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    • 3. 发明申请
    • INTEGRATED OPTICAL NEURAL PROBE
    • 综合光学神经探针
    • WO2013016350A2
    • 2013-01-31
    • PCT/US2012/047997
    • 2012-07-24
    • DIAGNOSTIC BIOCHIPS, LLCJAMIESON, BrianMATEO, Jennette
    • JAMIESON, BrianMATEO, Jennette
    • A61B5/04A61B6/00
    • A61B5/6868A61B5/0084A61B5/04001A61B5/6848A61B2018/2266A61B2018/2272A61B2562/046A61N5/0622A61N2005/0612A61N2005/065
    • In certain embodiments, a neural probe comprises a substrate comprising elongated shanks for penetrating neural tissue, each comprising a proximal end and a distal end; at least one optical source integral to the neural probe for illuminating the neural tissue; and microelectrodes located proximate the distal end of the elongated shanks for monitoring neuronal activity. In certain embodiments, a method of monitoring neuronal activity comprises implanting the neural probe into a test subject such that the elongated shanks protrude into neural tissue of the test subject; illuminating the neural tissue with the at least one optical source; and measuring neuronal activity in response to illuminating the neural tissue. In certain embodiments, a device comprises a semiconductor chip; at least one optical source integral to the semiconductor chip; and sensor elements integral to the semiconductor chip for collecting data responsive to light emitted from the at least one optical source.
    • 在某些实施例中,神经探针包括基底,其包括用于穿透神经组织的细长柄,每个包括近端和远端; 至少一个与神经探针成一体的光源,用于照射神经组织; 和微电极位于细长柄的远端附近,用于监测神经元活动。 在某些实施方案中,监测神经元活性的方法包括将神经探针植入测试对象中,使得细长柄突出到测试对象的神经组织中; 用所述至少一个光源照亮所述神经组织; 并测量响应照射神经组织的神经元活动。 在某些实施例中,装置包括半导体芯片; 至少一个与半导体芯片成一体的光源; 以及与所述半导体芯片成一体的传感器元件,用于响应于从所述至少一个光源发射的光收集数据。