)号：WO03019195A2
公开(公告)日：2003-03-06
申请号：PCT/FR0202937
申请日：2002-08-27
申请人： INST NAT SANTE RECH MED , GAHERY-SEGARD HANNE , GUILLET JEAN-GERARD
发明人： GAHERY-SEGARD HANNE , GUILLET JEAN-GERARD
IPC分类号： G01N33/53 , C07K7/04 , C12Q1/02 , G01N33/68 , G01N33/543
CPC分类号： G01N33/505 , C07K14/005 , C12N2710/16122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , G01N33/6854
摘要： The invention concerns a method for detecting cellular immunity (with respect to an antigen), using a solid support whereon is fixed an assortment of peptides constituting T cell epitopes of the antigen to be tested, kits for implementing said method.
摘要翻译：本发明涉及一种用于检测细胞免疫（相对于抗原）的方法，使用固体支持物固定各种构成待测抗原T细胞表位的肽，用于实施所述方法的试剂盒。

9. 发明申请

WO9927954A3 MIXED LIPOPEPTIDE MICELLES FOR INDUCING AN IMMUNE RESPONSE 审中-公开
标题翻译：用于诱导免疫应答的混合脂质体细胞
公开(公告)号：WO9927954A3
公开(公告)日：1999-08-26
申请号：PCT/FR9802605
申请日：1998-12-02
申请人： INST NAT SANTE RECH MED , CENTRE NAT RECH SCIENT , PASTEUR INSTITUT , GRAS MASSE HELENE , BOSSUS MARC , LIPPENS GUY , WIERUSZESKI JEAN MICHEL , TARTAR ANDRE , GUILLET JEAN GERARD , BOURGAULT VILLADA ISABELLE
发明人： GRAS-MASSE HELENE , BOSSUS MARC , LIPPENS GUY , WIERUSZESKI JEAN-MICHEL , TARTAR ANDRE , GUILLET JEAN-GERARD , BOURGAULT-VILLADA ISABELLE
IPC分类号： A61K39/00 , A61K9/00 , A61K9/107 , A61K38/17 , A61K39/015 , A61K39/08 , A61K39/12 , A61K39/215 , A61P37/04 , C07K14/02 , C07K14/025 , C07K14/155 , C07K14/445 , C07K14/82 , A61K39/39
CPC分类号： A61K39/015 , A61K9/1075 , A61K39/12 , A61K39/385 , A61K2039/55577 , A61K2039/6018 , A61K2039/70 , C12N2740/15034 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： The invention concerns mixed micelles or micro-aggregates for inducing an immune response containing at least: a first lipopeptide comprising a CTL epitope and at least a first lipid motif; and a second lipopeptide comprising at least an auxiliary T epitope and at least a lipid motif, whereof the type can be different from the first lipopeptide motif. Said micelles can be used as medicines and vaccines.
摘要翻译：本发明涉及用于诱导至少包含至少包含CTL表位和至少第一种脂质基序的第一种脂肽的混合胶束或微聚集物; 和至少包含辅助T表位和至少一种脂质基序的第二种脂肽，其类型可以不同于第一种脂肽基序。所述胶束可用作药物和疫苗。

10. 发明申请

WO9850423A3 PEPTIDE ANALOGUES, AND THEIR USES IN PARTICULAR IN PHARMACEUTICAL COMPOSITIONS AND FOR DIAGNOSIS 审中-公开
标题翻译：肽类似物及其在药物组合物和诊断中的用途
公开(公告)号：WO9850423A3
公开(公告)日：1999-08-19
申请号：PCT/FR9800923
申请日：1998-05-07
申请人： CENTRE NAT RECH SCIENT , INST NAT SANTE RECH MED , GUILLET JEAN GERARD , GUICHARD GILLES , OSTANKOVITCH MARINA , CONNAN FRANCINE , QUESNEL ANNE , CHOPPIN JEANNINE , BRIAND JEAN PAUL , MULLER SYLVIANE
发明人： GUILLET JEAN-GERARD , GUICHARD GILLES , OSTANKOVITCH MARINA , CONNAN FRANCINE , QUESNEL ANNE , CHOPPIN JEANNINE , BRIAND JEAN-PAUL , MULLER SYLVIANE
IPC分类号： A61K39/00 , A61K39/145 , C07K14/11 , C07K14/47 , G01N33/569 , A61K38/17 , G01N33/68
CPC分类号： C07K14/005 , A61K39/00 , A61K39/0005 , A61K39/0011 , A61K39/12 , A61K39/145 , C07K14/4748 , C12N2760/16022 , C12N2760/16034 , G01N33/56977 , G01N2500/00
摘要： The invention concerns the use of parent peptide analogues, characterised in that they correspond to said parent peptide in which: at least a peptide bond -CO-NH- of the peptide chain, is modified, except for retro or retro-inverso type modifications; or at least an amino acid of the peptide chain, is substituted by a non-proteinogenic amino acid; or at least a peptide bond -CO-NH- of the peptide chain is substituted by a non proteinogenic amino acid. Said peptide analogues are used for: preparing medicines for preventing or treating the pathologies mentioned in the description; or preparing a composition for diagnosing said pathologies, or for assessing in vivo the immune response concerning said pathologies, using a hypersensitivity cutaneous reaction by intradermal injection of said composition; or implementing an in vitro diagnostic method of said pathologies.
摘要翻译：本发明涉及亲代肽类似物的用途，其特征在于它们对应于所述亲本肽，其中：肽链的至少一个肽键-CO-NH-被修饰，除了复古或逆转型改型之外; 或肽链的至少一个氨基酸被非蛋白质氨基酸取代; 或肽链的至少肽键-CO-NH-被非蛋白质氨基酸取代。所述肽类似物用于：制备用于预防或治疗描述中提到的病症的药物; 或制备用于诊断所述病理学的组合物，或用于通过皮内注射所述组合物使用超敏反应皮肤反应体内评估关于所述病理的免疫应答。或实施所述病理学的体外诊断方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式