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1. 发明申请

WO2012083185A2 PEPTIDE-BASED IN VIVO SIRNA DELIVERY SYSTEM 审中-公开
标题翻译：基于肽基于血液SIRNA递送系统
公开(公告)号：WO2012083185A2
公开(公告)日：2012-06-21
申请号：PCT/US2011065525
申请日：2011-12-16
申请人： ARROWHEAD RES CORPORATIONS , ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H , KITAS ERIC , HADWIGER PHILIPP , WOLFF JON A , ROEHL INGO , MOHR PETER , HOFFMAN TORSTEN , JAHN-HOFMANN KERSTIN , MUELLER HANS MARTIN , OTT GUENTHER , BLOKHIN ANDREI V , BENSON JONATHAN D , CARLSON JEFFREY C
发明人： ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H , KITAS ERIC , HADWIGER PHILIPP , WOLFF JON A , ROEHL INGO , MOHR PETER , HOFFMAN TORSTEN , JAHN-HOFMANN KERSTIN , MUELLER HANS MARTIN , OTT GUENTHER , BLOKHIN ANDREI V , BENSON JONATHAN D , CARLSON JEFFREY C
CPC分类号： A61K47/48261 , A61K47/549 , A61K47/64 , A61K47/6415 , C12N15/111 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/32
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted me!ittm dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
摘要翻译：本发明是用于在体内靶向将RNA干扰（RNAi）多核苷酸递送至肝细胞的组合物。靶向的RNAi多核苷酸与共同靶向的我和其他多肽一起施用。去卵肽提供膜穿透力，用于从细胞外部到细胞内的RNAi多核苷酸的移动。可逆修饰提供对递送肽的生理反应性。

2. 发明申请

WO2012083185A3 PEPTIDE-BASED IN VIVO SIRNA DELIVERY SYSTEM 审中-公开
标题翻译：基于肽基于血液SIRNA递送系统
公开(公告)号：WO2012083185A3
公开(公告)日：2013-10-10
申请号：PCT/US2011065525
申请日：2011-12-16
申请人： ARROWHEAD RES CORP , ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H , KITAS ERIC , HADWIGER PHILIPP , WOLFF JON A , ROEHL INGO , MOHR PETER , HOFFMAN TORSTEN , JAHN-HOFMANN KERSTIN , MUELLER HANS MARTIN , OTT GUENTHER , BLOKHIN ANDREI V , BENSON JONATHAN D , CARLSON JEFFREY C
发明人： ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H , KITAS ERIC , HADWIGER PHILIPP , WOLFF JON A , ROEHL INGO , MOHR PETER , HOFFMAN TORSTEN , JAHN-HOFMANN KERSTIN , MUELLER HANS MARTIN , OTT GUENTHER , BLOKHIN ANDREI V , BENSON JONATHAN D , CARLSON JEFFREY C
IPC分类号： A61K31/713
CPC分类号： A61K47/48261 , A61K47/549 , A61K47/64 , A61K47/6415 , C12N15/111 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/32
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted me!ittm dehvery peptides. Dehvery peptides provide membrane penetration faction for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
摘要翻译：本发明是用于在体内靶向将RNA干扰（RNAi）多核苷酸递送至肝细胞的组合物。靶向的RNAi多核苷酸与共同靶向的我和其他多肽一起施用。去卵肽提供膜穿透力，用于从细胞外部到细胞内的RNAi多核苷酸的移动。可逆修饰提供对递送肽的生理反应性。

3. 发明申请

WO2012092373A3 IN VIVO POLYNUCLEOTIDE DELIVERY CONJUGATES HAVING ENZYME SENSITIVE LINKAGES 审中-公开
标题翻译：具有酶敏感性连接的生物多核苷酸转运途径
公开(公告)号：WO2012092373A3
公开(公告)日：2013-10-24
申请号：PCT/US2011067588
申请日：2011-12-28
申请人： ARROWHEAD RES CORP , ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H , KITAS ERIC A , HADWIGER PHILIPP , WOLFF JON A , ROEHL INGO , MOHR PETER , HOFFMANN TORSTEN , JAHN-HOFMANN KERSTIN , MUELLER HANS MARTIN , OTT GUENTHER , BLOKHIN ANDREI V , CARLSON JEFFREY C , BENSON JONATHAN D
发明人： ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H , KITAS ERIC A , HADWIGER PHILIPP , WOLFF JON A , ROEHL INGO , MOHR PETER , HOFFMANN TORSTEN , JAHN-HOFMANN KERSTIN , MUELLER HANS MARTIN , OTT GUENTHER , BLOKHIN ANDREI V , CARLSON JEFFREY C , BENSON JONATHAN D
IPC分类号： A61K48/00 , A61K31/675
CPC分类号： C07K5/06034 , A61K47/58 , A61K47/60 , C07K5/06078 , C07K5/06104 , C07K5/06113 , C12N15/111 , C12N15/87 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , C12N2800/95 , C12N2810/10
摘要： The present invention is directed compositions for delivery of RNA interference (RNAi) polynucleotides to cells in vivo. The compositions comprise amphipathic membrane active polyamines reversibly modified with enzyme cleavable dipeptide-amidobenzyl-carbonate masking agents. Modification masks membrane activity of the polymer while reversibility provides physiological responsiveness. The reversibly modified polyamines (dynamic polyconjugate or DPC) are further covalently linked to an RNAi polynucleotide or co-administered with a targeted RNAi polynucleotide-targeting molecule conjugate.
摘要翻译：本发明涉及用于将RNA干扰（RNAi）多核苷酸递送至细胞体内的组合物。组合物包含用酶切割二肽 - 氨基苄基 - 碳酸酯掩蔽剂可逆地修饰的两亲膜活性多胺。改性掩盖聚合物的膜活性，而可逆性提供生理反应性。可逆修饰的多胺（动态多偶联物或DPC）进一步与RNAi多核苷酸共价连接或与靶向RNAi多核苷酸靶向分子缀合物共同施用。

4. 发明申请

WO2012083046A2 GALACTOSE CLUSTER-PHARMACOKINETIC MODULATOR TARGETING MOIETY FOR SIRNA 审中-公开
标题翻译：用于SIRNA的半乳糖聚糖 - 药物动力学调节剂
公开(公告)号：WO2012083046A2
公开(公告)日：2012-06-21
申请号：PCT/US2011065210
申请日：2011-12-15
申请人： ARROWHEAD RES CORP , HADWIGER PHILIPP , HOFFMAN TORSTEN , KITAS ERIC , MOHR PETER , ROEHL INGO , VALIS LINDA , ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H
发明人： HADWIGER PHILIPP , HOFFMAN TORSTEN , KITAS ERIC , MOHR PETER , ROEHL INGO , VALIS LINDA , ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H
CPC分类号： C07K5/1021 , C07H21/02
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to cell in vivo. The pharmacokinetic modulator improve in vivo targeting compared to the targeting ligand alone. Targeting ligand-pharmacokinetic modulator targeting moiety targeted RNAi polynucleotides can be administered in vivo alone or together with co- targeted delivery polymers.
摘要翻译：本发明涉及用于体内靶向递送RNA干扰（RNAi）多核苷酸至细胞的组合物。与单独的靶向配体相比，药代动力学调节剂改善体内靶向。靶向靶向部分靶向的RNAi多核苷酸的靶向配体 - 药代动力学调节剂可以单独体内施用或与共靶向递送聚合物一起施用。

5. 发明申请

WO2008022309A3 POLYCONJUGATES FOR IN VIVO DELIVERY OF POLYNUCLEOTIDES 审中-公开
标题翻译： POLYCONJUGATES在VIVO交付多核苷酸
公开(公告)号：WO2008022309A3
公开(公告)日：2008-11-20
申请号：PCT/US2007076202
申请日：2007-08-17
申请人： HOFFMANN LA ROCHE , ROZEMA DAVID B , WAKEFIELD DARREN H , WOLFF JON A , WONG SO , KLEIN JASON , LEWIS DAVID L , HAGSTROM JAMES E , BLOKHIN ANDREI , TRUBETSKOY VLADIMIR , HERWEIJER HANS
发明人： ROZEMA DAVID B , WAKEFIELD DARREN H , WOLFF JON A , WONG SO , KLEIN JASON , LEWIS DAVID L , HAGSTROM JAMES E , BLOKHIN ANDREI , TRUBETSKOY VLADIMIR , HERWEIJER HANS
IPC分类号： A61K31/00 , A61K9/127
CPC分类号： C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要： The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti- aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译：本发明涉及可用于将多核苷酸或其它细胞不可渗透分子递送至哺乳动物细胞的化合物，组合物和方法。描述了将靶向，抗调理作用，抗聚集和转染活性引入小生物相容性体内递送载体的多结合体系。使用连接组分部分的多个可逆连接提供了生理响应活性调节。

6. 发明专利

AU2011343532A1 Peptide-based in vivo siRNA delivery system 未知
公开(公告)号：AU2011343532A1
公开(公告)日：2013-05-09
申请号：AU2011343532
申请日：2011-12-16
申请人： ARROWHEAD RES CORPORATIONS
发明人： ROZEMA DAVID B , LEWIS DAVID L , WAKEFIELD DARREN H , KITAS ERIC , HADWIGER PHILIPP , WOLFF JON A , ROEHL INGO , MOHR PETER , HOFFMAN TORSTEN , JAHN-HOFMANN KERSTIN , MUELLER HANS MARTIN , OTT GUENTHER , BLOKHIN ANDREI V , BENSON JONATHAN D , CARLSON JEFFREY C
IPC分类号： A61K47/00
摘要： The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepaiocytes

7. 发明申请

WO2010051060A3 NECK RING AND METHOD OF MAKING FOR A GLASS CONTAINER FORMING MACHINE 审中-公开
标题翻译：颈环和制造玻璃容器成形机的方法
公开(公告)号：WO2010051060A3
公开(公告)日：2010-06-24
申请号：PCT/US2009039845
申请日：2009-04-08
申请人： OWENS BROCKWAY GLASS CONTAINER , FLYNN ROBIN L , LEWIS DAVID L
发明人： FLYNN ROBIN L , LEWIS DAVID L
IPC分类号： C03B9/48 , C03B9/325
CPC分类号： C03B9/325 , C03B9/48 , Y02P40/57
摘要： A neck ring for molding a glass container neck finish that includes at least one closure attachment feature. The neck ring includes two semi-annular bi-metal neck ring sections (12, 14), each consisting essentially of a neck ring insert (20, 22) of wear- resistant metal construction and a neck ring body (16, 18) of heat-conductive metal construction different from said wear-resistant metal construction and formed around said neck ring insert so as to embed it in said neck ring body. Each of said neck ring halves has a glass-contacting cavity face that includes a first surface portion (30, 32) formed by said inserts for molding the at least one closure attachment feature on the neck finish and a second surface portion (34, 36) formed by said bodies for molding portions of the neck finish excluding the at least one closure attachment feature.
摘要翻译：用于模制玻璃容器瓶颈的颈环，其包括至少一个闭合附件特征。该颈环包括两个半环形双金属颈环部分（12,14），每个半环形双金属颈环部分基本上由耐磨金属结构的颈环插入件（20,22）和颈环主体（16,18）组成，导热金属结构不同于所述耐磨金属结构并围绕所述颈环嵌件形成，以便将其嵌入所述颈环主体中。每个所述颈环半部具有玻璃接触腔面，所述玻璃接触腔面包括由所述插入件形成的第一表面部分（30,32），所述第一表面部分用于模制颈部饰面上的至少一个闭合件附接部件，并且第二表面部分（34,36 ）由所述主体形成，用于模制除了所述至少一个闭合件附接部件之外的颈部部分的部分。

8. 发明专利

CA2739649C AN ENERGY BARRIER, A RAIL FOR AN ENERGY BARRIER FOR A BUILDING FRAME CAVITY INSULATION SYSTEM AND A METHOD OF ASSEMBLING STACKED LAYERS OF REFLECTIVE DEAD AIR SPACES 未知
公开(公告)号：CA2739649C
公开(公告)日：2015-06-23
申请号：CA2739649
申请日：2011-05-04
申请人： LEWIS DAVID L
发明人： LEWIS DAVID L
IPC分类号： E04B1/62 , E04B2/00
摘要： An energy barrier is made of adjustable width insulating rails, reflective insulation panels and a gasketing element to create a single layer or multi-layer stack of reflective dead air spaces within cavity spaces of framing members of a building envelope where an efficient energy barrier is desired.

9. 发明专利

CA2739647C RADIANT THERMAL BARRIER 未知
公开(公告)号：CA2739647C
公开(公告)日：2018-08-07
申请号：CA2739647
申请日：2011-05-05
申请人： LEWIS DAVID L
发明人： LEWIS DAVID L
IPC分类号： E04B1/62 , E04B1/76 , F16L59/02 , F16L59/08
摘要： A thermal barrier is formed into a hat-shape by folding sections of an extended length of board formed for assembly and insertion as a barrier to thermal radiation into a space between two joists or studs of a floor, wall, roof, or ceiling of a building for completely covering the space while also covering protruding edges of the joists or studs so as to reduce thermal energy transfer through the joists or studs themselves. A thermal barrier assembly is shown with an outer reflective surface and is also shown for assembly into a form having an inner enclosure for enclosing an inner thermal barrier also having a reflective surface for reducing thermal radiation transfer by reflection and protected from dust by virtue of the enclosure.

10. 发明专利

CA2696273A1 RADIANT THERMAL BARRIER 未知
公开(公告)号：CA2696273A1
公开(公告)日：2010-09-16
申请号：CA2696273
申请日：2010-03-11
申请人： LEWIS DAVID L
发明人： LEWIS DAVID L
IPC分类号： E04B1/62 , F16L59/02 , F16L59/08 , F16L59/12
摘要： Fan-folded panels are provided with longitudinal cuts or fold lines along an extended length of the panels to enable folding of edge sections of the panels into channel walls on either side of an intermediate panel section together forming a channel having a heat reflective surface inside the channel, the channel for insertion between two facing joists or studs so that tops of the channel walls are pushed up against a facing surface supported by the joists to form an air cavity between the facing surface and the channel acting as the radiant thermal barrier. A hydronic under floor heating pipe may be pre-installed attached to the facing surface supported by the joists or studs with the result that a proper air cavity is maintained with the radiant thermal barrier.

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