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1. 发明专利

HK1225735A1 絲氨酸/蘇氨酸激酶抑制劑未知
公开(公告)号：HK1225735A1
公开(公告)日：2017-09-15
申请号：HK16114196
申请日：2016-12-14
申请人： ARRAY BIOPHARMA INC , GENENTECH INC
发明人： BLAKE JAMES F , COOK ADAM , GAUDINO JOHN , GUNAWARDANA INDRANI W , HICKEN ERIK JAMES , HUNT KEVIN W , LYON MICHAEL , METCALF ANDREW T , MOHR PETER J , MORENO DAVID A , NEWHOUSE BRAD , REN LI , SCHWARZ JACOB , CHEN HUIFEN , GAZZARD LEWIS , SCHMIDT JANE , DO STEVE
IPC分类号： C07D20060101 , A61K20060101 , A61P20060101

2. 发明专利

AR080865A1 DERIVADOS DE ESPIROTETRAHIDRONAFTALENO, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN, PROCESO DE PREPARACION Y USO DE LOS MISMOS PARA TRATAR ENFERMEDADES NEURODEGENERATIVAS,TAL COMO ALZHEIMER. 未知
公开(公告)号：AR080865A1
公开(公告)日：2012-05-16
申请号：ARP110101073
申请日：2011-03-31
申请人： ARRAY BIOPHARMA INC , GENENTECH INC
发明人： COOK ADAM , GUNAWARDANA INDRANI W , HUNT KEVIN W , KALLAN NICHOLAS , SIU MICHAEL , THOMAS ALLEN A , CLARK CHRISTOPHER T , VOLGRAF MATHEW
IPC分类号： C07D233/46 , C07D401/10 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/14 , C07D413/10 , C07D417/10 , A61K31/4178 , A61K31/4166 , A61K31/4168 , A61K31/422 , A61P25/28
摘要： Reivindicacion 1: Un compuesto seleccionado desde la formula (1) y esteroisomeros, diaesteroisomeros, enantiomeros, tautomeros y sales farmacéuticamente aceptables de los mismos caracterizados porque W es un enlace o CR10R11; Y es O, S o NR1; Z es CR12R13 o C(=O), proporcionado cuando Z es C(=O) entonces Y es NR1; X1, X2 y X3 se seleccionan independientemente desde CR9 y N, caracterizado porque solamente uno de X1, X2 o X3 puede ser N; R1 se selecciona desde hidrogeno, alquilo, aralquilo, heteroarilo o heteroaralquilo; R2 se selecciona desde hidroxi, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo, aciloxi, alcoxicarbonilo, sulfonilo, sulfinilo, sulfanilo, ariloxi, un carbociclo o un heterociclo caracterizado porque dicho alquilo, alcoxi, acilo, aciloxi, alcoxicarbonilo, sulfonilo, sulfinilo, sulfanilo, ariloxi, carbociclo y heterociclo se sustituyen opcionalmente con hidroxi, halogeno, amino, ciano, nitro, oxo, alquilo opcionalmente sustituido, alcoxi opcionalmente sustituido, sulfanilo, acilo, alcoxicarbonilo, haloalquilo, carbociclo opcionalmente sustituido o heterociclo; R3 y R4 se seleccionan independientemente desde hidrogeno, halogeno y alquilo, o R3 y R4 juntos forman un grupo oxo; R5 y R6 son independientemente hidrogeno, hidroxi, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo, aciloxi, alcoxicarbonilo, sulfonilo, sulfinilo, sulfanilo, un carbociclo o un heterociclo caracterizado porque, dicho alquilo, alcoxi, acilo, aciloxi, alcoxicarbonilo, sulfonilo, sulfinilo, sulfanilo, carbociclo y heterociclo se sustituyen opcionalmente con hidroxi, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo, haloalquilo, un carbociclo opcionalmente sustituido y un heterociclo opcionalmente sustituido, o R5 y R6 juntos forman un carbociclo de 3 a 6 miembros o un heterociclo opcionalmente sustituido con hidroxi, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo y haloalquilo; R7 y R8 son independientemente hidrogeno, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo, aciloxi, alcoxicarbonilo, sulfonilo, sulfinilo, sulfanilo, un carbociclo o un heterociclo caracterizado porque dicho alquilo, alcoxi, acilo, aciloxi, alcoxicarbonilo, sulfonilo, sulfinilo, sulfanilo carbociclo y heterociclo se sustituyen opcionalmente con hidroxi, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo, haloalquilo, un carbociclo y un heterociclo opcionalmente sustituido, o R7 y R8 juntos forman un carbociclo de 3 a 6 miembros o un heterociclo opcionalmente sustituido por hidroxi, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo y haloalquilo; R9 es independientemente hidrogeno, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo, aciloxi, alcoxicarbonilo, sulfonilo, sulfinilo, sulfanilo, un carbociclo o un heterociclo caracterizado porque dicho alquilo, alcoxi, acilo, aciloxi, alcoxicarbonilo, sulfonilo, sulfinilo, sulfanilo, carbociclo y heterociclo se sustituyen opcionalmente con hidroxi, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo y haloalquilo, o R5 y R7 juntos forman un carbociclo de 3 a 4 miembros o heterociclo opcionalmente sustituido por hidroxi, halogeno, amino, ciano, nitro, alquilo, alcoxi, acilo y haloalquilo; cada R9 se selecciona independientemente del hidrogeno, halogeno o metilo; R10 y R11 se seleccionan independientemente desde hidrogeno y alquilo, o R10 y R11 juntos forman el átomo al cual se unen para formar un carbociclo de 3 a 6 miembros o un heterociclo; y R12 y R13 se seleccionan independientemente desde hidrogeno, alquilo y un carbociclo.

3. 发明专利

CA2934709C SERINE/THREONINE KINASE INHIBITORS 未知
公开(公告)号：CA2934709C
公开(公告)日：2022-08-30
申请号：CA2934709
申请日：2014-12-29
申请人： ARRAY BIOPHARMA INC , GENENTECH INC
发明人： BLAKE JAMES F , COOK ADAM , GAUDINO JOHN , GUNAWARDANA INDRANI W , HICKEN ERIK JAMES , HUNT KEVIN W , LYON MICHAEL , METCALF ANDREW T , MOHR PETER J , MORENO DAVID A , NEWHOUSE BRAD , REN LI , SCHWARZ JACOB , CHEN HUIFEN , GAZZARD LEWIS , SCHMIDT JANE , DO STEVE
IPC分类号： C07D487/04 , A61K31/444 , A61K31/506 , A61P29/00
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are selective inhibitors of ERK and are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro , in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

4. 发明专利

HK1223877A1 絲氨酸/蘇氨酸激酶抑制劑未知
公开(公告)号：HK1223877A1
公开(公告)日：2017-08-11
申请号：HK16111117
申请日：2016-09-22
申请人： GENENTECH INC , ARRAY BIOPHARMA INC
发明人： BLAKE JAMES F , COOK ADAM , GUNAWARDANA INDRANI W , HUNT KEVIN W , LYON MICHAEL , METCALF ANDREW T , MOHR PETER J , MORENO DAVID A , NEWHOUSE BRAD , REN LI , TANG TONY P , THOMAS ALLEN A , SCHWARZ JACOB , SCHMIDT JANE , GAZZARD LEWIS , CHEN HUIFEN
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101

5. 发明专利

CA2934709A1 SERINE/THREONINE KINASE INHIBITORS 未知
公开(公告)号：CA2934709A1
公开(公告)日：2015-07-09
申请号：CA2934709
申请日：2014-12-29
申请人： ARRAY BIOPHARMA INC , GENENTECH INC
发明人： BLAKE JAMES F , COOK ADAM , GAUDINO JOHN , GUNAWARDANA INDRANI W , HICKEN ERIK JAMES , HUNT KEVIN W , LYON MICHAEL , METCALF ANDREW T , MOHR PETER J , MORENO DAVID A , NEWHOUSE BRAD , REN LI , SCHWARZ JACOB , CHEN HUIFEN , GAZZARD LEWIS , SCHMIDT JANE , DO STEVE
IPC分类号： C07D487/04 , A61K31/444 , A61K31/506 , A61P29/00
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases, or associated pathological conditions are disclosed.

6. 发明专利

CA2934679A1 SERINE/THREONINE KINASE INHIBITORS 未知
公开(公告)号：CA2934679A1
公开(公告)日：2015-07-09
申请号：CA2934679
申请日：2014-12-29
申请人： GENENTECH INC , ARRAY BIOPHARMA INC
发明人： BLAKE JAMES F , COOK ADAM , GUNAWARDANA INDRANI W , HUNT KEVIN W , LYON MICHAEL , METCALF ANDREW T , MOHR PETER J , MORENO DAVID A , NEWHOUSE BRAD , REN LI , TANG TONY P , THOMAS ALLEN A , SCHWARZ JACOB , SCHMIDT JANE , GAZZARD LEWIS , CHEN HUIFEN
IPC分类号： C07D403/14 , A61K31/444 , A61K31/506 , A61P29/00 , A61P35/00 , C07D401/14 , C07D403/10 , C07D405/14 , C07D417/14
摘要： Compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof are provided, which are useful for the treatment of hyperproliferative, pain and inflammatory diseases. Methods of using compounds of Formula I or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

7. 发明申请

WO2012040641A3 COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：治疗神经退行性疾病的化合物
公开(公告)号：WO2012040641A3
公开(公告)日：2012-06-07
申请号：PCT/US2011053118
申请日：2011-09-23
申请人： ARRAY BIOPHARMA INC , HUNT KEVIN W , TANG TONY P , THOMAS ALLEN A
发明人： HUNT KEVIN W , TANG TONY P , THOMAS ALLEN A
IPC分类号： C07D491/107 , A61K31/4188 , A61P25/28 , C07D491/20
CPC分类号： A61K31/4188 , C07D491/107 , C07D491/20
摘要： The invention provides novel tricyclic compounds of Formula I' that inhibit ß-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
摘要翻译：本发明提供了抑制APP的β-分泌酶裂解并且可用作治疗神经退行性疾病的治疗剂的式I'的新三环化合物。

8. 发明申请

WO2006023452A2 CYCLOSPORIN ANALOGS FOR THE TREATMENT OF IMMUNOREGULATORY DISORDERS AND RESPIRATORY DISEASES 审中-公开
标题翻译：用于治疗免疫缺陷性疾病和呼吸道疾病的环磷酰胺类似物
公开(公告)号：WO2006023452A2
公开(公告)日：2006-03-02
申请号：PCT/US2005029003
申请日：2005-08-15
申请人： ARRAY BIOPHARMA INC , HUNT KEVIN W , BURGESS LAURENCE E
发明人： HUNT KEVIN W , BURGESS LAURENCE E
IPC分类号： A61K38/13 , C07K7/64
CPC分类号： A61K38/13 , A61K47/54 , A61K47/545 , C07K7/645
摘要： Provided are novel cyclosporin analogs, methods for their production, and their use for treating immunoregulatory and respiratory diseases, disorders, and conditions.
摘要翻译：提供新的环孢菌素类似物，其生产方法及其用于治疗免疫调节和呼吸系统疾病，病症和病症的用途。

9. 发明专利

AU2016341445A1 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases 未知
公开(公告)号：AU2016341445A1
公开(公告)日：2018-05-10
申请号：AU2016341445
申请日：2016-10-24
申请人： ARRAY BIOPHARMA INC
发明人： ANDREWS STEVEN W , BLAKE JAMES F , COOK ADAM , GUNAWARDANA INDRANI W , HUNT KEVIN W , METCALF ANDREW T , MORENO DAVID , REN LI , TANG TONY P
IPC分类号： C07D401/14 , A61K31/444 , A61P35/00 , C07D403/14
摘要： Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R

10. 发明专利

CA3002560A1 2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES 未知
公开(公告)号：CA3002560A1
公开(公告)日：2017-04-27
申请号：CA3002560
申请日：2016-10-24
申请人： ARRAY BIOPHARMA INC
发明人： ANDREWS STEVEN W , BLAKE JAMES F , COOK ADAM , GUNAWARDANA INDRANI W , HUNT KEVIN W , METCALF ANDREW T , MORENO DAVID , REN LI , TANG TONY P
IPC分类号： C07D401/14 , A61K31/444 , A61P35/00 , C07D403/14
摘要： Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X, R1, R2, R3, Ring A and z have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.

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