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1. 发明申请

WO2012040641A3 COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES 审中-公开
标题翻译：治疗神经退行性疾病的化合物
公开(公告)号：WO2012040641A3
公开(公告)日：2012-06-07
申请号：PCT/US2011053118
申请日：2011-09-23
申请人： ARRAY BIOPHARMA INC , HUNT KEVIN W , TANG TONY P , THOMAS ALLEN A
发明人： HUNT KEVIN W , TANG TONY P , THOMAS ALLEN A
IPC分类号： C07D491/107 , A61K31/4188 , A61P25/28 , C07D491/20
CPC分类号： A61K31/4188 , C07D491/107 , C07D491/20
摘要： The invention provides novel tricyclic compounds of Formula I' that inhibit ß-secretase cleavage of APP and are useful as therapeutic agents for treating neurodegenerative diseases.
摘要翻译：本发明提供了抑制APP的β-分泌酶裂解并且可用作治疗神经退行性疾病的治疗剂的式I'的新三环化合物。

3. 发明专利

CO2022003782A2 Inhibidores de kras g12d 未知
公开(公告)号：CO2022003782A2
公开(公告)日：2022-07-08
申请号：CO2022003782
申请日：2022-03-29
申请人： ARRAY BIOPHARMA INC , MIRATI THERAPEUTICS INC
发明人： WANG XIAOLUN , BURNS AARON CRAIG , CHRISTENSEN JAMES GAIL , KETCHAM JOHN MICHAEL , LAWSON JOHN DAVID , MARX MATTHEW ARNOLD , SMITH CHRISTOPHER RONALD , ALLEN SHELLEY , BLAKE JAMES FRANCIS , CHICARELLI MARK JOSEPH , DAHLKE JOSHUA RYAN , DAI DONGHUA , FELL JAY BRADFORD , FISCHER JOHN PETER , MEJIA MACEDONIO J , NEWHOUSE BRAD , NGUYEN PHONG , O'LEARY JACOB MATTHEW , PAJK SPENCER , RODRIGUEZ MARTHA E , SAVECHENKOV PAVEL , TANG TONY P , VIGERS GUY P A , ZHAO QIAN , KAHN DEAN RUSSELL , GAUDINO JOHN , HILTON MICHAEL CHRISTOPHER
IPC分类号： A61K31/435 , A61K31/4375 , A61K31/517 , C07D471/00 , C07D471/02 , C07D471/04
摘要： La presente invención se refiere a compuestos que inhiben KRas G12D. En particular, la presente invención se refiere a compuestos que inhiben la actividad de KRas G12D, composiciones farmacéuticas que comprenden los compuestos y métodos de uso de las mismas.

4. 发明专利

UA125030C2 ЗАМІЩЕНІ ПІРАЗОЛО[1,5-a]ПІРИДИНОВІ СПОЛУКИ ЯК ІНГІБІТОРИ RET-КІНАЗИ 未知
公开(公告)号：UA125030C2
公开(公告)日：2021-12-29
申请号：UAA201903994
申请日：2017-10-10
申请人： ARRAY BIOPHARMA INC
发明人： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , TANG TONY P , REN LI
摘要： УданомудокументізапропонованісполукиформулиІ іїхстереоізомери, іфармацевтичноприйнятнісоліабосольвати, вякихА, В, X1, X2, X3, X4, кільце D іΕ маютьзначення, наведенів описі, якіявляютьсобоюінгібітори RET-кіназиі корисніприлікуванніі профілактицізахворювань, якіможутьлікуватисяінгібітором RET-кінази, включаючизахворюванняі розлади, пов'язаніз RET.

5. 发明专利

TN2019000110A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS 未知
公开(公告)号：TN2019000110A1
公开(公告)日：2020-10-05
申请号：TN2019000110
申请日：2017-10-10
申请人： ARRAY BIOPHARMA INC
发明人： MORENO DAVID A , MCFADDIN ELIZABETH A , TANG TONY P , HAAS JULIA , JIANG YUTONG , BRANDHUBER BARBARA J , ARONOW SEAN , MCNULTY OREN T , METCALF ANDREW T , ANDREWS STEVEN W , BLAKE JAMES F , KOLAKOWSKI GABRIELLE R , COOK ADAM , MCKENNEY MEGAN L , REN LI
IPC分类号： A61K31/437 , A61P35/00 , C07D471/04
摘要： Provided herein are compounds of the Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X 1 , X 2 , X 3 , X 4 , Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

6. 发明专利

CR20190218A COMPUESTOS DE PIRAZOLO[1,5-A]PIRIDINA SUSTITUIDOS COMO INHIBIDORES DE LA QUINASA RET 未知
公开(公告)号：CR20190218A
公开(公告)日：2019-10-14
申请号：CR20190218
申请日：2017-10-10
申请人： ARRAY BIOPHARMA INC
发明人： BRANDHUBER BARBARA J , COOK ADAM , METCALF ANDREW T , MORENO DAVID A , REN LI , ANDREWS STEVEN W , ARONOW SEAN , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , BLAKE JAMES F , JIANG YUTONG , MCKENNEY MEGAN L , MCNULTY OREN T , TANG TONY P , HAAS JULIA
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Se proporciona en la presente compuestos de la Fórmula I: y estereoisómeros y sales o solvatos aceptables desde el punto de vista farmacéutico de estos, en donde A, B, X1, X2, X3, X4, Anillo D y E tienen los significados dados en la memoria descriptiva, que son inhibidores de quinasa RET y son útiles en el tratamiento y prevención de enfermedades que se pueden tratar con un inhibidor de quinasa RET, lo que incluye enfermedades y trastornos asociados con RET.Provided herein are compounds of the Formula I and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

7. 发明专利

UA120065C2 4,6-ЗАМІЩЕНІ ПІРАЗОЛО[1,5-a]-ПІРАЗИНИ ЯК ІНГІБІТОРИ JAK-КІНАЗИ 未知
公开(公告)号：UA120065C2
公开(公告)日：2019-09-25
申请号：UAA201707008
申请日：2015-12-04
申请人： ARRAY BIOPHARMA INC , CELGENE CORP
发明人： ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
摘要： СполукиформулиІ Іі їхстереоізомериі фармацевтичноприйнятнісоліі сольвати, де R1, R2, R3 і R4 маютьзначення, наведеніу описі, являютьсобоюінгібіториоднієїабобільшекіназ JAK іефективніприлікуваннізахворюваньаборозладів, пов'язанихз кіназами JAK, такихякаутоімуннізахворювання, запальнізахворювання, відторгненнятрансплантованихорганів, тканині клітин, атакожгематологічнірозладиі злоякісніновоутворенняі їхсупутнізахворювання.

8. 发明专利

ECSP19033052A COMPUESTOS DE PIRAZOLO[1,5-A]PIRIDINA SUSTITUIDOS COMO INHIBIDORES DE LA QUINASA RET 未知
公开(公告)号：ECSP19033052A
公开(公告)日：2019-07-31
申请号：ECDI201933052
申请日：2019-05-10
申请人： ARRAY BIOPHARMA INC
发明人： MORENO DAVID A , HAAS JULIA , BLAKE JAMES F , REN LI , BRANDHUBER BARBARA J , MCNULTY OREN T , ARONOW SEAN , JIANG YUTONG , ANDREWS STEVEN W , COLLIER JAMES , MCKENNEY MEGAN L , COOK ADAM , RAMANN GINELLE A , KOLAKOWSKI GABRIELLE R , METCALF ANDREW T , TANG TONY P , MCFADDIN ELIZABETH A , WALLS SHANE M
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Se proporciona en la presente compuestos de la Fórmula I o sales o solvatos aceptables desde el punto de vista farmacéutico de estos, en donde A, B, X1, X2, X3, X4, Anillo D, E, Ra, Rb, n y m tienen los significados dados en la memoria descriptiva, que son inhibidores de quinasa RET y son útiles en el tratamiento y prevención de enfermedades que se pueden tratara con un inhibidor de quinasa RET, lo que incluye enfermedades y trastornos.

9. 发明专利

SG11201903144PA SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS 未知
公开(公告)号：SG11201903144PA
公开(公告)日：2019-05-30
申请号：SG11201903144P
申请日：2017-10-10
申请人： ARRAY BIOPHARMA INC
发明人： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , TANG TONY P , REN LI
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
摘要： INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1#11101111 0 11101 HOE 3E1 0 0111101111 01011101110 El MEV OEN Organization International Bureau (10) International Publication Number (43) International Publication Date ......0\" WO 2018/071447 Al 19 April 2018 (19.04.2018) WIP0 1 PCT (51) International Patent Classification: Street, Boulder, Colorado 80301 (US). MORENO, David CO7D 471/04 (2006.01) A61P 35/00 (2006.01) A. [US/US]; c/o Array BioPharma Inc., 3200 Walnut Street, A61K 31/437 (2006.01) Boulder, Colorado 80301 (US). TANG, Tony P. [US/US]; (21) International Application Number: c/o Array BioPharma Inc., 3200 Walnut Street, Boulder, Colorado 80301 (US). REN, Li [US/US]; c/o Array Bio- PCT/US2017/055983 Pharma Inc., 3200 Walnut Street, Boulder, Colorado 80301 (22) International Filing Date: (US). 10 October 2017 (10.10.2017) (74) Agent: FOLLETT, Angela D. et al.; Fish & Richardson (25) Filing Language: English P.C., P.O. Box 1022, Minneapolis, Minnesota 55440-1022 (26) Publication Language: English (US). (81) Designated States (unless otherwise indicated, for every (30) Priority Data: kind of national protection available): AE, AG, AL, AM, 62/406,252 10 October 2016 (10.10.2016) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/447,850 18 January 2017 (18.01.2017) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, 62/491,164 27 April 2017 (27.04.2017) US DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, 62/554,817 06 September 2017 (06.09.2017) US HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 62/566,093 29 September 2017 (29.09.2017) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (72) Inventors; and MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, _ (71) Applicants: ANDREWS, Steven W. [US/US]; c/o Array OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, BioPharma Inc., 3200 Walnut Street, Boulder, Colorado SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 80301 (US). ARONOW, Sean [US/US]; c/o Array Bio- TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — = Pharma, Inc., 3200 Walnut St., Boulder, Colorado 80301 (84) Designated States (unless otherwise indicated, for every (US). BLAKE, James F. [US/US]; c/o Array BioPhar- kind of regional protection available): ARIPO (BW, GH, ma Inc., 3200 Walnut Street, Boulder, Colorado 80301 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = ——_ BRANDHUBER, Barbara J. Array (US). [US/US]; c/o UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, BioPharma Inc., 3200 Walnut Street, Boulder, Colorado TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 80301 (US). COOK, Adam [US/US]; c/o Array BioPharma EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Inc., 3200 Walnut Street, Boulder, Colorado 80301 (US). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, HAAS, Julia [US/US]; c/o Array BioPharma Inc., 3200 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, = = _ = Walnut Street, Boulder, Colorado 80301 (US). JIANG, Yu- KM, ML, MR, NE, SN, TD, TG). tong [US/US]; c/o Array BioPharma Inc., 3200 Walnut Street, Boulder, Colorado 80301 (US). KOLAKOWSKI, = Published: Gabrielle R. [US/US]; c/o Array BioPharma Inc., 3200 — with international search report (Art. 21(3)) Walnut Street, Boulder, Colorado 80301 (US). MCFAD- — DIN, Elizabeth A. [US/US]; c/o Array BioPharma, Inc., with sequence listing part of description (Rule 5.2(a)) = 3200 Walnut St., Boulder, Colorado 80301 (US). MCKEN- NEY, Megan L. [US/US]; c/o Array BioPharma, Inc., 3200 Walnut St., Boulder, Colorado 80301 (US). MCNULTY, = = Oren T. [US/US]; c/o Array BioPharma, Inc., 3200 Wal- nut St., Boulder, Colorado 80301 (US). METCALF, An- _ = drew T. [US/US]; c/o Array BioPharma Inc., 3200 Walnut = (54) Title: SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS (57) : Provided herein are compounds of the Formula I and stereoiso- mers and pharmaceutically acceptable salts or solvates thereof, in which A, B, N —— IN / X 1 , X 2 , X 3 , X 4 , Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and preven- 71' I 3 tion of diseases which can be treated with a RET kinase inhibitor, including 71' 11 B' r)(X2 O I (I) RET-associated diseases and disorders. Il 0X 4 , -:..t, X 1 NI.-. E (..?../ 0 ei C

10. 发明专利

CA3039760A1 SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS 未知
公开(公告)号：CA3039760A1
公开(公告)日：2018-04-19
申请号：CA3039760
申请日：2017-10-10
申请人： ARRAY BIOPHARMA INC
发明人： ANDREWS STEVEN W , ARONOW SEAN , BLAKE JAMES F , BRANDHUBER BARBARA J , COOK ADAM , HAAS JULIA , JIANG YUTONG , KOLAKOWSKI GABRIELLE R , MCFADDIN ELIZABETH A , MCKENNEY MEGAN L , MCNULTY OREN T , METCALF ANDREW T , MORENO DAVID A , TANG TONY P , REN LI
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
摘要： Provided herein are compounds of the Formula I and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which A, B, X1, X2, X3, X4, Ring D, and E have the meanings given in the specification, which are inhibitors of RET kinase and are useful in the treatment and prevention of diseases which can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders.

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